Abnormal myeloid leukocyte morphology

0010974

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

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Sex Split

Interactive Plot

Statistics

Case	Control
45880	414314

Phenotype Definition

An abnormality of myeloid leukocytes. [HPO:probinson]

Phenotype Comment

A myeloid leukocyte refers to a cell of the monocyte, granulocyte, or mast cell lineage.

Top SNP Information

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr5:167170953	rs13436693	TENM2	A>C	10441	88437	40.47	1.993e-10	1.072
chr3:49210732	rs7617480	KLHDC8B	C>A	22362	195048	27.84	1.318e-07	1.043
chr3:49213637	rs9586	KLHDC8B	T>C	22031	192201	27.2	1.839e-07	1.043
chr22:42448761	rs5758563	WBP2NL	G>T	1250	13126	27.01	2.026e-07	0.8567
chr2:206117273	rs72940337	PARD3B	C>T	6229	60006	26.58	2.522e-07	0.9315
chr12:58002599	rs2306390	DTX3	C>T	24496	227544	26.44	2.716e-07	0.9608
chr8:73857454	rs4738295	-	A>C	4143	40413	24.78	6.426e-07	0.9204
chr2:56111309	rs3791675	EFEMP1	C>T	22245	206727	24.47	7.56e-07	0.961
chr11:125143775	rs10400381	PKNOX2	A>G	4853	40656	24.47	7.53e-07	1.08
chr12:57985204	rs11537654	PIP4K2C	C>T	24657	228643	24.08	9.226e-07	0.9626
chr2:56096892	rs3791679	EFEMP1	A>G	21549	200429	23.96	9.821e-07	0.961
chr3:196749408	rs17129227	MELTF	C>A	12661	109360	23.81	1.064e-06	1.05
chr6:31542308	rs1799964	-	T>C	20909	182683	23.7	1.124e-06	1.041
chr6:93645908	rs77956657	-	T>C	1353	13973	23.22	1.444e-06	0.871
chr8:117494802	rs13268307	-	G>A	14341	134469	23.14	1.504e-06	0.9552
chr6:31556581	rs1052248	LST1	T>A	26008	228217	23.09	1.542e-06	1.038
chr20:16747222	rs6044297	OTOR	G>A	28452	249969	23.03	1.598e-06	1.036
chr12:57968715	rs1678542	KIF5A	C>G	35940	330878	22.74	1.852e-06	0.9672
chr1:193952059	rs61833019	-	C>T	3537	29337	22.72	1.878e-06	1.09
chr8:117583802	rs6982244	-	C>T	18313	170623	22.37	2.247e-06	0.96
chr5:167170953	rs13436693	TENM2	A>C	9532	81223	31.89	1.632e-08	1.067
chr2:206117273	rs72940337	PARD3B	C>T	5872	56775	26.43	2.731e-07	0.9297
chr20:16747222	rs6044297	OTOR	G>A	26512	232879	24.71	6.677e-07	1.039
chr1:193952059	rs61833019	-	C>T	3477	28774	24.56	7.221e-07	1.095
chr6:31542308	rs1799964	-	T>C	19562	170971	23.97	9.797e-07	1.043
chr3:196749408	rs17129227	MELTF	C>A	11411	98539	23.32	1.371e-06	1.052
chr12:58002599	rs2306390	DTX3	C>T	22948	213235	22.71	1.885e-06	0.9625
chr3:49210732	rs7617480	KLHDC8B	C>A	21190	185588	22.65	1.946e-06	1.04
chr6:31556581	rs1052248	LST1	T>A	23970	210565	22.44	2.172e-06	1.038
chr12:57985204	rs11537654	PIP4K2C	C>T	23049	214075	22.38	2.239e-06	0.9628
chr6:31564821	rs2844480	-	C>T	18604	162576	22.35	2.272e-06	1.042
chr12:57968715	rs1678542	KIF5A	C>G	33097	305455	22.28	2.353e-06	0.9664
chr12:58065448	rs2640629	-	T>C	30002	277401	22.05	2.661e-06	0.9658
chr22:41646738	rs11703267	RANGAP1	A>G	39154	360459	21.89	2.889e-06	0.9676
chr3:49213637	rs9586	KLHDC8B	T>C	20825	182522	21.26	4.013e-06	1.039
chr22:41704872	rs34011394	ZC3H7B	C>T	39125	359693	20.86	4.947e-06	0.9684
chr12:58018979	rs1871417	AC025165.6	C>T	28551	263789	20.74	5.266e-06	0.9663
chr19:15677710	rs1273516	-	G>A	34742	319995	20.59	5.695e-06	0.968
chr6:31275211	rs28367687	HLA-B	G>C	4064	39445	20.25	6.795e-06	0.927
chr1:109679313	rs591209	KIAA1324	C>T	30123	278170	20.07	7.46e-06	0.9673

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr6:396321	rs12203592	IRF4	C>T	20167	20736	53.59	2.475e-13	0.9208
chr6:32452707	rs115484013	-	C>T	17170	17725	48.3	3.649e-12	0.9205
chr6:32666526	rs1794282	-	C>T	11489	12048	45.9	1.246e-11	0.9096
chr6:32303692	rs1265754	TSBP1	T>A	11693	12231	44.44	2.623e-11	0.9116
chr6:32302382	rs1265757	TSBP1	C>T	11657	12198	44.21	2.952e-11	0.9117
chr6:32261252	rs7775397	TSBP1	T>G	11693	12230	43.72	3.786e-11	0.9123
chr6:32333827	rs3129927	TSBP1	A>C	11696	12225	43.38	4.5e-11	0.9126
chr6:32408497	rs3135394	HLA-DRA	A>G	11635	12164	43.15	5.064e-11	0.9126
chr6:32345689	rs2894254	-	T>G	11644	12169	42.73	6.274e-11	0.9131
chr6:32395726	rs3129843	-	A>G	11603	12127	42.55	6.893e-11	0.9131
chr6:32310863	rs2849018	TSBP1	T>C	11704	12226	42.21	8.206e-11	0.9137
chr6:32325562	rs2395149	TSBP1	G>A	11692	12213	42.16	8.392e-11	0.9138
chr6:421281	rs62389423	-	G>A	16353	16840	42.13	8.547e-11	0.9241
chr6:32659645	rs2856674	-	A>G	13301	13813	41.44	1.215e-10	0.9186
chr6:32605884	rs2187668	HLA-DQA1	C>T	13017	13506	41.39	1.247e-10	0.9179
chr6:32603007	rs2040406	HLA-DQA1	A>G	15915	16393	40.76	1.724e-10	0.9245
chr6:32765585	rs9276731	-	G>T	10826	11332	40.72	1.757e-10	0.9125
chr6:32284108	rs9268219	TSBP1	T>G	10999	11490	40.68	1.791e-10	0.913
chr6:32657436	rs3129716	-	T>C	13237	13724	40.26	2.222e-10	0.9196
chr6:32442261	rs6901541	-	T>C	18929	19360	40.06	2.469e-10	0.9297

Associated Diseases ^ⓘ

ID	Name	Top Correlation
ICD: R69	Unknown and unspecified causes of morbidity	1/20

ID	Name	Top Correlation
ICD-10: A408	Other streptococcal septicaemia	0/20
ICD-10: A415	Septicaemia due to other Gram-negative organisms	0/20
ICD-10: A418	Other specified septicaemia	0/20
ICD-10: A490	Staphylococcal infection, unspecified	0/20
ICD-10: C672	Lateral wall of bladder	0/20
ICD-10: C772	Intra-abdominal lymph nodes	0/20
ICD-10: C830	Small cell (diffuse)	0/20
ICD-10: D70	Agranulocytosis	0/20
ICD-10: D721	Eosinophilia	0/20
ICD-10: D759	Disease of blood and blood-forming organs, unspecified	0/20
ICD-10: D868	Sarcoidosis of other and combined sites	0/20
ICD-10: D869	Sarcoidosis, unspecified	0/20
ICD-10: J14	Pneumonia due to Haemophilus influenzae	0/20
ICD-10: J42	Unspecified chronic bronchitis	0/20
ICD-10: K350	Acute appendicitis with generalised peritonitis	0/20
ICD-10: M073	Other psoriatic arthropathies	0/20
ICD-10: M313	Wegener's granulomatosis	0/20
ICD-10: M950	Acquired deformity of nose	0/20
ICD-10: N300	Acute cystitis	0/20
ICD-10: N303	Trigonitis	0/20
ICD-10: N390	Urinary tract infection, site not specified	0/20
ICD-10: N771	Vaginitis, vulvitis and vulvovaginitis in infectious and parasitic diseases classified elsewhere	0/20
ICD-10: N990	Postprocedural renal failure	0/20
ICD-10: O234	Unspecified infection of urinary tract in pregnancy	0/20
ICD-10: R093	Abnormal sputum	0/20
ICD-10: R300	Dysuria	0/20
ICD-10: R309	Painful micturition, unspecified	0/20
ICD-10: R500	Fever with chills	0/20
ICD-10: R688	Other specified general symptoms and signs	0/20
ICD-10: R829	Other and unspecified abnormal finding in urine	0/20

Abnormal myeloid leukocyte morphology

0010974

Normal Case/Contol ⓘ

Sibling Case/Control ⓘ

Links

Statistics

Phenotype Definition

Phenotype Comment

Top SNP Information Show Normal Table Show Sibling SNP

Associated Diseases ⓘ Shared SNP diseases No shared SNP diseases

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

Top SNP Information

Associated Diseases ^ⓘ