Statistics
| Case | Control |
|---|---|
| 10405 | 449789 |
Phenotype Definition
An abnormality of the cerebral subcortex. [HPO:probinson]
Phenotype Comment
The cerebral subcortex contains the basal ganglia and the cerebral white matter.
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:137344363 | rs1744080 | IL20RA | G>A | 485 | 16125 | 32.19 | 1.398e-08 | 1.302 |
| chr6:137313319 | rs1744088 | - | A>G | 405 | 13242 | 30.71 | 2.997e-08 | 1.325 |
| chr1:159174683 | rs2814778 | ACKR1 | T>C | 550 | 18827 | 28.89 | 7.67e-08 | 1.265 |
| chr1:173579034 | rs12065033 | AL139142.2 | C>T | 443 | 14898 | 27.01 | 2.022e-07 | 1.287 |
| chr13:33393342 | rs6561581 | - | G>A | 1173 | 43562 | 26.55 | 2.572e-07 | 1.169 |
| chr10:114925758 | rs1056877 | TCF7L2 | T>C | 367 | 12084 | 26.21 | 3.056e-07 | 1.314 |
| chr1:145094900 | rs28758781 | - | C>T | 2453 | 95658 | 25.95 | 3.5e-07 | 1.117 |
| chr6:137325847 | rs1555498 | IL20RA | T>C | 388 | 12949 | 25.07 | 5.515e-07 | 1.296 |
| chr10:1411012 | rs12762472 | ADARB2 | G>C | 298 | 9591 | 25.01 | 5.712e-07 | 1.343 |
| chr4:138433162 | rs9683944 | - | A>G | 5085 | 205718 | 24.55 | 7.255e-07 | 1.083 |
| chr4:76788564 | rs34155925 | PPEF2 | C>T | 296 | 9582 | 23.94 | 9.943e-07 | 1.336 |
| chr8:116631902 | rs7823278 | TRPS1 | C>A | 335 | 11024 | 23.91 | 1.01e-06 | 1.313 |
| chr23:148151708 | Affx-34694529 | - | A>C | 262 | 8589 | 23.84 | 1.047e-06 | 1.36 |
| chr22:24953349 | rs2298389 | SNRPD3 | T>C | 507 | 17584 | 23.81 | 1.065e-06 | 1.248 |
| chr16:82182229 | rs3751862 | MPHOSPH6 | A>C | 425 | 14451 | 23.52 | 1.236e-06 | 1.272 |
| chr10:123261694 | rs2912754 | FGFR2 | T>C | 759 | 27503 | 22.71 | 1.884e-06 | 1.195 |
| chr4:7333181 | rs28446774 | SORCS2 | C>T | 328 | 10863 | 22.61 | 1.981e-06 | 1.307 |
| chr5:101155096 | rs72770602 | - | C>T | 7224 | 325574 | 22.21 | 2.441e-06 | 0.934 |
| chr10:97883062 | rs78130758 | - | C>T | 1022 | 38062 | 22.05 | 2.655e-06 | 1.164 |
| chr17:29268139 | rs9907098 | ADAP2 | C>A | 499 | 17416 | 21.87 | 2.922e-06 | 1.239 |
| chr10:97883062 | rs78130758 | - | C>T | 1007 | 37327 | 24.3 | 8.223e-07 | 1.175 |
| chr18:2550858 | rs9949044 | METTL4 | C>A | 667 | 34699 | 23.06 | 1.573e-06 | 0.8265 |
| chr21:31638959 | rs2832733 | - | G>A | 2358 | 92965 | 22.21 | 2.44e-06 | 1.11 |
| chr18:2554807 | rs34143130 | METTL4 | T>G | 679 | 35022 | 21.73 | 3.133e-06 | 0.8324 |
| chr15:77386384 | rs113792865 | - | G>A | 805 | 29595 | 21.13 | 4.296e-06 | 1.182 |
| chr15:80985287 | rs11629662 | ABHD17C | A>G | 3188 | 127824 | 20.3 | 6.625e-06 | 1.092 |
| chr21:31744310 | rs3804010 | KRTAP13-2 | G>C | 2386 | 94405 | 20.25 | 6.786e-06 | 1.104 |
| chr1:4362747 | rs77897177 | - | T>C | 863 | 43310 | 19.88 | 8.233e-06 | 0.8552 |
| chr2:212077276 | rs12478428 | - | A>G | 5796 | 263215 | 19.71 | 9.017e-06 | 0.9329 |
| chr4:39391549 | rs115673757 | - | A>G | 326 | 17982 | 19.5 | 1.006e-05 | 0.7802 |
| chr2:15362114 | rs7594619 | NBAS | G>T | 256 | 8422 | 18.78 | 1.464e-05 | 1.318 |
| chr1:98687691 | rs12129731 | - | C>T | 5263 | 239572 | 18.76 | 1.483e-05 | 0.9325 |
| chr4:74925367 | rs76446141 | - | C>T | 572 | 20637 | 18.62 | 1.593e-05 | 1.203 |
| chr21:31707455 | rs2832806 | - | G>A | 2360 | 93744 | 18.61 | 1.606e-05 | 1.1 |
| chr10:98059377 | rs72811052 | - | C>T | 308 | 17002 | 18.56 | 1.65e-05 | 0.7797 |
| chr3:170849513 | rs115419280 | TNIK | A>C | 821 | 30569 | 18.5 | 1.7e-05 | 1.168 |
| chr11:134320204 | rs116972688 | - | C>T | 450 | 15869 | 18.49 | 1.71e-05 | 1.231 |
| chr15:31552308 | rs11633553 | - | C>A | 505 | 18031 | 18.42 | 1.772e-05 | 1.216 |
| chr4:176069166 | rs17061161 | - | C>A | 7559 | 339884 | 18.36 | 1.83e-05 | 0.9394 |
| chr10:97637383 | rs17470060 | AL365273.2 | T>C | 683 | 25060 | 18.26 | 1.932e-05 | 1.183 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr10:85072264 | rs10886114 | - | G>A | 8647 | 28795 | 27.59 | 1.498e-07 | 1.088 |
| chr10:85129166 | rs11198340 | - | C>T | 8360 | 27987 | 26.35 | 2.85e-07 | 1.087 |
| chr4:74925367 | rs76446141 | - | C>T | 572 | 1588 | 23.36 | 1.342e-06 | 1.269 |
| chr6:32968929 | rs12199692 | - | T>G | 6670 | 22162 | 21.51 | 3.515e-06 | 1.082 |
| chr1:99326002 | rs74451565 | - | C>T | 1079 | 4392 | 20.74 | 5.258e-06 | 0.8531 |
| chr6:32968276 | rs2395300 | - | G>A | 6685 | 22242 | 20.19 | 7.023e-06 | 1.079 |
| chr11:61126858 | rs4939517 | CYB561A3 | T>C | 2691 | 10313 | 19.92 | 8.089e-06 | 0.9015 |
| chr13:72652461 | rs726250 | - | G>T | 1727 | 5366 | 19.87 | 8.273e-06 | 1.137 |
| chr6:32968693 | rs2395301 | - | C>T | 6671 | 22196 | 19.86 | 8.316e-06 | 1.078 |
| chr11:61159661 | rs10750955 | - | C>T | 2718 | 10409 | 19.84 | 8.405e-06 | 0.9021 |
| chr4:107443416 | rs4956073 | - | A>C | 9253 | 31185 | 19.7 | 9.078e-06 | 1.073 |
| chr6:32967741 | rs12216336 | - | G>C | 6697 | 22274 | 19.67 | 9.198e-06 | 1.078 |
| chr8:102038447 | rs72667386 | - | G>A | 566 | 1604 | 19.59 | 9.582e-06 | 1.245 |
| chr10:97883062 | rs78130758 | - | C>T | 1007 | 3017 | 19.59 | 9.622e-06 | 1.179 |
| chr6:32967914 | rs12190787 | - | G>C | 6709 | 22351 | 19.55 | 9.82e-06 | 1.077 |
| chr21:31638959 | rs2832733 | - | G>A | 2358 | 7494 | 19.41 | 1.053e-05 | 1.117 |
| chr7:8075387 | rs111304183 | GLCCI1 | G>A | 531 | 2288 | 19.19 | 1.181e-05 | 0.8077 |
| chr2:212077276 | rs12478428 | - | A>G | 5796 | 21455 | 19.13 | 1.22e-05 | 0.9264 |
| chr11:61165741 | rs10897158 | TMEM216 | C>G | 3087 | 11733 | 19.03 | 1.284e-05 | 0.9086 |
| chr12:15693895 | rs2268140 | PTPRO | A>G | 1206 | 4835 | 18.83 | 1.432e-05 | 0.866 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: I678 | Other specified cerebrovascular diseases | 5/20 |
| ICD: O140 | Moderate preeclampsia | 6/20 |