Statistics
| Female Case | Female Control | % Female |
|---|---|---|
| 763 | 249094 | 56% |
| Male Case | Male Control | % Male |
|---|---|---|
| 594 | 209743 | 44% |
Phenotype Definition
Absence of the semicircular canal. [DDD:dfitzpatrick]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr15:60648931 | rs116841473 | ANXA2 | C>T | 75 | 13257 | 28.38 | 9.971e-08 | 1.862 |
| chr14:65948076 | rs76389600 | FUT8 | T>G | 56 | 9398 | 25.03 | 5.636e-07 | 1.954 |
| chr14:65946948 | rs79092574 | FUT8 | A>G | 72 | 13084 | 24.82 | 6.286e-07 | 1.81 |
| chr2:234991454 | rs77743342 | - | A>G | 91 | 17696 | 24.8 | 6.36e-07 | 1.703 |
| chr1:10027540 | rs2890358 | NMNAT1 | A>G | 360 | 92020 | 23.57 | 1.202e-06 | 1.336 |
| chr2:234966035 | rs28903995 | SPP2 | T>C | 91 | 17910 | 23.45 | 1.281e-06 | 1.679 |
| chr11:25941885 | rs35436595 | - | G>A | 42 | 6644 | 22.56 | 2.035e-06 | 2.072 |
| chr10:77710913 | rs16932737 | LRMDA | A>G | 78 | 14910 | 22.46 | 2.15e-06 | 1.724 |
| chr14:66257203 | rs79607292 | - | G>T | 53 | 9135 | 21.84 | 2.97e-06 | 1.903 |
| chr1:10003320 | rs1234694 | LZIC | A>G | 358 | 92287 | 21.68 | 3.222e-06 | 1.321 |
| chr7:93454125 | rs10252731 | GNGT1 | A>G | 64 | 11710 | 21.54 | 3.459e-06 | 1.795 |
| chr6:4069685 | rs639905 | FAM217A | C>T | 385 | 101140 | 21.18 | 4.182e-06 | 1.308 |
| chr16:84802172 | rs11149681 | USP10 | G>A | 564 | 154735 | 20.88 | 4.886e-06 | 1.268 |
| chr12:113565933 | rs34598602 | RASAL1 | G>A | 162 | 36915 | 20.57 | 5.751e-06 | 1.454 |
| chr23:86650738 | rs147253858 | - | C>T | 90 | 18220 | 20.46 | 6.09e-06 | 1.627 |
| chr4:153661060 | rs115154496 | - | C>T | 36 | 5579 | 20.3 | 6.617e-06 | 2.105 |
| chr1:237284996 | rs115303770 | RYR2 | C>T | 35 | 5386 | 20.21 | 6.935e-06 | 2.123 |
| chr17:72212289 | rs12602043 | TTYH2 | A>G | 41 | 6640 | 20.07 | 7.478e-06 | 2.007 |
| chr12:129601389 | rs117112480 | TMEM132D | A>C | 85 | 17091 | 20.0 | 7.757e-06 | 1.639 |
| chr14:36397680 | rs1168987 | BRMS1L | C>T | 156 | 35711 | 19.97 | 7.88e-06 | 1.455 |
| chr15:60648931 | rs116841473 | ANXA2 | C>T | 74 | 13052 | 29.27 | 6.288e-08 | 1.889 |
| chr14:65946948 | rs79092574 | FUT8 | A>G | 72 | 12844 | 27.6 | 1.492e-07 | 1.87 |
| chr14:65948076 | rs76389600 | FUT8 | T>G | 56 | 9294 | 26.9 | 2.144e-07 | 2.002 |
| chr14:66257203 | rs79607292 | - | G>T | 53 | 9033 | 23.53 | 1.23e-06 | 1.95 |
| chr2:234966035 | rs28903995 | SPP2 | T>C | 81 | 15712 | 23.14 | 1.507e-06 | 1.723 |
| chr12:113565933 | rs34598602 | RASAL1 | G>A | 160 | 36173 | 22.88 | 1.724e-06 | 1.489 |
| chr11:25941885 | rs35436595 | - | G>A | 41 | 6496 | 22.7 | 1.895e-06 | 2.095 |
| chr4:153661060 | rs115154496 | - | C>T | 36 | 5453 | 22.39 | 2.222e-06 | 2.183 |
| chr1:151146276 | rs7521416 | TMOD4 | C>T | 37 | 5674 | 22.21 | 2.441e-06 | 2.155 |
| chr2:234991454 | rs77743342 | - | A>G | 81 | 15908 | 22.21 | 2.446e-06 | 1.704 |
| chr15:60578052 | rs117150939 | - | T>C | 66 | 12330 | 21.45 | 3.623e-06 | 1.78 |
| chr12:129601389 | rs117112480 | TMEM132D | A>C | 84 | 16825 | 21.14 | 4.26e-06 | 1.668 |
| chr23:16426063 | rs73204659 | - | G>A | 120 | 26109 | 20.95 | 4.719e-06 | 1.542 |
| chr2:74323500 | rs828869 | TET3 | A>G | 689 | 196632 | 20.88 | 4.884e-06 | 1.265 |
| chr17:72212289 | rs12602043 | TTYH2 | A>G | 34 | 5191 | 20.48 | 6.013e-06 | 2.157 |
| chr16:54408434 | rs117223174 | - | G>A | 47 | 8048 | 20.4 | 6.289e-06 | 1.933 |
| chr6:39218583 | rs114870945 | - | G>A | 50 | 8793 | 19.99 | 7.781e-06 | 1.885 |
| chr5:132135372 | rs256869 | SEPTIN8 | T>C | 178 | 42314 | 19.93 | 8.027e-06 | 1.426 |
| chr1:237284996 | rs115303770 | RYR2 | C>T | 34 | 5315 | 19.42 | 1.046e-05 | 2.115 |
| chr13:24932135 | rs56069023 | - | A>G | 563 | 157563 | 18.98 | 1.318e-05 | 1.26 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr1:163831730 | rs1339995 | - | C>A | 490 | 205594 | 25.49 | 4.435e-07 | 0.747 |
| chr7:7795408 | rs56352031 | UMAD1 | G>A | 68 | 13505 | 24.51 | 7.381e-07 | 1.839 |
| chr11:111992592 | rs11214093 | AP002884.2 | C>T | 552 | 173535 | 21.27 | 3.985e-06 | 1.314 |
| chr2:131631493 | rs272144 | ARHGEF4 | G>A | 51 | 9680 | 21.01 | 4.562e-06 | 1.908 |
| chr6:15734884 | rs12213366 | - | G>A | 70 | 14617 | 20.74 | 5.265e-06 | 1.741 |
| chr7:44246317 | rs56298219 | YKT6 | C>T | 100 | 23128 | 19.99 | 7.797e-06 | 1.589 |
| chr22:34803550 | rs11089669 | - | C>T | 297 | 84026 | 19.38 | 1.073e-05 | 1.339 |
| chr14:62056250 | rs75007442 | AL355916.3 | T>C | 111 | 26605 | 18.93 | 1.358e-05 | 1.538 |
| chr22:35370103 | rs4821334 | - | A>G | 31 | 5157 | 18.85 | 1.415e-05 | 2.165 |
| chr11:48018395 | rs74679637 | PTPRJ | G>A | 80 | 17860 | 18.74 | 1.494e-05 | 1.643 |
| chr14:39062778 | rs8014198 | - | G>A | 502 | 152874 | 18.67 | 1.557e-05 | 1.283 |
| chr4:78542259 | rs17416208 | - | A>G | 58 | 11875 | 18.55 | 1.654e-05 | 1.773 |
| chr4:10176686 | rs73218792 | - | T>C | 152 | 38813 | 18.54 | 1.662e-05 | 1.45 |
| chr9:112193018 | rs79301918 | PTPN3 | T>C | 54 | 10880 | 18.48 | 1.713e-05 | 1.806 |
| chr4:8220424 | rs7679311 | SH3TC1 | C>T | 249 | 112062 | 18.3 | 1.89e-05 | 0.7392 |
| chr11:112085316 | rs2250417 | BCO2 | C>T | 670 | 211431 | 18.28 | 1.905e-05 | 1.274 |
| chr10:25486278 | rs117080668 | GPR158 | A>G | 46 | 8863 | 18.18 | 2.007e-05 | 1.881 |
| chr18:55558984 | rs117838846 | - | G>T | 38 | 6896 | 18.05 | 2.148e-05 | 1.99 |
| chr4:126136676 | rs56376065 | - | C>A | 58 | 12023 | 17.82 | 2.429e-05 | 1.753 |
| chr2:104609698 | rs17345090 | - | G>A | 60 | 12559 | 17.81 | 2.445e-05 | 1.738 |
| chr1:163831730 | rs1339995 | - | C>A | 457 | 191509 | 25.52 | 4.374e-07 | 0.7404 |
| chr7:7795408 | rs56352031 | UMAD1 | G>A | 67 | 13251 | 23.86 | 1.038e-06 | 1.834 |
| chr2:131631493 | rs272144 | ARHGEF4 | G>A | 51 | 9461 | 21.96 | 2.79e-06 | 1.936 |
| chr10:25486278 | rs117080668 | GPR158 | A>G | 45 | 8051 | 21.84 | 2.959e-06 | 2.01 |
| chr10:25451311 | rs113658056 | - | T>C | 45 | 8135 | 21.47 | 3.593e-06 | 1.998 |
| chr22:35371444 | rs5755470 | - | A>G | 28 | 4240 | 21.34 | 3.837e-06 | 2.363 |
| chr22:35370103 | rs4821334 | - | A>G | 27 | 4058 | 20.94 | 4.751e-06 | 2.378 |
| chr6:15734884 | rs12213366 | - | G>A | 68 | 14169 | 19.73 | 8.915e-06 | 1.732 |
| chr14:39062778 | rs8014198 | - | G>A | 477 | 143227 | 19.12 | 1.228e-05 | 1.295 |
| chr14:62056250 | rs75007442 | AL355916.3 | T>C | 108 | 25539 | 18.97 | 1.329e-05 | 1.548 |
| chr11:114009229 | rs4936289 | ZBTB16 | A>G | 528 | 160709 | 18.89 | 1.384e-05 | 1.289 |
| chr7:44246317 | rs56298219 | YKT6 | C>T | 97 | 22394 | 18.71 | 1.518e-05 | 1.577 |
| chr11:112085316 | rs2250417 | BCO2 | C>T | 623 | 193582 | 18.7 | 1.526e-05 | 1.285 |
| chr4:10176686 | rs73218792 | - | T>C | 151 | 38249 | 18.51 | 1.687e-05 | 1.453 |
| chr11:48018395 | rs74679637 | PTPRJ | G>A | 79 | 17515 | 18.35 | 1.843e-05 | 1.64 |
| chr23:135895198 | rs73566916 | - | C>G | 19 | 2619 | 18.31 | 1.878e-05 | 2.621 |
| chr18:55558984 | rs117838846 | - | G>T | 38 | 6819 | 18.24 | 1.947e-05 | 1.998 |
| chr6:40427748 | rs62395902 | LRFN2 | C>T | 151 | 38328 | 18.11 | 2.083e-05 | 1.447 |
| chr6:165180463 | rs9355506 | - | A>G | 331 | 95502 | 18.03 | 2.17e-05 | 1.316 |
| chr7:66429414 | rs77266199 | - | G>A | 57 | 11620 | 18.03 | 2.18e-05 | 1.768 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: H811 | Benign paroxysmal vertigo | 1/20 |
| ICD: H830 | Labyrinthitis | 2/20 |
| ID | Name | Top Correlation |
|---|