Statistics
| Case | Control |
|---|---|
| 16633 | 443561 |
Phenotype Definition
Delivery of a fetus through surgical incisions made through the abdominal wall (laparotomy) and the uterine wall (hysterotomy). []
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 2968 | 64090 | 112.8 | 2.428e-26 | 1.231 |
| chr23:106146349 | rs5962774 | MORC4 | T>C | 649 | 10377 | 103.6 | 2.513e-24 | 1.512 |
| chr23:64367019 | rs7064929 | - | G>A | 961 | 16605 | 101.2 | 8.26e-24 | 1.402 |
| chr23:128718936 | rs2362937 | OCRL | T>C | 1072 | 18879 | 100.4 | 1.232e-23 | 1.376 |
| chr23:9689127 | rs6638956 | TBL1X | A>C | 2760 | 55294 | 93.82 | 3.451e-22 | 1.219 |
| chr5:33958959 | rs28777 | SLC45A2 | A>C | 2519 | 54473 | 93.21 | 4.698e-22 | 1.226 |
| chr6:136480972 | rs9483910 | PDE7B | C>T | 1044 | 20326 | 89.04 | 3.876e-21 | 1.354 |
| chr15:48392165 | rs1834640 | - | A>G | 1472 | 30152 | 87.21 | 9.744e-21 | 1.289 |
| chr23:63410110 | rs61730681 | AMER1 | T>C | 1242 | 22891 | 85.4 | 2.436e-20 | 1.315 |
| chr2:66725070 | rs12995572 | MEIS1 | G>C | 1281 | 25870 | 84.98 | 3.014e-20 | 1.307 |
| chr23:128902863 | rs859585 | XPNPEP2 | G>A | 1890 | 36731 | 84.5 | 3.836e-20 | 1.25 |
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 1295 | 26231 | 83.85 | 5.326e-20 | 1.303 |
| chr9:117110112 | Affx-52344420 | AKNA | T>TG | 742 | 13837 | 82.72 | 9.467e-20 | 1.411 |
| chr23:19209307 | rs960190 | - | T>C | 1298 | 24183 | 81.99 | 1.366e-19 | 1.301 |
| chr23:63423664 | rs5964740 | AMER1 | C>T | 1233 | 22867 | 81.08 | 2.171e-19 | 1.307 |
| chr19:42392441 | rs16975619 | ARHGEF1 | T>C | 971 | 19039 | 78.63 | 7.48e-19 | 1.343 |
| chr19:42391425 | rs28521795 | ARHGEF1 | G>A | 919 | 17903 | 77.93 | 1.067e-18 | 1.352 |
| chr8:145639681 | rs1871534 | SLC39A4 | G>C | 889 | 17256 | 77.81 | 1.132e-18 | 1.358 |
| chr23:128912059 | rs6637657 | - | A>C | 1191 | 22085 | 77.67 | 1.22e-18 | 1.306 |
| chr23:19215613 | rs5955734 | - | C>G | 1494 | 28531 | 77.44 | 1.368e-18 | 1.27 |
| chr2:44073656 | rs41360247 | ABCG8 | T>C | 2391 | 55899 | 42.71 | 6.334e-11 | 1.152 |
| chr2:44066247 | Affx-20090007 | ABCG8 | G>C | 2478 | 58124 | 41.94 | 9.425e-11 | 1.148 |
| chr2:44065090 | Affx-20089987 | ABCG5 | G>A | 2370 | 55738 | 38.35 | 5.901e-10 | 1.144 |
| chr15:80985287 | rs11629662 | ABHD17C | A>G | 5061 | 125951 | 26.99 | 2.044e-07 | 1.084 |
| chr25:154999134 | rs6642320 | - | G>A | 12141 | 311222 | 26.41 | 2.764e-07 | 1.063 |
| chr2:7028137 | rs10198816 | RSAD2 | A>G | 4286 | 106684 | 22.29 | 2.349e-06 | 1.082 |
| chr1:59037867 | rs11207262 | - | G>A | 6132 | 154670 | 22.16 | 2.513e-06 | 1.07 |
| chr3:35188947 | rs115887553 | - | C>T | 1136 | 26387 | 21.4 | 3.734e-06 | 1.153 |
| chr11:11243840 | rs78799917 | - | C>A | 1550 | 36763 | 21.29 | 3.952e-06 | 1.13 |
| chr4:95116623 | rs12507487 | - | A>G | 4207 | 104976 | 20.31 | 6.574e-06 | 1.079 |
| chr19:40427903 | rs7252127 | FCGBP | C>A | 10517 | 270319 | 20.07 | 7.452e-06 | 1.055 |
| chr15:80955913 | rs72734111 | - | T>C | 2678 | 65666 | 19.81 | 8.566e-06 | 1.096 |
| chr16:79013461 | rs8063569 | WWOX | G>C | 13168 | 361961 | 19.65 | 9.313e-06 | 0.9506 |
| chr10:22284140 | rs7089656 | DNAJC1 | G>T | 9283 | 238037 | 19.33 | 1.097e-05 | 1.056 |
| chr3:118044825 | rs779202 | - | T>C | 3124 | 89851 | 19.05 | 1.272e-05 | 0.9199 |
| chr23:9689127 | rs6638956 | TBL1X | A>C | 1664 | 36764 | 18.88 | 1.395e-05 | 1.119 |
| chr4:61723786 | rs190521415 | - | T>C | 289 | 9942 | 18.43 | 1.764e-05 | 0.7737 |
| chr5:144809230 | rs114414817 | - | T>C | 494 | 10820 | 18.43 | 1.76e-05 | 1.22 |
| chr4:189187191 | rs7667712 | - | C>T | 9909 | 273881 | 18.3 | 1.889e-05 | 0.9491 |
| chr6:164034223 | rs6928128 | - | G>A | 10953 | 302205 | 18.3 | 1.884e-05 | 0.9503 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr2:44066247 | Affx-20090007 | ABCG8 | G>C | 2478 | 1754 | 32.0 | 1.544e-08 | 1.2 |
| chr2:44073656 | rs41360247 | ABCG8 | T>C | 2391 | 1699 | 29.63 | 5.22e-08 | 1.195 |
| chr2:44065090 | Affx-20089987 | ABCG5 | G>A | 2370 | 1690 | 27.98 | 1.226e-07 | 1.19 |
| chr3:194837951 | rs78205589 | XXYLT1 | C>T | 705 | 439 | 24.85 | 6.209e-07 | 1.356 |
| chr5:122359640 | rs451195 | SNX24 | T>C | 11052 | 9803 | 24.37 | 7.96e-07 | 0.919 |
| chr5:122360403 | rs17388251 | SNX24 | T>C | 12273 | 10833 | 23.38 | 1.327e-06 | 0.9222 |
| chr5:122309792 | rs246318 | SNX24 | A>G | 10570 | 9383 | 22.73 | 1.865e-06 | 0.9207 |
| chr2:182491511 | rs72885368 | CERKL | C>T | 3265 | 3066 | 22.07 | 2.633e-06 | 0.8827 |
| chr19:46177235 | rs55669001 | GIPR | T>C | 3162 | 2976 | 22.04 | 2.67e-06 | 0.8813 |
| chr25:2691012 | rs142162416 | - | A>G | 1454 | 1444 | 21.83 | 2.974e-06 | 0.8371 |
| chr3:194977790 | rs74718347 | XXYLT1 | G>A | 597 | 369 | 21.81 | 3.011e-06 | 1.364 |
| chr11:123351341 | rs2846059 | GRAMD1B | C>T | 9165 | 8160 | 21.78 | 3.062e-06 | 0.9195 |
| chr25:155058865 | rs73234550 | - | G>A | 988 | 656 | 21.66 | 3.255e-06 | 1.268 |
| chr5:50669444 | rs80351662 | - | A>G | 1190 | 810 | 21.61 | 3.342e-06 | 1.24 |
| chr3:152677098 | rs2177303 | - | C>A | 2788 | 2060 | 20.99 | 4.62e-06 | 1.149 |
| chr18:6437844 | rs1426333 | - | T>C | 8544 | 6723 | 20.63 | 5.578e-06 | 1.089 |
| chr3:194789125 | rs185858765 | XXYLT1 | G>A | 691 | 441 | 20.62 | 5.599e-06 | 1.321 |
| chr17:781040 | Affx-14346374 | NXN | C>T | 8232 | 7354 | 20.55 | 5.807e-06 | 0.9191 |
| chr15:80985287 | rs11629662 | ABHD17C | A>G | 5061 | 3884 | 20.41 | 6.24e-06 | 1.11 |
| chr8:113930332 | rs117821887 | CSMD3 | A>G | 828 | 861 | 19.91 | 8.102e-06 | 0.8026 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD-10: O660 | Obstructed labour due to shoulder dystocia | 0/20 |