Statistics
| Case | Control |
|---|---|
| 8588 | 451606 |
Phenotype Definition
Delivery of newborn by means of a ventouse, a vacuum device used to assist the delivery of a baby when the second stage of labour has not progressed adequately. [DDD:hfirth]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 951 | 26575 | 340.2 | 5.898e-76 | 1.849 |
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 1917 | 65141 | 316.4 | 8.899e-71 | 1.539 |
| chr1:159174683 | rs2814778 | ACKR1 | T>C | 703 | 18674 | 294.1 | 6.411e-66 | 1.933 |
| chr15:48392165 | rs1834640 | - | A>G | 1023 | 30601 | 286.0 | 3.743e-64 | 1.726 |
| chr5:33958959 | rs28777 | SLC45A2 | A>C | 1637 | 55355 | 273.6 | 1.867e-61 | 1.538 |
| chr23:128718936 | rs2362937 | OCRL | T>C | 856 | 19095 | 260.6 | 1.254e-58 | 1.767 |
| chr8:145639681 | rs1871534 | SLC39A4 | G>C | 640 | 17505 | 244.1 | 5.004e-55 | 1.876 |
| chr17:58508582 | rs8071181 | C17orf64 | G>A | 560 | 14857 | 234.2 | 7.272e-53 | 1.929 |
| chr19:42393286 | rs717225 | ARHGEF1 | A>G | 735 | 21208 | 232.8 | 1.465e-52 | 1.779 |
| chr19:42392441 | rs16975619 | ARHGEF1 | T>C | 679 | 19331 | 224.7 | 8.624e-51 | 1.799 |
| chr2:66725070 | rs12995572 | MEIS1 | G>C | 862 | 26289 | 222.5 | 2.513e-50 | 1.686 |
| chr19:42391425 | rs28521795 | ARHGEF1 | G>A | 645 | 18177 | 221.0 | 5.48e-50 | 1.817 |
| chr15:45491394 | rs1648299 | SHF | T>C | 599 | 16560 | 219.1 | 1.398e-49 | 1.851 |
| chr18:4157690 | rs6506185 | DLGAP1 | T>C | 472 | 12238 | 211.8 | 5.669e-48 | 1.97 |
| chr5:147863034 | rs9325101 | HTR4 | A>G | 583 | 16157 | 211.4 | 6.761e-48 | 1.846 |
| chr23:106146349 | rs5962774 | MORC4 | T>C | 515 | 10511 | 210.4 | 1.138e-47 | 1.919 |
| chr4:110940045 | rs4698804 | - | T>C | 622 | 17642 | 208.7 | 2.656e-47 | 1.805 |
| chr6:144665357 | rs6917261 | UTRN | T>C | 480 | 12635 | 206.1 | 9.815e-47 | 1.942 |
| chr5:147671850 | rs7724380 | - | G>A | 669 | 19514 | 203.4 | 3.713e-46 | 1.757 |
| chr1:173579034 | rs12065033 | AL139142.2 | C>T | 540 | 14801 | 202.9 | 4.968e-46 | 1.864 |
| chr25:155058865 | rs73234550 | - | G>A | 366 | 29645 | 70.65 | 4.271e-17 | 0.6418 |
| chr25:154999134 | rs6642320 | - | G>A | 6524 | 316839 | 65.29 | 6.458e-16 | 1.14 |
| chr25:154935282 | rs112437556 | - | C>T | 715 | 28106 | 61.98 | 3.471e-15 | 1.355 |
| chr25:154986418 | rs142918084 | - | C>G | 756 | 29945 | 60.89 | 6.036e-15 | 1.341 |
| chr25:2692710 | rs2259750 | - | A>G | 2789 | 165813 | 54.53 | 1.529e-13 | 0.8568 |
| chr25:155183483 | rs73237015 | - | G>A | 3506 | 166436 | 45.71 | 1.373e-11 | 1.138 |
| chr25:2653913 | rs111628445 | - | G>A | 6708 | 375305 | 44.34 | 2.761e-11 | 0.9001 |
| chr25:155085824 | rs1969622 | - | G>C | 2069 | 124646 | 43.44 | 4.367e-11 | 0.8557 |
| chr25:2691012 | rs142162416 | - | A>G | 925 | 39515 | 41.35 | 1.27e-10 | 1.245 |
| chr25:155013081 | rs146997510 | - | T>A | 350 | 25799 | 41.0 | 1.519e-10 | 0.7072 |
| chr25:2654460 | rs112372310 | - | A>G | 7982 | 441486 | 39.41 | 3.428e-10 | 0.9075 |
| chr25:2661556 | rs73188900 | - | A>C | 230 | 17884 | 36.57 | 1.476e-09 | 0.6693 |
| chr25:2645366 | rs311083 | - | C>G | 5929 | 330627 | 34.97 | 3.34e-09 | 0.9085 |
| chr25:155104608 | rs5940618 | - | G>A | 3189 | 183844 | 33.92 | 5.753e-09 | 0.8909 |
| chr25:154974730 | rs144759332 | - | C>G | 530 | 21669 | 33.64 | 6.64e-09 | 1.295 |
| chr25:155053713 | rs28884873 | - | G>A | 2361 | 138688 | 33.09 | 8.778e-09 | 0.8793 |
| chr25:2679949 | rs311121 | - | G>T | 2697 | 128091 | 32.79 | 1.025e-08 | 1.129 |
| chr25:155016369 | rs28425172 | - | T>C | 7521 | 414949 | 32.33 | 1.298e-08 | 0.9155 |
| chr25:2676160 | rs312232 | - | C>T | 4013 | 195585 | 29.7 | 5.031e-08 | 1.104 |
| chr25:2649832 | rs311088 | - | T>C | 7155 | 394604 | 28.33 | 1.025e-07 | 0.9202 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr25:155058865 | rs73234550 | - | G>A | 366 | 1278 | 28.18 | 1.105e-07 | 0.7281 |
| chr25:2692710 | rs2259750 | - | A>G | 2789 | 7915 | 27.85 | 1.31e-07 | 0.8801 |
| chr2:44073656 | rs41360247 | ABCG8 | T>C | 1010 | 3080 | 24.75 | 6.535e-07 | 0.8303 |
| chr25:2653913 | rs111628445 | - | G>A | 6708 | 18149 | 24.57 | 7.158e-07 | 0.9128 |
| chr25:2654460 | rs112372310 | - | A>G | 7982 | 21396 | 23.29 | 1.394e-06 | 0.9166 |
| chr25:2691012 | rs142162416 | - | A>G | 925 | 1973 | 22.74 | 1.859e-06 | 1.215 |
| chr1:85084120 | rs2945138 | - | G>A | 619 | 1262 | 22.34 | 2.28e-06 | 1.265 |
| chr10:104573017 | rs284859 | WBP1L | G>T | 3198 | 7510 | 20.55 | 5.795e-06 | 1.112 |
| chr25:154935282 | rs112437556 | - | C>T | 715 | 1503 | 20.41 | 6.252e-06 | 1.233 |
| chr9:18893166 | rs34622226 | ADAMTSL1 | C>T | 5383 | 14646 | 20.38 | 6.35e-06 | 0.9164 |
| chr25:154986418 | rs142918084 | - | C>G | 756 | 1588 | 20.27 | 6.716e-06 | 1.226 |
| chr3:1762720 | rs116468710 | - | A>C | 150 | 575 | 19.85 | 8.383e-06 | 0.6652 |
| chr17:30902216 | rs79886469 | MYO1D | A>G | 394 | 769 | 19.83 | 8.474e-06 | 1.321 |
| chr1:200246944 | rs16846399 | - | G>A | 2268 | 5239 | 19.56 | 9.766e-06 | 1.126 |
| chr5:150048185 | rs73796413 | MYOZ3 | T>C | 913 | 1977 | 19.46 | 1.028e-05 | 1.199 |
| chr25:155183483 | rs73237015 | - | G>A | 3506 | 8311 | 19.44 | 1.037e-05 | 1.104 |
| chr6:35357674 | rs9658105 | PPARD | C>T | 529 | 1682 | 19.33 | 1.099e-05 | 0.8006 |
| chr13:22010086 | rs4769165 | ZDHHC20 | G>A | 5546 | 13398 | 19.31 | 1.114e-05 | 1.089 |
| chr2:44065090 | Affx-20089987 | ABCG5 | G>A | 1019 | 3041 | 19.2 | 1.179e-05 | 0.8491 |
| chr2:44349397 | rs725364 | - | C>G | 2679 | 6256 | 19.08 | 1.254e-05 | 1.116 |