Statistics
| Case | Control |
|---|---|
| 81223 | 378971 |
Phenotype Definition
Any cardiac rhythm other than the normal sinus rhythm. Such a rhythm may be either of sinus or ectopic origin and either regular or irregular. An arrhythmia may be due to a disturbance in impulse formation or conduction or both. [DDD:dbrown, PMID:19063792]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr4:111718067 | rs6843082 | - | A>G | 37087 | 162102 | 145.2 | 1.947e-33 | 1.081 |
| chr4:111665917 | rs1906610 | - | G>A | 18145 | 77408 | 116.8 | 3.103e-27 | 1.099 |
| chr4:111653211 | rs17042081 | - | G>T | 20205 | 86847 | 115.4 | 6.51e-27 | 1.093 |
| chr4:111710169 | rs2200733 | - | C>T | 20332 | 87478 | 112.2 | 3.236e-26 | 1.092 |
| chr4:111708287 | rs17042171 | - | C>A | 20318 | 87509 | 109.6 | 1.215e-25 | 1.091 |
| chr4:111641053 | rs1448817 | - | A>G | 45939 | 205677 | 71.7 | 2.504e-17 | 1.052 |
| chr4:111761487 | rs3853445 | - | T>C | 42560 | 205605 | 69.34 | 8.295e-17 | 0.9499 |
| chr4:111728614 | rs13141190 | - | G>A | 65343 | 295610 | 63.42 | 1.67e-15 | 1.045 |
| chr6:161010118 | rs10455872 | LPA | A>G | 13812 | 59887 | 59.44 | 1.263e-14 | 1.079 |
| chr6:160997118 | rs74617384 | LPA | A>T | 13440 | 58387 | 55.03 | 1.19e-13 | 1.077 |
| chr4:174612666 | rs2067518 | - | A>G | 2548 | 13876 | 54.78 | 1.346e-13 | 0.8516 |
| chr4:111608485 | rs2723298 | - | C>T | 50519 | 227948 | 53.59 | 2.464e-13 | 1.044 |
| chr9:22096055 | rs10757274 | - | A>G | 85006 | 387546 | 52.74 | 3.812e-13 | 1.039 |
| chr9:22098574 | rs4977574 | - | A>G | 84616 | 385805 | 52.15 | 5.139e-13 | 1.039 |
| chr9:22124477 | rs10757278 | - | A>G | 83859 | 382241 | 51.74 | 6.329e-13 | 1.039 |
| chr9:22125503 | rs1333049 | - | G>C | 83881 | 382557 | 49.1 | 2.436e-12 | 1.038 |
| chr6:170242949 | rs9396958 | - | T>C | 2515 | 13599 | 49.09 | 2.439e-12 | 0.8581 |
| chr4:111625464 | rs1375302 | - | T>C | 53501 | 241933 | 48.62 | 3.099e-12 | 1.041 |
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 4440 | 23086 | 48.1 | 4.05e-12 | 0.8913 |
| chr24:14850341 | rs2032598 | USP9Y | T>C | 426 | 2386 | 46.97 | 7.191e-12 | 0.6974 |
| chr4:111718067 | rs6843082 | - | A>G | 33529 | 145923 | 163.9 | 1.571e-37 | 1.091 |
| chr4:111710169 | rs2200733 | - | C>T | 18362 | 78060 | 144.1 | 3.4e-33 | 1.11 |
| chr4:111708287 | rs17042171 | - | C>A | 18244 | 77721 | 137.2 | 1.071e-31 | 1.108 |
| chr4:111665917 | rs1906610 | - | G>A | 16718 | 70934 | 130.4 | 3.282e-30 | 1.11 |
| chr4:111653211 | rs17042081 | - | G>T | 18609 | 79867 | 119.6 | 7.55e-28 | 1.099 |
| chr4:111761487 | rs3853445 | - | T>C | 40137 | 195169 | 77.25 | 1.504e-18 | 0.9457 |
| chr4:111641053 | rs1448817 | - | A>G | 41499 | 185742 | 77.15 | 1.588e-18 | 1.057 |
| chr4:111728614 | rs13141190 | - | G>A | 58998 | 266994 | 68.78 | 1.098e-16 | 1.048 |
| chr6:161010118 | rs10455872 | LPA | A>G | 13623 | 59127 | 62.9 | 2.175e-15 | 1.082 |
| chr6:160997118 | rs74617384 | LPA | A>T | 13250 | 57638 | 57.88 | 2.786e-14 | 1.079 |
| chr4:111788675 | rs521511 | - | C>T | 32096 | 155993 | 55.34 | 1.012e-13 | 0.9503 |
| chr4:111608485 | rs2723298 | - | C>T | 46366 | 209620 | 53.56 | 2.506e-13 | 1.045 |
| chr4:111625464 | rs1375302 | - | T>C | 49366 | 223591 | 50.57 | 1.148e-12 | 1.043 |
| chr6:160608804 | rs16891156 | SLC22A2 | A>C | 3653 | 15046 | 47.0 | 7.089e-12 | 1.136 |
| chr9:22124477 | rs10757278 | - | A>G | 79631 | 364475 | 45.75 | 1.345e-11 | 1.038 |
| chr16:73051620 | rs2106261 | ZFHX3 | C>T | 28079 | 125821 | 44.5 | 2.544e-11 | 1.05 |
| chr9:22125503 | rs1333049 | - | G>C | 79572 | 364346 | 44.3 | 2.823e-11 | 1.037 |
| chr9:22096055 | rs10757274 | - | A>G | 80662 | 369491 | 43.77 | 3.688e-11 | 1.037 |
| chr9:22098574 | rs4977574 | - | A>G | 80399 | 368327 | 43.29 | 4.726e-11 | 1.037 |
| chr9:22088260 | rs10757272 | - | C>T | 80085 | 367121 | 40.51 | 1.953e-10 | 1.035 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr4:111718067 | rs6843082 | - | A>G | 33529 | 6588 | 46.52 | 9.066e-12 | 1.108 |
| chr4:111710169 | rs2200733 | - | C>T | 18362 | 3507 | 40.72 | 1.753e-10 | 1.132 |
| chr4:111708287 | rs17042171 | - | C>A | 18244 | 3494 | 39.17 | 3.892e-10 | 1.13 |
| chr4:111653211 | rs17042081 | - | G>T | 18609 | 3600 | 33.48 | 7.209e-09 | 1.118 |
| chr4:111665917 | rs1906610 | - | G>A | 16718 | 3244 | 29.87 | 4.625e-08 | 1.117 |
| chr4:111641053 | rs1448817 | - | A>G | 41499 | 8368 | 29.83 | 4.709e-08 | 1.078 |
| chr3:111546084 | rs73226334 | PLCXD2 | T>G | 22314 | 5113 | 24.41 | 7.77e-07 | 0.9205 |
| chr11:12289058 | rs2706652 | MICAL2 | G>A | 64534 | 13278 | 23.3 | 1.383e-06 | 1.061 |
| chr4:111728614 | rs13141190 | - | G>A | 58998 | 12118 | 22.57 | 2.023e-06 | 1.061 |
| chr15:37729549 | rs2124973 | - | T>C | 7158 | 1729 | 22.26 | 2.375e-06 | 0.8785 |
| chr3:111541640 | rs9842341 | PLCXD2 | C>A | 30019 | 6773 | 21.14 | 4.275e-06 | 0.9334 |
| chr4:111625464 | rs1375302 | - | T>C | 49366 | 10096 | 20.95 | 4.723e-06 | 1.061 |
| chr4:111761487 | rs3853445 | - | T>C | 40137 | 8972 | 19.98 | 7.84e-06 | 0.941 |
| chr3:111745656 | rs4682339 | - | T>C | 55897 | 12371 | 19.96 | 7.906e-06 | 0.9462 |
| chr15:37782466 | rs10518953 | - | G>C | 6193 | 1498 | 19.69 | 9.09e-06 | 0.8777 |
| chr5:83276027 | rs16900806 | EDIL3 | T>C | 10186 | 1955 | 19.67 | 9.198e-06 | 1.119 |
| chr2:164236862 | rs77656639 | - | C>T | 5098 | 1249 | 19.6 | 9.527e-06 | 0.8674 |
| chr1:65187899 | rs4916000 | - | T>G | 20607 | 4703 | 19.36 | 1.085e-05 | 0.9264 |
| chr4:144228178 | rs80331195 | - | G>A | 1925 | 510 | 19.2 | 1.179e-05 | 0.8031 |
| chr13:68462349 | rs289050 | - | A>G | 12651 | 2941 | 18.86 | 1.408e-05 | 0.9113 |