Statistics
| Case | Control |
|---|---|
| 20597 | 439597 |
Phenotype Definition
Block of conduction of electrical impulses along the Bundle of His or along one of its bundle branches. [DDD:dbrown, HPO:probinson]
Phenotype Comment
The Bundle of His conducts the electrical impulse from the atrioventricular node into the ventricles. THe Bundle of His divides into right and left bundle branches. A universal feature of a bundle branch block is a prolongation of the time required for depolarization of a portion of the ventricles, reflected in an abnormality of the QRS complex.
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:161010118 | rs10455872 | LPA | A>G | 3852 | 69847 | 99.65 | 1.819e-23 | 1.189 |
| chr6:160997118 | rs74617384 | LPA | A>T | 3751 | 68076 | 95.81 | 1.266e-22 | 1.187 |
| chr9:22125503 | rs1333049 | - | G>C | 21870 | 444568 | 77.4 | 1.395e-18 | 1.09 |
| chr9:22098574 | rs4977574 | - | A>G | 22027 | 448394 | 76.47 | 2.238e-18 | 1.089 |
| chr9:22124477 | rs10757278 | - | A>G | 21846 | 444254 | 76.39 | 2.326e-18 | 1.089 |
| chr9:22096055 | rs10757274 | - | A>G | 22128 | 450424 | 75.21 | 4.241e-18 | 1.088 |
| chr9:22088260 | rs10757272 | - | C>T | 22095 | 449653 | 74.35 | 6.528e-18 | 1.088 |
| chr9:22125347 | rs1333048 | - | A>C | 22613 | 461044 | 72.3 | 1.846e-17 | 1.087 |
| chr13:113979972 | Affx-80297025 | GRTP1 | A>ACACT | 409 | 12298 | 48.89 | 2.705e-12 | 0.7038 |
| chr13:113979968 | rs200506581 | GRTP1 | C>CCACA | 412 | 12314 | 47.51 | 5.459e-12 | 0.7081 |
| chr24:14850341 | rs2032598 | USP9Y | T>C | 87 | 2725 | 47.4 | 5.803e-12 | 0.4792 |
| chr8:145639681 | rs1871534 | SLC39A4 | G>C | 626 | 17519 | 47.0 | 7.081e-12 | 0.7558 |
| chr9:22081850 | rs6475606 | - | C>T | 22456 | 461813 | 45.94 | 1.222e-11 | 1.069 |
| chr9:22115959 | rs2383207 | - | G>A | 20077 | 441962 | 45.2 | 1.78e-11 | 0.9362 |
| chr9:22083404 | rs1333040 | - | T>C | 17402 | 384214 | 41.95 | 9.35e-11 | 0.9374 |
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 1020 | 26506 | 41.17 | 1.398e-10 | 0.8132 |
| chr13:72441665 | rs3759505 | - | C>T | 585 | 16130 | 39.17 | 3.887e-10 | 0.7676 |
| chr6:160922870 | rs117733303 | - | A>G | 985 | 17113 | 38.49 | 5.491e-10 | 1.228 |
| chr6:160848743 | rs9457925 | SLC22A3 | G>A | 979 | 17019 | 38.13 | 6.629e-10 | 1.227 |
| chr6:160961137 | rs3798220 | LPA | T>C | 967 | 16790 | 38.06 | 6.878e-10 | 1.229 |
| chr6:161010118 | rs10455872 | LPA | A>G | 3796 | 68954 | 101.9 | 5.902e-24 | 1.193 |
| chr6:160997118 | rs74617384 | LPA | A>T | 3695 | 67193 | 97.74 | 4.775e-23 | 1.191 |
| chr9:22125503 | rs1333049 | - | G>C | 20645 | 423273 | 60.75 | 6.485e-15 | 1.082 |
| chr9:22124477 | rs10757278 | - | A>G | 20634 | 423472 | 57.98 | 2.648e-14 | 1.08 |
| chr9:22096055 | rs10757274 | - | A>G | 20889 | 429264 | 55.64 | 8.714e-14 | 1.078 |
| chr9:22098574 | rs4977574 | - | A>G | 20813 | 427913 | 55.35 | 1.007e-13 | 1.078 |
| chr9:22125347 | rs1333048 | - | A>C | 21289 | 437852 | 55.15 | 1.117e-13 | 1.078 |
| chr9:22088260 | rs10757272 | - | C>T | 20759 | 426447 | 54.96 | 1.233e-13 | 1.078 |
| chr6:160961137 | rs3798220 | LPA | T>C | 938 | 15844 | 49.55 | 1.935e-12 | 1.27 |
| chr9:22081850 | rs6475606 | - | C>T | 20599 | 424163 | 49.39 | 2.093e-12 | 1.073 |
| chr6:160848743 | rs9457925 | SLC22A3 | G>A | 950 | 16095 | 48.97 | 2.595e-12 | 1.266 |
| chr6:160922870 | rs117733303 | - | A>G | 947 | 16037 | 48.85 | 2.765e-12 | 1.266 |
| chr9:22115959 | rs2383207 | - | G>A | 19276 | 426745 | 48.12 | 4.014e-12 | 0.9323 |
| chr12:112277084 | rs12370770 | - | C>T | 2714 | 51616 | 36.56 | 1.479e-09 | 1.131 |
| chr9:22083404 | rs1333040 | - | T>C | 16456 | 364102 | 35.1 | 3.126e-09 | 0.9408 |
| chr6:160687412 | rs10080815 | SLC22A2 | T>G | 974 | 17163 | 34.74 | 3.762e-09 | 1.217 |
| chr12:111872722 | rs12371484 | SH2B3 | T>C | 2639 | 50367 | 33.18 | 8.386e-09 | 1.126 |
| chr6:12903957 | rs9349379 | PHACTR1 | A>G | 17210 | 355758 | 27.81 | 1.34e-07 | 1.055 |
| chr1:222826481 | rs2291832 | MIA3 | A>G | 11208 | 249534 | 25.44 | 4.561e-07 | 0.9444 |
| chr5:166189274 | rs6891017 | - | A>C | 5443 | 123956 | 25.4 | 4.664e-07 | 0.9278 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr1:25467172 | rs75174976 | - | T>G | 580 | 279 | 25.23 | 5.09e-07 | 0.6926 |
| chr8:139781866 | rs7844608 | COL22A1 | C>T | 6546 | 1969 | 21.16 | 4.227e-06 | 1.136 |
| chr7:109819073 | rs1525516 | - | C>T | 7707 | 2831 | 20.88 | 4.88e-06 | 0.8937 |
| chr10:1342788 | rs76897791 | ADARB2 | C>G | 1541 | 638 | 20.61 | 5.631e-06 | 0.804 |
| chr10:130532090 | rs7070568 | - | T>C | 16130 | 5703 | 20.3 | 6.607e-06 | 0.9136 |
| chr10:77664460 | rs78390601 | LRMDA | G>C | 2339 | 646 | 20.22 | 6.913e-06 | 1.227 |
| chr5:33695738 | rs72741435 | ADAMTS12 | C>A | 1871 | 758 | 20.18 | 7.066e-06 | 0.8201 |
| chr6:121651596 | rs9320806 | TBC1D32 | G>A | 6314 | 1900 | 20.04 | 7.572e-06 | 1.135 |
| chr10:2142589 | rs79347043 | - | T>C | 3516 | 1014 | 19.61 | 9.478e-06 | 1.178 |
| chr6:30800577 | rs1264344 | - | C>T | 18006 | 5741 | 19.52 | 9.974e-06 | 1.092 |
| chr8:10390452 | rs4406360 | PRSS51 | C>T | 14363 | 5104 | 19.06 | 1.266e-05 | 0.9146 |
| chr22:45812648 | rs35453561 | RIBC2 | G>C | 2954 | 1145 | 18.9 | 1.374e-05 | 0.8541 |
| chr11:61656117 | rs174455 | FADS3 | A>G | 14894 | 4713 | 18.85 | 1.417e-05 | 1.094 |
| chr3:437339 | rs12491604 | CHL1 | G>A | 4686 | 1379 | 18.69 | 1.542e-05 | 1.15 |
| chr3:156200074 | rs114906288 | KCNAB1 | G>T | 479 | 227 | 18.58 | 1.625e-05 | 0.7059 |
| chr10:1383260 | rs181310122 | ADARB2 | C>A | 568 | 262 | 18.54 | 1.667e-05 | 0.724 |
| chr5:28880760 | rs78287360 | - | G>A | 1513 | 619 | 18.23 | 1.958e-05 | 0.8123 |
| chr1:114943348 | rs72693901 | TRIM33 | G>T | 11337 | 3549 | 17.95 | 2.27e-05 | 1.099 |
| chr15:47305186 | rs2055947 | - | C>T | 2994 | 858 | 17.86 | 2.379e-05 | 1.184 |
| chr10:9190859 | rs76730373 | - | C>T | 1499 | 612 | 17.67 | 2.628e-05 | 0.8141 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: I258 | Other forms of chronic ischaemic heart disease | 15/20 |
| ICD: I447 | Left bundle-branch block, unspecified | 4/20 |