Statistics
| Case | Control |
|---|---|
| 8123 | 452071 |
Phenotype Definition
A conduction block of the left branch of the bundle of His. This manifests as a generalized disturbance of QRS morphology on EKG. [DDD:dbrown, HPO:probinson]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 335 | 27191 | 47.75 | 4.833e-12 | 0.6829 |
| chr15:72053984 | rs922917 | THSD4 | C>T | 619 | 44486 | 40.54 | 1.927e-10 | 0.7697 |
| chr15:72054830 | rs7402101 | THSD4 | C>T | 638 | 45435 | 38.57 | 5.29e-10 | 0.7775 |
| chr5:147671850 | rs7724380 | - | G>A | 241 | 19942 | 37.67 | 8.364e-10 | 0.6717 |
| chr9:129979758 | rs3780318 | RALGPS1 | G>A | 186 | 16055 | 35.62 | 2.393e-09 | 0.6446 |
| chr15:48392165 | rs1834640 | - | A>G | 418 | 31206 | 35.57 | 2.461e-09 | 0.7436 |
| chr9:140957557 | rs11137360 | CACNA1B | A>G | 257 | 20749 | 35.29 | 2.838e-09 | 0.6883 |
| chr9:129984107 | rs3739553 | RALGPS1 | G>A | 176 | 15237 | 34.33 | 4.657e-09 | 0.6422 |
| chr13:113979972 | Affx-80297025 | GRTP1 | A>ACACT | 137 | 12570 | 34.29 | 4.752e-09 | 0.6066 |
| chr5:147666044 | rs7707813 | - | T>C | 226 | 18537 | 33.72 | 6.37e-09 | 0.6779 |
| chr1:207782889 | rs17047661 | CR1 | A>G | 161 | 14158 | 33.53 | 7.01e-09 | 0.6331 |
| chr2:236294462 | rs57088602 | - | T>C | 463 | 33694 | 33.0 | 9.197e-09 | 0.7621 |
| chr20:30135990 | rs1115713 | HM13 | A>G | 1939 | 122473 | 32.16 | 1.418e-08 | 0.8713 |
| chr17:29268139 | rs9907098 | ADAP2 | C>A | 217 | 17698 | 31.46 | 2.031e-08 | 0.6817 |
| chr13:113979968 | rs200506581 | GRTP1 | C>CCACA | 141 | 12585 | 31.4 | 2.097e-08 | 0.6237 |
| chr8:145639681 | rs1871534 | SLC39A4 | G>C | 221 | 17924 | 30.88 | 2.741e-08 | 0.6863 |
| chr17:29338545 | rs7211961 | - | G>C | 288 | 22231 | 30.55 | 3.245e-08 | 0.7195 |
| chr6:137344363 | rs1744080 | IL20RA | G>A | 199 | 16411 | 30.44 | 3.451e-08 | 0.6749 |
| chr5:147863034 | rs9325101 | HTR4 | A>G | 201 | 16539 | 30.4 | 3.519e-08 | 0.6763 |
| chr18:9536315 | rs14336 | RALBP1 | A>C | 145 | 12722 | 29.93 | 4.485e-08 | 0.6345 |
| chr4:23818884 | rs2932971 | PPARGC1A | C>T | 4299 | 222689 | 29.48 | 5.645e-08 | 1.102 |
| chr4:23851538 | rs76327932 | PPARGC1A | C>T | 4611 | 240406 | 26.57 | 2.539e-07 | 1.095 |
| chr18:59598753 | rs12967946 | PIGN | A>C | 844 | 55705 | 25.97 | 3.461e-07 | 0.8342 |
| chr18:42439886 | rs991014 | SETBP1 | C>T | 6952 | 369003 | 25.86 | 3.676e-07 | 1.085 |
| chr18:42456653 | rs663651 | SETBP1 | A>G | 6666 | 388882 | 25.18 | 5.209e-07 | 0.9222 |
| chr2:36673555 | rs7562790 | CRIM1 | T>G | 6862 | 365075 | 23.84 | 1.045e-06 | 1.081 |
| chr8:720794 | rs11784310 | DLGAP2 | A>G | 5100 | 300221 | 23.17 | 1.483e-06 | 0.9211 |
| chr16:85982521 | rs305086 | - | G>A | 2821 | 144655 | 22.08 | 2.621e-06 | 1.103 |
| chr2:161355044 | rs115435626 | - | T>C | 486 | 33322 | 21.73 | 3.146e-06 | 0.8059 |
| chr7:147702692 | rs2214681 | CNTNAP2 | G>A | 7465 | 399311 | 21.62 | 3.326e-06 | 1.077 |
| chr18:42456670 | rs3085861 | SETBP1 | CTCTT>C | 6816 | 395506 | 21.6 | 3.354e-06 | 0.9282 |
| chr6:166087403 | rs35511241 | PDE10A | C>T | 7880 | 421814 | 21.52 | 3.506e-06 | 1.076 |
| chr14:58536728 | rs10129164 | ARMH4 | T>C | 6901 | 368050 | 20.82 | 5.037e-06 | 1.076 |
| chr15:72053984 | rs922917 | THSD4 | C>T | 385 | 26898 | 20.42 | 6.225e-06 | 0.7912 |
| chr15:72055493 | rs73432450 | THSD4 | A>G | 375 | 26231 | 20.06 | 7.497e-06 | 0.7905 |
| chr2:112915809 | rs35898589 | FBLN7 | A>G | 890 | 42754 | 19.74 | 8.862e-06 | 1.167 |
| chr4:23788341 | rs2970882 | PPARGC1A | T>C | 5555 | 294479 | 19.51 | 9.986e-06 | 1.077 |
| chr6:161010118 | rs10455872 | LPA | A>G | 1435 | 71315 | 19.46 | 1.026e-05 | 1.131 |
| chr17:53407592 | rs11657291 | - | A>G | 4830 | 283451 | 19.42 | 1.048e-05 | 0.9264 |
| chr25:154986418 | rs142918084 | - | C>G | 442 | 30259 | 19.4 | 1.061e-05 | 0.8074 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr7:22253524 | rs6957641 | RAPGEF5 | A>C | 1812 | 3171 | 22.71 | 1.88e-06 | 0.8612 |
| chr3:157854877 | rs112477586 | RSRC1 | A>G | 312 | 662 | 22.67 | 1.92e-06 | 0.7195 |
| chr2:36673555 | rs7562790 | CRIM1 | T>G | 6862 | 9963 | 22.14 | 2.53e-06 | 1.101 |
| chr17:53376942 | rs17817857 | HLF | C>T | 3816 | 6342 | 20.94 | 4.751e-06 | 0.8969 |
| chr2:180173005 | rs13001918 | - | C>T | 1633 | 2160 | 20.75 | 5.246e-06 | 1.171 |
| chr16:10711883 | rs112414296 | - | A>C | 179 | 411 | 20.67 | 5.448e-06 | 0.6656 |
| chr5:99662193 | rs114297956 | - | T>C | 985 | 1796 | 20.37 | 6.383e-06 | 0.8312 |
| chr1:153337121 | rs74807144 | - | A>G | 460 | 534 | 19.81 | 8.551e-06 | 1.331 |
| chr14:30602994 | rs61978362 | PRKD1 | G>A | 5097 | 7306 | 19.58 | 9.649e-06 | 1.102 |
| chr13:106836359 | rs9558705 | - | T>G | 1476 | 2591 | 18.77 | 1.477e-05 | 0.862 |
| chr15:72055493 | rs73432450 | THSD4 | A>G | 375 | 753 | 18.72 | 1.515e-05 | 0.7587 |
| chr15:72050671 | rs924557 | THSD4 | G>A | 651 | 1226 | 18.7 | 1.532e-05 | 0.8073 |
| chr18:65109675 | rs4268859 | - | G>A | 1872 | 3230 | 18.7 | 1.526e-05 | 0.8745 |
| chr11:103627041 | rs113696422 | - | A>G | 457 | 536 | 18.45 | 1.749e-05 | 1.318 |
| chr19:57980167 | rs6510074 | AC004076.1 | T>C | 6097 | 8845 | 18.43 | 1.762e-05 | 1.094 |
| chr15:72053984 | rs922917 | THSD4 | C>T | 385 | 768 | 18.32 | 1.866e-05 | 0.7633 |
| chr18:55865613 | rs292444 | NEDD4L | T>G | 5354 | 8734 | 18.32 | 1.872e-05 | 0.9127 |
| chr7:22131881 | rs4722094 | - | T>C | 3435 | 4838 | 18.27 | 1.918e-05 | 1.113 |
| chr1:216802900 | rs35878150 | ESRRG | C>T | 367 | 417 | 18.22 | 1.972e-05 | 1.36 |
| chr18:42439886 | rs991014 | SETBP1 | C>T | 6952 | 10144 | 18.13 | 2.062e-05 | 1.091 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: I447 | Left bundle-branch block, unspecified | 6/20 |