Statistics
| Case | Control |
|---|---|
| 19638 | 440556 |
Phenotype Definition
Pain in the lower back and hip radiating in the distribution of the sciatic nerve. [HPO:probinson, PMID:17872935]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr23:64367019 | rs7064929 | - | G>A | 1123 | 16443 | 159.6 | 1.353e-36 | 1.483 |
| chr1:159174683 | rs2814778 | ACKR1 | T>C | 1194 | 18183 | 157.0 | 5.014e-36 | 1.459 |
| chr9:129979758 | rs3780318 | RALGPS1 | G>A | 1013 | 15228 | 142.3 | 8.411e-33 | 1.476 |
| chr8:145639681 | rs1871534 | SLC39A4 | G>C | 1105 | 17040 | 136.6 | 1.472e-31 | 1.441 |
| chr23:63410110 | rs61730681 | AMER1 | T>C | 1439 | 22694 | 133.9 | 5.69e-31 | 1.377 |
| chr23:63423664 | rs5964740 | AMER1 | C>T | 1437 | 22663 | 133.7 | 6.255e-31 | 1.377 |
| chr9:117110112 | Affx-52344420 | AKNA | T>TG | 913 | 13666 | 131.0 | 2.511e-30 | 1.481 |
| chr9:129984107 | rs3739553 | RALGPS1 | G>A | 956 | 14457 | 129.9 | 4.239e-30 | 1.466 |
| chr18:9536315 | rs14336 | RALBP1 | A>C | 816 | 12051 | 124.9 | 5.453e-29 | 1.5 |
| chr23:148151708 | Affx-34694529 | - | A>C | 609 | 8242 | 124.3 | 7.103e-29 | 1.597 |
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 3479 | 63579 | 123.3 | 1.197e-28 | 1.223 |
| chr23:106146349 | rs5962774 | MORC4 | T>C | 729 | 10297 | 123.3 | 1.172e-28 | 1.533 |
| chr12:132549300 | rs7136109 | EP400 | A>G | 690 | 9940 | 119.2 | 9.601e-28 | 1.537 |
| chr23:110685534 | rs16986503 | - | C>T | 803 | 11680 | 117.1 | 2.727e-27 | 1.487 |
| chr17:29290106 | rs55861543 | - | C>T | 1216 | 19543 | 117.0 | 2.846e-27 | 1.381 |
| chr23:142717383 | rs73577386 | SLITRK4 | A>G | 533 | 7089 | 116.9 | 3.083e-27 | 1.624 |
| chr17:29298304 | rs7225888 | RNF135 | C>G | 1174 | 18761 | 116.8 | 3.145e-27 | 1.389 |
| chr17:29350769 | rs8073072 | - | T>G | 1464 | 24242 | 115.6 | 5.853e-27 | 1.341 |
| chr15:45556163 | rs8023604 | SLC28A2 | T>C | 806 | 12105 | 113.4 | 1.799e-26 | 1.475 |
| chr16:17200685 | rs8046024 | XYLT1 | C>T | 1161 | 18616 | 113.0 | 2.113e-26 | 1.384 |
| chr6:34546560 | rs2814982 | - | C>T | 4357 | 89495 | 35.89 | 2.088e-09 | 1.104 |
| chr15:67367706 | rs1498507 | SMAD3 | A>C | 17594 | 407089 | 31.04 | 2.53e-08 | 0.9438 |
| chr19:1957079 | rs11084923 | CSNK1G2 | T>C | 16980 | 392776 | 26.37 | 2.815e-07 | 0.9479 |
| chr19:1952841 | rs2396366 | CSNK1G2 | C>T | 14399 | 334032 | 25.66 | 4.067e-07 | 0.9472 |
| chr19:1967121 | rs11671909 | CSNK1G2 | T>C | 14927 | 345695 | 25.59 | 4.224e-07 | 0.9475 |
| chr9:31144887 | rs13286518 | - | A>G | 12351 | 287710 | 25.12 | 5.399e-07 | 0.9459 |
| chr1:198214462 | rs12046935 | NEK7 | G>A | 4283 | 89124 | 25.01 | 5.69e-07 | 1.087 |
| chr10:21889083 | rs12356674 | MLLT10 | G>T | 11623 | 250628 | 24.85 | 6.202e-07 | 1.058 |
| chr19:1952280 | rs11084921 | CSNK1G2 | C>T | 14936 | 346192 | 24.65 | 6.892e-07 | 0.9486 |
| chr9:31233220 | rs13292646 | - | T>C | 12821 | 298334 | 24.47 | 7.561e-07 | 0.947 |
| chr1:198237879 | rs3885821 | NEK7 | C>T | 4413 | 92198 | 23.96 | 9.861e-07 | 1.083 |
| chr1:227309961 | rs596131 | CDC42BPA | A>G | 9999 | 234302 | 23.95 | 9.868e-07 | 0.9437 |
| chr1:182263984 | rs75534956 | - | T>G | 1569 | 31110 | 23.68 | 1.136e-06 | 1.137 |
| chr17:62245560 | rs9908831 | TEX2 | A>G | 2156 | 43562 | 23.67 | 1.143e-06 | 1.117 |
| chr17:62365976 | rs4968618 | - | G>T | 1753 | 35047 | 23.09 | 1.548e-06 | 1.128 |
| chr6:34552797 | rs2814944 | - | G>A | 6089 | 128920 | 22.9 | 1.709e-06 | 1.071 |
| chr1:45863019 | rs72686459 | AL451136.1 | C>T | 4738 | 99425 | 22.63 | 1.959e-06 | 1.078 |
| chr16:2128670 | rs79518513 | TSC2 | C>T | 4158 | 86813 | 22.6 | 1.999e-06 | 1.083 |
| chr2:22515568 | rs12373752 | - | A>G | 18926 | 413971 | 22.35 | 2.272e-06 | 1.05 |
| chr1:45890155 | rs12139364 | AL451136.1 | T>C | 19518 | 427035 | 22.32 | 2.314e-06 | 1.05 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr9:136142355 | rs643434 | ABO | G>A | 13424 | 3167 | 26.59 | 2.519e-07 | 1.131 |
| chr7:21892495 | rs2074327 | DNAH11 | T>C | 1571 | 516 | 25.18 | 5.233e-07 | 0.7708 |
| chr9:136139265 | rs657152 | ABO | C>A | 13388 | 3160 | 25.1 | 5.432e-07 | 1.128 |
| chr7:21912138 | rs78452109 | DNAH11 | C>T | 1251 | 420 | 23.85 | 1.041e-06 | 0.7557 |
| chr6:16254095 | rs7763322 | GMPR | T>C | 14689 | 4024 | 23.41 | 1.309e-06 | 0.8951 |
| chr9:136149229 | rs505922 | ABO | T>C | 12488 | 2949 | 23.41 | 1.311e-06 | 1.125 |
| chr9:136132908 | rs8176719 | ABO | T>TC | 13395 | 3170 | 23.3 | 1.384e-06 | 1.123 |
| chr4:173059279 | rs6839159 | GALNTL6 | A>G | 16149 | 4404 | 22.88 | 1.728e-06 | 0.8976 |
| chr4:172993734 | rs6815499 | GALNTL6 | C>T | 19166 | 5177 | 22.64 | 1.952e-06 | 0.8989 |
| chr9:136143442 | rs612169 | ABO | A>G | 12539 | 2967 | 21.86 | 2.932e-06 | 1.121 |
| chr8:54624508 | rs117495223 | - | C>T | 494 | 188 | 21.74 | 3.128e-06 | 0.6701 |
| chr9:136142203 | rs514659 | ABO | A>C | 12069 | 2871 | 21.19 | 4.166e-06 | 1.121 |
| chr9:136137065 | rs687621 | ABO | A>G | 12523 | 2975 | 20.64 | 5.528e-06 | 1.117 |
| chr14:35211038 | rs17526363 | - | G>A | 16554 | 4503 | 20.27 | 6.733e-06 | 0.9012 |
| chr4:173088087 | rs17058085 | GALNTL6 | G>T | 14893 | 4062 | 20.0 | 7.726e-06 | 0.9029 |
| chr4:42867440 | rs73238001 | - | T>C | 1085 | 198 | 20.0 | 7.758e-06 | 1.416 |
| chr7:21966708 | rs12532102 | CDCA7L | G>A | 3218 | 964 | 19.92 | 8.054e-06 | 0.8421 |
| chr2:232882748 | rs114401834 | DIS3L2 | T>G | 504 | 188 | 19.81 | 8.576e-06 | 0.6829 |
| chr4:52751082 | rs12507876 | DCUN1D4 | C>T | 5619 | 1614 | 19.52 | 9.974e-06 | 0.873 |
| chr9:136134472 | rs638756 | ABO | A>C | 9517 | 2653 | 19.48 | 1.016e-05 | 0.8935 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: M543 | Sciatica | 4/20 |
| ICD: M545 | Low back pain | 13/20 |
| ICD: M549 | Dorsalgia, unspecified | 14/20 |