Statistics
| Case | Control |
|---|---|
| 2135 | 458059 |
Phenotype Definition
Inflammation and fibrosis of the bronchioles leading to partial or complete obstruction of these airways. [HPO:probinson]
Phenotype Comment
Note that Bronchiolitis obliterans is not to be confused with the similarly named feature Bronchiolitis obliterans organizing pneumonia.
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr16:17416916 | rs76179402 | XYLT1 | T>C | 280 | 45444 | 25.55 | 4.306e-07 | 1.366 |
| chr1:12751429 | rs72644525 | - | C>T | 182 | 27599 | 24.59 | 7.091e-07 | 1.454 |
| chr3:60456745 | rs473944 | FHIT | T>C | 1515 | 363660 | 23.18 | 1.473e-06 | 0.8585 |
| chr5:96523921 | rs4869151 | - | G>T | 1744 | 412881 | 21.75 | 3.107e-06 | 0.8659 |
| chr6:114736654 | rs72958237 | - | C>T | 102 | 14125 | 21.43 | 3.674e-06 | 1.586 |
| chr2:97143761 | rs115706318 | - | T>C | 175 | 26970 | 21.16 | 4.219e-06 | 1.425 |
| chr14:57618531 | rs73298586 | - | C>T | 32 | 15246 | 20.83 | 5.031e-06 | 0.4539 |
| chr6:123122391 | rs139425917 | SMPDL3A | T>C | 87 | 11744 | 20.25 | 6.8e-06 | 1.623 |
| chr6:5104459 | rs17139428 | LYRM4 | A>G | 77 | 10099 | 20.19 | 6.995e-06 | 1.67 |
| chr13:36515114 | rs79214738 | DCLK1 | C>T | 115 | 16629 | 19.61 | 9.503e-06 | 1.517 |
| chr3:121617739 | rs76681827 | SLC15A2 | A>G | 161 | 24833 | 19.58 | 9.665e-06 | 1.425 |
| chr7:117582736 | rs62471815 | - | G>A | 2163 | 438969 | 19.54 | 9.869e-06 | 1.142 |
| chr23:73725976 | rs5937837 | SLC16A2 | A>C | 774 | 200234 | 19.15 | 1.207e-05 | 0.8353 |
| chr9:27341338 | rs7041639 | MOB3B | A>G | 532 | 96716 | 19.05 | 1.271e-05 | 1.224 |
| chr9:136887757 | rs7047706 | - | T>C | 329 | 90062 | 18.87 | 1.399e-05 | 0.7798 |
| chr8:34147715 | rs73672189 | - | C>T | 39 | 16675 | 18.78 | 1.471e-05 | 0.5044 |
| chr7:97406264 | rs6465617 | - | T>C | 577 | 147922 | 18.76 | 1.479e-05 | 0.8242 |
| chr19:4901760 | rs77298069 | ARRDC5 | A>C | 132 | 19822 | 18.67 | 1.553e-05 | 1.463 |
| chr20:57768655 | rs61743779 | ZNF831 | G>A | 77 | 10292 | 18.64 | 1.58e-05 | 1.637 |
| chr13:45356737 | rs9533968 | - | C>G | 208 | 33855 | 18.2 | 1.989e-05 | 1.354 |
| chr9:27341338 | rs7041639 | MOB3B | A>G | 496 | 85900 | 25.14 | 5.343e-07 | 1.271 |
| chr16:17416916 | rs76179402 | XYLT1 | T>C | 276 | 44767 | 23.05 | 1.575e-06 | 1.348 |
| chr1:12751429 | rs72644525 | - | C>T | 177 | 26783 | 22.41 | 2.199e-06 | 1.437 |
| chr5:96523921 | rs4869151 | - | G>T | 1683 | 393931 | 22.38 | 2.235e-06 | 0.8615 |
| chr7:97406264 | rs6465617 | - | T>C | 541 | 138992 | 21.16 | 4.232e-06 | 0.8092 |
| chr17:48124582 | rs16948609 | - | T>G | 699 | 127757 | 20.97 | 4.655e-06 | 1.209 |
| chr6:114736654 | rs72958237 | - | C>T | 102 | 14002 | 20.95 | 4.71e-06 | 1.578 |
| chr6:5104459 | rs17139428 | LYRM4 | A>G | 77 | 9914 | 20.58 | 5.724e-06 | 1.678 |
| chr7:117582736 | rs62471815 | - | G>A | 2091 | 417313 | 20.39 | 6.3e-06 | 1.149 |
| chr8:3602244 | rs115025706 | CSMD1 | A>G | 79 | 10276 | 20.3 | 6.631e-06 | 1.662 |
| chr3:60456745 | rs473944 | FHIT | T>C | 1405 | 331158 | 19.44 | 1.04e-05 | 0.866 |
| chr6:123122391 | rs139425917 | SMPDL3A | T>C | 86 | 11531 | 19.42 | 1.051e-05 | 1.612 |
| chr2:97143761 | rs115706318 | - | T>C | 167 | 25534 | 19.28 | 1.13e-05 | 1.414 |
| chr1:95356258 | rs9432608 | SLC44A3 | G>A | 616 | 111971 | 19.05 | 1.271e-05 | 1.21 |
| chr3:121617739 | rs76681827 | SLC15A2 | A>G | 157 | 23899 | 19.03 | 1.286e-05 | 1.425 |
| chr13:36515114 | rs79214738 | DCLK1 | C>T | 114 | 16358 | 18.85 | 1.412e-05 | 1.508 |
| chr20:6983761 | rs6085823 | - | C>T | 280 | 46789 | 18.53 | 1.672e-05 | 1.305 |
| chr5:115178487 | rs114783079 | AP3S1 | G>A | 101 | 14208 | 18.39 | 1.804e-05 | 1.537 |
| chr20:57768655 | rs61743779 | ZNF831 | G>A | 76 | 10063 | 18.06 | 2.138e-05 | 1.63 |
| chr1:238929572 | rs75407889 | - | G>A | 209 | 33434 | 18.0 | 2.211e-05 | 1.351 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr4:156561940 | rs4691812 | - | C>T | 971 | 4813 | 24.53 | 7.304e-07 | 1.218 |
| chr9:44812496 | rs72707565 | - | C>A | 164 | 620 | 24.11 | 9.119e-07 | 1.546 |
| chr9:27341338 | rs7041639 | MOB3B | A>G | 496 | 2288 | 22.75 | 1.849e-06 | 1.284 |
| chr16:17416916 | rs76179402 | XYLT1 | T>C | 276 | 1172 | 22.29 | 2.341e-06 | 1.384 |
| chr3:60456745 | rs473944 | FHIT | T>C | 1405 | 9020 | 22.03 | 2.688e-06 | 0.8479 |
| chr3:38369584 | rs76491829 | - | C>A | 78 | 253 | 20.62 | 5.606e-06 | 1.795 |
| chr3:121617739 | rs76681827 | SLC15A2 | A>G | 157 | 609 | 20.45 | 6.108e-06 | 1.506 |
| chr7:97406264 | rs6465617 | - | T>C | 541 | 3766 | 20.16 | 7.107e-06 | 0.8017 |
| chr17:48124582 | rs16948609 | - | T>G | 699 | 3401 | 19.8 | 8.582e-06 | 1.223 |
| chr20:52914728 | rs6023096 | - | A>G | 254 | 1089 | 19.31 | 1.112e-05 | 1.369 |
| chr4:162647296 | rs1982122 | FSTL5 | C>T | 149 | 578 | 19.27 | 1.135e-05 | 1.503 |
| chr5:96523921 | rs4869151 | - | G>T | 1683 | 10579 | 18.62 | 1.593e-05 | 0.8635 |
| chr13:61276558 | rs17803331 | - | A>G | 173 | 700 | 18.11 | 2.084e-05 | 1.443 |
| chr8:116180577 | rs777819 | - | T>C | 162 | 650 | 18.1 | 2.094e-05 | 1.46 |
| chr20:6983761 | rs6085823 | - | C>T | 280 | 1230 | 18.05 | 2.149e-05 | 1.336 |
| chr2:221946001 | rs73993848 | - | G>A | 59 | 183 | 17.96 | 2.261e-05 | 1.874 |
| chr8:4122438 | rs117645899 | CSMD1 | C>A | 197 | 817 | 17.95 | 2.27e-05 | 1.408 |
| chr13:36515114 | rs79214738 | DCLK1 | C>T | 114 | 424 | 17.89 | 2.345e-05 | 1.565 |
| chr5:96578141 | rs13162261 | - | A>G | 2122 | 11384 | 17.77 | 2.491e-05 | 1.151 |
| chr8:40517440 | rs77892744 | ZMAT4 | G>C | 195 | 810 | 17.63 | 2.68e-05 | 1.406 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: J984 | Other disorders of lung | 5/20 |
| ID | Name | Top Correlation |
|---|---|---|
| ICD-10: C343 | Lower lobe, bronchus or lung | 0/20 |