Entrapment neuropathy

0012181

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

Links

Sex Split

Interactive Plot

Statistics

Case	Control
30677	429517

Phenotype Definition

Malfunction of a peripheral nerve resulting from mechanical compression of the nerve roots from internal or external causes and leading to a conduction block or axonal loss. [HPO:probinson]

Phenotype Comment

An entrapment neuropathy is an isolated peripheral nerve injury due to mechanical contriction in a fibrous or fibro-osseous tunnel or to deformation of the nerve by a fibrous band.

Top SNP Information

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr1:159174683	rs2814778	ACKR1	T>C	1572	17805	62.9	2.172e-15	1.235
chr23:64367019	rs7064929	-	G>A	1452	16114	52.89	3.523e-13	1.224
chr15:45556163	rs8023604	SLC28A2	T>C	1070	11841	52.58	4.128e-13	1.262
chr10:21957229	rs2183271	MLLT10	T>C	23967	321998	46.99	7.133e-12	1.06
chr12:56755058	rs4301822	APOF	A>G	1035	11577	46.43	9.498e-12	1.249
chr17:29326735	rs10221206	RNF135	C>G	1346	15472	46.41	9.592e-12	1.216
chr17:29375177	rs6505228	-	A>G	1796	21198	46.4	9.648e-12	1.185
chr2:66725070	rs12995572	MEIS1	G>C	2092	25059	45.03	1.936e-11	1.168
chr23:19215613	rs5955734	-	C>G	2359	27666	45.02	1.952e-11	1.159
chr10:21834536	rs7098100	MLLT10	G>A	22937	307665	44.25	2.897e-11	1.058
chr17:29290106	rs55861543	-	C>T	1628	19131	44.08	3.16e-11	1.189
chr6:136480972	rs9483910	PDE7B	C>T	1672	19698	43.91	3.446e-11	1.186
chr10:21824727	rs10828249	MLLT10	G>A	23147	310765	43.1	5.198e-11	1.057
chr11:67220175	rs1638560	GPR152	A>G	925	10307	42.79	6.099e-11	1.253
chr17:29298304	rs7225888	RNF135	C>G	1564	18371	42.56	6.86e-11	1.19
chr23:55287820	rs5913807	PAGE3	G>T	2043	23808	42.35	7.633e-11	1.165
chr4:117145549	rs2030796	-	G>A	882	9796	41.83	9.966e-11	1.257
chr23:55985953	rs7885685	-	A>G	2349	27722	41.21	1.37e-10	1.151
chr17:29350769	rs8073072	-	T>G	1976	23730	41.09	1.456e-10	1.164
chr11:67218909	rs949252	GPR152	A>G	887	9889	40.81	1.68e-10	1.252
chr10:21957229	rs2183271	MLLT10	T>C	22395	302869	41.53	1.159e-10	1.058
chr10:21824727	rs10828249	MLLT10	G>A	21755	294147	37.82	7.745e-10	1.055
chr10:21834536	rs7098100	MLLT10	G>A	21425	289943	34.66	3.922e-09	1.053
chr2:218144954	rs10203066	-	G>A	8227	122571	34.45	4.367e-09	0.9306
chr10:22141442	rs1086899	DNAJC1	C>T	18197	245949	29.74	4.949e-08	1.051
chr10:21889083	rs12356674	MLLT10	G>T	18062	244189	28.46	9.582e-08	1.05
chr1:44289397	rs37459	AL451062.4	A>G	20975	302495	27.95	1.246e-07	0.9545
chr16:1364281	rs4984806	UBE2I	C>T	7384	109640	27.09	1.937e-07	0.9354
chr2:218149208	rs13412814	-	A>G	11623	170116	26.84	2.205e-07	0.9463
chr19:52224171	rs4802855	HAS1	T>G	16556	240209	26.05	3.329e-07	0.9531
chr19:52223121	rs7248778	HAS1	G>A	16131	234048	25.64	4.106e-07	0.9528
chr1:44290530	rs37458	AL451062.4	A>G	20682	298328	25.5	4.417e-07	0.9562
chr10:22284140	rs7089656	DNAJC1	G>T	17005	230315	24.06	9.351e-07	1.047
chr10:21782842	rs5011832	-	T>C	22353	304387	23.94	9.913e-07	1.043
chr2:60509080	rs1553933	-	T>C	24697	354330	23.66	1.152e-06	0.9594
chr10:22037809	rs6482190	-	G>A	16483	223829	23.45	1.279e-06	1.047
chr1:169519049	rs6025	F5	C>T	1578	19504	23.39	1.321e-06	1.137
chr7:154699709	rs62473030	-	T>G	1698	26774	23.27	1.411e-06	0.8848
chr1:44222570	rs11587515	AL451062.4	C>T	18320	264396	23.1	1.536e-06	0.957
chr11:125760995	rs4937066	HYLS1	C>T	11989	174863	22.57	2.028e-06	0.9512

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr3:7702538	rs9874612	GRM7	G>A	28561	20665	25.01	5.712e-07	0.9388
chr22:26937087	rs5761587	TPST2	C>A	5762	4424	24.1	9.151e-07	0.9018
chr2:218144954	rs10203066	-	G>A	8227	6192	22.48	2.126e-06	0.9176
chr9:88748683	rs56159808	-	G>A	5611	3574	21.95	2.794e-06	1.111
chr10:44429049	rs77897657	-	C>T	624	566	20.4	6.278e-06	0.7687
chr4:141026720	rs7655497	MAML3	T>C	3211	1981	20.26	6.775e-06	1.141
chr2:66377647	rs77275462	-	C>T	2945	1811	20.04	7.582e-06	1.147
chr3:69796492	rs56386221	MITF	A>G	13751	10129	20.0	7.74e-06	0.9354
chr10:53255311	rs10997796	PRKG1	C>T	1204	683	19.47	1.019e-05	1.237
chr3:7689333	rs28627576	GRM7	G>A	22278	16135	19.37	1.077e-05	0.9442
chr2:168385904	rs6725601	-	A>G	3840	2978	19.32	1.107e-05	0.8949
chr12:11031563	rs117317367	PRH1	C>G	771	677	19.24	1.15e-05	0.7927
chr2:11284415	rs6713473	C2orf50	A>G	994	851	19.18	1.187e-05	0.8138
chr4:141024195	rs72935774	MAML3	T>C	1489	866	19.08	1.254e-05	1.207
chr5:96237738	rs41276277	ERAP2	A>G	1086	926	19.02	1.29e-05	0.8213
chr1:4995026	rs12049256	-	T>C	28478	20501	18.93	1.357e-05	0.9465
chr17:73987590	Affx-14328116	TEN1-CDK3	G>T	1475	1216	18.62	1.595e-05	0.8443
chr2:218067808	rs11689537	-	C>A	7417	5570	18.6	1.611e-05	0.9215
chr4:10784440	rs75126244	-	A>G	2903	2282	18.54	1.667e-05	0.8838
chr16:60272504	rs62050933	-	C>T	19406	14104	18.54	1.661e-05	0.9436

Associated Diseases ^ⓘ

ID	Name	Top Correlation
ICD: D170	Benign lipomatous neoplasm of skin and subcutaneous tissue of head, face and neck	2/20
ICD: D171	Benign lipomatous neoplasm of skin and subcutaneous tissue of trunk	7/20
ICD: D176	Benign lipomatous neoplasm of spermatic cord	3/20
ICD: D179	Benign lipomatous neoplasm, unspecified	1/20
ICD: M674	Ganglion	3/20

ID	Name	Top Correlation
ICD-10: D172	Benign lipomatous neoplasm of skin and subcutaneous tissue of limbs	0/20
ICD-10: D173	Benign lipomatous neoplasm of skin and subcutaneous tissue of other and unspecified sites	0/20
ICD-10: D175	Benign lipomatous neoplasm of intra-abdominal organs	0/20
ICD-10: D177	Benign lipomatous neoplasm of other sites	0/20
ICD-10: G560	Carpal tunnel syndrome	0/20
ICD-10: G562	Lesion of ulnar nerve	0/20
ICD-10: G571	Meralgia paraesthetica	0/20
ICD-10: M754	Impingement syndrome of shoulder	0/20
ICD-10: M770	Medial epicondylitis	0/20
ICD-10: R521	Chronic intractable pain	0/20