Statistics
| Case | Control |
|---|---|
| 36240 | 423954 |
Phenotype Definition
Inflammation of the large airways in the lung including any part of the bronchi from the primary bronchi to the tertiary bronchi. [HPO:probinson]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 1671 | 25855 | 120.6 | 4.733e-28 | 0.7562 |
| chr6:170242949 | rs9396958 | - | T>C | 926 | 15188 | 97.26 | 6.086e-23 | 0.7158 |
| chr15:48392165 | rs1834640 | - | A>G | 2021 | 29603 | 92.86 | 5.618e-22 | 0.7992 |
| chr2:136407479 | rs1446585 | R3HDM1 | A>G | 19735 | 246663 | 86.55 | 1.362e-20 | 0.9231 |
| chr2:135837906 | rs7570971 | RAB3GAP1 | C>A | 22647 | 280926 | 81.32 | 1.916e-19 | 0.9283 |
| chr2:211717706 | rs12995612 | - | C>G | 988 | 15484 | 77.23 | 1.521e-18 | 0.7488 |
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 4660 | 62398 | 76.12 | 2.673e-18 | 0.8723 |
| chr2:135911422 | Affx-17900027 | RAB3GAP1 | T>C | 17823 | 222783 | 75.19 | 4.282e-18 | 0.9258 |
| chr15:78754000 | rs1964678 | IREB2 | G>A | 28845 | 354325 | 74.76 | 5.322e-18 | 0.935 |
| chr15:78789488 | rs13180 | IREB2 | T>C | 29008 | 356240 | 74.61 | 5.721e-18 | 0.9351 |
| chr15:78774271 | rs8042238 | IREB2 | T>C | 29015 | 356144 | 73.05 | 1.265e-17 | 0.9358 |
| chr5:147863034 | rs9325101 | HTR4 | A>G | 1017 | 15723 | 72.0 | 2.149e-17 | 0.7591 |
| chr5:33958959 | rs28777 | SLC45A2 | A>C | 3932 | 53060 | 71.23 | 3.18e-17 | 0.8666 |
| chr2:136825272 | rs932206 | - | T>C | 28054 | 344271 | 68.85 | 1.062e-16 | 0.937 |
| chr6:396321 | rs12203592 | IRF4 | C>T | 16638 | 184567 | 67.97 | 1.662e-16 | 1.078 |
| chr2:171380643 | rs34020565 | MYO3B | T>G | 1599 | 23260 | 67.91 | 1.714e-16 | 0.8066 |
| chr14:33956209 | rs1012023 | NPAS3 | C>A | 2196 | 30864 | 65.85 | 4.854e-16 | 0.8339 |
| chr6:22050187 | rs1736507 | - | C>A | 879 | 13634 | 64.17 | 1.142e-15 | 0.7561 |
| chr10:49805216 | rs11101394 | ARHGAP22 | C>T | 1149 | 17208 | 64.13 | 1.163e-15 | 0.7824 |
| chr6:3665772 | rs9502040 | - | G>A | 1095 | 16500 | 63.94 | 1.28e-15 | 0.7782 |
| chr15:78754000 | rs1964678 | IREB2 | G>A | 26706 | 324747 | 59.72 | 1.092e-14 | 0.9399 |
| chr15:78789488 | rs13180 | IREB2 | T>C | 26856 | 326404 | 58.78 | 1.764e-14 | 0.9404 |
| chr15:78774271 | rs8042238 | IREB2 | T>C | 26855 | 326306 | 57.97 | 2.666e-14 | 0.9408 |
| chr6:396321 | rs12203592 | IRF4 | C>T | 16447 | 182468 | 51.96 | 5.677e-13 | 1.069 |
| chr15:78898723 | rs12914385 | CHRNA3 | C>T | 28457 | 322396 | 43.96 | 3.353e-11 | 1.054 |
| chr15:78783277 | rs11858836 | IREB2 | G>A | 23897 | 269469 | 43.95 | 3.368e-11 | 1.056 |
| chr15:78907656 | rs6495308 | CHRNA3 | T>C | 15861 | 194671 | 43.87 | 3.504e-11 | 0.94 |
| chr15:78873119 | rs569207 | CHRNA5 | C>T | 15817 | 194006 | 42.56 | 6.86e-11 | 0.9408 |
| chr15:78863472 | rs667282 | CHRNA5 | T>C | 15792 | 193659 | 42.43 | 7.327e-11 | 0.9408 |
| chr15:78896547 | rs938682 | CHRNA3 | A>G | 15872 | 194572 | 42.19 | 8.287e-11 | 0.9411 |
| chr15:78814046 | rs10519203 | HYKK | A>G | 25118 | 283830 | 42.16 | 8.423e-11 | 1.054 |
| chr15:78891627 | rs12910984 | CHRNA3 | A>G | 15859 | 194489 | 41.98 | 9.232e-11 | 0.9412 |
| chr15:78911181 | rs8040868 | CHRNA3 | T>C | 29227 | 331519 | 41.93 | 9.448e-11 | 1.052 |
| chr15:78802869 | rs9788721 | HYKK | T>C | 25406 | 287171 | 41.44 | 1.213e-10 | 1.054 |
| chr15:78826180 | rs931794 | HYKK | A>G | 25079 | 283610 | 39.75 | 2.888e-10 | 1.053 |
| chr15:78806023 | rs8034191 | HYKK | T>C | 24990 | 282539 | 39.54 | 3.21e-10 | 1.053 |
| chr15:78857939 | rs55853698 | CHRNA5 | T>G | 24965 | 282478 | 38.43 | 5.688e-10 | 1.052 |
| chr15:78878541 | rs951266 | CHRNA5 | G>A | 24619 | 278453 | 38.09 | 6.751e-10 | 1.052 |
| chr9:128721295 | rs7867968 | PBX3 | T>C | 21843 | 264840 | 37.99 | 7.098e-10 | 0.9494 |
| chr15:78873993 | rs7180002 | CHRNA5 | A>T | 24609 | 278376 | 37.82 | 7.776e-10 | 1.052 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr15:78789488 | rs13180 | IREB2 | T>C | 26856 | 12706 | 31.1 | 2.451e-08 | 0.9264 |
| chr15:78774271 | rs8042238 | IREB2 | T>C | 26855 | 12697 | 30.52 | 3.297e-08 | 0.927 |
| chr15:78754000 | rs1964678 | IREB2 | G>A | 26706 | 12631 | 30.38 | 3.547e-08 | 0.9271 |
| chr15:96952908 | rs8025140 | - | G>A | 30839 | 14414 | 20.37 | 6.398e-06 | 0.941 |
| chr23:137560779 | rs6654348 | - | T>C | 6827 | 3484 | 20.23 | 6.861e-06 | 0.9042 |
| chr1:203336822 | rs61825728 | - | C>A | 3914 | 1549 | 20.2 | 6.958e-06 | 1.148 |
| chr18:30044928 | rs117263732 | GAREM1 | T>C | 3212 | 1254 | 19.73 | 8.931e-06 | 1.163 |
| chr1:187405684 | rs115015024 | - | A>G | 3571 | 1407 | 19.64 | 9.327e-06 | 1.153 |
| chr3:173191653 | rs115626912 | NLGN1 | C>T | 2270 | 1196 | 19.55 | 9.807e-06 | 0.8516 |
| chr13:95826164 | rs9524816 | ABCC4 | G>A | 6169 | 3061 | 19.43 | 1.043e-05 | 0.9028 |
| chr7:71050482 | rs10807732 | GALNT17 | A>G | 19166 | 8237 | 19.29 | 1.124e-05 | 1.069 |
| chr18:24448129 | rs72878799 | - | A>G | 12874 | 5446 | 19.29 | 1.124e-05 | 1.081 |
| chr10:48511877 | rs4598610 | - | G>T | 30580 | 13335 | 19.23 | 1.156e-05 | 1.061 |
| chr3:54486470 | rs9654001 | CACNA2D3 | T>C | 34221 | 14970 | 19.17 | 1.194e-05 | 1.06 |
| chr1:90310183 | rs72716315 | AC093423.3 | C>T | 3536 | 1806 | 19.08 | 1.251e-05 | 0.8783 |
| chr2:1493604 | rs13413321 | TPO | G>T | 31768 | 13882 | 18.81 | 1.447e-05 | 1.06 |
| chr23:97126872 | rs6523129 | - | G>A | 2748 | 1472 | 18.61 | 1.605e-05 | 0.8665 |
| chr1:187243169 | rs75066068 | - | T>C | 3483 | 1375 | 18.49 | 1.704e-05 | 1.15 |
| chr15:78898723 | rs12914385 | CHRNA3 | C>T | 28457 | 12386 | 18.49 | 1.71e-05 | 1.061 |
| chr15:78868636 | rs72740964 | CHRNA5 | G>A | 24331 | 10552 | 18.47 | 1.73e-05 | 1.063 |