Statistics
| Case | Control |
|---|---|
| 28218 | 431976 |
Phenotype Definition
Inflammation of the large airways of the lung with rapid onset and short course usually associated with cough, mucus production, shortness of breath, wheezing, and chest tightness. [HPO:probinson]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr2:136407479 | rs1446585 | R3HDM1 | A>G | 15522 | 250876 | 54.5 | 1.556e-13 | 0.9314 |
| chr2:135837906 | rs7570971 | RAB3GAP1 | C>A | 17797 | 285776 | 51.08 | 8.889e-13 | 0.9362 |
| chr2:135911422 | Affx-17900027 | RAB3GAP1 | T>C | 14023 | 226583 | 46.46 | 9.352e-12 | 0.9344 |
| chr4:100239319 | rs1229984 | ADH1B | C>T | 1607 | 28869 | 39.25 | 3.727e-10 | 0.8499 |
| chr6:170242949 | rs9396958 | - | T>C | 797 | 15317 | 38.94 | 4.364e-10 | 0.7963 |
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 1440 | 26086 | 38.9 | 4.454e-10 | 0.843 |
| chr1:37584326 | rs215765 | - | C>T | 768 | 14802 | 38.64 | 5.109e-10 | 0.7937 |
| chr11:15985572 | rs730994 | - | C>G | 565 | 11281 | 38.0 | 7.076e-10 | 0.7662 |
| chr2:136825272 | rs932206 | - | T>C | 22065 | 350260 | 37.53 | 9.007e-10 | 0.9477 |
| chr2:211717706 | rs12995612 | - | C>G | 822 | 15650 | 37.09 | 1.126e-09 | 0.8033 |
| chr6:32303848 | rs28361060 | TSBP1 | G>A | 13671 | 200189 | 36.37 | 1.634e-09 | 1.063 |
| chr2:136643555 | rs309125 | - | C>T | 13956 | 224188 | 36.31 | 1.684e-09 | 0.9417 |
| chr6:32333341 | rs9268362 | TSBP1 | A>G | 13706 | 200705 | 35.98 | 1.997e-09 | 1.062 |
| chr6:32282854 | rs6910071 | TSBP1 | A>G | 13646 | 199954 | 35.06 | 3.199e-09 | 1.061 |
| chr15:78789488 | rs13180 | IREB2 | T>C | 22881 | 362367 | 35.03 | 3.248e-09 | 0.9499 |
| chr15:78774271 | rs8042238 | IREB2 | T>C | 22885 | 362274 | 34.94 | 3.4e-09 | 0.95 |
| chr15:78754000 | rs1964678 | IREB2 | G>A | 22765 | 360405 | 34.44 | 4.399e-09 | 0.9503 |
| chr2:135954405 | rs1375132 | ZRANB3 | A>G | 13232 | 212692 | 34.16 | 5.086e-09 | 0.9423 |
| chr15:78907656 | rs6495308 | CHRNA3 | T>C | 13636 | 218789 | 33.77 | 6.218e-09 | 0.9433 |
| chr2:136594158 | rs2236783 | LCT | A>G | 13464 | 216212 | 33.65 | 6.604e-09 | 0.9431 |
| chr2:136407479 | rs1446585 | R3HDM1 | A>G | 13041 | 209419 | 37.24 | 1.042e-09 | 0.9391 |
| chr6:32607376 | rs34250758 | HLA-DQA1 | G>A | 11781 | 171509 | 35.73 | 2.262e-09 | 1.066 |
| chr6:32602396 | rs9272226 | HLA-DQA1 | T>C | 21444 | 317768 | 35.1 | 3.13e-09 | 1.055 |
| chr2:135837906 | rs7570971 | RAB3GAP1 | C>A | 15210 | 242676 | 34.74 | 3.775e-09 | 0.9439 |
| chr6:32303848 | rs28361060 | TSBP1 | G>A | 13389 | 195848 | 34.01 | 5.48e-09 | 1.061 |
| chr6:32333341 | rs9268362 | TSBP1 | A>G | 13425 | 196357 | 33.63 | 6.67e-09 | 1.061 |
| chr6:32282854 | rs6910071 | TSBP1 | A>G | 13365 | 195615 | 32.85 | 9.932e-09 | 1.06 |
| chr15:78774271 | rs8042238 | IREB2 | T>C | 21028 | 332133 | 31.82 | 1.696e-08 | 0.9506 |
| chr6:32577380 | rs660895 | - | A>G | 12488 | 182479 | 31.72 | 1.778e-08 | 1.061 |
| chr15:78789488 | rs13180 | IREB2 | T>C | 21031 | 332229 | 31.51 | 1.989e-08 | 0.9508 |
| chr15:78754000 | rs1964678 | IREB2 | G>A | 20925 | 330528 | 31.46 | 2.038e-08 | 0.9508 |
| chr6:32257284 | rs9268145 | TSBP1 | T>G | 13351 | 195644 | 31.38 | 2.12e-08 | 1.059 |
| chr6:32581973 | rs521539 | - | G>A | 12488 | 182607 | 30.78 | 2.888e-08 | 1.06 |
| chr2:135911422 | Affx-17900027 | RAB3GAP1 | T>C | 11641 | 186777 | 30.58 | 3.197e-08 | 0.9424 |
| chr2:136643555 | rs309125 | - | C>T | 11822 | 189472 | 29.95 | 4.431e-08 | 0.9433 |
| chr6:32582650 | rs3104413 | - | C>G | 11098 | 162096 | 29.34 | 6.086e-08 | 1.061 |
| chr2:136594158 | rs2236783 | LCT | A>G | 11362 | 182306 | 29.32 | 6.145e-08 | 0.9431 |
| chr6:32577973 | rs532965 | - | T>G | 11192 | 163475 | 28.61 | 8.832e-08 | 1.06 |
| chr15:78907656 | rs6495308 | CHRNA3 | T>C | 12394 | 198138 | 28.61 | 8.866e-08 | 0.9455 |
| chr6:32583357 | rs6931277 | - | A>T | 10965 | 159991 | 28.27 | 1.057e-07 | 1.06 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr20:9471369 | rs116922661 | - | C>T | 922 | 330 | 24.23 | 8.538e-07 | 0.7277 |
| chr12:10511662 | rs10743886 | - | T>C | 8738 | 2063 | 21.62 | 3.332e-06 | 1.131 |
| chr11:81490999 | rs11232859 | - | G>A | 1530 | 301 | 21.43 | 3.661e-06 | 1.342 |
| chr14:23989818 | rs73589269 | - | G>A | 1582 | 313 | 21.41 | 3.705e-06 | 1.334 |
| chr6:36763413 | rs72856431 | CPNE5 | C>T | 980 | 342 | 21.29 | 3.944e-06 | 0.7468 |
| chr8:79098123 | Affx-32637272 | - | C>G | 2764 | 863 | 21.19 | 4.15e-06 | 0.8315 |
| chr5:155193973 | rs114980758 | - | C>T | 956 | 334 | 20.82 | 5.036e-06 | 0.7466 |
| chr1:26474444 | rs116453500 | - | G>T | 1223 | 414 | 20.61 | 5.634e-06 | 0.7703 |
| chr23:115492023 | rs143792619 | - | C>T | 510 | 191 | 19.74 | 8.894e-06 | 0.6854 |
| chr2:145118699 | rs75558964 | - | A>G | 1371 | 455 | 19.35 | 1.089e-05 | 0.7858 |
| chr22:22484599 | rs5750563 | - | G>T | 3142 | 963 | 19.12 | 1.228e-05 | 0.8469 |
| chr18:50737358 | rs62100766 | DCC | G>T | 22251 | 6129 | 19.01 | 1.301e-05 | 0.9213 |
| chr11:133279288 | rs12269822 | OPCML | G>A | 1029 | 352 | 18.99 | 1.314e-05 | 0.7624 |
| chr3:157845784 | rs62288315 | RSRC1 | C>T | 1415 | 466 | 18.95 | 1.342e-05 | 0.7901 |
| chr9:884420 | rs6477354 | DMRT1 | G>A | 15869 | 3894 | 18.85 | 1.414e-05 | 1.095 |
| chr9:5375261 | rs55853249 | PLGRKT | G>A | 1905 | 395 | 18.64 | 1.582e-05 | 1.273 |
| chr3:50420554 | rs2236950 | CACNA2D2 | C>A | 10027 | 2406 | 18.52 | 1.677e-05 | 1.113 |
| chr6:32410087 | rs16822618 | HLA-DRA | T>C | 4272 | 1278 | 18.5 | 1.698e-05 | 0.8666 |
| chr17:80764011 | rs869228 | TBCD | G>A | 3812 | 1150 | 18.42 | 1.773e-05 | 0.8607 |
| chr6:32409996 | rs6911777 | HLA-DRA | T>C | 4264 | 1275 | 18.38 | 1.81e-05 | 0.8669 |