Statistics
| Case | Control |
|---|---|
| 27803 | 432391 |
Phenotype Definition
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the leg. [ORCID:0000-0001-5208-3432]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr23:64367019 | rs7064929 | - | G>A | 1476 | 16090 | 137.8 | 8.066e-32 | 1.381 |
| chr1:159174683 | rs2814778 | ACKR1 | T>C | 1551 | 17826 | 120.9 | 3.95e-28 | 1.342 |
| chr9:117110112 | Affx-52344420 | AKNA | T>TG | 1203 | 13376 | 115.8 | 5.245e-27 | 1.385 |
| chr23:148151708 | Affx-34694529 | - | A>C | 796 | 8055 | 112.1 | 3.32e-26 | 1.483 |
| chr23:109671384 | rs768312 | AMMECR1 | T>C | 1295 | 14344 | 108.6 | 2.031e-25 | 1.357 |
| chr23:110685534 | rs16986503 | - | C>T | 1060 | 11423 | 105.3 | 1.058e-24 | 1.393 |
| chr6:37328215 | Affx-28571852 | RNF8 | C>CT | 1521 | 17795 | 104.6 | 1.508e-24 | 1.318 |
| chr15:45556163 | rs8023604 | SLC28A2 | T>C | 1062 | 11849 | 99.92 | 1.583e-23 | 1.379 |
| chr18:9536315 | rs14336 | RALBP1 | A>C | 1057 | 11810 | 98.59 | 3.113e-23 | 1.377 |
| chr23:63423664 | rs5964740 | AMER1 | C>T | 1881 | 22219 | 98.46 | 3.322e-23 | 1.274 |
| chr23:19215613 | rs5955734 | - | C>G | 2294 | 27731 | 98.43 | 3.361e-23 | 1.247 |
| chr23:63410110 | rs61730681 | AMER1 | T>C | 1882 | 22251 | 98.17 | 3.83e-23 | 1.274 |
| chr6:136480972 | rs9483910 | PDE7B | C>T | 1652 | 19718 | 97.61 | 5.087e-23 | 1.292 |
| chr16:17200759 | rs8044934 | XYLT1 | G>A | 1522 | 17973 | 97.51 | 5.351e-23 | 1.305 |
| chr16:17200685 | rs8046024 | XYLT1 | C>T | 1541 | 18236 | 97.19 | 6.298e-23 | 1.302 |
| chr9:137925543 | rs7027926 | - | G>A | 1333 | 15487 | 96.1 | 1.094e-22 | 1.326 |
| chr23:142717383 | rs73577386 | SLITRK4 | A>G | 686 | 6936 | 96.1 | 1.094e-22 | 1.481 |
| chr23:53347028 | rs1547218 | IQSEC2 | T>C | 2923 | 36330 | 96.04 | 1.128e-22 | 1.214 |
| chr8:145639681 | rs1871534 | SLC39A4 | G>C | 1424 | 16721 | 95.85 | 1.239e-22 | 1.313 |
| chr15:45695612 | rs1346265 | SPATA5L1 | C>T | 967 | 10703 | 95.53 | 1.458e-22 | 1.39 |
| chr6:34546560 | rs2814982 | - | C>T | 6122 | 87730 | 42.67 | 6.494e-11 | 1.096 |
| chr6:34552797 | rs2814944 | - | G>A | 8613 | 126396 | 32.11 | 1.459e-08 | 1.071 |
| chr1:63538050 | rs77665570 | - | A>G | 1302 | 17466 | 27.62 | 1.474e-07 | 1.165 |
| chr6:34618893 | rs2814993 | ILRUN | G>A | 8178 | 120406 | 26.8 | 2.252e-07 | 1.066 |
| chr6:34683635 | rs6938239 | - | A>G | 8174 | 120433 | 26.05 | 3.333e-07 | 1.065 |
| chr11:115104610 | rs10891814 | CADM1 | C>A | 19653 | 314801 | 25.84 | 3.709e-07 | 0.9545 |
| chr5:136600241 | rs11746865 | SPOCK1 | A>G | 928 | 12176 | 25.34 | 4.806e-07 | 1.188 |
| chr6:34616322 | rs3800461 | ILRUN | G>C | 6688 | 98025 | 25.26 | 5.001e-07 | 1.07 |
| chr1:210334081 | rs17188183 | SYT14 | T>C | 7188 | 118177 | 24.43 | 7.688e-07 | 0.9377 |
| chr6:34825662 | rs16894959 | UHRF1BP1 | T>C | 8180 | 120756 | 24.23 | 8.57e-07 | 1.063 |
| chr19:1952841 | rs2396366 | CSNK1G2 | C>T | 20513 | 327918 | 24.05 | 9.376e-07 | 0.9565 |
| chr2:105451046 | rs10201472 | - | A>G | 24653 | 374338 | 23.38 | 1.328e-06 | 1.044 |
| chr18:53175966 | rs12956276 | TCF4 | G>A | 20092 | 303911 | 23.25 | 1.423e-06 | 1.045 |
| chr2:22515568 | rs12373752 | - | A>G | 26686 | 406211 | 22.84 | 1.761e-06 | 1.043 |
| chr19:1967121 | rs11671909 | CSNK1G2 | T>C | 21265 | 339357 | 22.79 | 1.806e-06 | 0.9578 |
| chr19:1957079 | rs11084923 | CSNK1G2 | T>C | 24209 | 385547 | 22.44 | 2.171e-06 | 0.959 |
| chr4:173105236 | rs76470327 | GALNTL6 | C>T | 2896 | 49206 | 22.41 | 2.205e-06 | 0.9112 |
| chr8:30999280 | rs1801195 | WRN | G>T | 24691 | 392675 | 22.34 | 2.283e-06 | 0.9592 |
| chr6:34498923 | rs6919434 | PACSIN1 | C>T | 5219 | 76096 | 22.27 | 2.363e-06 | 1.074 |
| chr6:34827085 | rs9469913 | UHRF1BP1 | A>T | 9318 | 138425 | 22.19 | 2.472e-06 | 1.057 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr4:173105236 | rs76470327 | GALNTL6 | C>T | 2896 | 903 | 31.39 | 2.108e-08 | 0.8025 |
| chr4:173035782 | rs62331103 | GALNTL6 | C>T | 2960 | 911 | 28.24 | 1.07e-07 | 0.8125 |
| chr6:32441100 | rs9269081 | - | C>A | 15006 | 3510 | 24.71 | 6.674e-07 | 1.114 |
| chr6:32439964 | rs5026743 | - | T>G | 21729 | 5184 | 24.13 | 9.017e-07 | 1.101 |
| chr6:32428186 | rs6923504 | - | C>G | 15400 | 3610 | 24.06 | 9.362e-07 | 1.111 |
| chr6:32428285 | rs6903608 | - | T>C | 15353 | 3592 | 24.04 | 9.434e-07 | 1.111 |
| chr8:133437151 | rs72721069 | KCNQ3 | T>C | 833 | 293 | 23.98 | 9.722e-07 | 0.7158 |
| chr6:32431147 | rs9268877 | - | G>A | 21504 | 5138 | 23.76 | 1.093e-06 | 1.1 |
| chr6:32429594 | Affx-28475675 | - | G>A | 21780 | 5203 | 23.58 | 1.198e-06 | 1.099 |
| chr16:53906234 | rs6499654 | FTO | T>C | 3761 | 1116 | 23.54 | 1.226e-06 | 0.842 |
| chr11:129764757 | rs1733455 | NFRKB | A>G | 16505 | 4460 | 20.48 | 6.029e-06 | 0.912 |
| chr18:11519389 | rs75306162 | - | A>C | 3152 | 938 | 20.09 | 7.398e-06 | 0.8418 |
| chr3:121325420 | rs77357569 | FBXO40 | C>T | 10454 | 2878 | 19.42 | 1.051e-05 | 0.9014 |
| chr21:23279070 | rs116971926 | - | C>T | 2310 | 471 | 19.17 | 1.195e-05 | 1.252 |
| chr1:115829313 | rs6330 | NGF | G>A | 25198 | 6662 | 18.88 | 1.39e-05 | 0.921 |
| chr20:36068389 | rs17194885 | - | A>C | 1574 | 306 | 18.59 | 1.623e-05 | 1.312 |
| chr3:79419101 | rs7617893 | ROBO1 | C>G | 24807 | 5999 | 18.53 | 1.676e-05 | 1.086 |
| chr11:27811712 | rs117097517 | - | C>T | 1273 | 410 | 18.47 | 1.724e-05 | 0.7812 |
| chr16:1512731 | rs35523252 | CLCN7 | A>G | 7194 | 2016 | 18.41 | 1.785e-05 | 0.89 |
| chr12:118666427 | rs445926 | TAOK3 | T>C | 1789 | 555 | 18.1 | 2.101e-05 | 0.8103 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: M543 | Sciatica | 3/20 |
| ICD: M545 | Low back pain | 12/20 |
| ICD: M549 | Dorsalgia, unspecified | 12/20 |
| ICD: M796 | Pain in limb | 5/20 |