Statistics
| Case | Control |
|---|---|
| 20261 | 439933 |
Phenotype Definition
A deviation from the norm of the intracranial pressure. [HPO:probinson]
Phenotype Comment
Intracranial pressure (i.e., the pressure inside the skull) represents the pressue in the brain tissue and in the cerebrospinal fluid (CSF). Deviations from normal are generally identified by measuring the pressure of the CSF.
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 3373 | 63685 | 55.39 | 9.877e-14 | 1.147 |
| chr5:33958959 | rs28777 | SLC45A2 | A>C | 2858 | 54134 | 44.41 | 2.66e-11 | 1.141 |
| chr23:148045160 | rs6655003 | AFF2 | A>G | 2484 | 45957 | 42.06 | 8.857e-11 | 1.149 |
| chr23:148151708 | Affx-34694529 | - | A>C | 519 | 8332 | 36.74 | 1.35e-09 | 1.317 |
| chr3:74539235 | rs9831786 | CNTN3 | T>C | 878 | 15370 | 34.1 | 5.237e-09 | 1.227 |
| chr23:147980413 | rs1867024 | AFF2 | T>C | 2123 | 39439 | 33.75 | 6.277e-09 | 1.143 |
| chr23:102191083 | rs5987498 | - | G>T | 835 | 14439 | 32.29 | 1.33e-08 | 1.227 |
| chr23:37890673 | rs7881956 | AF241726.2 | C>T | 1421 | 25765 | 31.36 | 2.139e-08 | 1.168 |
| chr5:33955673 | rs35391 | SLC45A2 | C>T | 2055 | 38925 | 31.34 | 2.166e-08 | 1.138 |
| chr5:33955326 | rs35390 | SLC45A2 | A>C | 2063 | 39084 | 31.31 | 2.197e-08 | 1.138 |
| chr2:22594727 | rs1533046 | - | G>A | 19557 | 431920 | 31.14 | 2.407e-08 | 0.9464 |
| chr23:19223321 | rs5955542 | - | C>T | 2199 | 41167 | 30.89 | 2.735e-08 | 1.134 |
| chr23:102522244 | rs61558955 | - | G>T | 1267 | 22811 | 30.69 | 3.026e-08 | 1.177 |
| chr23:128718936 | rs2362937 | OCRL | T>C | 1064 | 18887 | 30.4 | 3.508e-08 | 1.193 |
| chr14:65770947 | rs58184395 | - | A>G | 818 | 14488 | 28.72 | 8.364e-08 | 1.214 |
| chr17:40957849 | rs61995868 | CNTD1 | G>A | 588 | 10094 | 27.89 | 1.286e-07 | 1.252 |
| chr9:136523166 | rs3025425 | DBH | C>T | 921 | 16549 | 27.81 | 1.338e-07 | 1.197 |
| chr23:110414666 | rs57204200 | PAK3 | C>T | 1056 | 18910 | 27.3 | 1.738e-07 | 1.183 |
| chr2:98175863 | rs6718109 | ANKRD36B | C>T | 15436 | 319606 | 27.29 | 1.751e-07 | 1.055 |
| chr23:50659210 | Affx-52372905 | BMP15 | C>CTCT | 608 | 10330 | 27.06 | 1.977e-07 | 1.244 |
| chr1:159629194 | rs1446976 | - | A>G | 13672 | 308375 | 29.51 | 5.555e-08 | 0.9433 |
| chr2:22594727 | rs1533046 | - | G>A | 18665 | 416816 | 26.93 | 2.109e-07 | 0.9484 |
| chr2:152996974 | rs17398329 | STAM2 | C>T | 20984 | 444998 | 23.0 | 1.621e-06 | 1.05 |
| chr11:28613337 | rs7118207 | - | A>G | 7661 | 158128 | 22.87 | 1.732e-06 | 1.064 |
| chr8:73279185 | rs73302752 | - | T>C | 778 | 14197 | 22.24 | 2.406e-06 | 1.191 |
| chr2:22594027 | rs12616949 | - | G>A | 14063 | 295984 | 21.8 | 3.03e-06 | 1.053 |
| chr19:36276767 | rs120960 | ARHGAP33 | G>A | 18136 | 383365 | 21.54 | 3.469e-06 | 1.049 |
| chr6:145055982 | rs4896739 | UTRN | T>C | 3913 | 91103 | 20.54 | 5.835e-06 | 0.9251 |
| chr12:109034978 | rs75617154 | - | G>A | 1358 | 26066 | 20.02 | 7.648e-06 | 1.135 |
| chr14:49755449 | rs4075191 | - | C>T | 7378 | 152644 | 19.96 | 7.904e-06 | 1.061 |
| chr12:14548314 | rs7954210 | ATF7IP | C>A | 18645 | 415036 | 19.91 | 8.122e-06 | 0.9555 |
| chr1:159616629 | rs2592900 | - | A>G | 9350 | 211451 | 19.78 | 8.686e-06 | 0.9476 |
| chr10:43548659 | rs3116709 | - | G>A | 14352 | 302238 | 19.4 | 1.061e-05 | 1.048 |
| chr2:22646064 | rs72799358 | - | T>C | 967 | 24183 | 19.3 | 1.116e-05 | 0.8644 |
| chr12:14656768 | rs1600 | PLBD1 | G>C | 20529 | 436107 | 19.27 | 1.133e-05 | 1.046 |
| chr13:110983707 | rs9588139 | COL4A2 | G>T | 3502 | 81709 | 19.07 | 1.259e-05 | 0.9242 |
| chr23:6847912 | rs5934247 | PUDP | C>T | 14256 | 296318 | 19.03 | 1.29e-05 | 1.052 |
| chr2:144227603 | rs77601553 | ARHGAP15 | T>C | 9741 | 203226 | 18.96 | 1.332e-05 | 1.053 |
| chr2:22515568 | rs12373752 | - | A>G | 19481 | 413416 | 18.92 | 1.362e-05 | 1.045 |
| chr11:28190747 | rs1351787 | METTL15 | G>A | 7079 | 146434 | 18.92 | 1.363e-05 | 1.06 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr1:159629194 | rs1446976 | - | A>G | 13672 | 122458 | 25.35 | 4.783e-07 | 0.9457 |
| chr19:36276767 | rs120960 | ARHGAP33 | G>A | 18136 | 152164 | 23.47 | 1.269e-06 | 1.052 |
| chr14:49755449 | rs4075191 | - | C>T | 7378 | 60500 | 21.53 | 3.488e-06 | 1.065 |
| chr6:145055982 | rs4896739 | UTRN | T>C | 3913 | 36353 | 21.18 | 4.179e-06 | 0.9217 |
| chr12:109034978 | rs75617154 | - | G>A | 1358 | 10335 | 19.6 | 9.555e-06 | 1.139 |
| chr22:34250471 | rs2018292 | LARGE1 | A>G | 9410 | 77872 | 19.3 | 1.116e-05 | 1.056 |
| chr13:32705349 | rs7330619 | FRY | G>A | 11802 | 105577 | 19.09 | 1.244e-05 | 0.9508 |
| chr4:125824727 | rs75801512 | - | C>T | 3250 | 30307 | 18.74 | 1.498e-05 | 0.92 |
| chr2:152996974 | rs17398329 | STAM2 | C>T | 20984 | 177326 | 18.53 | 1.673e-05 | 1.046 |
| chr5:55392944 | rs111296580 | - | A>G | 845 | 6246 | 18.53 | 1.67e-05 | 1.173 |
| chr4:11302032 | rs9997158 | - | C>A | 1721 | 16538 | 18.52 | 1.678e-05 | 0.8946 |
| chr13:110983707 | rs9588139 | COL4A2 | G>T | 3502 | 32531 | 18.47 | 1.722e-05 | 0.9231 |
| chr19:36079704 | rs756783 | - | T>C | 18269 | 153860 | 18.42 | 1.768e-05 | 1.046 |
| chr22:17749096 | rs5749002 | - | G>A | 5784 | 52766 | 18.18 | 2.013e-05 | 0.9382 |
| chr2:22646064 | rs72799358 | - | T>C | 967 | 9614 | 18.12 | 2.073e-05 | 0.8648 |
| chr9:78657775 | rs17719947 | PCSK5 | G>A | 1815 | 14135 | 18.01 | 2.202e-05 | 1.114 |
| chr17:27430853 | rs62065161 | MYO18A | A>G | 1278 | 9750 | 17.89 | 2.346e-05 | 1.136 |
| chr17:8287893 | rs117363977 | - | A>G | 653 | 4739 | 17.67 | 2.633e-05 | 1.193 |
| chr10:43548659 | rs3116709 | - | G>A | 14352 | 120288 | 17.56 | 2.777e-05 | 1.047 |
| chr2:22594727 | rs1533046 | - | G>A | 18665 | 165015 | 17.36 | 3.1e-05 | 0.957 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: M512 | Other specified intervertebral disk displacement | 3/20 |
| ICD: R51 | Headache | 5/20 |