Statistics
| Case | Control |
|---|---|
| 27507 | 432687 |
Phenotype Definition
Impaired conduction of cardiac impulse occurring anywhere along the conduction pathway. [HPO:probinson]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:161010118 | rs10455872 | LPA | A>G | 5135 | 68564 | 134.4 | 4.363e-31 | 1.192 |
| chr6:160997118 | rs74617384 | LPA | A>T | 5006 | 66821 | 131.3 | 2.103e-30 | 1.192 |
| chr9:22124477 | rs10757278 | - | A>G | 29247 | 436853 | 124.0 | 8.626e-29 | 1.1 |
| chr9:22125503 | rs1333049 | - | G>C | 29263 | 437175 | 122.6 | 1.72e-28 | 1.099 |
| chr9:22098574 | rs4977574 | - | A>G | 29474 | 440947 | 121.3 | 3.311e-28 | 1.099 |
| chr9:22088260 | rs10757272 | - | C>T | 29569 | 442179 | 121.1 | 3.672e-28 | 1.098 |
| chr9:22096055 | rs10757274 | - | A>G | 29606 | 442946 | 120.1 | 6.061e-28 | 1.098 |
| chr9:22125347 | rs1333048 | - | A>C | 30245 | 453412 | 115.1 | 7.569e-27 | 1.096 |
| chr9:22115959 | rs2383207 | - | G>A | 26670 | 435369 | 76.16 | 2.617e-18 | 0.928 |
| chr9:22081850 | rs6475606 | - | C>T | 30008 | 454261 | 70.89 | 3.771e-17 | 1.074 |
| chr8:145639681 | rs1871534 | SLC39A4 | G>C | 822 | 17323 | 70.4 | 4.854e-17 | 0.7404 |
| chr9:22083404 | rs1333040 | - | T>C | 23110 | 378506 | 69.94 | 6.118e-17 | 0.9297 |
| chr1:159174683 | rs2814778 | ACKR1 | T>C | 901 | 18476 | 63.43 | 1.666e-15 | 0.7611 |
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 1345 | 26181 | 61.77 | 3.855e-15 | 0.801 |
| chr24:14850341 | rs2032598 | USP9Y | T>C | 123 | 2689 | 59.46 | 1.248e-14 | 0.497 |
| chr6:12903957 | rs9349379 | PHACTR1 | A>G | 24392 | 367806 | 59.34 | 1.324e-14 | 1.069 |
| chr18:4157690 | rs6506185 | DLGAP1 | T>C | 557 | 12153 | 59.23 | 1.404e-14 | 0.7164 |
| chr9:22068652 | rs4977756 | - | A>G | 22161 | 361895 | 57.59 | 3.223e-14 | 0.9354 |
| chr2:226686177 | rs7581591 | - | T>C | 940 | 18895 | 56.51 | 5.604e-14 | 0.7768 |
| chr13:113979972 | Affx-80297025 | GRTP1 | A>ACACT | 567 | 12140 | 53.64 | 2.409e-13 | 0.7298 |
| chr6:161010118 | rs10455872 | LPA | A>G | 5063 | 67687 | 135.8 | 2.219e-31 | 1.195 |
| chr6:160997118 | rs74617384 | LPA | A>T | 4934 | 65954 | 132.5 | 1.187e-30 | 1.195 |
| chr9:22125503 | rs1333049 | - | G>C | 27678 | 416240 | 99.7 | 1.777e-23 | 1.092 |
| chr9:22124477 | rs10757278 | - | A>G | 27668 | 416438 | 96.65 | 8.259e-23 | 1.09 |
| chr9:22088260 | rs10757272 | - | C>T | 27837 | 419369 | 93.85 | 3.401e-22 | 1.089 |
| chr9:22096055 | rs10757274 | - | A>G | 28001 | 422152 | 92.74 | 5.971e-22 | 1.088 |
| chr9:22098574 | rs4977574 | - | A>G | 27902 | 420824 | 91.89 | 9.162e-22 | 1.088 |
| chr9:22125347 | rs1333048 | - | A>C | 28532 | 430609 | 91.87 | 9.248e-22 | 1.088 |
| chr9:22115959 | rs2383207 | - | G>A | 25612 | 420409 | 85.5 | 2.315e-20 | 0.9217 |
| chr9:22081850 | rs6475606 | - | C>T | 27603 | 417159 | 80.83 | 2.464e-19 | 1.082 |
| chr9:22083404 | rs1333040 | - | T>C | 21852 | 358706 | 64.38 | 1.025e-15 | 0.9304 |
| chr6:160961137 | rs3798220 | LPA | T>C | 1233 | 15549 | 56.99 | 4.378e-14 | 1.253 |
| chr6:160922870 | rs117733303 | - | A>G | 1245 | 15739 | 56.29 | 6.247e-14 | 1.25 |
| chr6:160848743 | rs9457925 | SLC22A3 | G>A | 1244 | 15801 | 53.9 | 2.112e-13 | 1.244 |
| chr9:22068652 | rs4977756 | - | A>G | 21282 | 347358 | 45.43 | 1.58e-11 | 0.9409 |
| chr6:12903957 | rs9349379 | PHACTR1 | A>G | 23031 | 349937 | 43.69 | 3.842e-11 | 1.061 |
| chr9:21974218 | rs3731239 | AL359922.1 | A>G | 19362 | 316345 | 41.24 | 1.348e-10 | 0.9426 |
| chr6:160687412 | rs10080815 | SLC22A2 | T>G | 1278 | 16859 | 37.75 | 8.038e-10 | 1.197 |
| chr9:22003223 | rs3217992 | AL359922.1 | C>T | 20746 | 315504 | 36.32 | 1.677e-09 | 1.056 |
| chr9:22033366 | rs2157719 | - | T>C | 23126 | 375096 | 35.72 | 2.275e-09 | 0.9481 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: I252 | Old myocardial infarction | 15/20 |
| ICD: I258 | Other forms of chronic ischaemic heart disease | 15/20 |
| ICD: I447 | Left bundle-branch block, unspecified | 3/20 |