Statistics
| Case | Control |
|---|---|
| 1203 | 458991 |
Phenotype Definition
Disturbance in the atrial activation that is caused by transient failure of impulse conduction from the sinoatrial node to the cardiac atria. [HPO:probinson]
Phenotype Comment
Sinoatrial block is characterized by a delayed in heartbeat and pauses between P waves as demonstrated by electrocardiography.
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr12:53298582 | rs11554495 | KRT8 | C>A | 52 | 10071 | 25.64 | 4.12e-07 | 2.008 |
| chr7:113363243 | rs62488270 | - | C>T | 46 | 35530 | 24.36 | 7.974e-07 | 0.4871 |
| chr2:99523815 | rs7607186 | KIAA1211L | G>C | 495 | 155214 | 23.37 | 1.34e-06 | 1.274 |
| chr23:30444558 | rs141210698 | - | G>A | 66 | 14104 | 22.52 | 2.082e-06 | 1.799 |
| chr18:68135689 | rs7228596 | - | G>T | 94 | 22646 | 21.0 | 4.597e-06 | 1.613 |
| chr21:35645849 | rs116046186 | - | G>A | 76 | 17421 | 20.88 | 4.891e-06 | 1.694 |
| chr17:7735063 | rs57985356 | DNAH2 | T>G | 284 | 84132 | 20.37 | 6.38e-06 | 1.328 |
| chr5:31871346 | rs905836 | PDZD2 | C>T | 1369 | 480421 | 20.3 | 6.611e-06 | 1.197 |
| chr10:126221465 | rs17621431 | LHPP | G>C | 77 | 17864 | 20.29 | 6.661e-06 | 1.677 |
| chr21:40938269 | rs596320 | B3GALT5 | T>C | 820 | 274658 | 20.2 | 6.98e-06 | 1.21 |
| chr21:35647161 | rs116628212 | - | G>C | 77 | 17802 | 20.11 | 7.318e-06 | 1.673 |
| chr2:181996045 | rs13010713 | - | A>G | 986 | 420410 | 20.02 | 7.657e-06 | 0.8334 |
| chr17:54778817 | rs227724 | - | A>T | 956 | 326058 | 19.69 | 9.116e-06 | 1.2 |
| chr10:6095490 | rs41294917 | IL2RA | C>G | 52 | 10813 | 19.58 | 9.66e-06 | 1.845 |
| chr13:23748557 | rs1415133 | - | G>A | 216 | 61791 | 19.57 | 9.704e-06 | 1.369 |
| chr19:19361152 | rs55989964 | NCAN | C>G | 152 | 41085 | 19.52 | 9.945e-06 | 1.445 |
| chr5:31873151 | rs6883234 | PDZD2 | T>C | 1333 | 468357 | 19.23 | 1.157e-05 | 1.191 |
| chr2:116321386 | rs116015691 | DPP10 | G>A | 45 | 9112 | 19.08 | 1.251e-05 | 1.911 |
| chr4:111708287 | rs17042171 | - | C>A | 350 | 107477 | 18.99 | 1.316e-05 | 1.285 |
| chr1:168911905 | rs10489367 | - | T>C | 280 | 83587 | 18.92 | 1.365e-05 | 1.317 |
| chr7:113363243 | rs62488270 | - | C>T | 40 | 33036 | 25.92 | 3.56e-07 | 0.4532 |
| chr12:53298582 | rs11554495 | KRT8 | C>A | 51 | 9966 | 24.17 | 8.8e-07 | 1.983 |
| chr18:68135689 | rs7228596 | - | G>T | 91 | 21532 | 21.59 | 3.384e-06 | 1.637 |
| chr2:99523815 | rs7607186 | KIAA1211L | G>C | 477 | 149737 | 21.41 | 3.7e-06 | 1.267 |
| chr17:7735063 | rs57985356 | DNAH2 | T>G | 267 | 77679 | 21.26 | 4.019e-06 | 1.348 |
| chr3:69422342 | rs9985338 | FRMD4B | C>T | 557 | 178362 | 21.17 | 4.196e-06 | 1.249 |
| chr10:6095490 | rs41294917 | IL2RA | C>G | 52 | 10565 | 20.81 | 5.062e-06 | 1.88 |
| chr7:106091219 | rs78828664 | - | C>A | 49 | 9877 | 20.73 | 5.298e-06 | 1.91 |
| chr21:15875108 | rs17240640 | SAMSN1 | C>A | 48 | 9709 | 20.15 | 7.162e-06 | 1.906 |
| chr4:111718067 | rs6843082 | - | A>G | 557 | 178895 | 20.12 | 7.287e-06 | 1.242 |
| chr10:126221465 | rs17621431 | LHPP | G>C | 76 | 17550 | 20.07 | 7.448e-06 | 1.679 |
| chr19:19361152 | rs55989964 | NCAN | C>G | 151 | 40440 | 20.01 | 7.71e-06 | 1.454 |
| chr9:98172156 | rs35580252 | FANCC | G>A | 54 | 11426 | 19.64 | 9.366e-06 | 1.827 |
| chr14:62912124 | rs28694334 | - | G>A | 873 | 294580 | 19.54 | 9.864e-06 | 1.207 |
| chr5:17232808 | rs10037574 | BASP1 | C>T | 156 | 42146 | 19.49 | 1.014e-05 | 1.439 |
| chr4:111708287 | rs17042171 | - | C>A | 317 | 95648 | 19.27 | 1.136e-05 | 1.303 |
| chr13:23748557 | rs1415133 | - | G>A | 213 | 60720 | 19.25 | 1.144e-05 | 1.369 |
| chr3:186238554 | rs61606279 | - | T>G | 196 | 55662 | 19.16 | 1.199e-05 | 1.385 |
| chr14:62912605 | rs2105426 | - | G>A | 875 | 296073 | 18.92 | 1.363e-05 | 1.203 |
| chr21:15866169 | rs74875101 | SAMSN1 | A>G | 36 | 6759 | 18.89 | 1.387e-05 | 2.047 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr12:53298582 | rs11554495 | KRT8 | C>A | 51 | 683 | 25.09 | 5.481e-07 | 2.053 |
| chr7:113363243 | rs62488270 | - | C>T | 40 | 2327 | 25.04 | 5.618e-07 | 0.4563 |
| chr3:69422342 | rs9985338 | FRMD4B | C>T | 557 | 12519 | 22.7 | 1.898e-06 | 1.264 |
| chr2:99523815 | rs7607186 | KIAA1211L | G>C | 477 | 10570 | 21.5 | 3.54e-06 | 1.273 |
| chr12:13058306 | rs76352426 | GPRC5A | C>G | 47 | 650 | 20.87 | 4.923e-06 | 1.981 |
| chr8:109354102 | rs4734174 | EIF3E | G>A | 946 | 22611 | 20.67 | 5.466e-06 | 1.213 |
| chr1:213555691 | rs4655360 | - | C>T | 843 | 25857 | 20.44 | 6.156e-06 | 0.8216 |
| chr10:32680846 | rs10827048 | - | T>C | 687 | 15968 | 20.02 | 7.677e-06 | 1.229 |
| chr13:30666126 | rs9508626 | - | A>G | 1047 | 25386 | 19.46 | 1.025e-05 | 1.203 |
| chr9:98172156 | rs35580252 | FANCC | G>A | 54 | 795 | 19.27 | 1.135e-05 | 1.849 |
| chr14:62912124 | rs28694334 | - | G>A | 873 | 20878 | 19.18 | 1.186e-05 | 1.209 |
| chr21:15866169 | rs74875101 | SAMSN1 | A>G | 36 | 466 | 19.13 | 1.224e-05 | 2.106 |
| chr3:186238554 | rs61606279 | - | T>G | 196 | 3921 | 19.12 | 1.229e-05 | 1.394 |
| chr1:182216854 | rs6676250 | - | G>A | 131 | 2430 | 18.81 | 1.444e-05 | 1.488 |
| chr17:7735063 | rs57985356 | DNAH2 | T>G | 267 | 5565 | 18.81 | 1.444e-05 | 1.333 |
| chr18:68135689 | rs7228596 | - | G>T | 91 | 1559 | 18.71 | 1.522e-05 | 1.602 |
| chr21:15875108 | rs17240640 | SAMSN1 | C>A | 48 | 693 | 18.54 | 1.662e-05 | 1.893 |
| chr1:100353675 | rs555929 | AGL | A>G | 635 | 19828 | 18.37 | 1.823e-05 | 0.8176 |
| chr14:62912605 | rs2105426 | - | G>A | 875 | 20996 | 18.34 | 1.85e-05 | 1.204 |
| chr1:227543027 | rs4653497 | - | T>C | 827 | 25216 | 18.29 | 1.898e-05 | 0.8297 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: I495 | Sick sinus syndrome | 4/20 |
| ID | Name | Top Correlation |
|---|---|---|
| ICD-10: I494 | Other and unspecified premature depolarisation | 0/20 |
| ICD-10: O622 | Other uterine inertia | 0/20 |