Statistics
| Female Case | Female Control | % Female |
|---|---|---|
| 662 | 249195 | 55% |
| Male Case | Male Control | % Male |
|---|---|---|
| 541 | 209796 | 45% |
Phenotype Definition
Disturbance in the atrial activation that is caused by transient failure of impulse conduction from the sinoatrial node to the cardiac atria. [HPO:probinson]
Phenotype Comment
Sinoatrial block is characterized by a delayed in heartbeat and pauses between P waves as demonstrated by electrocardiography.
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr19:8741220 | rs77680407 | LINC01862 | C>A | 37 | 5750 | 30.27 | 3.768e-08 | 2.435 |
| chr3:129336433 | rs2811441 | - | T>G | 64 | 12514 | 27.86 | 1.307e-07 | 1.944 |
| chr6:165063192 | rs80317264 | - | A>G | 46 | 8220 | 26.1 | 3.239e-07 | 2.118 |
| chr8:23642424 | rs11135773 | - | T>C | 151 | 38021 | 25.15 | 5.311e-07 | 1.536 |
| chr9:139428909 | rs60544817 | NOTCH1 | C>T | 112 | 26685 | 24.27 | 8.383e-07 | 1.619 |
| chr9:139432026 | rs56264830 | NOTCH1 | T>C | 83 | 18342 | 23.88 | 1.027e-06 | 1.728 |
| chr14:49821858 | rs2776472 | - | C>T | 328 | 95510 | 23.84 | 1.047e-06 | 1.359 |
| chr5:71711324 | rs76654146 | - | C>T | 97 | 22759 | 22.23 | 2.419e-06 | 1.636 |
| chr23:30444558 | rs141210698 | - | G>A | 51 | 10023 | 21.78 | 3.055e-06 | 1.926 |
| chr4:5614828 | rs73198121 | EVC2 | A>G | 101 | 23998 | 21.47 | 3.598e-06 | 1.608 |
| chr5:121781287 | rs56369505 | SNCAIP | G>T | 108 | 26080 | 21.46 | 3.608e-06 | 1.585 |
| chr14:49812430 | rs8023061 | - | A>G | 284 | 82521 | 21.02 | 4.547e-06 | 1.355 |
| chr11:38175341 | rs12285360 | - | T>C | 93 | 21767 | 21.0 | 4.601e-06 | 1.629 |
| chr21:27887346 | rs222924 | CYYR1 | T>C | 571 | 181982 | 20.87 | 4.92e-06 | 1.28 |
| chr5:85972213 | rs76714101 | - | T>C | 61 | 12861 | 20.63 | 5.565e-06 | 1.799 |
| chr1:93110600 | rs12143685 | EVI5 | T>C | 44 | 8444 | 20.25 | 6.803e-06 | 1.97 |
| chr12:7564190 | rs78915410 | CD163L1 | C>T | 49 | 9777 | 20.08 | 7.424e-06 | 1.9 |
| chr11:123678538 | rs74690701 | - | T>C | 75 | 16887 | 19.7 | 9.055e-06 | 1.685 |
| chr18:75587367 | rs79655856 | - | A>G | 49 | 9829 | 19.68 | 9.14e-06 | 1.889 |
| chr13:106931017 | rs7983975 | - | T>G | 612 | 197958 | 19.61 | 9.493e-06 | 1.268 |
| chr6:165063192 | rs80317264 | - | A>G | 44 | 7745 | 26.84 | 2.207e-07 | 2.175 |
| chr19:8741220 | rs77680407 | LINC01862 | C>A | 26 | 3739 | 25.93 | 3.533e-07 | 2.647 |
| chr5:147863034 | rs9325101 | HTR4 | A>G | 10 | 864 | 25.58 | 4.25e-07 | 4.379 |
| chr5:71711324 | rs76654146 | - | C>T | 96 | 22159 | 24.73 | 6.582e-07 | 1.686 |
| chr5:85972213 | rs76714101 | - | T>C | 58 | 11653 | 23.99 | 9.661e-07 | 1.912 |
| chr5:121781287 | rs56369505 | SNCAIP | G>T | 103 | 24401 | 23.42 | 1.3e-06 | 1.637 |
| chr8:23642424 | rs11135773 | - | T>C | 131 | 32844 | 23.39 | 1.323e-06 | 1.557 |
| chr5:121802585 | rs72789048 | - | A>G | 79 | 17697 | 22.25 | 2.395e-06 | 1.719 |
| chr9:139432026 | rs56264830 | NOTCH1 | T>C | 62 | 13004 | 22.2 | 2.457e-06 | 1.831 |
| chr3:129336433 | rs2811441 | - | T>G | 46 | 8788 | 22.13 | 2.552e-06 | 2.001 |
| chr1:93110600 | rs12143685 | EVI5 | T>C | 43 | 8167 | 21.11 | 4.332e-06 | 2.013 |
| chr21:27887346 | rs222924 | CYYR1 | T>C | 539 | 172772 | 21.04 | 4.509e-06 | 1.292 |
| chr12:7564190 | rs78915410 | CD163L1 | C>T | 48 | 9531 | 20.71 | 5.348e-06 | 1.932 |
| chr14:49821858 | rs2776472 | - | C>T | 285 | 83813 | 20.54 | 5.83e-06 | 1.353 |
| chr1:206665837 | rs11118256 | IKBKE | G>A | 8 | 698 | 20.12 | 7.28e-06 | 4.328 |
| chr19:58207385 | rs1009158 | ZNF551 | T>C | 513 | 165183 | 19.52 | 9.973e-06 | 1.283 |
| chr1:100353675 | rs555929 | AGL | A>G | 328 | 151065 | 19.34 | 1.095e-05 | 0.7561 |
| chr22:17529814 | rs947822 | - | C>T | 625 | 205631 | 19.28 | 1.129e-05 | 1.274 |
| chr4:61030524 | rs115902972 | - | T>C | 77 | 17774 | 19.24 | 1.155e-05 | 1.666 |
| chr8:113223076 | rs62514376 | - | C>T | 60 | 13022 | 19.13 | 1.223e-05 | 1.771 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr12:53298582 | rs11554495 | KRT8 | C>A | 31 | 4622 | 33.01 | 9.187e-09 | 2.738 |
| chr11:47503036 | rs75818156 | CELF1 | C>T | 67 | 14530 | 26.0 | 3.411e-07 | 1.884 |
| chr1:64607352 | rs72686913 | ROR1 | T>A | 38 | 6903 | 24.76 | 6.489e-07 | 2.23 |
| chr14:40753630 | rs75225700 | - | A>G | 48 | 9532 | 24.57 | 7.16e-07 | 2.05 |
| chr1:39396424 | rs12042694 | RHBDL2 | C>T | 239 | 123144 | 24.5 | 7.42e-07 | 0.6976 |
| chr1:39407589 | rs11811894 | - | C>A | 170 | 93944 | 24.39 | 7.87e-07 | 0.6645 |
| chr12:91228255 | rs77472605 | - | C>T | 46 | 9036 | 23.97 | 9.778e-07 | 2.061 |
| chr11:47346465 | rs79187134 | MADD | C>T | 50 | 10112 | 23.93 | 9.965e-07 | 2.005 |
| chr14:66166400 | rs4902409 | FUT8 | C>T | 68 | 15197 | 23.75 | 1.094e-06 | 1.826 |
| chr14:65955517 | rs8020287 | FUT8 | A>G | 68 | 15283 | 23.14 | 1.508e-06 | 1.812 |
| chr11:47848495 | rs116983862 | NUP160 | G>T | 63 | 13947 | 22.81 | 1.793e-06 | 1.843 |
| chr13:23792252 | rs73168655 | SGCG | A>C | 108 | 27609 | 22.78 | 1.821e-06 | 1.615 |
| chr3:107316938 | rs9288851 | BBX | A>G | 250 | 75530 | 22.43 | 2.185e-06 | 1.403 |
| chr4:148399460 | rs77192844 | - | G>A | 47 | 9561 | 22.3 | 2.336e-06 | 1.997 |
| chr21:44752768 | rs73220980 | - | G>A | 53 | 11341 | 21.37 | 3.777e-06 | 1.899 |
| chr8:60470205 | rs17251327 | - | T>C | 50 | 10478 | 21.23 | 4.084e-06 | 1.928 |
| chr4:114273272 | rs78720788 | ANK2 | C>T | 36 | 6812 | 20.79 | 5.136e-06 | 2.13 |
| chr9:1881679 | rs72683720 | - | C>G | 76 | 18172 | 20.73 | 5.288e-06 | 1.709 |
| chr18:2840104 | rs77746967 | - | G>T | 54 | 11725 | 20.73 | 5.291e-06 | 1.87 |
| chr8:12888743 | rs13281744 | TRMT9B | A>G | 561 | 192137 | 20.71 | 5.349e-06 | 1.311 |
| chr12:53298582 | rs11554495 | KRT8 | C>A | 30 | 4574 | 28.98 | 7.332e-08 | 2.619 |
| chr11:47503036 | rs75818156 | CELF1 | C>T | 66 | 13871 | 26.41 | 2.767e-07 | 1.903 |
| chr1:39407589 | rs11811894 | - | C>A | 163 | 89691 | 26.13 | 3.193e-07 | 0.6495 |
| chr1:64607352 | rs72686913 | ROR1 | T>A | 38 | 6828 | 24.01 | 9.581e-07 | 2.205 |
| chr14:40753630 | rs75225700 | - | A>G | 46 | 8955 | 23.38 | 1.333e-06 | 2.044 |
| chr11:47346465 | rs79187134 | MADD | C>T | 49 | 9715 | 23.28 | 1.403e-06 | 2.0 |
| chr12:91228255 | rs77472605 | - | C>T | 45 | 8679 | 23.18 | 1.477e-06 | 2.053 |
| chr11:47848495 | rs116983862 | NUP160 | G>T | 62 | 13337 | 22.96 | 1.658e-06 | 1.856 |
| chr4:148399460 | rs77192844 | - | G>A | 46 | 9038 | 22.67 | 1.922e-06 | 2.023 |
| chr1:78524475 | rs56236539 | GIPC2 | A>G | 30 | 5032 | 22.48 | 2.118e-06 | 2.35 |
| chr13:23792252 | rs73168655 | SGCG | A>C | 108 | 27073 | 22.37 | 2.252e-06 | 1.61 |
| chr1:39387607 | rs4418560 | RHBDL2 | A>G | 132 | 74518 | 22.05 | 2.653e-06 | 0.6464 |
| chr23:122570930 | rs524654 | GRIA3 | C>A | 132 | 35392 | 21.84 | 2.964e-06 | 1.591 |
| chr7:150263909 | rs17553490 | - | A>G | 559 | 186873 | 21.57 | 3.415e-06 | 1.326 |
| chr7:103899860 | rs76435307 | - | T>C | 34 | 6126 | 21.2 | 4.128e-06 | 2.191 |
| chr3:107316938 | rs9288851 | BBX | A>G | 248 | 73711 | 21.14 | 4.279e-06 | 1.393 |
| chr21:44752768 | rs73220980 | - | G>A | 53 | 11179 | 20.83 | 5.015e-06 | 1.885 |
| chr8:4397759 | rs17416011 | CSMD1 | G>C | 138 | 36949 | 20.75 | 5.226e-06 | 1.511 |
| chr1:39396424 | rs12042694 | RHBDL2 | C>T | 225 | 112043 | 20.68 | 5.421e-06 | 0.7116 |
| chr4:114273272 | rs78720788 | ANK2 | C>T | 36 | 6699 | 20.46 | 6.079e-06 | 2.119 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: I495 | Sick sinus syndrome | 4/20 |
| ID | Name | Top Correlation |
|---|---|---|
| ICD-10: I494 | Other and unspecified premature depolarisation | 0/20 |
| ICD-10: O622 | Other uterine inertia | 0/20 |