Case | Control |
---|---|
16848 | 443346 |
A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. [HPO:probinson, PMID:17540788]
The European Respiratory Society Task Force recommended two possible definitions of cough: (1) A three-phase expulsive motor act characterized by an inspiratory effort (inspiratory phase) followed by a forced expiratory effort against a closed glottis (compressive phase) and then by opening of the glottis and rapid expiratory airflow (expulsive phase);and (2) A forced expiratory manoeuvre, usually against a closed glottis and associated with a characteristic sound. The term Cough or any of its more specific descendents can be modified by the terms Acute (HP:0011009), Subacute (HP:0011011), and Chronic (HP:0011010). There is agreement that an actue cough lasts less than 3 weeks, a subacute cough from 3 to 8 weeks, and a chronic cough longer than 8 weeks.
Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
---|---|---|---|---|---|---|---|---|
chr23:19223321 | rs5955542 | - | C>T | 1809 | 41557 | 35.26 | 2.884e-09 | 1.159 |
chr7:12317890 | rs72584561 | - | A>G | 1342 | 29692 | 33.51 | 7.073e-09 | 1.179 |
chr23:19215613 | rs5955734 | - | C>G | 1278 | 28747 | 32.5 | 1.189e-08 | 1.181 |
chr15:65114484 | rs8031690 | PIF1 | G>A | 548 | 11172 | 31.18 | 2.349e-08 | 1.278 |
chr7:137187739 | rs7800321 | DGKI | T>C | 609 | 12608 | 30.36 | 3.583e-08 | 1.259 |
chr16:129223 | rs710079 | MPG | C>T | 1205 | 26837 | 28.2 | 1.097e-07 | 1.172 |
chr5:145285452 | rs2569011 | GRXCR2 | T>C | 4112 | 98844 | 26.94 | 2.097e-07 | 1.092 |
chr6:27915087 | rs276370 | - | C>T | 6531 | 159888 | 26.83 | 2.221e-07 | 1.075 |
chr6:28699369 | rs7755641 | - | T>C | 2470 | 57871 | 26.83 | 2.22e-07 | 1.116 |
chr15:45694768 | rs1834686 | SPATA5L1 | G>T | 477 | 9742 | 26.67 | 2.416e-07 | 1.275 |
chr6:28699691 | rs10498733 | - | G>A | 2465 | 57797 | 26.47 | 2.677e-07 | 1.116 |
chr13:102162080 | rs9518426 | ITGBL1 | C>T | 3497 | 83527 | 26.15 | 3.155e-07 | 1.097 |
chr9:32528088 | rs10758141 | - | T>G | 475 | 9725 | 25.98 | 3.456e-07 | 1.272 |
chr8:34797403 | rs17249529 | - | G>T | 11023 | 274713 | 25.71 | 3.977e-07 | 1.061 |
chr5:33951693 | rs16891982 | SLC45A2 | G>C | 2726 | 64332 | 25.67 | 4.049e-07 | 1.108 |
chr8:34842416 | rs11782611 | - | T>C | 10870 | 270827 | 25.33 | 4.822e-07 | 1.061 |
chr4:1802278 | rs3135872 | FGFR3 | A>G | 5564 | 135602 | 25.32 | 4.866e-07 | 1.078 |
chr16:51044008 | rs7499482 | - | T>G | 2074 | 48301 | 24.88 | 6.109e-07 | 1.122 |
chr16:123220 | rs2541636 | RHBDF1 | A>G | 1118 | 24995 | 24.73 | 6.585e-07 | 1.167 |
chr23:19236102 | rs6633216 | - | T>C | 1655 | 38679 | 24.6 | 7.043e-07 | 1.137 |
chr8:34797403 | rs17249529 | - | G>T | 10634 | 267397 | 30.43 | 3.464e-08 | 1.068 |
chr8:34842416 | rs11782611 | - | T>C | 10478 | 263592 | 28.94 | 7.461e-08 | 1.067 |
chr2:225633209 | rs3754623 | DOCK10 | G>T | 5848 | 162819 | 22.0 | 2.723e-06 | 0.9336 |
chr6:28699369 | rs7755641 | - | T>C | 2184 | 52158 | 20.96 | 4.695e-06 | 1.109 |
chr2:91942165 | rs2456603 | - | A>G | 2801 | 67742 | 20.82 | 5.037e-06 | 1.096 |
chr3:65187875 | rs116408216 | - | C>T | 1092 | 32955 | 20.56 | 5.783e-06 | 0.8679 |
chr6:28699691 | rs10498733 | - | G>A | 2179 | 52097 | 20.5 | 5.953e-06 | 1.108 |
chr12:19371221 | rs79834800 | PLEKHA5 | A>G | 709 | 15733 | 20.19 | 7.007e-06 | 1.19 |
chr6:39365008 | rs72850615 | KIF6 | G>A | 537 | 11637 | 19.59 | 9.596e-06 | 1.217 |
chr2:90251468 | rs111782239 | - | G>A | 2619 | 63675 | 19.55 | 9.796e-06 | 1.096 |
chr8:101453450 | rs62518312 | - | G>A | 6480 | 179197 | 19.11 | 1.233e-05 | 0.9403 |
chr2:65155592 | rs12471353 | - | A>C | 4203 | 117797 | 18.9 | 1.377e-05 | 0.9296 |
chr12:94189185 | rs7968218 | CRADD | T>C | 2488 | 60115 | 18.56 | 1.648e-05 | 1.096 |
chr3:65015822 | rs11706761 | - | T>G | 1238 | 36822 | 18.37 | 1.816e-05 | 0.8815 |
chr23:91442674 | rs7881327 | PCDH11X | G>A | 6779 | 173407 | 18.36 | 1.826e-05 | 1.064 |
chr3:178212523 | rs79053340 | KCNMB2 | G>A | 1976 | 47254 | 18.32 | 1.864e-05 | 1.107 |
chr7:117960973 | rs41943 | ANKRD7 | T>C | 14275 | 394401 | 18.32 | 1.867e-05 | 0.951 |
chr20:61881074 | rs78618692 | NKAIN4 | C>T | 742 | 22863 | 18.29 | 1.9e-05 | 0.8512 |
chr8:10277269 | rs35112858 | MSRA | C>T | 10862 | 276177 | 18.27 | 1.92e-05 | 1.052 |
chr16:21033688 | rs172958 | DNAH3 | T>C | 15752 | 403963 | 18.14 | 2.049e-05 | 1.049 |
Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
---|---|---|---|---|---|---|---|---|
chr8:34797403 | rs17249529 | - | G>T | 10634 | 62639 | 21.24 | 4.055e-06 | 1.06 |
chr11:77313290 | rs55810326 | CLNS1A | A>G | 1628 | 8846 | 21.11 | 4.344e-06 | 1.135 |
chr2:225633209 | rs3754623 | DOCK10 | G>T | 5848 | 37918 | 19.31 | 1.111e-05 | 0.9343 |
chr16:79906409 | rs75964719 | - | G>T | 2224 | 15019 | 19.3 | 1.116e-05 | 0.9019 |
chr1:160503839 | rs7555581 | - | C>T | 1781 | 12167 | 19.26 | 1.141e-05 | 0.8919 |
chr22:45446874 | rs5765139 | - | A>G | 9338 | 54920 | 19.15 | 1.207e-05 | 1.059 |
chr19:10107618 | rs73005199 | COL5A3 | C>T | 471 | 3568 | 18.96 | 1.332e-05 | 0.8068 |
chr8:34842416 | rs11782611 | - | T>C | 10478 | 61869 | 18.65 | 1.574e-05 | 1.056 |
chr23:91442674 | rs7881327 | PCDH11X | G>A | 6779 | 39514 | 18.29 | 1.896e-05 | 1.068 |
chr7:117960973 | rs41943 | ANKRD7 | T>C | 14275 | 90341 | 18.14 | 2.054e-05 | 0.9484 |
chr18:2260023 | rs74346835 | - | C>T | 773 | 5565 | 17.92 | 2.298e-05 | 0.8485 |
chr18:64994851 | rs57783421 | - | C>T | 2353 | 13212 | 17.73 | 2.55e-05 | 1.103 |
chr2:206698554 | rs76325945 | - | C>T | 2228 | 14970 | 17.71 | 2.573e-05 | 0.9058 |
chr10:126583230 | rs74663393 | - | C>T | 552 | 4089 | 17.69 | 2.598e-05 | 0.8253 |
chr1:160513456 | rs1503860 | CD84 | A>G | 2443 | 16337 | 17.33 | 3.145e-05 | 0.9105 |
chr2:57933828 | rs17813526 | - | G>A | 694 | 5019 | 17.08 | 3.585e-05 | 0.8445 |
chr2:4650529 | rs72631529 | - | C>A | 15848 | 99660 | 17.06 | 3.624e-05 | 0.9524 |
chr8:101453450 | rs62518312 | - | G>A | 6480 | 41758 | 17.01 | 3.71e-05 | 0.9405 |
chr8:18898789 | rs2063076 | PSD3 | A>C | 11670 | 73952 | 16.98 | 3.778e-05 | 0.9504 |
chr1:79107372 | rs41309155 | IFI44L | G>A | 340 | 2636 | 16.76 | 4.237e-05 | 0.7893 |
ID | Name | Top Correlation |
---|---|---|
ICD: R060 | Dyspnoea | 4/20 |