0012735

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Statistics

Case	Control
16848	443346

Phenotype Definition

A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. [HPO:probinson, PMID:17540788]

Phenotype Comment

The European Respiratory Society Task Force recommended two possible definitions of cough: (1) A three-phase expulsive motor act characterized by an inspiratory effort (inspiratory phase) followed by a forced expiratory effort against a closed glottis (compressive phase) and then by opening of the glottis and rapid expiratory airflow (expulsive phase);and (2) A forced expiratory manoeuvre, usually against a closed glottis and associated with a characteristic sound. The term Cough or any of its more specific descendents can be modified by the terms Acute (HP:0011009), Subacute (HP:0011011), and Chronic (HP:0011010). There is agreement that an actue cough lasts less than 3 weeks, a subacute cough from 3 to 8 weeks, and a chronic cough longer than 8 weeks.

Top SNP Information

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr23:19223321	rs5955542	-	C>T	1809	41557	35.26	2.884e-09	1.159
chr7:12317890	rs72584561	-	A>G	1342	29692	33.51	7.073e-09	1.179
chr23:19215613	rs5955734	-	C>G	1278	28747	32.5	1.189e-08	1.181
chr15:65114484	rs8031690	PIF1	G>A	548	11172	31.18	2.349e-08	1.278
chr7:137187739	rs7800321	DGKI	T>C	609	12608	30.36	3.583e-08	1.259
chr16:129223	rs710079	MPG	C>T	1205	26837	28.2	1.097e-07	1.172
chr5:145285452	rs2569011	GRXCR2	T>C	4112	98844	26.94	2.097e-07	1.092
chr6:27915087	rs276370	-	C>T	6531	159888	26.83	2.221e-07	1.075
chr6:28699369	rs7755641	-	T>C	2470	57871	26.83	2.22e-07	1.116
chr15:45694768	rs1834686	SPATA5L1	G>T	477	9742	26.67	2.416e-07	1.275
chr6:28699691	rs10498733	-	G>A	2465	57797	26.47	2.677e-07	1.116
chr13:102162080	rs9518426	ITGBL1	C>T	3497	83527	26.15	3.155e-07	1.097
chr9:32528088	rs10758141	-	T>G	475	9725	25.98	3.456e-07	1.272
chr8:34797403	rs17249529	-	G>T	11023	274713	25.71	3.977e-07	1.061
chr5:33951693	rs16891982	SLC45A2	G>C	2726	64332	25.67	4.049e-07	1.108
chr8:34842416	rs11782611	-	T>C	10870	270827	25.33	4.822e-07	1.061
chr4:1802278	rs3135872	FGFR3	A>G	5564	135602	25.32	4.866e-07	1.078
chr16:51044008	rs7499482	-	T>G	2074	48301	24.88	6.109e-07	1.122
chr16:123220	rs2541636	RHBDF1	A>G	1118	24995	24.73	6.585e-07	1.167
chr23:19236102	rs6633216	-	T>C	1655	38679	24.6	7.043e-07	1.137
chr8:34797403	rs17249529	-	G>T	10634	267397	30.43	3.464e-08	1.068
chr8:34842416	rs11782611	-	T>C	10478	263592	28.94	7.461e-08	1.067
chr2:225633209	rs3754623	DOCK10	G>T	5848	162819	22.0	2.723e-06	0.9336
chr6:28699369	rs7755641	-	T>C	2184	52158	20.96	4.695e-06	1.109
chr2:91942165	rs2456603	-	A>G	2801	67742	20.82	5.037e-06	1.096
chr3:65187875	rs116408216	-	C>T	1092	32955	20.56	5.783e-06	0.8679
chr6:28699691	rs10498733	-	G>A	2179	52097	20.5	5.953e-06	1.108
chr12:19371221	rs79834800	PLEKHA5	A>G	709	15733	20.19	7.007e-06	1.19
chr6:39365008	rs72850615	KIF6	G>A	537	11637	19.59	9.596e-06	1.217
chr2:90251468	rs111782239	-	G>A	2619	63675	19.55	9.796e-06	1.096
chr8:101453450	rs62518312	-	G>A	6480	179197	19.11	1.233e-05	0.9403
chr2:65155592	rs12471353	-	A>C	4203	117797	18.9	1.377e-05	0.9296
chr12:94189185	rs7968218	CRADD	T>C	2488	60115	18.56	1.648e-05	1.096
chr3:65015822	rs11706761	-	T>G	1238	36822	18.37	1.816e-05	0.8815
chr23:91442674	rs7881327	PCDH11X	G>A	6779	173407	18.36	1.826e-05	1.064
chr3:178212523	rs79053340	KCNMB2	G>A	1976	47254	18.32	1.864e-05	1.107
chr7:117960973	rs41943	ANKRD7	T>C	14275	394401	18.32	1.867e-05	0.951
chr20:61881074	rs78618692	NKAIN4	C>T	742	22863	18.29	1.9e-05	0.8512
chr8:10277269	rs35112858	MSRA	C>T	10862	276177	18.27	1.92e-05	1.052
chr16:21033688	rs172958	DNAH3	T>C	15752	403963	18.14	2.049e-05	1.049

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr8:34797403	rs17249529	-	G>T	10634	62639	21.24	4.055e-06	1.06
chr11:77313290	rs55810326	CLNS1A	A>G	1628	8846	21.11	4.344e-06	1.135
chr2:225633209	rs3754623	DOCK10	G>T	5848	37918	19.31	1.111e-05	0.9343
chr16:79906409	rs75964719	-	G>T	2224	15019	19.3	1.116e-05	0.9019
chr1:160503839	rs7555581	-	C>T	1781	12167	19.26	1.141e-05	0.8919
chr22:45446874	rs5765139	-	A>G	9338	54920	19.15	1.207e-05	1.059
chr19:10107618	rs73005199	COL5A3	C>T	471	3568	18.96	1.332e-05	0.8068
chr8:34842416	rs11782611	-	T>C	10478	61869	18.65	1.574e-05	1.056
chr23:91442674	rs7881327	PCDH11X	G>A	6779	39514	18.29	1.896e-05	1.068
chr7:117960973	rs41943	ANKRD7	T>C	14275	90341	18.14	2.054e-05	0.9484
chr18:2260023	rs74346835	-	C>T	773	5565	17.92	2.298e-05	0.8485
chr18:64994851	rs57783421	-	C>T	2353	13212	17.73	2.55e-05	1.103
chr2:206698554	rs76325945	-	C>T	2228	14970	17.71	2.573e-05	0.9058
chr10:126583230	rs74663393	-	C>T	552	4089	17.69	2.598e-05	0.8253
chr1:160513456	rs1503860	CD84	A>G	2443	16337	17.33	3.145e-05	0.9105
chr2:57933828	rs17813526	-	G>A	694	5019	17.08	3.585e-05	0.8445
chr2:4650529	rs72631529	-	C>A	15848	99660	17.06	3.624e-05	0.9524
chr8:101453450	rs62518312	-	G>A	6480	41758	17.01	3.71e-05	0.9405
chr8:18898789	rs2063076	PSD3	A>C	11670	73952	16.98	3.778e-05	0.9504
chr1:79107372	rs41309155	IFI44L	G>A	340	2636	16.76	4.237e-05	0.7893

Associated Diseases ^ⓘ

ID	Name	Top Correlation
ICD: R060	Dyspnoea	4/20

ID	Name	Top Correlation
ICD-10: B441	Other pulmonary aspergillosis	0/20
ICD-10: C342	Middle lobe, bronchus or lung	0/20
ICD-10: H000	Hordeolum and other deep inflammation of eyelid	0/20
ICD-10: H579	Disorder of eye and adnexa, unspecified	0/20
ICD-10: J14	Pneumonia due to Haemophilus influenzae	0/20
ICD-10: J387	Other diseases of larynx	0/20
ICD-10: J869	Pyothorax without fistula	0/20
ICD-10: K528	Other specified non-infective gastro-enteritis and colitis	0/20
ICD-10: R042	Haemoptysis	0/20
ICD-10: R05	Cough	0/20
ICD-10: R062	Wheezing	0/20
ICD-10: R070	Pain in throat	0/20
ICD-10: R071	Chest pain on breathing	0/20

Cough

0012735

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

Links

Statistics

Phenotype Definition

Phenotype Comment

Top SNP Information

Associated Diseases ^ⓘ

Cough

0012735

Normal Case/Contol ⓘ

Sibling Case/Control ⓘ

Links

Statistics

Phenotype Definition

Phenotype Comment

Top SNP Information Show Normal Table Show Sibling SNP

Associated Diseases ⓘ Shared SNP diseases No shared SNP diseases

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

Top SNP Information

Associated Diseases ^ⓘ