Statistics
| Case | Control |
|---|---|
| 795 | 459399 |
Phenotype Definition
Hearing loss that occurs acutely and resolves completely. [PMID:21776317]
Phenotype Comment
Transient hearing loss is particularly common in childhood as a result of inadequate ventilation of the middle ear.
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr1:57829694 | rs115659376 | DAB1 | G>A | 95 | 33866 | 23.09 | 1.547e-06 | 1.653 |
| chr16:59101340 | rs12921248 | - | C>T | 116 | 43493 | 22.76 | 1.84e-06 | 1.577 |
| chr5:7912602 | rs115995177 | - | C>T | 79 | 27061 | 22.37 | 2.252e-06 | 1.715 |
| chr5:37824837 | rs116214935 | GDNF | T>G | 90 | 31996 | 22.11 | 2.577e-06 | 1.657 |
| chr13:51030743 | rs76286156 | - | C>A | 40 | 11188 | 22.04 | 2.671e-06 | 2.087 |
| chr20:12066947 | rs78004623 | - | C>T | 62 | 20117 | 21.83 | 2.979e-06 | 1.817 |
| chr9:77987260 | rs77144004 | - | C>A | 67 | 22098 | 21.81 | 3.008e-06 | 1.777 |
| chr10:36172484 | rs78648013 | - | A>C | 43 | 12380 | 21.77 | 3.074e-06 | 2.028 |
| chr10:96267404 | rs56175117 | TBC1D12 | T>C | 226 | 97372 | 21.56 | 3.425e-06 | 1.392 |
| chr19:46390280 | rs7259871 | - | T>C | 411 | 193628 | 21.07 | 4.423e-06 | 1.297 |
| chr19:46387344 | rs11550348 | IRF2BP1 | G>A | 275 | 122481 | 20.99 | 4.624e-06 | 1.351 |
| chr6:21474854 | rs78368624 | - | G>A | 72 | 24629 | 20.51 | 5.931e-06 | 1.715 |
| chr6:35772755 | rs2766524 | LHFPL5 | G>A | 121 | 46848 | 20.46 | 6.078e-06 | 1.528 |
| chr10:36193006 | rs708427 | - | A>C | 73 | 25107 | 20.37 | 6.399e-06 | 1.706 |
| chr5:9843228 | rs78227206 | - | C>T | 66 | 22406 | 19.38 | 1.071e-05 | 1.728 |
| chr4:93084126 | rs113075406 | - | C>T | 57 | 18605 | 19.32 | 1.103e-05 | 1.795 |
| chr10:86576640 | rs117569716 | - | G>A | 64 | 21555 | 19.31 | 1.112e-05 | 1.74 |
| chr2:3074566 | rs74810155 | - | A>G | 53 | 17125 | 18.62 | 1.595e-05 | 1.812 |
| chr19:46387503 | rs3745926 | IRF2BP1 | T>C | 394 | 186946 | 18.27 | 1.919e-05 | 1.278 |
| chr16:20343627 | rs74457213 | - | A>G | 103 | 40113 | 18.09 | 2.105e-05 | 1.538 |
| chr5:7912602 | rs115995177 | - | C>T | 79 | 26563 | 24.23 | 8.552e-07 | 1.753 |
| chr5:37824837 | rs116214935 | GDNF | T>G | 89 | 31334 | 22.98 | 1.64e-06 | 1.678 |
| chr13:51030743 | rs76286156 | - | C>A | 40 | 11080 | 22.79 | 1.807e-06 | 2.113 |
| chr1:57829694 | rs115659376 | DAB1 | G>A | 91 | 32404 | 22.4 | 2.212e-06 | 1.659 |
| chr9:77987260 | rs77144004 | - | C>A | 66 | 21646 | 22.09 | 2.595e-06 | 1.792 |
| chr19:46387344 | rs11550348 | IRF2BP1 | G>A | 258 | 113393 | 22.02 | 2.703e-06 | 1.375 |
| chr10:36172484 | rs78648013 | - | A>C | 42 | 12001 | 21.88 | 2.902e-06 | 2.049 |
| chr4:93084126 | rs113075406 | - | C>T | 55 | 17185 | 21.83 | 2.977e-06 | 1.881 |
| chr4:92697953 | rs114960567 | - | C>A | 44 | 12898 | 21.23 | 4.064e-06 | 1.997 |
| chr9:125560607 | rs7849259 | - | G>A | 56 | 17831 | 20.75 | 5.227e-06 | 1.843 |
| chr10:96267404 | rs56175117 | TBC1D12 | T>C | 220 | 95288 | 20.44 | 6.168e-06 | 1.387 |
| chr10:28504944 | rs11006923 | MPP7 | T>C | 114 | 44010 | 19.87 | 8.291e-06 | 1.538 |
| chr16:59101340 | rs12921248 | - | C>T | 111 | 42531 | 19.81 | 8.534e-06 | 1.545 |
| chr16:20343627 | rs74457213 | - | A>G | 96 | 36230 | 19.49 | 1.013e-05 | 1.587 |
| chr5:9843228 | rs78227206 | - | C>T | 65 | 21996 | 19.39 | 1.064e-05 | 1.736 |
| chr10:86576640 | rs117569716 | - | G>A | 63 | 21209 | 19.19 | 1.185e-05 | 1.745 |
| chr19:46385997 | rs11880219 | - | T>A | 355 | 166175 | 18.95 | 1.342e-05 | 1.299 |
| chr19:46390280 | rs7259871 | - | T>C | 369 | 173968 | 18.92 | 1.364e-05 | 1.294 |
| chr1:59212509 | rs113038349 | - | A>G | 63 | 21350 | 18.73 | 1.505e-05 | 1.734 |
| chr20:12066947 | rs78004623 | - | C>T | 59 | 19819 | 18.58 | 1.628e-05 | 1.76 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr2:217294627 | rs114141421 | SMARCAL1 | A>T | 40 | 258 | 24.07 | 9.271e-07 | 2.272 |
| chr4:92697953 | rs114960567 | - | C>A | 44 | 297 | 23.79 | 1.072e-06 | 2.179 |
| chr4:93084126 | rs113075406 | - | C>T | 55 | 409 | 22.87 | 1.733e-06 | 1.984 |
| chr19:46387344 | rs11550348 | IRF2BP1 | G>A | 258 | 2807 | 22.3 | 2.328e-06 | 1.396 |
| chr2:198182012 | rs78596680 | - | T>C | 102 | 922 | 21.83 | 2.985e-06 | 1.646 |
| chr20:12066947 | rs78004623 | - | C>T | 59 | 461 | 21.65 | 3.277e-06 | 1.905 |
| chr5:7912602 | rs115995177 | - | C>T | 79 | 672 | 21.08 | 4.416e-06 | 1.738 |
| chr5:37824837 | rs116214935 | GDNF | T>G | 89 | 785 | 20.88 | 4.9e-06 | 1.682 |
| chr16:59101340 | rs12921248 | - | C>T | 111 | 1035 | 20.74 | 5.271e-06 | 1.595 |
| chr10:96267404 | rs56175117 | TBC1D12 | T>C | 220 | 2360 | 20.64 | 5.554e-06 | 1.409 |
| chr5:9843228 | rs78227206 | - | C>T | 65 | 529 | 20.25 | 6.799e-06 | 1.813 |
| chr1:57829694 | rs115659376 | DAB1 | G>A | 91 | 817 | 19.86 | 8.343e-06 | 1.651 |
| chr11:130494322 | rs117572323 | - | G>A | 54 | 420 | 19.58 | 9.637e-06 | 1.896 |
| chr10:28504944 | rs11006923 | MPP7 | T>C | 114 | 1088 | 19.37 | 1.075e-05 | 1.562 |
| chr16:25097500 | rs4787690 | - | T>G | 825 | 10670 | 19.11 | 1.235e-05 | 1.255 |
| chr15:37740195 | rs1457259 | - | T>C | 804 | 10366 | 18.52 | 1.678e-05 | 1.25 |
| chr2:26948154 | rs10865438 | KCNK3 | C>T | 88 | 799 | 18.39 | 1.803e-05 | 1.633 |
| chr6:42647900 | rs115706339 | UBR2 | T>C | 73 | 635 | 18.08 | 2.115e-05 | 1.702 |
| chr10:36172484 | rs78648013 | - | A>C | 42 | 308 | 18.03 | 2.178e-05 | 2.001 |
| chr3:34911744 | rs115764512 | - | G>A | 44 | 328 | 18.01 | 2.201e-05 | 1.97 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: N301 | Interstitial cystitis (chronic) | 1/20 |
| ID | Name | Top Correlation |
|---|---|---|
| ICD-10: H699 | Eustachian tube disorder, unspecified | 0/20 |