Bloody diarrhea

0025085

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

Links

Sex Split

Interactive Plot

Statistics

Case	Control
82519	377675

Phenotype Definition

Passage of many stools containing blood. []

Phenotype Comment

Diarrhea that contains bright red or maroon-colored blood may be referred to as hematochezia, while melena is used to describe black, tarry, and smelly diarrhea.

Top SNP Information

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr15:48426484	rs1426654	SLC24A5	A>G	3955	23571	226.0	4.365e-51	0.7705
chr15:48392165	rs1834640	-	A>G	4649	26975	212.3	4.415e-48	0.7913
chr5:33951693	rs16891982	SLC45A2	G>C	10595	56463	193.6	5.204e-44	0.859
chr1:159174683	rs2814778	ACKR1	T>C	2728	16649	185.2	3.468e-42	0.7539
chr5:33958959	rs28777	SLC45A2	A>C	8944	48048	180.4	4.025e-41	0.8532
chr17:58786625	rs2643103	BCAS3	G>A	2790	16468	145.9	1.359e-33	0.7798
chr8:145639681	rs1871534	SLC39A4	G>C	2612	15533	145.4	1.74e-33	0.7739
chr1:207782889	rs17047661	CR1	A>G	2003	12316	143.1	5.703e-33	0.7491
chr6:3185712	rs7754077	-	C>T	2706	15966	141.0	1.641e-32	0.7802
chr15:45491394	rs1648299	SHF	T>C	2463	14696	140.1	2.502e-32	0.7719
chr9:129557967	rs7863211	-	G>A	2797	16405	138.5	5.651e-32	0.7849
chr5:54280007	rs1508890	ESM1	C>A	2679	15737	134.4	4.403e-31	0.7837
chr2:226686177	rs7581591	-	T>C	2909	16926	134.2	4.885e-31	0.7913
chr1:173579034	rs12065033	AL139142.2	C>T	2184	13157	133.9	5.847e-31	0.7647
chr17:58508582	rs8071181	C17orf64	G>A	2198	13219	132.8	9.977e-31	0.7661
chr9:117110112	Affx-52344420	AKNA	T>TG	2065	12514	132.6	1.106e-30	0.76
chr10:31512098	rs2484992	-	C>T	3423	19486	129.3	5.728e-30	0.8085
chr10:31515132	rs2484990	-	C>T	3454	19638	128.8	7.461e-30	0.8096
chr4:110940045	rs4698804	-	T>C	2667	15597	128.7	8.003e-30	0.7874
chr3:123429182	rs820338	MYLK	C>T	2556	15021	128.4	9.263e-30	0.7837
chr9:136149229	rs505922	ABO	T>C	50849	241044	75.39	3.865e-18	0.9502
chr9:136137065	rs687621	ABO	A>G	51024	241723	73.36	1.082e-17	0.9509
chr9:136143442	rs612169	ABO	A>G	51109	242034	71.85	2.324e-17	0.9515
chr9:136139265	rs657152	ABO	C>A	54513	257458	68.33	1.385e-16	0.9534
chr9:136142203	rs514659	ABO	A>C	49407	233727	67.05	2.643e-16	0.9524
chr9:136132908	rs8176719	ABO	T>TC	54536	257747	66.58	3.353e-16	0.9539
chr9:136142355	rs643434	ABO	G>A	54712	258312	66.39	3.707e-16	0.9541
chr9:136155000	rs635634	-	C>T	28927	138035	50.6	1.135e-12	0.9506
chr9:136149399	rs507666	ABO	G>A	29156	138968	48.63	3.089e-12	0.9517
chr9:136153875	rs651007	-	C>T	33150	157256	43.69	3.848e-11	0.9563
chr6:396321	rs12203592	IRF4	C>T	36675	162240	43.27	4.762e-11	1.044
chr9:136154867	rs495828	-	G>T	33122	157026	42.94	5.637e-11	0.9566
chr9:136154168	rs579459	-	T>C	33174	157259	42.48	7.136e-11	0.9569
chr6:98364895	rs9482094	-	G>A	59878	280387	42.13	8.527e-11	0.964
chr9:136323754	rs4962153	ADAMTS13	G>A	21727	103675	36.28	1.712e-09	0.9529
chr6:98331937	rs9401305	-	A>C	75420	351090	33.75	6.269e-09	0.9688
chr6:98545611	rs62422661	-	G>T	63661	297049	33.17	8.441e-09	0.9684
chr12:104161253	rs77344054	-	C>T	17299	75564	33.12	8.674e-09	1.053
chr11:107286893	Affx-4153709	CWF19L2	T>TG	76674	356600	32.96	9.427e-09	0.9692
chr9:136147702	rs581107	ABO	T>C	77483	348855	32.42	1.243e-08	1.032

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr8:118247064	rs1695723	-	G>A	82366	6951	24.98	5.797e-07	0.9138
chr4:29157743	rs114351697	-	A>G	6365	624	22.37	2.248e-06	0.8164
chr13:107589889	rs74113764	-	C>T	3233	183	22.36	2.262e-06	1.433
chr4:135301152	rs1486979	-	G>A	68010	5206	22.1	2.589e-06	1.091
chr7:131490537	rs13245780	-	A>G	5946	582	20.59	5.702e-06	0.8178
chr22:40726762	rs139921	TNRC6B	G>A	79691	6700	20.47	6.055e-06	0.9217
chr4:135252930	rs12649164	-	T>C	68292	5241	20.39	6.305e-06	1.087
chr1:241225234	rs2945543	RGS7	T>C	55287	4211	19.55	9.784e-06	1.089
chr6:133663589	rs11753937	EYA4	C>T	52434	4477	19.55	9.8e-06	0.919
chr4:57154517	rs493228	CRACD	A>C	67628	5719	19.48	1.016e-05	0.9226
chr3:138685057	rs114043550	-	C>T	3668	375	19.23	1.16e-05	0.7862
chr20:22808892	rs113252684	-	C>T	3552	363	19.05	1.275e-05	0.7841
chr23:8910520	rs67177050	-	T>C	3208	341	18.83	1.431e-05	0.7784
chr22:35155956	rs79007422	-	T>G	12512	872	18.82	1.438e-05	1.17
chr3:132725363	rs1013391	-	A>C	70244	5413	18.53	1.67e-05	1.082
chr3:144479205	rs116375283	-	G>A	2886	301	18.39	1.796e-05	0.7695
chr1:235170979	rs66548517	-	A>C	80900	6266	18.37	1.818e-05	1.08
chr10:44759215	rs75046680	-	A>G	5135	504	18.04	2.164e-05	0.8173
chr23:10332484	rs5934884	-	G>T	5738	573	17.87	2.362e-05	0.8269
chr3:132751699	rs1464403	-	C>T	71424	5518	17.6	2.722e-05	1.08

Associated Diseases ^ⓘ

ID	Name	Top Correlation
ICD: D124	Descending colon	2/20
ICD: D125	Sigmoid colon	8/20
ICD: D128	Rectum	7/20
ICD: K573	Diverticular disease of large intestine without perforation or abscess	7/20
ICD: K579	Diverticular disease of intestine, part unspecified, without perforation or abscess	7/20
ICD: K649	Haemorrhoids, unspecified	2/20
ICD: K922	Gastro-intestinal haemorrhage, unspecified	1/20
ICD: R194	Change in bowel habit	8/20

ID	Name	Top Correlation
ICD-10: A045	Campylobacter enteritis	0/20
ICD-10: A084	Viral intestinal infection, unspecified	0/20
ICD-10: C185	Splenic flexure	0/20
ICD-10: C186	Descending colon	0/20
ICD-10: C187	Sigmoid colon	0/20
ICD-10: C19	Malignant neoplasm of rectosigmoid junction	0/20
ICD-10: D127	Rectosigmoid junction	0/20
ICD-10: D375	Rectum	0/20
ICD-10: D62	Acute posthaemorrhagic anaemia	0/20
ICD-10: I842	Internal haemorrhoids without complication	0/20
ICD-10: I845	External haemorrhoids without complication	0/20
ICD-10: I846	Residual haemorrhoidal skin tags	0/20
ICD-10: I849	Unspecified haemorrhoids without complication	0/20
ICD-10: I859	Oesophageal varices without bleeding	0/20
ICD-10: K226	Gastro-oesophageal laceration-haemorrhage syndrome	0/20
ICD-10: K290	Acute haemorrhagic gastritis	0/20
ICD-10: K512	Ulcerative (chronic) proctitis	0/20
ICD-10: K513	Ulcerative (chronic) rectosigmoiditis	0/20
ICD-10: K552	Angiodysplasia of colon	0/20
ICD-10: K571	Diverticular disease of small intestine without perforation or abscess	0/20
ICD-10: K572	Diverticular disease of large intestine with perforation and abscess	0/20
ICD-10: K578	Diverticular disease of intestine, part unspecified, with perforation and abscess	0/20
ICD-10: K600	Acute anal fissure	0/20
ICD-10: K627	Radiation proctitis	0/20
ICD-10: K640	First degree haemorrhoids	0/20
ICD-10: K641	Second degree haemorrhoids	0/20
ICD-10: K642	Third degree haemorrhoids	0/20
ICD-10: K644	Residual haemorrhoidal skin tags	0/20
ICD-10: K648	Other specified haemorrhoids	0/20
ICD-10: K920	Haematemesis	0/20
ICD-10: K921	Melaena	0/20