Statistics
| Case | Control |
|---|---|
| 17060 | 443134 |
Phenotype Definition
Decreased tolerance to sound. []
Phenotype Comment
Sound sensitivity impliees a difficulty tolerating sounds which do not seem loud or unpleasant to others.
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 3002 | 64056 | 97.69 | 4.898e-23 | 1.212 |
| chr5:33958959 | rs28777 | SLC45A2 | A>C | 2547 | 54445 | 80.57 | 2.811e-19 | 1.207 |
| chr1:159174683 | rs2814778 | ACKR1 | T>C | 948 | 18429 | 68.17 | 1.496e-16 | 1.32 |
| chr16:17200685 | rs8046024 | XYLT1 | C>T | 965 | 18812 | 67.89 | 1.73e-16 | 1.316 |
| chr16:17200759 | rs8044934 | XYLT1 | G>A | 952 | 18543 | 67.25 | 2.393e-16 | 1.317 |
| chr23:64367019 | rs7064929 | - | G>A | 905 | 16661 | 63.84 | 1.352e-15 | 1.318 |
| chr8:10557760 | rs57041981 | RP1L1 | A>G | 820 | 15828 | 61.95 | 3.526e-15 | 1.329 |
| chr23:23300031 | rs12009896 | - | T>G | 978 | 18319 | 60.55 | 7.177e-15 | 1.295 |
| chr11:61095368 | rs7397033 | DDB1 | T>C | 742 | 14184 | 59.91 | 9.928e-15 | 1.341 |
| chr6:136480972 | rs9483910 | PDE7B | C>T | 1018 | 20352 | 59.15 | 1.46e-14 | 1.284 |
| chr2:66725070 | rs12995572 | MEIS1 | G>C | 1261 | 25890 | 58.27 | 2.283e-14 | 1.25 |
| chr5:33955326 | rs35390 | SLC45A2 | A>C | 1839 | 39308 | 57.27 | 3.806e-14 | 1.203 |
| chr9:140957557 | rs11137360 | CACNA1B | A>G | 998 | 20008 | 56.55 | 5.488e-14 | 1.28 |
| chr6:37328215 | Affx-28571852 | RNF8 | C>CT | 925 | 18391 | 55.84 | 7.868e-14 | 1.29 |
| chr19:42393286 | rs717225 | ARHGEF1 | A>G | 1036 | 20907 | 55.45 | 9.6e-14 | 1.271 |
| chr23:128718936 | rs2362937 | OCRL | T>C | 997 | 18954 | 54.88 | 1.281e-13 | 1.277 |
| chr9:122405879 | rs7028119 | - | G>A | 825 | 16218 | 54.38 | 1.653e-13 | 1.304 |
| chr5:33955673 | rs35391 | SLC45A2 | C>T | 1824 | 39156 | 54.26 | 1.758e-13 | 1.198 |
| chr6:46976812 | rs1226475 | ADGRF1 | T>C | 683 | 13105 | 53.64 | 2.411e-13 | 1.335 |
| chr11:61063156 | rs10897150 | - | T>G | 1159 | 23816 | 52.99 | 3.345e-13 | 1.249 |
| chr5:26109554 | rs13175469 | - | A>G | 11589 | 288866 | 27.76 | 1.374e-07 | 1.063 |
| chr5:40486213 | rs111340452 | - | T>C | 1206 | 27012 | 26.07 | 3.293e-07 | 1.165 |
| chr5:447779 | rs72717434 | EXOC3 | C>A | 805 | 17566 | 24.06 | 9.36e-07 | 1.196 |
| chr5:40509405 | rs113233093 | - | A>G | 1099 | 24731 | 22.44 | 2.163e-06 | 1.16 |
| chr14:87064047 | rs79111821 | - | C>T | 570 | 18046 | 22.12 | 2.557e-06 | 0.8175 |
| chr22:42341308 | rs7293091 | CENPM | A>G | 7075 | 174620 | 21.72 | 3.148e-06 | 1.066 |
| chr2:206497639 | rs6435298 | - | A>G | 13585 | 342007 | 21.46 | 3.604e-06 | 1.054 |
| chr1:99179608 | rs9434426 | SNX7 | C>T | 11948 | 299474 | 20.9 | 4.842e-06 | 1.054 |
| chr7:51282063 | rs35038651 | COBL | A>G | 497 | 15832 | 20.55 | 5.821e-06 | 0.8125 |
| chr2:221033386 | rs4465761 | - | G>T | 13216 | 332284 | 20.44 | 6.168e-06 | 1.053 |
| chr6:29622220 | rs1233367 | - | C>G | 11951 | 300092 | 20.15 | 7.165e-06 | 1.053 |
| chr6:50703325 | rs9395617 | TFAP2D | G>A | 12076 | 303488 | 19.65 | 9.285e-06 | 1.053 |
| chr5:424615 | rs72717406 | AHRR | C>T | 839 | 18677 | 19.59 | 9.585e-06 | 1.171 |
| chr13:31814318 | rs12428887 | B3GLCT | T>C | 6542 | 178531 | 19.54 | 9.857e-06 | 0.9399 |
| chr11:32123882 | rs72904106 | AL035078.4 | C>A | 450 | 14395 | 19.36 | 1.084e-05 | 0.8093 |
| chr2:58302152 | rs75435120 | VRK2 | G>A | 740 | 22597 | 19.34 | 1.092e-05 | 0.8471 |
| chr13:52520435 | rs1801248 | ATP7B | C>T | 1576 | 36654 | 19.27 | 1.136e-05 | 1.122 |
| chr6:16894167 | rs9477250 | - | C>T | 1358 | 31318 | 19.21 | 1.169e-05 | 1.132 |
| chr8:70372973 | rs7829823 | - | A>G | 3534 | 98381 | 19.09 | 1.25e-05 | 0.924 |
| chr5:8916950 | rs2963353 | - | G>A | 14131 | 356645 | 19.08 | 1.254e-05 | 1.05 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr5:26109554 | rs13175469 | - | A>G | 11589 | 95307 | 27.3 | 1.746e-07 | 1.065 |
| chr5:40486213 | rs111340452 | - | T>C | 1206 | 8898 | 24.99 | 5.748e-07 | 1.169 |
| chr5:40509405 | rs113233093 | - | A>G | 1099 | 8102 | 23.1 | 1.54e-06 | 1.17 |
| chr8:19484445 | rs73214651 | CSGALNACT1 | G>A | 413 | 4476 | 20.99 | 4.622e-06 | 0.7894 |
| chr18:47027023 | rs12958032 | - | G>A | 14142 | 117603 | 20.65 | 5.516e-06 | 1.054 |
| chr5:447779 | rs72717434 | EXOC3 | C>A | 805 | 5845 | 20.33 | 6.501e-06 | 1.187 |
| chr1:3083712 | rs2651899 | PRDM16 | T>C | 14962 | 124723 | 20.03 | 7.625e-06 | 1.053 |
| chr13:52520435 | rs1801248 | ATP7B | C>T | 1576 | 12030 | 19.96 | 7.912e-06 | 1.13 |
| chr10:12967652 | rs4750287 | CCDC3 | G>C | 6972 | 56873 | 19.82 | 8.521e-06 | 1.065 |
| chr2:58302152 | rs75435120 | VRK2 | G>A | 740 | 7510 | 19.56 | 9.748e-06 | 0.8419 |
| chr4:41623302 | rs78523290 | LIMCH1 | G>A | 2586 | 24217 | 19.27 | 1.135e-05 | 0.9098 |
| chr7:25354265 | rs62451649 | - | C>A | 4923 | 39734 | 19.26 | 1.139e-05 | 1.074 |
| chr5:40616589 | rs2055645 | TTC33 | T>C | 978 | 7260 | 19.25 | 1.147e-05 | 1.164 |
| chr1:157778634 | rs7538531 | FCRL1 | T>C | 13912 | 122892 | 18.6 | 1.609e-05 | 0.951 |
| chr12:3155321 | rs11614503 | - | G>T | 1172 | 8811 | 18.54 | 1.66e-05 | 1.146 |
| chr7:51282063 | rs35038651 | COBL | A>G | 497 | 5204 | 18.36 | 1.825e-05 | 0.8168 |
| chr9:74069700 | rs1367628 | - | T>G | 6410 | 52216 | 18.24 | 1.943e-05 | 1.065 |
| chr22:42341308 | rs7293091 | CENPM | A>G | 7075 | 57828 | 18.21 | 1.981e-05 | 1.062 |
| chr4:4276054 | rs75010360 | LYAR | G>A | 429 | 4559 | 18.17 | 2.023e-05 | 0.8055 |
| chr5:75566448 | rs2972830 | SV2C | T>C | 16364 | 144081 | 18.16 | 2.036e-05 | 0.9523 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: G442 | Tension-type headache | 2/20 |
| ICD: R51 | Headache | 15/20 |