Statistics
| Case | Control |
|---|---|
| 7430 | 452764 |
Phenotype Definition
A sudden sensation of feeling cold. []
Phenotype Comment
The word chills can also refer to an episode of shivering, accompanied by paleness and feeling cold.
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr2:185043361 | rs1997132 | - | T>C | 274 | 10354 | 57.51 | 3.362e-14 | 1.59 |
| chr23:64367019 | rs7064929 | - | G>A | 437 | 17129 | 55.56 | 9.08e-14 | 1.441 |
| chr12:56722060 | rs1918496 | PAN2 | G>T | 289 | 11328 | 51.42 | 7.446e-13 | 1.534 |
| chr12:56593900 | rs10876877 | - | A>G | 239 | 9120 | 48.41 | 3.454e-12 | 1.577 |
| chr6:136480972 | rs9483910 | PDE7B | C>T | 479 | 20891 | 47.95 | 4.375e-12 | 1.382 |
| chr16:17200685 | rs8046024 | XYLT1 | C>T | 448 | 19329 | 47.71 | 4.934e-12 | 1.395 |
| chr8:10557760 | rs57041981 | RP1L1 | A>G | 386 | 16262 | 47.35 | 5.945e-12 | 1.429 |
| chr16:17200759 | rs8044934 | XYLT1 | G>A | 442 | 19053 | 47.33 | 5.992e-12 | 1.397 |
| chr1:64273591 | rs659592 | ROR1 | A>G | 697 | 32220 | 46.67 | 8.389e-12 | 1.306 |
| chr2:66725070 | rs12995572 | MEIS1 | G>C | 588 | 26563 | 46.55 | 8.923e-12 | 1.335 |
| chr23:106146349 | rs5962774 | MORC4 | T>C | 287 | 10739 | 46.19 | 1.071e-11 | 1.504 |
| chr1:159174683 | rs2814778 | ACKR1 | T>C | 435 | 18942 | 43.91 | 3.436e-11 | 1.383 |
| chr10:111855748 | rs10400168 | ADD3 | C>A | 319 | 13205 | 43.12 | 5.159e-11 | 1.453 |
| chr12:56755058 | rs4301822 | APOF | A>G | 301 | 12311 | 43.07 | 5.284e-11 | 1.468 |
| chr10:111798867 | rs7920065 | ADD3 | C>T | 291 | 11865 | 42.49 | 7.091e-11 | 1.474 |
| chr19:42393286 | rs717225 | ARHGEF1 | A>G | 482 | 21461 | 41.87 | 9.745e-11 | 1.352 |
| chr11:61095368 | rs7397033 | DDB1 | T>C | 345 | 14581 | 41.46 | 1.201e-10 | 1.423 |
| chr15:45695612 | rs1346265 | SPATA5L1 | C>T | 280 | 11390 | 41.35 | 1.273e-10 | 1.477 |
| chr16:29790864 | rs235636 | ZG16 | A>G | 303 | 12518 | 41.27 | 1.328e-10 | 1.455 |
| chr20:32484835 | rs6057933 | - | T>C | 1343 | 67622 | 41.21 | 1.368e-10 | 1.203 |
| chr8:61927738 | rs7815976 | - | A>G | 545 | 40330 | 21.47 | 3.596e-06 | 0.8161 |
| chr6:51855211 | rs113232354 | PKHD1 | C>A | 1134 | 60460 | 21.35 | 3.833e-06 | 1.155 |
| chr1:246171978 | rs74905578 | SMYD3 | T>C | 490 | 36596 | 21.24 | 4.045e-06 | 0.8083 |
| chr2:205089262 | rs16840902 | - | A>G | 284 | 22690 | 21.16 | 4.221e-06 | 0.7585 |
| chr4:18152521 | rs77885923 | - | C>T | 449 | 22111 | 20.24 | 6.837e-06 | 1.243 |
| chr17:22077692 | rs17736200 | - | A>G | 1222 | 65773 | 20.0 | 7.753e-06 | 1.144 |
| chr12:20125065 | rs73080193 | - | A>G | 617 | 31463 | 19.89 | 8.222e-06 | 1.203 |
| chr9:14078878 | rs16931322 | - | G>A | 1209 | 65156 | 19.51 | 1.002e-05 | 1.143 |
| chr17:22030997 | rs117909628 | - | C>T | 922 | 48724 | 19.44 | 1.036e-05 | 1.163 |
| chr3:16470125 | rs17042260 | RFTN1 | T>C | 941 | 49869 | 19.07 | 1.257e-05 | 1.16 |
| chr17:25354665 | rs117814481 | - | C>T | 1209 | 65224 | 19.05 | 1.272e-05 | 1.141 |
| chr6:51700849 | rs11753254 | PKHD1 | T>C | 1161 | 62525 | 18.58 | 1.631e-05 | 1.142 |
| chr22:19773308 | rs5993830 | GNB1L | T>C | 4794 | 307134 | 18.5 | 1.695e-05 | 0.9267 |
| chr3:195022428 | rs41266997 | ACAP2 | G>A | 1480 | 100294 | 18.49 | 1.704e-05 | 0.8881 |
| chr18:11192145 | rs12955040 | - | C>T | 6120 | 357581 | 18.48 | 1.714e-05 | 1.075 |
| chr7:55662486 | rs4313106 | - | T>G | 280 | 22009 | 18.43 | 1.76e-05 | 0.7711 |
| chr14:36649246 | rs944289 | - | T>C | 6368 | 372378 | 18.0 | 2.208e-05 | 1.074 |
| chr6:160581374 | rs651164 | - | G>A | 4631 | 267566 | 17.82 | 2.43e-05 | 1.078 |
| chr1:108753610 | rs74112082 | - | G>A | 154 | 13149 | 17.81 | 2.436e-05 | 0.7102 |
| chr11:114675848 | rs78576377 | - | G>C | 670 | 34772 | 17.65 | 2.652e-05 | 1.182 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr8:61927738 | rs7815976 | - | A>G | 545 | 20311 | 22.12 | 2.558e-06 | 0.8125 |
| chr2:205089262 | rs16840902 | - | A>G | 284 | 11455 | 21.95 | 2.795e-06 | 0.7533 |
| chr4:18152521 | rs77885923 | - | C>T | 449 | 10985 | 21.67 | 3.233e-06 | 1.255 |
| chr17:22077692 | rs17736200 | - | A>G | 1222 | 32935 | 20.09 | 7.388e-06 | 1.146 |
| chr12:20125065 | rs73080193 | - | A>G | 617 | 15740 | 20.04 | 7.565e-06 | 1.206 |
| chr1:246171978 | rs74905578 | SMYD3 | T>C | 490 | 18222 | 19.51 | 1.002e-05 | 0.8144 |
| chr17:22030997 | rs117909628 | - | C>T | 922 | 24395 | 19.51 | 1.002e-05 | 1.165 |
| chr7:55662486 | rs4313106 | - | T>G | 280 | 11119 | 19.28 | 1.127e-05 | 0.7653 |
| chr6:51855211 | rs113232354 | PKHD1 | C>A | 1134 | 30503 | 19.12 | 1.229e-05 | 1.147 |
| chr17:25354665 | rs117814481 | - | C>T | 1209 | 32701 | 18.79 | 1.462e-05 | 1.141 |
| chr1:178891522 | rs76688191 | - | C>G | 411 | 10135 | 18.58 | 1.632e-05 | 1.245 |
| chr4:88343290 | rs55824708 | - | T>C | 1893 | 63476 | 18.44 | 1.755e-05 | 0.8983 |
| chr6:106922633 | rs35893085 | CRYBG1 | A>G | 311 | 7439 | 18.23 | 1.962e-05 | 1.283 |
| chr18:11192145 | rs12955040 | - | C>T | 6120 | 179344 | 18.2 | 1.99e-05 | 1.075 |
| chr9:14078878 | rs16931322 | - | G>A | 1209 | 32803 | 17.97 | 2.25e-05 | 1.138 |
| chr3:195022428 | rs41266997 | ACAP2 | G>A | 1480 | 50234 | 17.85 | 2.391e-05 | 0.8892 |
| chr2:235779029 | rs1863818 | - | T>C | 1387 | 47277 | 17.84 | 2.4e-05 | 0.8861 |
| chr16:50000712 | rs9939549 | - | G>T | 6321 | 185233 | 17.75 | 2.521e-05 | 1.074 |
| chr6:51700849 | rs11753254 | PKHD1 | T>C | 1161 | 31450 | 17.38 | 3.053e-05 | 1.139 |
| chr4:88356799 | rs7690728 | NUDT9 | C>T | 2136 | 71025 | 17.32 | 3.159e-05 | 0.9059 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: M791 | Myalgia | 1/20 |
| ICD: R53 | Malaise and fatigue | 2/20 |