Statistics
| Case | Control |
|---|---|
| 1662 | 458532 |
Phenotype Definition
Involuntary contraction or twitching of the muscles. []
Phenotype Comment
Shivering is a physiologic method of heat production in man and other mammals. Shivering is a bodily function in response to fever, early hypothermia or feeling cold.
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:32654714 | rs9275184 | - | T>C | 452 | 96804 | 27.2 | 1.832e-07 | 1.3 |
| chr21:22667298 | rs8132279 | NCAM2 | A>G | 164 | 29699 | 26.9 | 2.142e-07 | 1.511 |
| chr6:32682429 | rs9275599 | - | C>T | 438 | 93322 | 26.63 | 2.463e-07 | 1.301 |
| chr20:895038 | rs525608 | ANGPT4 | G>A | 95 | 15241 | 26.4 | 2.782e-07 | 1.698 |
| chr11:107530433 | rs73557781 | ELMOD1 | A>C | 216 | 41409 | 25.97 | 3.476e-07 | 1.428 |
| chr21:42551626 | rs16998089 | BACE2 | G>A | 159 | 28868 | 25.81 | 3.762e-07 | 1.507 |
| chr6:32667850 | rs9275356 | - | C>G | 454 | 97882 | 25.03 | 5.655e-07 | 1.285 |
| chr6:32681483 | rs7454108 | - | T>C | 453 | 97808 | 24.95 | 5.872e-07 | 1.285 |
| chr3:21469554 | rs61700909 | ZNF385D | T>C | 68 | 10163 | 24.24 | 8.507e-07 | 1.815 |
| chr6:32682019 | rs3998159 | - | A>C | 454 | 98407 | 24.06 | 9.353e-07 | 1.279 |
| chr6:32681530 | rs3957146 | - | T>C | 451 | 97799 | 24.0 | 9.643e-07 | 1.28 |
| chr16:30017283 | rs1129003 | DOC2A | G>C | 321 | 66549 | 23.65 | 1.156e-06 | 1.33 |
| chr23:38403432 | rs6520495 | AF241726.2 | G>T | 124 | 19660 | 23.59 | 1.195e-06 | 1.557 |
| chr6:32667107 | rs9275334 | - | T>C | 440 | 95011 | 23.57 | 1.203e-06 | 1.281 |
| chr19:31830343 | rs2867600 | TSHZ3 | C>T | 587 | 131345 | 23.34 | 1.358e-06 | 1.244 |
| chr6:32628189 | rs9273489 | HLA-DQB1 | A>G | 537 | 118986 | 23.3 | 1.388e-06 | 1.253 |
| chr23:106146349 | rs5962774 | MORC4 | T>C | 77 | 10949 | 22.94 | 1.67e-06 | 1.73 |
| chr13:24677119 | rs75172025 | AL359736.1 | C>T | 349 | 73606 | 22.8 | 1.797e-06 | 1.308 |
| chr16:30010475 | rs60978850 | INO80E | T>C | 335 | 70318 | 22.77 | 1.825e-06 | 1.315 |
| chr6:32682137 | Affx-28502500 | - | A>G | 455 | 99260 | 22.68 | 1.918e-06 | 1.27 |
| chr3:21469554 | rs61700909 | ZNF385D | T>C | 64 | 8447 | 36.2 | 1.785e-09 | 2.106 |
| chr20:895038 | rs525608 | ANGPT4 | G>A | 78 | 11715 | 29.94 | 4.46e-08 | 1.857 |
| chr6:32682429 | rs9275599 | - | C>T | 418 | 89462 | 29.76 | 4.899e-08 | 1.33 |
| chr6:32654714 | rs9275184 | - | T>C | 431 | 93185 | 28.77 | 8.154e-08 | 1.319 |
| chr6:32667850 | rs9275356 | - | C>G | 434 | 94179 | 27.79 | 1.35e-07 | 1.312 |
| chr6:32681483 | rs7454108 | - | T>C | 433 | 94104 | 27.72 | 1.403e-07 | 1.311 |
| chr6:32681530 | rs3957146 | - | T>C | 431 | 94096 | 26.68 | 2.399e-07 | 1.305 |
| chr6:32667107 | rs9275334 | - | T>C | 421 | 91354 | 26.48 | 2.666e-07 | 1.308 |
| chr6:32682137 | Affx-28502500 | - | A>G | 434 | 94858 | 26.36 | 2.833e-07 | 1.302 |
| chr6:32682019 | rs3998159 | - | A>C | 432 | 94591 | 25.87 | 3.651e-07 | 1.3 |
| chr6:32675634 | rs9275532 | - | C>G | 427 | 93670 | 25.2 | 5.178e-07 | 1.297 |
| chr6:32628189 | rs9273489 | HLA-DQB1 | A>G | 503 | 112857 | 24.2 | 8.7e-07 | 1.269 |
| chr6:32626272 | rs9273363 | - | C>A | 1129 | 275476 | 23.95 | 9.903e-07 | 1.196 |
| chr6:32631570 | Affx-28498032 | HLA-DQB1 | G>A | 688 | 160363 | 23.53 | 1.231e-06 | 1.231 |
| chr2:6346506 | rs2044648 | - | C>A | 551 | 182206 | 22.98 | 1.636e-06 | 0.7997 |
| chr6:32629549 | rs28724252 | HLA-DQB1 | G>A | 685 | 159743 | 22.87 | 1.735e-06 | 1.228 |
| chr6:32628389 | rs9273502 | HLA-DQB1 | A>C | 687 | 160517 | 22.8 | 1.799e-06 | 1.227 |
| chr6:32805049 | rs2239701 | AL669918.1 | T>C | 1622 | 410562 | 22.31 | 2.324e-06 | 1.178 |
| chr12:92535333 | rs28399549 | BTG1 | T>C | 73 | 11584 | 22.17 | 2.493e-06 | 1.737 |
| chr6:32626302 | rs9273364 | - | T>G | 1092 | 268410 | 22.1 | 2.582e-06 | 1.191 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr3:21469554 | rs61700909 | ZNF385D | T>C | 64 | 4317 | 35.28 | 2.853e-09 | 2.093 |
| chr20:895038 | rs525608 | ANGPT4 | G>A | 78 | 5917 | 30.28 | 3.734e-08 | 1.867 |
| chr6:32682429 | rs9275599 | - | C>T | 418 | 45544 | 29.02 | 7.156e-08 | 1.326 |
| chr6:32654714 | rs9275184 | - | T>C | 431 | 47532 | 27.58 | 1.505e-07 | 1.312 |
| chr6:32667850 | rs9275356 | - | C>G | 434 | 47998 | 26.84 | 2.208e-07 | 1.306 |
| chr6:32681483 | rs7454108 | - | T>C | 433 | 47944 | 26.83 | 2.225e-07 | 1.306 |
| chr6:32681530 | rs3957146 | - | T>C | 431 | 47933 | 25.85 | 3.684e-07 | 1.301 |
| chr6:32682137 | Affx-28502500 | - | A>G | 434 | 48285 | 25.68 | 4.023e-07 | 1.299 |
| chr6:32667107 | rs9275334 | - | T>C | 421 | 46591 | 25.49 | 4.455e-07 | 1.302 |
| chr6:32682019 | rs3998159 | - | A>C | 432 | 48144 | 25.23 | 5.102e-07 | 1.296 |
| chr6:32675634 | rs9275532 | - | C>G | 427 | 47733 | 24.29 | 8.279e-07 | 1.292 |
| chr6:32628189 | rs9273489 | HLA-DQB1 | A>G | 503 | 57424 | 23.63 | 1.17e-06 | 1.266 |
| chr12:92535333 | rs28399549 | BTG1 | T>C | 73 | 5822 | 22.96 | 1.655e-06 | 1.757 |
| chr6:32631570 | Affx-28498032 | HLA-DQB1 | G>A | 688 | 81630 | 22.77 | 1.822e-06 | 1.227 |
| chr6:32629549 | rs28724252 | HLA-DQB1 | G>A | 685 | 81279 | 22.21 | 2.442e-06 | 1.225 |
| chr6:32628389 | rs9273502 | HLA-DQB1 | A>C | 687 | 81696 | 22.08 | 2.61e-06 | 1.224 |
| chr2:6346506 | rs2044648 | - | C>A | 551 | 92034 | 21.57 | 3.405e-06 | 0.805 |
| chr6:32626272 | rs9273363 | - | C>A | 1129 | 140796 | 21.39 | 3.753e-06 | 1.185 |
| chr6:32667343 | rs9275338 | - | A>T | 501 | 57973 | 20.95 | 4.713e-06 | 1.249 |
| chr6:32633320 | rs28746819 | HLA-DQB1 | T>C | 642 | 76493 | 20.88 | 4.888e-06 | 1.225 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: N751 | Abscess of Bartholin's gland | 1/20 |
| ID | Name | Top Correlation |
|---|---|---|
| ICD-10: J00 | Acute nasopharyngitis [common cold] | 0/20 |
| ICD-10: N764 | Abscess of vulva | 0/20 |
| ICD-10: R500 | Fever with chills | 0/20 |