Statistics
| Case | Control |
|---|---|
| 49305 | 410889 |
Phenotype Definition
Any anomaly of the function of a coronary artery. []
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 8526 | 58532 | 246.8 | 1.295e-55 | 1.209 |
| chr5:33958959 | rs28777 | SLC45A2 | A>C | 7248 | 49744 | 208.7 | 2.648e-47 | 1.207 |
| chr5:33955673 | rs35391 | SLC45A2 | C>T | 5235 | 35745 | 156.9 | 5.291e-36 | 1.209 |
| chr5:33955326 | rs35390 | SLC45A2 | A>C | 5254 | 35893 | 156.5 | 6.745e-36 | 1.208 |
| chr5:33951116 | rs35397 | SLC45A2 | T>G | 10843 | 79265 | 134.9 | 3.558e-31 | 1.134 |
| chr9:22115959 | rs2383207 | - | G>A | 48722 | 413317 | 106.6 | 5.316e-25 | 0.9348 |
| chr2:210564805 | rs13424278 | MAP2 | A>G | 2257 | 14756 | 100.9 | 9.815e-24 | 1.257 |
| chr9:22081850 | rs6475606 | - | C>T | 54273 | 429996 | 100.6 | 1.13e-23 | 1.067 |
| chr6:160608804 | rs16891156 | SLC22A2 | A>C | 3011 | 20352 | 98.95 | 2.587e-23 | 1.217 |
| chr6:161010118 | rs10455872 | LPA | A>G | 8815 | 64884 | 94.38 | 2.604e-22 | 1.122 |
| chr1:110689011 | rs76894936 | - | C>A | 1963 | 12755 | 92.42 | 7.016e-22 | 1.264 |
| chr23:102201216 | rs725570 | - | A>G | 2346 | 16624 | 92.11 | 8.198e-22 | 1.239 |
| chr9:22096055 | rs10757274 | - | A>G | 52921 | 419631 | 90.76 | 1.621e-21 | 1.064 |
| chr9:22124477 | rs10757278 | - | A>G | 52208 | 413892 | 89.68 | 2.798e-21 | 1.064 |
| chr9:22088260 | rs10757272 | - | C>T | 52816 | 418932 | 89.49 | 3.08e-21 | 1.063 |
| chr9:22098574 | rs4977574 | - | A>G | 52670 | 417751 | 89.42 | 3.192e-21 | 1.063 |
| chr23:102191083 | rs5987498 | - | G>T | 1921 | 13353 | 88.66 | 4.686e-21 | 1.261 |
| chr9:22125347 | rs1333048 | - | A>C | 54088 | 429569 | 88.16 | 6.024e-21 | 1.063 |
| chr6:160997118 | rs74617384 | LPA | A>T | 8564 | 63263 | 86.31 | 1.54e-20 | 1.118 |
| chr23:19209307 | rs960190 | - | T>C | 3058 | 22423 | 85.22 | 2.663e-20 | 1.199 |
| chr6:161010118 | rs10455872 | LPA | A>G | 8672 | 64078 | 120.0 | 6.308e-28 | 1.14 |
| chr6:160997118 | rs74617384 | LPA | A>T | 8421 | 62467 | 110.0 | 9.934e-26 | 1.136 |
| chr9:22124477 | rs10757278 | - | A>G | 49031 | 395075 | 95.02 | 1.886e-22 | 1.068 |
| chr9:22096055 | rs10757274 | - | A>G | 49672 | 400481 | 94.48 | 2.481e-22 | 1.068 |
| chr9:22098574 | rs4977574 | - | A>G | 49506 | 399220 | 93.67 | 3.727e-22 | 1.068 |
| chr9:22088260 | rs10757272 | - | C>T | 49326 | 397880 | 91.27 | 1.252e-21 | 1.067 |
| chr9:22125503 | rs1333049 | - | G>C | 48966 | 394952 | 89.24 | 3.491e-21 | 1.066 |
| chr9:22125347 | rs1333048 | - | A>C | 50570 | 408571 | 89.07 | 3.82e-21 | 1.066 |
| chr9:22115959 | rs2383207 | - | G>A | 46399 | 399622 | 87.95 | 6.721e-21 | 0.9386 |
| chr9:22081850 | rs6475606 | - | C>T | 48970 | 395792 | 79.14 | 5.796e-19 | 1.062 |
| chr6:160608804 | rs16891156 | SLC22A2 | A>C | 2361 | 16338 | 73.13 | 1.211e-17 | 1.21 |
| chr6:160848743 | rs9457925 | SLC22A3 | G>A | 2155 | 14890 | 67.58 | 2.019e-16 | 1.211 |
| chr6:160922870 | rs117733303 | - | A>G | 2144 | 14840 | 66.07 | 4.359e-16 | 1.209 |
| chr6:160961137 | rs3798220 | LPA | T>C | 2119 | 14663 | 65.26 | 6.576e-16 | 1.209 |
| chr6:160687412 | rs10080815 | SLC22A2 | T>G | 2275 | 15862 | 64.81 | 8.252e-16 | 1.2 |
| chr9:22083404 | rs1333040 | - | T>C | 39609 | 340949 | 62.57 | 2.573e-15 | 0.9471 |
| chr9:22003223 | rs3217992 | AL359922.1 | C>T | 37082 | 299168 | 55.93 | 7.513e-14 | 1.054 |
| chr9:22068652 | rs4977756 | - | A>G | 38439 | 330201 | 52.78 | 3.723e-13 | 0.951 |
| chr9:22043926 | rs1412829 | - | A>G | 40355 | 346091 | 51.04 | 9.05e-13 | 0.9522 |
| chr9:22033366 | rs2157719 | - | T>C | 41622 | 356600 | 50.99 | 9.294e-13 | 0.9524 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr2:44073656 | rs41360247 | ABCG8 | T>C | 6114 | 2585 | 30.11 | 4.072e-08 | 0.8752 |
| chr2:44065090 | Affx-20089987 | ABCG5 | G>A | 6119 | 2579 | 28.62 | 8.798e-08 | 0.8781 |
| chr2:44066247 | Affx-20090007 | ABCG8 | G>C | 6395 | 2683 | 27.52 | 1.553e-07 | 0.8824 |
| chr10:25591541 | rs58585465 | GPR158 | C>T | 8821 | 3606 | 22.68 | 1.917e-06 | 0.9057 |
| chr8:99040492 | rs1869611 | MATN2 | A>G | 2075 | 931 | 22.14 | 2.53e-06 | 0.8289 |
| chr17:22027011 | rs17808964 | - | G>T | 12247 | 4231 | 21.69 | 3.204e-06 | 1.092 |
| chr8:29743994 | rs6468360 | - | C>G | 15048 | 5990 | 21.2 | 4.141e-06 | 0.9261 |
| chr8:98976664 | rs2444872 | MATN2 | G>A | 2399 | 1058 | 21.0 | 4.593e-06 | 0.8426 |
| chr9:28086344 | rs2167644 | LINGO2 | A>G | 23888 | 8480 | 21.0 | 4.581e-06 | 1.068 |
| chr4:6800680 | rs114259602 | KIAA0232 | G>A | 1283 | 600 | 20.94 | 4.743e-06 | 0.7965 |
| chr3:110931594 | rs114298999 | NECTIN3 | C>T | 2503 | 1098 | 20.32 | 6.558e-06 | 0.8476 |
| chr3:194607718 | rs76374945 | - | C>T | 2850 | 901 | 20.25 | 6.786e-06 | 1.19 |
| chr23:88063578 | rs139929471 | - | G>A | 4797 | 1713 | 19.94 | 7.971e-06 | 1.138 |
| chr17:7807438 | rs117032670 | CHD3 | G>A | 1538 | 702 | 19.84 | 8.418e-06 | 0.8151 |
| chr9:28093874 | rs7847672 | LINGO2 | G>A | 36948 | 13314 | 19.72 | 8.982e-06 | 1.058 |
| chr12:90864623 | rs78045535 | - | G>T | 6800 | 2291 | 19.39 | 1.066e-05 | 1.116 |
| chr6:32739967 | rs1383264 | - | T>A | 45064 | 17317 | 19.37 | 1.076e-05 | 0.9475 |
| chr2:3996533 | rs1494053 | - | G>A | 37420 | 13496 | 19.34 | 1.093e-05 | 1.057 |
| chr11:34024046 | rs17771070 | - | C>T | 9760 | 3361 | 18.35 | 1.842e-05 | 1.094 |
| chr3:173310633 | rs1980298 | NLGN1 | G>C | 32120 | 12449 | 18.27 | 1.917e-05 | 0.9461 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: I208 | Other forms of angina pectoris | 8/20 |
| ICD: I209 | Angina pectoris, unspecified | 10/20 |
| ICD: R073 | Other chest pain | 3/20 |
| ICD: R074 | Chest pain, unspecified | 6/20 |
| ID | Name | Top Correlation |
|---|---|---|
| ICD-10: I201 | Angina pectoris with documented spasm | 0/20 |
| ICD-10: I460 | Cardiac arrest with successful resuscitation | 0/20 |