Statistics
| Case | Control |
|---|---|
| 3638 | 456556 |
Phenotype Definition
Occurence of excessive sweating during sleep. [HPO:probinson, PMID:23136329]
Phenotype Comment
Nighttime sweating is a symptom linked to menopause, malignancies, autoimmune diseases, and infections.
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr4:150571112 | rs17625185 | IQCM | G>A | 2291 | 263892 | 26.64 | 2.453e-07 | 1.138 |
| chr20:22233970 | rs117777956 | - | A>G | 139 | 11744 | 23.13 | 1.517e-06 | 1.509 |
| chr4:2760330 | rs71608235 | - | C>A | 448 | 45553 | 23.01 | 1.616e-06 | 1.264 |
| chr4:150483071 | rs9999580 | IQCM | A>C | 2395 | 279623 | 22.74 | 1.859e-06 | 1.125 |
| chr16:7444493 | rs17562905 | RBFOX1 | A>C | 553 | 57538 | 22.62 | 1.971e-06 | 1.234 |
| chr5:17707384 | rs55730786 | - | T>C | 1502 | 170575 | 21.57 | 3.41e-06 | 1.144 |
| chr18:70908288 | rs77900250 | - | A>G | 556 | 58209 | 21.27 | 3.979e-06 | 1.226 |
| chr1:157210709 | rs6672275 | - | G>A | 3189 | 429163 | 20.84 | 4.989e-06 | 0.8991 |
| chr1:157240942 | rs35477982 | - | T>C | 3168 | 426223 | 20.62 | 5.591e-06 | 0.8996 |
| chr1:157259757 | rs12088155 | - | T>C | 2822 | 381845 | 20.21 | 6.927e-06 | 0.8985 |
| chr19:51111061 | rs7258762 | - | G>A | 997 | 143840 | 20.04 | 7.588e-06 | 0.8581 |
| chr11:117403235 | rs3741280 | DSCAML1 | G>T | 1943 | 268187 | 19.67 | 9.198e-06 | 0.8897 |
| chr3:54892449 | rs34173987 | CACNA2D3 | A>G | 164 | 14725 | 19.62 | 9.444e-06 | 1.419 |
| chr2:53467440 | rs17634707 | - | A>C | 290 | 28427 | 19.51 | 9.996e-06 | 1.304 |
| chr14:51421179 | rs12431737 | - | G>T | 3802 | 457550 | 19.37 | 1.078e-05 | 1.106 |
| chr8:4078128 | rs117631407 | CSMD1 | G>A | 243 | 23273 | 19.32 | 1.106e-05 | 1.332 |
| chr3:148651695 | rs77913180 | - | C>T | 1884 | 218400 | 19.14 | 1.212e-05 | 1.124 |
| chr18:70753780 | rs117953707 | - | A>G | 573 | 60842 | 19.02 | 1.293e-05 | 1.209 |
| chr4:35123780 | rs12500113 | - | G>A | 1161 | 130679 | 18.72 | 1.515e-05 | 1.148 |
| chr5:20461098 | rs79167220 | CDH18 | G>A | 157 | 14121 | 18.65 | 1.572e-05 | 1.417 |
| chr16:7444493 | rs17562905 | RBFOX1 | A>C | 548 | 55990 | 24.54 | 7.272e-07 | 1.247 |
| chr9:90851591 | rs17053995 | - | A>G | 92 | 7169 | 21.31 | 3.905e-06 | 1.621 |
| chr4:150571112 | rs17625185 | IQCM | G>A | 2232 | 257099 | 21.0 | 4.597e-06 | 1.124 |
| chr4:2760330 | rs71608235 | - | C>A | 422 | 42808 | 20.37 | 6.385e-06 | 1.255 |
| chr14:51421179 | rs12431737 | - | G>T | 3674 | 437150 | 20.29 | 6.668e-06 | 1.112 |
| chr4:34987681 | rs1031572 | - | C>T | 1081 | 119431 | 19.81 | 8.546e-06 | 1.159 |
| chr20:22233970 | rs117777956 | - | A>G | 135 | 11594 | 19.68 | 9.16e-06 | 1.47 |
| chr4:35123780 | rs12500113 | - | G>A | 1142 | 127028 | 19.3 | 1.115e-05 | 1.153 |
| chr5:17707384 | rs55730786 | - | T>C | 1481 | 167617 | 19.2 | 1.178e-05 | 1.137 |
| chr4:150483071 | rs9999580 | IQCM | A>C | 2325 | 270577 | 19.18 | 1.188e-05 | 1.117 |
| chr16:5960848 | rs9927950 | RBFOX1 | A>G | 3232 | 383022 | 19.09 | 1.249e-05 | 1.109 |
| chr13:93258044 | rs7997099 | GPC5 | G>A | 1509 | 209490 | 19.0 | 1.309e-05 | 0.8811 |
| chr4:23771190 | rs115192829 | PPARGC1A | G>A | 133 | 24111 | 18.66 | 1.562e-05 | 0.686 |
| chr11:36994982 | rs7927935 | - | C>T | 178 | 16265 | 18.3 | 1.884e-05 | 1.384 |
| chr5:20461098 | rs79167220 | CDH18 | G>A | 155 | 13819 | 18.27 | 1.919e-05 | 1.415 |
| chr4:151030070 | rs9985766 | DCLK2 | A>G | 1745 | 199932 | 18.25 | 1.939e-05 | 1.125 |
| chr10:3004093 | rs3003516 | - | A>G | 437 | 66738 | 18.17 | 2.021e-05 | 0.8101 |
| chr8:4078128 | rs117631407 | CSMD1 | G>A | 235 | 22399 | 18.09 | 2.105e-05 | 1.327 |
| chr4:117624268 | rs4337794 | - | G>A | 1074 | 119420 | 18.0 | 2.213e-05 | 1.151 |
| chr3:54892449 | rs34173987 | CACNA2D3 | A>G | 161 | 14486 | 17.97 | 2.25e-05 | 1.402 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr16:7444493 | rs17562905 | RBFOX1 | A>C | 548 | 28168 | 25.53 | 4.365e-07 | 1.254 |
| chr4:150571112 | rs17625185 | IQCM | G>A | 2232 | 129886 | 21.1 | 4.36e-06 | 1.125 |
| chr4:2760330 | rs71608235 | - | C>A | 422 | 21610 | 20.51 | 5.925e-06 | 1.258 |
| chr16:5960848 | rs9927950 | RBFOX1 | A>G | 3232 | 193235 | 20.4 | 6.284e-06 | 1.114 |
| chr9:90851591 | rs17053995 | - | A>G | 92 | 3655 | 20.33 | 6.534e-06 | 1.607 |
| chr13:93258044 | rs7997099 | GPC5 | G>A | 1509 | 106257 | 20.14 | 7.201e-06 | 0.8774 |
| chr4:34987681 | rs1031572 | - | C>T | 1081 | 60343 | 19.87 | 8.298e-06 | 1.16 |
| chr4:35123780 | rs12500113 | - | G>A | 1142 | 64090 | 19.85 | 8.389e-06 | 1.156 |
| chr14:51421179 | rs12431737 | - | G>T | 3674 | 221119 | 19.83 | 8.474e-06 | 1.111 |
| chr16:5985987 | rs28411783 | RBFOX1 | T>G | 2758 | 163498 | 19.24 | 1.155e-05 | 1.113 |
| chr20:22233970 | rs117777956 | - | A>G | 135 | 5875 | 19.23 | 1.156e-05 | 1.467 |
| chr4:150483071 | rs9999580 | IQCM | A>C | 2325 | 136758 | 19.2 | 1.177e-05 | 1.117 |
| chr5:17707384 | rs55730786 | - | T>C | 1481 | 84761 | 19.02 | 1.295e-05 | 1.137 |
| chr8:4078128 | rs117631407 | CSMD1 | G>A | 235 | 11249 | 18.8 | 1.451e-05 | 1.336 |
| chr4:117624268 | rs4337794 | - | G>A | 1074 | 60200 | 18.75 | 1.49e-05 | 1.155 |
| chr9:137181823 | rs79082743 | - | G>A | 756 | 41251 | 18.7 | 1.531e-05 | 1.182 |
| chr23:144261189 | rs147825330 | - | T>G | 203 | 8322 | 18.63 | 1.588e-05 | 1.364 |
| chr18:70908288 | rs77900250 | - | A>G | 544 | 28837 | 18.51 | 1.692e-05 | 1.213 |
| chr4:35148907 | rs9997177 | - | G>A | 860 | 47609 | 18.15 | 2.042e-05 | 1.169 |
| chr18:70753780 | rs117953707 | - | A>G | 565 | 30142 | 18.0 | 2.207e-05 | 1.206 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|