Soft tissue sarcoma

0030448

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

Links

Sex Split

Interactive Plot

Statistics

Case	Control
38050	422144

Phenotype Definition

A type of sarcoma (A connective tissue neoplasm formed by proliferation of mesodermal cells) that develops from soft tissues like fat, muscle, nerves, fibrous tissues, blood vessels, or deep skin tissues. [HPO:probinson]

Phenotype Comment

Soft tissue sarcomas can be found in any part of the body but most often originate in the arms or legs. They can also be found in the trunk, head and neck area, internal organs, and in the retroperitoneum.

Top SNP Information

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr23:64367019	rs7064929	-	G>A	2925	14641	993.7	4.248e-218	1.897
chr23:106146349	rs5962774	MORC4	T>C	2028	8998	966.8	2.94e-212	2.131
chr1:159174683	rs2814778	ACKR1	T>C	2814	16563	958.1	2.303e-210	1.88
chr8:145639681	rs1871534	SLC39A4	G>C	2671	15474	957.1	3.834e-210	1.91
chr1:173579034	rs12065033	AL139142.2	C>T	2263	13078	812.5	1.058e-178	1.909
chr17:58508582	rs8071181	C17orf64	G>A	2247	13170	772.4	5.503e-170	1.882
chr18:9536315	rs14336	RALBP1	A>C	1932	10935	738.2	1.502e-162	1.946
chr6:136480972	rs9483910	PDE7B	C>T	2882	18488	730.4	7.367e-161	1.723
chr1:25589335	rs28670433	RSRP1	A>G	2125	12508	721.2	7.372e-159	1.873
chr1:159336315	Affx-5502610	-	G>A	2094	12312	712.4	6.141e-157	1.875
chr15:48426484	rs1426654	SLC24A5	A>G	3515	24011	698.9	5.264e-154	1.621
chr10:114925758	rs1056877	TCF7L2	T>C	1857	10594	691.9	1.687e-152	1.929
chr12:56722060	rs1918496	PAN2	G>T	1758	9859	689.9	4.723e-152	1.963
chr8:10557760	rs57041981	RP1L1	A>G	2331	14317	688.0	1.221e-151	1.796
chr9:129979758	rs3780318	RALGPS1	G>A	2285	13956	686.8	2.248e-151	1.806
chr3:188327555	rs7645635	LPP	T>C	2075	12301	686.6	2.42e-151	1.858
chr1:207782889	rs17047661	CR1	A>G	2066	12253	682.8	1.685e-150	1.857
chr9:117110112	Affx-52344420	AKNA	T>TG	2093	12486	679.0	1.096e-149	1.847
chr12:56755058	rs4301822	APOF	A>G	1862	10750	673.7	1.601e-148	1.911
chr6:137344363	rs1744080	IL20RA	G>A	2316	14294	673.1	2.069e-148	1.788
chr25:154986418	rs142918084	-	C>G	3064	27637	122.2	2.085e-28	1.24
chr25:2692710	rs2259750	-	A>G	13026	155576	81.78	1.522e-19	0.913
chr25:155104608	rs5940618	-	G>A	14604	172429	66.52	3.456e-16	0.9246
chr25:2679949	rs311121	-	G>T	11530	119258	60.16	8.764e-15	1.086
chr25:2645366	rs311083	-	C>G	26872	309684	57.04	4.272e-14	0.9418
chr25:154999134	rs6642320	-	G>A	27592	295771	54.63	1.454e-13	1.061
chr5:1279790	rs10069690	TERT	C>T	20430	216606	51.69	6.499e-13	1.063
chr25:155013081	rs146997510	-	T>A	1847	24302	51.67	6.555e-13	0.8391
chr25:2661556	rs73188900	-	A>C	1233	16881	51.46	7.291e-13	0.808
chr25:2644302	rs1136470	-	C>T	11055	114759	51.17	8.456e-13	1.08
chr25:2676160	rs312232	-	C>T	17263	182335	49.58	1.9e-12	1.066
chr10:105677897	rs4387287	STN1	C>A	12582	131545	48.89	2.708e-12	1.074
chr3:169492101	rs10936599	MYNN	C>T	17747	206392	47.72	4.921e-12	0.9401
chr25:155058865	rs73234550	-	G>A	2158	27853	47.25	6.237e-12	0.8558
chr25:154935282	rs112437556	-	C>T	2689	26132	45.31	1.68e-11	1.149
chr3:169497585	rs1317082	MYNN	A>G	17766	206356	45.02	1.948e-11	0.9418
chr10:105676465	rs9420907	STN1	A>C	10581	110305	43.56	4.115e-11	1.075
chr3:169481271	rs12696304	-	C>G	19315	223474	42.72	6.329e-11	0.9448
chr25:2691012	rs142162416	-	A>G	3694	36746	42.45	7.234e-11	1.122
chr3:169518455	rs6793295	LRRC34	T>C	18962	219475	41.38	1.256e-10	0.9451

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr10:59938336	rs12570088	-	A>G	3234	50	26.71	2.367e-07	0.4712
chr11:6948139	rs1491823	ZNF215	T>G	25651	137	25.6	4.208e-07	1.635
chr6:70878703	rs2296008	COL19A1	G>A	1806	32	24.26	8.414e-07	0.4167
chr11:6954539	rs4426121	ZNF215	G>C	25706	140	23.66	1.15e-06	1.599
chr17:77161084	rs8066998	RBFOX3	C>T	4877	66	23.49	1.256e-06	0.5339
chr17:77162921	rs56722191	RBFOX3	G>A	6910	86	23.32	1.373e-06	0.5709
chr15:95547484	rs78896827	-	C>A	8130	98	23.0	1.619e-06	0.5896
chr1:241236946	rs116968028	RGS7	A>G	883	19	22.13	2.545e-06	0.3468
chr11:6986426	rs7117376	ZNF215	C>T	25252	246	21.8	3.031e-06	0.6744
chr1:233353901	rs74503807	PCNX2	G>A	1412	26	21.7	3.181e-06	0.4019
chr17:57605741	rs76912389	-	G>A	822	18	21.7	3.187e-06	0.3413
chr18:58962191	rs12455598	-	C>T	2402	38	21.5	3.536e-06	0.4652
chr6:163772282	rs117036007	-	C>T	1518	27	20.73	5.282e-06	0.416
chr23:9078860	rs1466984	FAM9B	C>A	28567	109	20.54	5.827e-06	1.676
chr5:38253181	rs72736999	-	A>G	2382	37	20.48	6.04e-06	0.4691
chr4:88295123	rs116113712	HSD17B11	G>A	1300	24	20.08	7.418e-06	0.4021
chr14:52126584	rs17590534	FRMD6	T>C	1229	23	19.77	8.737e-06	0.3978
chr9:129474409	rs75772563	-	C>T	1086	21	19.65	9.317e-06	0.3838
chr21:24745658	rs2828092	-	C>T	4757	62	19.47	1.023e-05	0.5551
chr4:45757007	rs9291276	-	C>T	7422	88	19.42	1.046e-05	0.6018

Associated Diseases ^ⓘ

ID	Name	Top Correlation
ICD: D24	Benign neoplasm of breast	6/20
ICD: D250	Submucous leiomyoma of uterus	9/20
ICD: D252	Subserosal leiomyoma of uterus	6/20
ICD: D259	Leiomyoma of uterus, unspecified	15/20
ICD: K083	Retained dental root	10/20
ICD: L989	Disorder of skin and subcutaneous tissue, unspecified	2/20
ICD: M5496	Dorsalgia, unspecified (Lumbar region)	1/20
ICD: M5499	Dorsalgia, unspecified (Site unspecified)	8/20
ICD: N63	Unspecified lump in breast	1/20

ID	Name	Top Correlation
ICD-10: C492	Connective and soft tissue of lower limb, including hip	0/20
ICD-10: C780	Secondary malignant neoplasm of lung	0/20
ICD-10: C784	Secondary malignant neoplasm of small intestine	0/20
ICD-10: D210	Connective and other soft tissue of head, face and neck	0/20
ICD-10: D211	Connective and other soft tissue of upper limb, including shoulder	0/20
ICD-10: D212	Connective and other soft tissue of lower limb, including hip	0/20
ICD-10: D27	Benign neoplasm of ovary	0/20
ICD-10: D481	Connective and other soft tissue	0/20
ICD-10: D486	Breast	0/20
ICD-10: H050	Acute inflammation of orbit	0/20
ICD-10: J948	Other specified pleural conditions	0/20
ICD-10: K136	Irritative hyperplasia of oral mucosa	0/20
ICD-10: L089	Local infection of skin and subcutaneous tissue, unspecified	0/20
ICD-10: L929	Granulomatous disorder of skin and subcutaneous tissue, unspecified	0/20
ICD-10: L980	Pyogenic granuloma	0/20
ICD-10: M548	Other dorsalgia	0/20
ICD-10: M5490	Dorsalgia, unspecified (Multiple sites in spine)	0/20
ICD-10: M5494	Dorsalgia, unspecified (Thoracic region)	0/20
ICD-10: N600	Solitary cyst of breast	0/20
ICD-10: N601	Diffuse cystic mastopathy	0/20
ICD-10: N602	Fibroadenosis of breast	0/20
ICD-10: N62	Hypertrophy of breast	0/20
ICD-10: N649	Disorder of breast, unspecified	0/20
ICD-10: N841	Polyp of cervix uteri	0/20
ICD-10: Q850	Neurofibromatosis (nonmalignant)	0/20
ICD-10: R900	Intracranial space-occupying lesion	0/20