Statistics
| Case | Control |
|---|---|
| 46225 | 413969 |
Phenotype Definition
A high-pitched whistling sound associated with labored breathing. [HPO:probinson, PMID:26229557]
Phenotype Comment
Wheezes and rhonchi are continuous musical lung sounds. The American Thoracic Society (ATS) Committee on pulmonary nomenclature defines wheezes as high-pitched continuous sounds with a dominant frequency of 400 Hz or more, and rhonchi as low-pitched continuous musical sounds with a dominant frequency of about 200 Hz or less
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:32612430 | Affx-37072023 | HLA-DQA1 | C>T | 38684 | 366136 | 235.9 | 3.153e-53 | 0.8998 |
| chr6:32620775 | rs17843619 | - | A>C | 36670 | 347628 | 228.0 | 1.624e-51 | 0.9004 |
| chr6:32613712 | rs9273215 | HLA-DQA1 | A>G | 36794 | 348691 | 225.7 | 5.101e-51 | 0.9011 |
| chr6:32634838 | rs9274552 | HLA-DQB1 | C>A | 36234 | 343106 | 224.2 | 1.072e-50 | 0.9008 |
| chr6:32620399 | rs17843606 | - | T>G | 35852 | 340027 | 223.9 | 1.251e-50 | 0.9005 |
| chr6:32612488 | rs9273088 | HLA-DQA1 | C>A | 36662 | 347476 | 223.8 | 1.371e-50 | 0.9013 |
| chr6:32627714 | rs1063355 | HLA-DQB1 | G>T | 36817 | 348674 | 223.1 | 1.887e-50 | 0.9016 |
| chr6:32615458 | rs17612576 | - | A>G | 36634 | 346857 | 222.9 | 2.063e-50 | 0.9015 |
| chr6:32623430 | rs9273339 | - | A>G | 36839 | 348997 | 220.9 | 5.689e-50 | 0.902 |
| chr6:32625869 | Affx-28496566 | - | C>T | 35180 | 332782 | 218.0 | 2.452e-49 | 0.9008 |
| chr6:32635809 | rs3828790 | HLA-DQB1 | C>T | 36004 | 340211 | 211.5 | 6.35e-48 | 0.9034 |
| chr6:32636866 | rs3134996 | - | T>A | 32803 | 311302 | 196.8 | 1.031e-44 | 0.9049 |
| chr6:32582650 | rs3104413 | - | C>G | 19705 | 159364 | 196.3 | 1.329e-44 | 1.126 |
| chr6:32607376 | rs34250758 | HLA-DQA1 | G>A | 20847 | 169416 | 192.5 | 9.089e-44 | 1.121 |
| chr6:32577973 | rs532965 | - | T>G | 19854 | 160683 | 192.4 | 9.348e-44 | 1.124 |
| chr6:32583357 | rs6931277 | - | A>T | 19433 | 157259 | 187.4 | 1.157e-42 | 1.123 |
| chr6:32581973 | rs521539 | - | G>A | 22173 | 181624 | 167.3 | 2.899e-38 | 1.11 |
| chr6:32602430 | rs17211510 | HLA-DQA1 | C>A | 21434 | 206590 | 166.8 | 3.696e-38 | 0.9005 |
| chr6:32577380 | rs660895 | - | A>G | 22148 | 181499 | 164.8 | 1.02e-37 | 1.109 |
| chr6:32600057 | rs35242582 | HLA-DQA1 | A>G | 21890 | 210574 | 162.0 | 4.192e-37 | 0.9025 |
| chr6:32612430 | Affx-37072023 | HLA-DQA1 | C>T | 35524 | 340444 | 249.6 | 3.157e-56 | 0.8935 |
| chr6:32620775 | rs17843619 | - | A>C | 33789 | 324363 | 242.8 | 9.507e-55 | 0.8939 |
| chr6:32613712 | rs9273215 | HLA-DQA1 | A>G | 33907 | 325361 | 240.4 | 3.184e-54 | 0.8946 |
| chr6:32634838 | rs9274552 | HLA-DQB1 | C>A | 33392 | 320155 | 239.1 | 6.046e-54 | 0.8942 |
| chr6:32612488 | rs9273088 | HLA-DQA1 | C>A | 33780 | 324208 | 238.8 | 7.359e-54 | 0.8947 |
| chr6:32620399 | rs17843606 | - | T>G | 33036 | 317304 | 238.4 | 8.701e-54 | 0.8939 |
| chr6:32615458 | rs17612576 | - | A>G | 33760 | 323694 | 237.9 | 1.151e-53 | 0.8949 |
| chr6:32627714 | rs1063355 | HLA-DQB1 | G>T | 33931 | 325342 | 237.2 | 1.57e-53 | 0.8953 |
| chr6:32623430 | rs9273339 | - | A>G | 33944 | 325591 | 235.5 | 3.68e-53 | 0.8955 |
| chr6:32625869 | Affx-28496566 | - | C>T | 32423 | 310493 | 232.5 | 1.728e-52 | 0.8942 |
| chr6:32635809 | rs3828790 | HLA-DQB1 | C>T | 33172 | 317462 | 227.0 | 2.729e-51 | 0.8967 |
| chr6:32582650 | rs3104413 | - | C>G | 19050 | 154144 | 220.4 | 7.263e-50 | 1.136 |
| chr6:32607376 | rs34250758 | HLA-DQA1 | G>A | 20081 | 163209 | 218.3 | 2.143e-49 | 1.133 |
| chr6:32577973 | rs532965 | - | T>G | 19200 | 155467 | 216.0 | 6.783e-49 | 1.134 |
| chr6:32583357 | rs6931277 | - | A>T | 18798 | 152158 | 210.7 | 9.702e-48 | 1.134 |
| chr6:32636866 | rs3134996 | - | T>A | 30888 | 295948 | 197.4 | 7.549e-45 | 0.9019 |
| chr6:32581973 | rs521539 | - | G>A | 21219 | 173876 | 190.0 | 3.138e-43 | 1.121 |
| chr6:32577380 | rs660895 | - | A>G | 21194 | 173773 | 187.1 | 1.334e-42 | 1.12 |
| chr6:32602430 | rs17211510 | HLA-DQA1 | C>A | 19828 | 193739 | 179.0 | 8.162e-41 | 0.8935 |
| chr6:32428062 | rs9268833 | - | C>T | 31135 | 260980 | 177.9 | 1.399e-40 | 1.103 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:32620775 | rs17843619 | - | A>C | 33789 | 11472 | 73.18 | 1.185e-17 | 0.8886 |
| chr6:32612430 | Affx-37072023 | HLA-DQA1 | C>T | 35524 | 12021 | 73.08 | 1.243e-17 | 0.8895 |
| chr6:32613712 | rs9273215 | HLA-DQA1 | A>G | 33907 | 11494 | 71.54 | 2.72e-17 | 0.8899 |
| chr6:32627714 | rs1063355 | HLA-DQB1 | G>T | 33931 | 11498 | 70.91 | 3.741e-17 | 0.8904 |
| chr6:32612488 | rs9273088 | HLA-DQA1 | C>A | 33780 | 11458 | 70.58 | 4.43e-17 | 0.8904 |
| chr6:32634838 | rs9274552 | HLA-DQB1 | C>A | 33392 | 11298 | 70.28 | 5.15e-17 | 0.8901 |
| chr6:32615458 | rs17612576 | - | A>G | 33760 | 11434 | 69.81 | 6.523e-17 | 0.891 |
| chr6:32623430 | rs9273339 | - | A>G | 33944 | 11503 | 69.26 | 8.65e-17 | 0.8915 |
| chr6:32620399 | rs17843606 | - | T>G | 33036 | 11198 | 68.87 | 1.053e-16 | 0.8908 |
| chr6:32635809 | rs3828790 | HLA-DQB1 | C>T | 33172 | 11230 | 68.28 | 1.415e-16 | 0.8915 |
| chr6:32636866 | rs3134996 | - | T>A | 30888 | 10478 | 65.43 | 6.015e-16 | 0.8924 |
| chr6:32625869 | Affx-28496566 | - | C>T | 32423 | 10925 | 63.91 | 1.301e-15 | 0.8935 |
| chr6:32427748 | rs9268831 | - | C>T | 45756 | 13707 | 53.88 | 2.135e-13 | 1.104 |
| chr6:32582650 | rs3104413 | - | C>G | 19050 | 5441 | 53.03 | 3.293e-13 | 1.133 |
| chr6:32577973 | rs532965 | - | T>G | 19200 | 5499 | 50.62 | 1.121e-12 | 1.129 |
| chr6:32607376 | rs34250758 | HLA-DQA1 | G>A | 20081 | 5781 | 50.5 | 1.192e-12 | 1.126 |
| chr6:32428115 | rs9268835 | - | G>A | 31112 | 9165 | 49.96 | 1.567e-12 | 1.107 |
| chr6:32428062 | rs9268833 | - | C>T | 31135 | 9168 | 49.8 | 1.699e-12 | 1.107 |
| chr6:32667119 | rs3135006 | - | C>T | 20511 | 7045 | 49.4 | 2.091e-12 | 0.8949 |
| chr6:32376746 | rs3763316 | - | C>T | 29451 | 8664 | 47.64 | 5.109e-12 | 1.106 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: J22 | Unspecified acute lower respiratory infection | 6/20 |
| ICD: J459 | Asthma, unspecified | 18/20 |