Statistics
| Case | Control |
|---|---|
| 1205 | 458989 |
Phenotype Definition
Abnormal breath sounds characterized by low-pitched, snoring or rattle-like sounds. [PMID:26229557, UToronto:chum]
Phenotype Comment
Wheezes and rhonchi are continuous musical lung sounds. The American Thoracic Society (ATS) Committee on pulmonary nomenclature defines wheezes as high-pitched continuous sounds with a dominant frequency of 400 Hz or more, and rhonchi as low-pitched continuous musical sounds with a dominant frequency of about 200 Hz or less.
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr8:116631902 | rs7823278 | TRPS1 | C>A | 72 | 11287 | 54.92 | 1.255e-13 | 2.366 |
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 138 | 27388 | 54.12 | 1.89e-13 | 1.885 |
| chr9:129984107 | rs3739553 | RALGPS1 | G>A | 89 | 15324 | 53.39 | 2.73e-13 | 2.162 |
| chr7:107689844 | rs10260756 | LAMB4 | G>T | 112 | 20984 | 52.69 | 3.899e-13 | 1.992 |
| chr8:145639681 | rs1871534 | SLC39A4 | G>C | 100 | 18045 | 52.34 | 4.66e-13 | 2.062 |
| chr9:129979758 | rs3780318 | RALGPS1 | G>A | 92 | 16149 | 52.13 | 5.203e-13 | 2.118 |
| chr4:6619004 | rs4234764 | MAN2B2 | G>A | 98 | 18000 | 48.68 | 3.02e-12 | 2.024 |
| chr10:108763241 | rs73371935 | SORCS1 | C>G | 107 | 20386 | 47.74 | 4.87e-12 | 1.956 |
| chr3:122328753 | rs2173764 | PARP15 | A>G | 81 | 14038 | 47.57 | 5.312e-12 | 2.142 |
| chr3:188327555 | rs7645635 | LPP | T>C | 82 | 14294 | 47.36 | 5.898e-12 | 2.13 |
| chr4:27125152 | rs10027736 | - | C>T | 78 | 13382 | 47.26 | 6.215e-12 | 2.166 |
| chr8:10557760 | rs57041981 | RP1L1 | A>G | 91 | 16557 | 46.69 | 8.327e-12 | 2.045 |
| chr10:65924376 | rs4390238 | - | G>T | 71 | 11804 | 46.63 | 8.575e-12 | 2.23 |
| chr1:159174683 | rs2814778 | ACKR1 | T>C | 102 | 19275 | 46.59 | 8.76e-12 | 1.97 |
| chr23:106146349 | rs5962774 | MORC4 | T>C | 64 | 10962 | 44.43 | 2.631e-11 | 2.284 |
| chr3:124905146 | rs6784701 | SLC12A8 | C>T | 81 | 14419 | 44.04 | 3.224e-11 | 2.084 |
| chr12:76330446 | rs11180761 | - | G>C | 74 | 12774 | 43.93 | 3.399e-11 | 2.149 |
| chr13:104861837 | rs73594701 | - | A>G | 80 | 14176 | 43.82 | 3.606e-11 | 2.089 |
| chr10:108751262 | rs7091076 | SORCS1 | T>G | 110 | 22069 | 41.49 | 1.185e-10 | 1.857 |
| chr10:34398520 | rs12415499 | PARD3 | T>C | 106 | 21052 | 41.34 | 1.279e-10 | 1.875 |
| chr7:2913736 | rs2398571 | - | T>G | 1162 | 396513 | 24.85 | 6.186e-07 | 1.226 |
| chr3:191373458 | rs116255359 | - | A>C | 148 | 39044 | 21.35 | 3.836e-06 | 1.477 |
| chr8:38265795 | rs72067977 | LETM2 | GACT>G | 159 | 42183 | 21.2 | 4.132e-06 | 1.457 |
| chr10:51785728 | rs61848278 | - | G>T | 96 | 23172 | 20.95 | 4.725e-06 | 1.605 |
| chr8:97110318 | rs78994317 | - | T>C | 175 | 47734 | 20.64 | 5.548e-06 | 1.427 |
| chr4:74455628 | rs75495477 | RASSF6 | G>A | 227 | 64945 | 20.61 | 5.636e-06 | 1.372 |
| chr16:81508976 | rs2927334 | CMIP | C>T | 244 | 70859 | 19.54 | 9.833e-06 | 1.347 |
| chr1:77146739 | rs75019360 | - | G>A | 158 | 42912 | 19.48 | 1.017e-05 | 1.436 |
| chr4:149283684 | rs72729952 | NR3C2 | G>C | 107 | 26924 | 19.18 | 1.193e-05 | 1.538 |
| chr8:43504595 | rs62516434 | - | G>A | 87 | 20998 | 19.13 | 1.222e-05 | 1.607 |
| chr17:49339268 | rs74678447 | UTP18 | A>G | 227 | 65454 | 19.11 | 1.231e-05 | 1.356 |
| chr1:156255448 | rs116664767 | TMEM79 | A>G | 52 | 11008 | 18.55 | 1.654e-05 | 1.816 |
| chr5:149604397 | rs77905546 | CAMK2A | G>T | 64 | 14428 | 18.32 | 1.87e-05 | 1.711 |
| chr7:124178224 | rs4731191 | - | G>A | 1027 | 352360 | 18.24 | 1.946e-05 | 1.193 |
| chr19:58952608 | rs12979415 | - | T>A | 132 | 34990 | 18.2 | 1.984e-05 | 1.463 |
| chr1:98556115 | rs2802536 | - | C>T | 507 | 162951 | 17.73 | 2.541e-05 | 1.234 |
| chr4:124288412 | rs7659671 | - | G>T | 370 | 114966 | 17.68 | 2.609e-05 | 1.268 |
| chr8:1488606 | rs4876088 | DLGAP2 | A>G | 187 | 52978 | 17.61 | 2.716e-05 | 1.375 |
| chr15:36106506 | rs182276118 | - | C>A | 47 | 9798 | 17.6 | 2.726e-05 | 1.84 |
| chr20:30504235 | rs73102622 | TTLL9 | C>T | 192 | 54579 | 17.57 | 2.772e-05 | 1.37 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr8:38265795 | rs72067977 | LETM2 | GACT>G | 159 | 5399 | 22.65 | 1.944e-06 | 1.483 |
| chr7:2913736 | rs2398571 | - | T>G | 1162 | 51741 | 22.39 | 2.229e-06 | 1.215 |
| chr3:191373458 | rs116255359 | - | A>C | 148 | 5004 | 22.35 | 2.275e-06 | 1.498 |
| chr4:149283684 | rs72729952 | NR3C2 | G>C | 107 | 3408 | 21.04 | 4.492e-06 | 1.579 |
| chr16:81508976 | rs2927334 | CMIP | C>T | 244 | 9090 | 20.9 | 4.83e-06 | 1.366 |
| chr10:51785728 | rs61848278 | - | G>T | 96 | 3001 | 20.62 | 5.613e-06 | 1.609 |
| chr4:74455628 | rs75495477 | RASSF6 | G>A | 227 | 8492 | 19.26 | 1.141e-05 | 1.362 |
| chr4:124288412 | rs7659671 | - | G>T | 370 | 14798 | 18.77 | 1.474e-05 | 1.28 |
| chr19:58952608 | rs12979415 | - | T>A | 132 | 4501 | 18.69 | 1.538e-05 | 1.477 |
| chr8:97110318 | rs78994317 | - | T>C | 175 | 6282 | 18.61 | 1.6e-05 | 1.407 |
| chr11:125708293 | rs12224646 | PATE4 | T>G | 369 | 14764 | 18.54 | 1.667e-05 | 1.279 |
| chr4:96884847 | rs116748392 | - | C>T | 62 | 1783 | 18.25 | 1.94e-05 | 1.737 |
| chr4:179409526 | rs7677592 | - | A>G | 667 | 28560 | 18.23 | 1.961e-05 | 1.217 |
| chr17:49339268 | rs74678447 | UTP18 | A>G | 227 | 8531 | 18.2 | 1.992e-05 | 1.35 |
| chr8:43504595 | rs62516434 | - | G>A | 87 | 2742 | 18.16 | 2.031e-05 | 1.597 |
| chr20:31025163 | rs2295764 | ASXL1 | A>G | 963 | 42567 | 18.16 | 2.034e-05 | 1.196 |
| chr8:111665920 | rs34285191 | - | G>A | 382 | 15378 | 18.03 | 2.171e-05 | 1.27 |
| chr8:1488606 | rs4876088 | DLGAP2 | A>G | 187 | 6849 | 17.73 | 2.548e-05 | 1.382 |
| chr1:156255448 | rs116664767 | TMEM79 | A>G | 52 | 1444 | 17.36 | 3.088e-05 | 1.797 |
| chr21:25055899 | rs73232612 | - | G>A | 361 | 14534 | 17.27 | 3.241e-05 | 1.271 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|