Statistics
| Case | Control |
|---|---|
| 4794 | 455400 |
Phenotype Definition
Any anomaly measure by pulmonary function testing, which includes spirometry, measures of diffusing capacity, and plethysmography. [HPO:probinson]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr1:32266026 | rs552124 | SPOCD1 | G>A | 2304 | 242595 | 25.08 | 5.488e-07 | 0.8874 |
| chr12:40789032 | rs73094964 | MUC19 | A>T | 677 | 53987 | 24.53 | 7.325e-07 | 1.219 |
| chr19:1310537 | rs12710060 | - | G>A | 556 | 65198 | 24.0 | 9.646e-07 | 0.8069 |
| chr4:38916914 | rs4240248 | FAM114A1 | T>G | 3915 | 399222 | 23.73 | 1.11e-06 | 0.9047 |
| chr4:184813864 | rs1369444 | STOX2 | G>A | 2810 | 291498 | 23.17 | 1.484e-06 | 0.8981 |
| chr12:19230693 | rs4405370 | - | G>T | 125 | 18332 | 22.91 | 1.693e-06 | 0.6511 |
| chr2:168979699 | rs74742105 | STK39 | G>A | 203 | 27142 | 22.9 | 1.706e-06 | 0.7125 |
| chr20:41575123 | rs4812661 | PTPRT | C>T | 2570 | 227293 | 22.82 | 1.778e-06 | 1.116 |
| chr15:28335820 | rs4778138 | OCA2 | A>G | 1227 | 133548 | 22.39 | 2.227e-06 | 0.8653 |
| chr5:61910955 | rs115594051 | IPO11 | G>A | 205 | 14181 | 22.22 | 2.429e-06 | 1.396 |
| chr16:2838244 | rs7194680 | - | G>C | 2319 | 242482 | 22.11 | 2.571e-06 | 0.8942 |
| chr1:32315147 | rs7518553 | - | C>T | 2792 | 288963 | 21.82 | 2.992e-06 | 0.9008 |
| chr10:114595152 | rs34976625 | - | G>T | 292 | 21425 | 21.57 | 3.412e-06 | 1.319 |
| chr23:45552235 | rs1883675 | - | G>C | 1350 | 157757 | 21.47 | 3.59e-06 | 0.8689 |
| chr2:7847067 | rs13003823 | - | C>T | 1835 | 194394 | 21.41 | 3.717e-06 | 0.8869 |
| chr2:192237058 | rs12995500 | MYO1B | A>G | 180 | 24292 | 21.39 | 3.74e-06 | 0.7065 |
| chr15:86559463 | rs8032065 | - | T>G | 115 | 16875 | 21.18 | 4.181e-06 | 0.6506 |
| chr1:168370260 | rs2268544 | - | A>G | 298 | 37208 | 21.13 | 4.281e-06 | 0.7629 |
| chr2:192247808 | rs34460997 | MYO1B | G>A | 278 | 34985 | 21.01 | 4.581e-06 | 0.7566 |
| chr3:3472604 | rs6772761 | - | C>T | 2425 | 252068 | 20.93 | 4.758e-06 | 0.8984 |
| chr20:41575123 | rs4812661 | PTPRT | C>T | 2363 | 203354 | 29.58 | 5.37e-08 | 1.139 |
| chr10:128259966 | rs1836943 | C10orf90 | C>T | 372 | 28412 | 23.54 | 1.223e-06 | 1.294 |
| chr1:32315147 | rs7518553 | - | C>T | 2672 | 274240 | 22.57 | 2.027e-06 | 0.897 |
| chr12:40789032 | rs73094964 | MUC19 | A>T | 660 | 52479 | 21.83 | 2.983e-06 | 1.208 |
| chr1:32266026 | rs552124 | SPOCD1 | G>A | 2219 | 229820 | 21.49 | 3.556e-06 | 0.8933 |
| chr4:184813864 | rs1369444 | STOX2 | G>A | 2643 | 270999 | 21.35 | 3.834e-06 | 0.8993 |
| chr4:52703265 | rs6554329 | - | T>C | 2895 | 255629 | 21.11 | 4.341e-06 | 1.109 |
| chr4:38916914 | rs4240248 | FAM114A1 | T>G | 3599 | 362837 | 21.04 | 4.507e-06 | 0.9073 |
| chr23:6123171 | rs4826837 | NLGN4X | A>C | 544 | 46509 | 20.91 | 4.811e-06 | 1.228 |
| chr3:65268385 | rs751378 | - | A>G | 382 | 28858 | 20.45 | 6.118e-06 | 1.268 |
| chr3:161209750 | rs17478991 | - | T>G | 565 | 64499 | 20.27 | 6.713e-06 | 0.8221 |
| chr5:61910955 | rs115594051 | IPO11 | G>A | 202 | 13994 | 20.23 | 6.859e-06 | 1.378 |
| chr1:4012010 | rs74050439 | - | G>A | 510 | 39901 | 20.08 | 7.439e-06 | 1.227 |
| chr10:21718721 | rs35297193 | - | C>A | 270 | 19525 | 19.75 | 8.813e-06 | 1.317 |
| chr4:48982359 | rs4552435 | - | T>C | 3323 | 296866 | 19.41 | 1.055e-05 | 1.1 |
| chr10:114595152 | rs34976625 | - | G>T | 287 | 21085 | 19.29 | 1.124e-05 | 1.302 |
| chr6:31093066 | rs3095302 | PSORS1C1 | G>A | 3449 | 347848 | 19.26 | 1.139e-05 | 0.9103 |
| chr4:49063872 | rs1051447 | CWH43 | A>C | 2950 | 261527 | 19.06 | 1.268e-05 | 1.102 |
| chr6:31093482 | rs3131003 | PSORS1C1 | G>A | 3460 | 348004 | 18.84 | 1.422e-05 | 0.9114 |
| chr13:102996713 | rs1360974 | FGF14 | G>A | 2908 | 295328 | 18.82 | 1.44e-05 | 0.9075 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr20:41575123 | rs4812661 | PTPRT | C>T | 2570 | 57475 | 23.75 | 1.095e-06 | 1.121 |
| chr19:1310537 | rs12710060 | - | G>A | 556 | 16547 | 23.04 | 1.587e-06 | 0.8083 |
| chr12:40789032 | rs73094964 | MUC19 | A>T | 677 | 13745 | 22.75 | 1.85e-06 | 1.214 |
| chr16:2838244 | rs7194680 | - | G>C | 2319 | 61592 | 22.16 | 2.511e-06 | 0.8927 |
| chr4:38916914 | rs4240248 | FAM114A1 | T>G | 3915 | 101137 | 21.94 | 2.806e-06 | 0.9069 |
| chr2:192237058 | rs12995500 | MYO1B | A>G | 180 | 6211 | 21.93 | 2.824e-06 | 0.7008 |
| chr2:192247808 | rs34460997 | MYO1B | G>A | 278 | 8943 | 21.72 | 3.16e-06 | 0.7506 |
| chr1:32266026 | rs552124 | SPOCD1 | G>A | 2304 | 61191 | 21.43 | 3.677e-06 | 0.8941 |
| chr2:7847067 | rs13003823 | - | C>T | 1835 | 49377 | 21.4 | 3.727e-06 | 0.8854 |
| chr4:184813864 | rs1369444 | STOX2 | G>A | 2810 | 73808 | 21.31 | 3.903e-06 | 0.9007 |
| chr23:45552235 | rs1883675 | - | G>C | 1350 | 39430 | 21.09 | 4.378e-06 | 0.8684 |
| chr7:51298586 | rs77969049 | COBL | T>C | 168 | 2859 | 20.88 | 4.882e-06 | 1.439 |
| chr6:134738772 | rs9483703 | - | T>C | 548 | 16137 | 20.54 | 5.836e-06 | 0.8169 |
| chr1:32315147 | rs7518553 | - | C>T | 2792 | 73211 | 20.48 | 6.022e-06 | 0.9024 |
| chr10:114595152 | rs34976625 | - | G>T | 292 | 5445 | 20.47 | 6.057e-06 | 1.316 |
| chr20:41500679 | rs208186 | PTPRT | T>G | 2731 | 61712 | 20.44 | 6.158e-06 | 1.109 |
| chr2:168979699 | rs74742105 | STK39 | G>A | 203 | 6785 | 20.42 | 6.223e-06 | 0.7234 |
| chr1:168370260 | rs2268544 | - | A>G | 298 | 9404 | 20.06 | 7.487e-06 | 0.7658 |
| chr5:61910955 | rs115594051 | IPO11 | G>A | 205 | 3636 | 19.96 | 7.919e-06 | 1.381 |
| chr2:192280374 | rs1356447 | MYO1B | A>G | 278 | 8824 | 19.94 | 7.993e-06 | 0.7595 |
| chr20:41575123 | rs4812661 | PTPRT | C>T | 2363 | 51302 | 31.01 | 2.567e-08 | 1.145 |
| chr3:65268385 | rs751378 | - | A>G | 382 | 7188 | 22.71 | 1.888e-06 | 1.29 |
| chr1:32315147 | rs7518553 | - | C>T | 2672 | 69537 | 22.4 | 2.214e-06 | 0.8959 |
| chr10:128259966 | rs1836943 | C10orf90 | C>T | 372 | 7131 | 21.67 | 3.245e-06 | 1.287 |
| chr2:34543813 | rs4670346 | - | G>A | 3006 | 77532 | 20.53 | 5.855e-06 | 0.9032 |
| chr23:6123171 | rs4826837 | NLGN4X | A>C | 544 | 11572 | 20.43 | 6.169e-06 | 1.229 |
| chr12:40789032 | rs73094964 | MUC19 | A>T | 660 | 13347 | 20.16 | 7.125e-06 | 1.204 |
| chr20:41500679 | rs208186 | PTPRT | T>G | 2603 | 58023 | 19.99 | 7.799e-06 | 1.111 |
| chr1:32266026 | rs552124 | SPOCD1 | G>A | 2219 | 58085 | 19.76 | 8.803e-06 | 0.8961 |
| chr4:184813864 | rs1369444 | STOX2 | G>A | 2643 | 68505 | 19.4 | 1.058e-05 | 0.9024 |
| chr6:168690389 | rs62423947 | - | C>T | 1096 | 23211 | 19.01 | 1.299e-05 | 1.154 |
| chr4:38916914 | rs4240248 | FAM114A1 | T>G | 3599 | 91723 | 18.85 | 1.413e-05 | 0.9108 |
| chr4:52703265 | rs6554329 | - | T>C | 2895 | 65041 | 18.73 | 1.509e-05 | 1.104 |
| chr19:49377424 | rs11541192 | PPP1R15A | G>A | 1943 | 42725 | 18.65 | 1.573e-05 | 1.119 |
| chr1:4012010 | rs74050439 | - | G>A | 510 | 10150 | 18.58 | 1.633e-05 | 1.222 |
| chr16:2838244 | rs7194680 | - | G>C | 2170 | 56678 | 18.55 | 1.653e-05 | 0.8984 |
| chr15:102104049 | rs4965899 | - | T>G | 765 | 21435 | 18.51 | 1.688e-05 | 0.848 |
| chr7:25574197 | rs981903 | - | T>C | 1302 | 34992 | 18.39 | 1.804e-05 | 0.878 |
| chr2:52662683 | rs115143302 | - | A>G | 257 | 4720 | 18.35 | 1.842e-05 | 1.319 |
| chr5:61910955 | rs115594051 | IPO11 | G>A | 202 | 3577 | 18.34 | 1.848e-05 | 1.366 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|