Statistics
| Case | Control |
|---|---|
| 7028 | 453166 |
Phenotype Comment
The APGAR score was developed by Dr. Virginia Apgar to quickly assess the status of newborn children. It is determined based on scoing five criteria (Appearance, Pulse, Grimace, Activity, Respiration) on a scale of zero to two each and summing the five values. A score of 7 and above is considered normal, 4 to 6 low, and 3 or less critically low. The 1-minute score is used to assess how well the neonate tolerated the birthing process, and the 5-minute score is used to assess how well the neonate is adapting to the postnatal environment.
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr1:159174683 | rs2814778 | ACKR1 | T>C | 610 | 18767 | 306.0 | 1.665e-68 | 2.051 |
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 783 | 26743 | 284.8 | 6.721e-64 | 1.855 |
| chr15:48392165 | rs1834640 | - | A>G | 849 | 30775 | 250.0 | 2.65e-56 | 1.748 |
| chr8:145639681 | rs1871534 | SLC39A4 | G>C | 548 | 17597 | 241.4 | 1.967e-54 | 1.961 |
| chr1:173579034 | rs12065033 | AL139142.2 | C>T | 481 | 14860 | 237.2 | 1.638e-53 | 2.033 |
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 1542 | 65516 | 231.2 | 3.198e-52 | 1.507 |
| chr17:58508582 | rs8071181 | C17orf64 | G>A | 475 | 14942 | 221.9 | 3.491e-50 | 1.996 |
| chr23:128718936 | rs2362937 | OCRL | T>C | 691 | 19260 | 219.6 | 1.131e-49 | 1.784 |
| chr23:106146349 | rs5962774 | MORC4 | T>C | 438 | 10588 | 218.6 | 1.864e-49 | 2.046 |
| chr23:64367019 | rs7064929 | - | G>A | 622 | 16944 | 214.1 | 1.74e-48 | 1.824 |
| chr19:42393286 | rs717225 | ARHGEF1 | A>G | 613 | 21330 | 207.6 | 4.632e-47 | 1.81 |
| chr9:137925543 | rs7027926 | - | G>A | 498 | 16322 | 204.9 | 1.799e-46 | 1.916 |
| chr4:110940045 | rs4698804 | - | T>C | 530 | 17734 | 204.1 | 2.701e-46 | 1.878 |
| chr14:105953204 | rs12323571 | CRIP1 | C>T | 331 | 9506 | 200.2 | 1.915e-45 | 2.181 |
| chr15:45556163 | rs8023604 | SLC28A2 | T>C | 404 | 12507 | 197.6 | 6.871e-45 | 2.024 |
| chr9:117110112 | Affx-52344420 | AKNA | T>TG | 442 | 14137 | 196.5 | 1.235e-44 | 1.962 |
| chr5:147863034 | rs9325101 | HTR4 | A>G | 490 | 16250 | 193.9 | 4.459e-44 | 1.892 |
| chr19:42391425 | rs28521795 | ARHGEF1 | G>A | 536 | 18286 | 193.3 | 6.134e-44 | 1.841 |
| chr5:147671850 | rs7724380 | - | G>A | 563 | 19620 | 188.7 | 6.173e-43 | 1.803 |
| chr19:42392441 | rs16975619 | ARHGEF1 | T>C | 559 | 19451 | 188.6 | 6.424e-43 | 1.806 |
| chr25:154999134 | rs6642320 | - | G>A | 5334 | 318029 | 49.57 | 1.917e-12 | 1.134 |
| chr25:2661556 | rs73188900 | - | A>C | 173 | 17941 | 40.01 | 2.521e-10 | 0.6176 |
| chr25:154935282 | rs112437556 | - | C>T | 569 | 28252 | 39.99 | 2.553e-10 | 1.314 |
| chr25:154986418 | rs142918084 | - | C>G | 590 | 30111 | 34.35 | 4.613e-09 | 1.283 |
| chr25:155058865 | rs73234550 | - | G>A | 338 | 29673 | 33.06 | 8.949e-09 | 0.7282 |
| chr25:2653913 | rs111628445 | - | G>A | 5516 | 376497 | 30.99 | 2.59e-08 | 0.9076 |
| chr25:2654460 | rs112372310 | - | A>G | 6565 | 442903 | 27.58 | 1.51e-07 | 0.9144 |
| chr25:154974730 | rs144759332 | - | C>G | 430 | 21769 | 25.29 | 4.923e-07 | 1.282 |
| chr25:155104608 | rs5940618 | - | G>A | 2619 | 184414 | 25.07 | 5.525e-07 | 0.8963 |
| chr9:32416386 | rs10970969 | ACO1 | C>T | 5285 | 323094 | 23.28 | 1.402e-06 | 1.088 |
| chr25:155053713 | rs28884873 | - | G>A | 1951 | 139098 | 23.13 | 1.518e-06 | 0.8886 |
| chr2:4991533 | rs72769925 | - | A>G | 599 | 31967 | 22.06 | 2.638e-06 | 1.219 |
| chr25:155009856 | rs700449 | - | C>T | 5285 | 323859 | 21.0 | 4.587e-06 | 1.084 |
| chr1:37457302 | rs12746787 | GRIK3 | G>A | 321 | 16083 | 20.6 | 5.666e-06 | 1.294 |
| chr4:696848 | rs12646225 | - | C>T | 1627 | 94265 | 20.35 | 6.46e-06 | 1.127 |
| chr25:2596574 | rs28523739 | - | T>C | 3721 | 224808 | 20.17 | 7.103e-06 | 1.09 |
| chr25:155013081 | rs146997510 | - | T>A | 312 | 25837 | 20.13 | 7.25e-06 | 0.7728 |
| chr25:2679949 | rs311121 | - | G>T | 2177 | 128611 | 20.07 | 7.451e-06 | 1.111 |
| chr1:2460564 | rs115638831 | HES5 | C>T | 225 | 19472 | 19.88 | 8.26e-06 | 0.7406 |
| chr7:101496532 | rs4236557 | CUX1 | G>T | 4310 | 293814 | 19.7 | 9.053e-06 | 0.9214 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr25:154999134 | rs6642320 | - | G>A | 5334 | 53740 | 30.97 | 2.617e-08 | 1.109 |
| chr25:2661556 | rs73188900 | - | A>C | 173 | 2826 | 29.6 | 5.31e-08 | 0.6532 |
| chr25:154935282 | rs112437556 | - | C>T | 569 | 4893 | 26.36 | 2.831e-07 | 1.261 |
| chr15:94201928 | rs4489957 | - | G>A | 631 | 5581 | 21.91 | 2.856e-06 | 1.222 |
| chr25:155058865 | rs73234550 | - | G>A | 338 | 4679 | 21.18 | 4.172e-06 | 0.7696 |
| chr9:32416386 | rs10970969 | ACO1 | C>T | 5285 | 53796 | 21.08 | 4.406e-06 | 1.087 |
| chr4:189954865 | rs7660130 | - | T>G | 5445 | 61390 | 20.73 | 5.29e-06 | 0.9208 |
| chr11:125303807 | rs34141026 | - | A>G | 1893 | 18334 | 20.46 | 6.089e-06 | 1.124 |
| chr4:696848 | rs12646225 | - | C>T | 1627 | 15626 | 20.16 | 7.127e-06 | 1.132 |
| chr25:2653913 | rs111628445 | - | G>A | 5516 | 62093 | 20.08 | 7.435e-06 | 0.9222 |
| chr25:154986418 | rs142918084 | - | C>G | 590 | 5263 | 19.85 | 8.364e-06 | 1.219 |
| chr1:37457302 | rs12746787 | GRIK3 | G>A | 321 | 2666 | 19.33 | 1.099e-05 | 1.299 |
| chr1:204438643 | rs1553921 | PIK3C2B | T>G | 266 | 2159 | 18.91 | 1.372e-05 | 1.329 |
| chr10:95039397 | rs1222926 | - | A>C | 5275 | 53758 | 18.88 | 1.389e-05 | 1.082 |
| chr3:11596302 | rs8154 | ATG7 | T>C | 4676 | 47556 | 18.54 | 1.666e-05 | 1.084 |
| chr25:2654460 | rs112372310 | - | A>G | 6565 | 73172 | 18.33 | 1.86e-05 | 0.9271 |
| chr4:183868474 | rs13142421 | - | T>G | 258 | 2095 | 18.22 | 1.971e-05 | 1.327 |
| chr1:2460564 | rs115638831 | HES5 | C>T | 225 | 3226 | 18.2 | 1.986e-05 | 0.7441 |
| chr15:52389437 | rs66742869 | - | G>C | 2250 | 22132 | 18.05 | 2.157e-05 | 1.108 |
| chr19:52154629 | rs67970852 | - | C>A | 581 | 5200 | 18.0 | 2.215e-05 | 1.208 |