Abnormal renal corpuscle morphology

0031263

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

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Sex Split

Interactive Plot

Statistics

Case	Control
9492	450702

Phenotype Definition

Any anomolous structure of the renal corpuscle, which is the initial component of the nephron that filters blood. The renal corpuscle consists of a knot of capillaries (glomerulus) that is surrounded by a double-walled capsule (Bowman capsule) that opens into a renal tubule. []

Top SNP Information

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr5:33951693	rs16891982	SLC45A2	G>C	1124	65934	47.73	4.879e-12	0.8077
chr5:33958959	rs28777	SLC45A2	A>C	939	56053	46.67	8.415e-12	0.7947
chr5:33951116	rs35397	SLC45A2	T>G	1570	88538	44.55	2.48e-11	0.8379
chr15:48426484	rs1426654	SLC24A5	A>G	408	27118	44.19	2.987e-11	0.7164
chr7:78169182	rs10243724	MAGI2	G>C	240	16908	35.94	2.039e-09	0.6773
chr5:33955326	rs35390	SLC45A2	A>C	673	40474	35.14	3.074e-09	0.7915
chr5:33955673	rs35391	SLC45A2	C>T	673	40307	33.89	5.836e-09	0.7948
chr15:48392165	rs1834640	-	A>G	505	31119	32.07	1.485e-08	0.7736
chr5:142437930	rs2190779	ARHGAP26	C>G	744	43603	30.52	3.303e-08	0.8123
chr1:1220954	rs12751100	SCNN1D	G>A	921	52863	30.4	3.522e-08	0.8291
chr2:136594158	rs2236783	LCT	A>G	4358	225318	30.39	3.53e-08	0.909
chr2:136407479	rs1446585	R3HDM1	A>G	5092	261306	30.15	4e-08	0.9139
chr4:73051488	rs12642225	-	C>G	482	29622	29.93	4.489e-08	0.776
chr10:121086097	rs2230345	GRK5	A>T	261	17445	29.0	7.227e-08	0.7143
chr6:396321	rs12203592	IRF4	C>T	4409	196796	27.66	1.448e-07	1.095
chr3:123419733	rs3732486	MYLK	A>G	443	27230	27.46	1.605e-07	0.7763
chr12:3417813	rs729914	-	G>T	236	15851	26.93	2.114e-07	0.7113
chr15:80985287	rs11629662	ABHD17C	A>G	2966	130260	26.82	2.233e-07	1.11
chr2:135837906	rs7570971	RAB3GAP1	C>A	5868	297705	26.53	2.594e-07	0.9223
chr2:136527443	rs113881162	UBXN4	GTGAT>G	4082	210502	26.18	3.11e-07	0.9133
chr11:134177205	rs12272129	GLB1L3	G>T	4185	184999	25.61	4.177e-07	1.094
chr9:26153585	rs16910205	-	T>C	1332	72089	24.22	8.586e-07	0.8685
chr1:7146519	rs115093140	CAMTA1	A>G	138	9758	22.12	2.556e-06	0.669
chr14:32493840	rs74678887	-	G>A	367	13684	21.31	3.899e-06	1.279
chr24:14902414	rs20321	USP9Y	G>A	273	8881	20.91	4.807e-06	1.334
chr15:69558040	rs11636090	GLCE	T>C	856	34855	20.84	5.001e-06	1.175
chr17:65408079	rs117216304	PITPNC1	G>A	331	12256	20.82	5.05e-06	1.291
chr9:105607335	rs7023672	-	G>T	1624	69196	20.3	6.626e-06	1.125
chr15:80985287	rs11629662	ABHD17C	A>G	2916	128096	20.26	6.776e-06	1.096
chr18:30198572	rs79769183	-	C>T	2503	109302	19.74	8.894e-06	1.101
chr4:118093137	rs10433903	-	T>C	6818	310037	19.18	1.189e-05	1.069
chr3:120961790	rs61796886	STXBP5L	C>T	537	21134	19.0	1.31e-05	1.213
chr21:18997213	rs8133946	-	A>G	2783	142590	18.88	1.394e-05	0.9139
chr5:61150082	rs114641859	-	C>T	408	15612	18.77	1.475e-05	1.245
chr19:53408165	rs7258315	ZNF888	G>C	3872	195720	18.68	1.545e-05	0.9244
chr6:147680176	rs117319597	STXBP5	C>T	304	11254	18.67	1.556e-05	1.287
chr20:4139254	rs117910398	SMOX	A>G	395	15088	18.63	1.585e-05	1.248
chr6:396321	rs12203592	IRF4	C>T	4351	194564	18.59	1.623e-05	1.078
chr4:20902112	rs1491358	KCNIP4	T>C	3058	155993	18.57	1.637e-05	0.9177
chr13:22235525	rs75115016	-	T>C	1139	47727	18.35	1.838e-05	1.142

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr5:33951693	rs16891982	SLC45A2	G>C	1124	267	48.86	2.75e-12	0.6111
chr15:48426484	rs1426654	SLC24A5	A>G	408	122	47.27	6.186e-12	0.4924
chr5:33958959	rs28777	SLC45A2	A>C	939	226	43.42	4.406e-11	0.6056
chr5:33955326	rs35390	SLC45A2	A>C	673	172	40.94	1.57e-10	0.5741
chr7:113116165	rs12537382	-	T>C	342	102	39.32	3.593e-10	0.4944
chr5:33955673	rs35391	SLC45A2	C>T	673	170	38.7	4.938e-10	0.5814
chr7:113102172	rs12705876	-	T>C	353	104	38.67	5.009e-10	0.5008
chr7:113052230	rs28397921	-	C>T	482	130	37.0	1.183e-09	0.5463
chr1:115712579	rs17033324	-	C>T	524	138	36.33	1.664e-09	0.5591
chr6:170602429	rs17860704	DLL1	T>C	171	61	36.17	1.812e-09	0.416
chr15:48392165	rs1834640	-	A>G	505	133	35.02	3.271e-09	0.5593
chr7:7091410	rs6946332	-	T>C	201	67	33.88	5.866e-09	0.4459
chr1:206665837	rs11118256	IKBKE	G>A	164	58	33.64	6.637e-09	0.4203
chr22:20220111	rs1076449	-	T>G	596	150	33.64	6.641e-09	0.5848
chr1:35645343	rs11264112	SFPQ	A>C	435	117	32.8	1.023e-08	0.5495
chr10:127887041	rs73380597	ADAM12	C>G	150	54	32.68	1.089e-08	0.4125
chr1:35656664	rs11264115	SFPQ	G>A	597	149	32.53	1.176e-08	0.5892
chr12:110158581	rs10850607	FAM222A	T>C	578	145	32.39	1.26e-08	0.5857
chr7:100551445	rs113821643	MUC3A	C>G	496	129	32.32	1.309e-08	0.5677
chr23:128718936	rs2362937	OCRL	T>C	300	92	32.14	1.437e-08	0.509
chr18:63533974	rs7245106	CDH7	T>C	6440	1077	27.47	1.599e-07	0.8029
chr1:115712579	rs17033324	-	C>T	459	112	25.41	4.631e-07	0.5854
chr18:63518486	rs1843187	CDH7	T>G	5910	989	25.17	5.253e-07	0.8072
chr8:134267762	rs3824240	NDRG1	T>C	2682	487	24.28	8.349e-07	0.7659
chr11:90896800	rs7358353	-	G>A	270	73	23.21	1.453e-06	0.531
chr1:35645343	rs11264112	SFPQ	A>C	235	64	20.72	5.31e-06	0.5283
chr12:51864979	rs2292217	SLC4A8	C>T	8605	1375	20.23	6.869e-06	0.8322
chr1:58542251	rs75565527	DAB1	T>C	688	148	19.82	8.513e-06	0.6628
chr6:106317587	rs78415721	-	C>T	1667	314	19.67	9.222e-06	0.7495
chr12:124281322	rs76791219	DNAH10	T>C	1991	367	19.64	9.373e-06	0.7641
chr2:39377823	rs71439246	-	T>G	992	201	19.57	9.678e-06	0.7025
chr4:58078913	rs13117645	-	C>T	5282	654	19.57	9.695e-06	1.234
chr12:11609177	rs11832037	PRB2	G>A	271	70	19.46	1.028e-05	0.5543
chr10:65027610	rs10761731	JMJD1C	A>T	7848	1263	19.36	1.085e-05	0.8352
chr1:205807504	rs954206	PM20D1	C>T	5299	881	19.2	1.177e-05	0.8251
chr1:208626275	rs17012555	-	C>T	603	132	19.04	1.283e-05	0.6531
chr16:54499643	rs111888233	-	C>T	310	77	18.71	1.52e-05	0.5762
chr10:65048306	rs7080386	JMJD1C	C>A	7816	1255	18.68	1.548e-05	0.8377
chr10:65133822	rs7923609	JMJD1C	A>G	8926	1418	18.5	1.7e-05	0.8391
chr23:131989647	rs5977769	HS6ST2	T>C	2058	392	18.46	1.735e-05	0.7709

Associated Diseases ^ⓘ

ID	Name	Top Correlation
ICD: C440	Skin of lip	5/20
ICD: H530	Amblyopia ex anopsia	5/20
ICD: R296	Tendency to fall, not elsewhere classified	8/20
ICD: W199	Unspecified place	4/20

ID	Name	Top Correlation
ICD-10: A490	Staphylococcal infection, unspecified	0/20
ICD-10: D230	Skin of lip	0/20
ICD-10: H549	Unspecified visual impairment (binocular)	0/20
ICD-10: M313	Wegener's granulomatosis	0/20
ICD-10: N029	Unspecified	0/20
ICD-10: N039	Unspecified	0/20
ICD-10: N049	Unspecified	0/20
ICD-10: N059	Unspecified	0/20
ICD-10: N138	Other obstructive and reflux uropathy	0/20
ICD-10: N139	Obstructive and reflux uropathy, unspecified	0/20
ICD-10: Q600	Renal agenesis, unilateral	0/20
ICD-10: R80	Isolated proteinuria	0/20

Abnormal renal corpuscle morphology

0031263

Normal Case/Contol ⓘ

Sibling Case/Control ⓘ