0031466

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Case	Control
47319	412875

Phenotype Definition

A maladaptive personality trait characterized by moderate or greater impairment in personality (self /interpersonal) functioning. [PMID:23902698]

Phenotype Comment

The emergence of the self in childhood and adolescence is based on experience and perception, which then becomes organized into identity, which organizes further experience and perception. Identity is related to the individual's selfsameness and continuity in time.

Top SNP Information

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr6:93667780	rs9363020	-	G>A	993	10998	53.16	3.071e-13	0.7849
chr2:26113913	rs78404020	-	A>G	1164	12653	52.9	3.515e-13	0.7996
chr4:100239319	rs1229984	ADH1B	C>T	2799	27677	41.68	1.076e-10	0.8783
chr16:75787596	rs74250922	TERF2IP	A>G	2970	29252	41.49	1.182e-10	0.8817
chr23:113179454	rs72619782	-	T>G	1167	12255	41.13	1.426e-10	0.8206
chr1:54009583	rs41363049	GLIS1	C>T	1117	11882	41.11	1.439e-10	0.8175
chr6:396321	rs12203592	IRF4	C>T	21486	179719	39.55	3.191e-10	1.053
chr2:150445102	rs4618014	-	A>G	1392	14447	39.47	3.327e-10	0.8375
chr1:169510139	rs13306334	F5	G>A	993	10615	38.42	5.716e-10	0.8135
chr23:71651365	rs12007867	AL133500.1	C>T	914	9757	37.86	7.614e-10	0.8076
chr2:16579208	rs67642542	-	C>T	2546	25147	37.09	1.127e-09	0.8796
chr16:75590092	rs3743601	TMEM231	G>C	5474	51863	36.31	1.686e-09	0.9157
chr5:58532218	rs12658429	PDE4D	T>C	1196	12493	36.14	1.839e-09	0.8329
chr6:93645908	rs77956657	-	T>C	1355	13971	35.42	2.658e-09	0.8434
chr1:46990044	rs12408243	-	G>T	49231	420683	35.28	2.851e-09	1.04
chr7:83498179	rs35433560	-	TG>T	968	10282	34.93	3.409e-09	0.8192
chr16:75646576	rs3743599	ADAT1	G>T	5384	50941	34.54	4.182e-09	0.9171
chr1:46953362	rs12402727	-	G>A	44350	378333	34.46	4.353e-09	1.04
chr23:140968664	rs61348924	MAGEC3	C>T	1298	13272	34.08	5.286e-09	0.8428
chr7:22797207	rs73276345	-	A>G	5523	52157	34.02	5.449e-09	0.9186
chr6:396321	rs12203592	IRF4	C>T	21144	177771	31.23	2.286e-08	1.047
chr7:114223723	rs1229761	FOXP2	A>C	31025	278091	30.66	3.081e-08	0.9603
chr9:81339569	rs1757945	-	A>G	29103	261057	29.38	5.937e-08	0.9605
chr11:113283459	rs6277	DRD2	A>G	43277	370601	25.92	3.566e-07	1.036
chr11:113268059	rs11604671	ANKK1	G>A	47294	419674	24.68	6.77e-07	0.9664
chr10:8776296	rs17144411	-	G>T	18214	153474	24.65	6.862e-07	1.044
chr2:60441184	rs9309322	-	G>A	44978	385382	24.63	6.957e-07	1.035
chr18:50737358	rs62100766	DCC	G>T	38070	325262	24.58	7.124e-07	1.035
chr8:71368614	rs12547808	-	T>C	29291	249146	24.49	7.477e-07	1.037
chr2:60500144	rs10202231	-	A>T	44670	396856	24.43	7.695e-07	0.9665
chr9:127932402	rs7852933	PPP6C	G>A	28748	257459	24.42	7.748e-07	0.9638
chr1:15359710	rs77436600	KAZN	G>A	15748	142727	24.41	7.805e-07	0.9556
chr14:79826981	rs12889183	NRXN3	G>A	42640	365216	24.17	8.834e-07	1.035
chr2:212595435	rs62182991	ERBB4	T>C	29741	252842	23.91	1.008e-06	1.037
chr7:114015707	rs12705960	FOXP2	A>C	46661	400471	23.79	1.072e-06	1.034
chr1:232127128	rs2806468	DISC1	A>G	31893	271794	23.71	1.117e-06	1.036
chr24:14902414	rs20321	USP9Y	G>A	1051	8103	23.29	1.392e-06	1.176
chr18:50683306	rs4372758	DCC	T>C	42072	360316	23.27	1.41e-06	1.034
chr2:22515568	rs12373752	-	A>G	45211	387686	23.06	1.573e-06	1.034
chr12:117672338	Affx-52326728	NOS1	CT>C	19184	161971	22.99	1.63e-06	1.042

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr6:31298240	rs9265549	HLA-B	G>A	33315	84004	26.91	2.128e-07	0.9589
chr10:65006456	rs6479891	JMJD1C	C>T	14007	32804	25.45	4.532e-07	1.057
chr10:65315397	rs12411988	REEP3	G>C	13473	31528	25.28	4.96e-07	1.057
chr6:30972865	rs1634718	-	A>G	25372	64311	25.22	5.113e-07	0.9573
chr10:65106551	rs7081275	JMJD1C	T>G	14006	32817	25.17	5.251e-07	1.056
chr6:31462321	rs2516412	-	G>T	28649	72335	24.14	8.973e-07	0.9597
chr6:31465490	rs2534673	MICB	G>C	28617	72255	23.9	1.013e-06	0.9598
chr6:30957618	rs886403	MUC21	T>C	26803	67759	23.79	1.072e-06	0.9592
chr6:31478986	rs2246618	-	C>T	28012	70711	23.64	1.159e-06	0.9597
chr6:31463790	rs2534679	MICB	T>C	28569	72085	23.28	1.402e-06	0.9604
chr6:30937377	rs3095085	-	G>T	26829	67793	23.24	1.429e-06	0.9597
chr9:116745276	rs10441748	ZNF618	T>G	27763	66165	23.17	1.482e-06	1.042
chr6:31474000	Affx-28458228	MICB	G>A	28625	72266	22.99	1.628e-06	0.9606
chr6:31463491	rs2516408	MICB	G>A	28412	71698	22.85	1.755e-06	0.9607
chr6:30951561	rs1634714	MUC21	T>C	17163	43780	22.53	2.064e-06	0.9538
chr6:31465047	rs3094005	MICB	G>T	12841	33003	22.5	2.097e-06	0.9483
chr6:31514247	rs9267488	ATP6V1G2-DDX39B	A>G	12756	32786	22.23	2.417e-06	0.9484
chr15:47682079	rs281289	SEMA6D	A>G	33703	80726	22.21	2.45e-06	1.039
chr6:30949670	rs2517425	-	T>G	27183	68640	21.98	2.756e-06	0.9609
chr6:31442782	rs3131643	-	G>A	14679	37565	21.95	2.798e-06	0.9515

Associated Diseases ^ⓘ

ID	Name	Top Correlation
ICD: F10	Mental and behavioural disorders due to use of alcohol	2/20
ICD: F100	Acute intoxication	2/20
ICD: F101	Harmful use	2/20
ICD: F103	Withdrawal state	2/20
ICD: F171	Harmful use	2/20
ICD: F32	Depressive episode	2/20

ID	Name	Top Correlation
ICD-10: F06	Other mental disorders due to brain damage and dysfunction and to physical disease	0/20
ICD-10: F112	Dependence syndrome	0/20
ICD-10: F121	Harmful use	0/20
ICD-10: F172	Dependence syndrome	0/20
ICD-10: F20	Schizophrenia	0/20
ICD-10: F200	Paranoid schizophrenia	0/20
ICD-10: F220	Delusional disorder	0/20
ICD-10: F23	Acute and transient psychotic disorders	0/20
ICD-10: F259	Schizoaffective disorder, unspecified	0/20
ICD-10: F29	Unspecified nonorganic psychosis	0/20
ICD-10: F310	Bipolar affective disorder, current episode hypomanic	0/20
ICD-10: F311	Bipolar affective disorder, current episode manic without psychotic symptoms	0/20
ICD-10: F312	Bipolar affective disorder, current episode manic with psychotic symptoms	0/20
ICD-10: F313	Bipolar affective disorder, current episode mild or moderate depression	0/20
ICD-10: F319	Bipolar affective disorder, unspecified	0/20
ICD-10: F331	Recurrent depressive disorder, current episode moderate	0/20
ICD-10: F332	Recurrent depressive disorder, current episode severe without psychotic symptoms	0/20
ICD-10: F333	Recurrent depressive disorder, current episode severe with psychotic symptoms	0/20
ICD-10: F339	Recurrent depressive disorder, unspecified	0/20
ICD-10: F402	Specific (isolated) phobias	0/20
ICD-10: F410	Panic disorder [episodic paroxysmal anxiety]	0/20
ICD-10: F411	Generalised anxiety disorder	0/20
ICD-10: F412	Mixed anxiety and depressive disorder	0/20
ICD-10: F419	Anxiety disorder, unspecified	0/20
ICD-10: F429	Obsessive-compulsive disorder, unspecified	0/20
ICD-10: F430	Acute stress reaction	0/20
ICD-10: F431	Posttraumatic stress disorder	0/20
ICD-10: F432	Adjustment disorders	0/20
ICD-10: F458	Other somatoform disorders	0/20
ICD-10: F603	Emotionally unstable personality disorder	0/20
ICD-10: F609	Personality disorder, unspecified	0/20
ICD-10: F99	Mental disorder, not otherwise specified	0/20
ICD-10: M702	Olecranon bursitis	0/20
ICD-10: N739	Female pelvic inflammatory disease, unspecified	0/20
ICD-10: O351	Maternal care for (suspected) chromosomal abnormality in foetus	0/20
ICD-10: O700	First degree perineal laceration during delivery	0/20
ICD-10: R071	Chest pain on breathing	0/20
ICD-10: R452	Unhappiness	0/20
ICD-10: T432	Other and unspecified antidepressants	0/20
ICD-10: T435	Other and unspecified antipsychotics and neuroleptics	0/20

Impairment in personality functioning

0031466

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

Links

Statistics

Phenotype Definition

Phenotype Comment

Top SNP Information

Associated Diseases ^ⓘ

Impairment in personality functioning

0031466

Normal Case/Contol ⓘ

Sibling Case/Control ⓘ

Links

Statistics

Phenotype Definition

Phenotype Comment

Top SNP Information Show Normal Table Show Sibling SNP

Associated Diseases ⓘ Shared SNP diseases No shared SNP diseases

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

Top SNP Information

Associated Diseases ^ⓘ