Cardiac conduction abnormality

0031546

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

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Sex Split

Interactive Plot

Statistics

Case	Control
27507	432687

Phenotype Definition

Any anomaly of the progression of electrical impulses through the heart. []

Phenotype Comment

The conduction system of the heart initiates and coordinates the electric signal that causes the rhythmic and synchronized contractions of the atria and ventricles. In higher vertebrates, this system comprises the sinuatrial (SAN) and atrioventricular nodes (AVN) and the wiring of the ventricles. The latter comprises the atrioventricular bundle (AVB), the left and right bundle branches (BBs), and the peripheral ventricular conduction system (PVCS).

Top SNP Information

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr6:161010118	rs10455872	LPA	A>G	5135	68564	134.4	4.363e-31	1.192
chr6:160997118	rs74617384	LPA	A>T	5006	66821	131.3	2.103e-30	1.192
chr9:22124477	rs10757278	-	A>G	29247	436853	124.0	8.626e-29	1.1
chr9:22125503	rs1333049	-	G>C	29263	437175	122.6	1.72e-28	1.099
chr9:22098574	rs4977574	-	A>G	29474	440947	121.3	3.311e-28	1.099
chr9:22088260	rs10757272	-	C>T	29569	442179	121.1	3.672e-28	1.098
chr9:22096055	rs10757274	-	A>G	29606	442946	120.1	6.061e-28	1.098
chr9:22125347	rs1333048	-	A>C	30245	453412	115.1	7.569e-27	1.096
chr9:22115959	rs2383207	-	G>A	26670	435369	76.16	2.617e-18	0.928
chr9:22081850	rs6475606	-	C>T	30008	454261	70.89	3.771e-17	1.074
chr8:145639681	rs1871534	SLC39A4	G>C	822	17323	70.4	4.854e-17	0.7404
chr9:22083404	rs1333040	-	T>C	23110	378506	69.94	6.118e-17	0.9297
chr1:159174683	rs2814778	ACKR1	T>C	901	18476	63.43	1.666e-15	0.7611
chr15:48426484	rs1426654	SLC24A5	A>G	1345	26181	61.77	3.855e-15	0.801
chr24:14850341	rs2032598	USP9Y	T>C	123	2689	59.46	1.248e-14	0.497
chr6:12903957	rs9349379	PHACTR1	A>G	24392	367806	59.34	1.324e-14	1.069
chr18:4157690	rs6506185	DLGAP1	T>C	557	12153	59.23	1.404e-14	0.7164
chr9:22068652	rs4977756	-	A>G	22161	361895	57.59	3.223e-14	0.9354
chr2:226686177	rs7581591	-	T>C	940	18895	56.51	5.604e-14	0.7768
chr13:113979972	Affx-80297025	GRTP1	A>ACACT	567	12140	53.64	2.409e-13	0.7298
chr6:161010118	rs10455872	LPA	A>G	5063	67687	135.8	2.219e-31	1.195
chr6:160997118	rs74617384	LPA	A>T	4934	65954	132.5	1.187e-30	1.195
chr9:22125503	rs1333049	-	G>C	27678	416240	99.7	1.777e-23	1.092
chr9:22124477	rs10757278	-	A>G	27668	416438	96.65	8.259e-23	1.09
chr9:22088260	rs10757272	-	C>T	27837	419369	93.85	3.401e-22	1.089
chr9:22096055	rs10757274	-	A>G	28001	422152	92.74	5.971e-22	1.088
chr9:22098574	rs4977574	-	A>G	27902	420824	91.89	9.162e-22	1.088
chr9:22125347	rs1333048	-	A>C	28532	430609	91.87	9.248e-22	1.088
chr9:22115959	rs2383207	-	G>A	25612	420409	85.5	2.315e-20	0.9217
chr9:22081850	rs6475606	-	C>T	27603	417159	80.83	2.464e-19	1.082
chr9:22083404	rs1333040	-	T>C	21852	358706	64.38	1.025e-15	0.9304
chr6:160961137	rs3798220	LPA	T>C	1233	15549	56.99	4.378e-14	1.253
chr6:160922870	rs117733303	-	A>G	1245	15739	56.29	6.247e-14	1.25
chr6:160848743	rs9457925	SLC22A3	G>A	1244	15801	53.9	2.112e-13	1.244
chr9:22068652	rs4977756	-	A>G	21282	347358	45.43	1.58e-11	0.9409
chr6:12903957	rs9349379	PHACTR1	A>G	23031	349937	43.69	3.842e-11	1.061
chr9:21974218	rs3731239	AL359922.1	A>G	19362	316345	41.24	1.348e-10	0.9426
chr6:160687412	rs10080815	SLC22A2	T>G	1278	16859	37.75	8.038e-10	1.197
chr9:22003223	rs3217992	AL359922.1	C>T	20746	315504	36.32	1.677e-09	1.056
chr9:22033366	rs2157719	-	T>C	23126	375096	35.72	2.275e-09	0.9481

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr6:160997118	rs74617384	LPA	A>T	4934	11209	61.57	4.266e-15	1.151
chr6:161010118	rs10455872	LPA	A>G	5063	11546	59.91	9.909e-15	1.146
chr9:22125503	rs1333049	-	G>C	27678	68899	51.43	7.41e-13	1.075
chr9:22125347	rs1333048	-	A>C	28532	71195	48.03	4.19e-12	1.072
chr9:22124477	rs10757278	-	A>G	27668	68983	47.97	4.322e-12	1.072
chr9:22088260	rs10757272	-	C>T	27837	69409	47.34	5.983e-12	1.072
chr9:22096055	rs10757274	-	A>G	28001	69909	45.61	1.44e-11	1.07
chr9:22098574	rs4977574	-	A>G	27902	69693	45.18	1.799e-11	1.07
chr9:22115959	rs2383207	-	G>A	25612	68519	44.22	2.942e-11	0.9352
chr9:22081850	rs6475606	-	C>T	27603	68978	42.44	7.307e-11	1.068
chr9:22083404	rs1333040	-	T>C	21852	58470	34.42	4.448e-09	0.9416
chr9:21974218	rs3731239	AL359922.1	A>G	19362	51859	29.11	6.837e-08	0.9449
chr6:12903957	rs9349379	PHACTR1	A>G	23031	57640	28.04	1.188e-07	1.055
chr1:222826481	rs2291832	MIA3	A>G	14969	40339	27.02	2.018e-07	0.9432
chr1:222823529	rs17465637	MIA3	C>A	14992	40350	26.63	2.465e-07	0.9436
chr6:12901441	rs9369640	PHACTR1	A>C	19368	51774	26.6	2.506e-07	0.9473
chr6:12889004	rs1332844	PHACTR1	T>C	19201	51361	26.47	2.678e-07	0.9473
chr9:22068652	rs4977756	-	A>G	21282	56723	25.68	4.028e-07	0.9491
chr1:222814442	rs2133189	MIA3	T>C	14997	40429	25.48	4.462e-07	0.9447
chr1:222923351	rs6683071	FAM177B	G>A	9641	26282	25.38	4.698e-07	0.936

Associated Diseases ^ⓘ

ID	Name	Top Correlation
ICD: I252	Old myocardial infarction	15/20
ICD: I258	Other forms of chronic ischaemic heart disease	15/20
ICD: I447	Left bundle-branch block, unspecified	3/20

ID	Name	Top Correlation
ICD-10: I249	Acute ischaemic heart disease, unspecified	0/20
ICD-10: I440	Atrioventricular block, first degree	0/20
ICD-10: I441	Atrioventricular block, second degree	0/20
ICD-10: I442	Atrioventricular block, complete	0/20
ICD-10: I443	Other and unspecified atrioventricular block	0/20
ICD-10: I446	Other and unspecified fascicular block	0/20
ICD-10: I451	Other and unspecified right bundle-branch block	0/20
ICD-10: I452	Bifascicular block	0/20
ICD-10: I453	Trifascicular block	0/20
ICD-10: I455	Other specified heart block	0/20
ICD-10: I458	Other specified conduction disorders	0/20
ICD-10: I459	Conduction disorder, unspecified	0/20
ICD-10: I490	Ventricular fibrillation and flutter	0/20
ICD-10: I494	Other and unspecified premature depolarisation	0/20
ICD-10: I495	Sick sinus syndrome	0/20
ICD-10: O622	Other uterine inertia	0/20
ICD-10: R42	Dizziness and giddiness	0/20