Statistics
| Case | Control |
|---|---|
| 8779 | 451415 |
Phenotype Definition
An infection that is caused by a pathogen that would generally not be able to cause an infection in a host with a normal immune system. Such pathogens take advantage of the opportunity, so to speak, that is provided by a weakened immune system. [HPO:probinson]
Phenotype Comment
Opportunistic infection are infections that occur more often or are more severe in people with weakened immune systems than in those with normal immune system functioning.
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 1524 | 65534 | 42.24 | 8.072e-11 | 1.192 |
| chr5:33958959 | rs28777 | SLC45A2 | A>C | 1305 | 55687 | 39.34 | 3.566e-10 | 1.199 |
| chr11:61144707 | rs1377458 | - | T>C | 494 | 19096 | 35.55 | 2.484e-09 | 1.316 |
| chr7:80833070 | rs7790541 | - | G>T | 395 | 14842 | 34.69 | 3.864e-09 | 1.353 |
| chr1:196552378 | rs28620995 | KCNT2 | G>A | 338 | 12450 | 33.93 | 5.709e-09 | 1.381 |
| chr5:35790252 | rs6875303 | SPEF2 | A>G | 288 | 10362 | 33.24 | 8.13e-09 | 1.412 |
| chr16:82033612 | rs16956174 | SDR42E1 | T>C | 672 | 27312 | 32.4 | 1.255e-08 | 1.253 |
| chr10:27981793 | rs57704247 | MKX | G>A | 296 | 10789 | 31.63 | 1.87e-08 | 1.394 |
| chr16:123220 | rs2541636 | RHBDF1 | A>G | 629 | 25484 | 31.36 | 2.145e-08 | 1.258 |
| chr16:82081240 | rs7200711 | HSD17B2 | G>A | 595 | 24121 | 29.33 | 6.12e-08 | 1.256 |
| chr1:31907102 | rs7417775 | SERINC2 | G>A | 905 | 38334 | 29.09 | 6.916e-08 | 1.204 |
| chr4:75160824 | rs16850864 | MTHFD2L | C>T | 485 | 19212 | 29.05 | 7.072e-08 | 1.284 |
| chr16:82031277 | rs9933207 | SDR42E1 | G>A | 637 | 26091 | 28.76 | 8.19e-08 | 1.244 |
| chr12:76330446 | rs11180761 | - | G>C | 332 | 12516 | 28.46 | 9.566e-08 | 1.347 |
| chr23:148151708 | Affx-34694529 | - | A>C | 231 | 8620 | 28.4 | 9.885e-08 | 1.428 |
| chr15:65114484 | rs8031690 | PIF1 | G>A | 306 | 11414 | 28.17 | 1.111e-07 | 1.362 |
| chr1:204446313 | rs2999479 | PIK3C2B | C>T | 667 | 27499 | 28.15 | 1.123e-07 | 1.235 |
| chr3:25898413 | rs6810033 | - | G>A | 4056 | 190380 | 27.94 | 1.249e-07 | 1.099 |
| chr10:28997732 | rs72809676 | - | C>T | 364 | 13956 | 27.85 | 1.309e-07 | 1.326 |
| chr20:46570855 | rs4809668 | - | G>A | 1764 | 79063 | 27.52 | 1.558e-07 | 1.142 |
| chr6:31369151 | rs2523451 | MICA | G>A | 6341 | 309686 | 24.31 | 8.187e-07 | 1.082 |
| chr2:119474615 | rs114211048 | - | C>A | 556 | 23325 | 23.21 | 1.451e-06 | 1.233 |
| chr6:31367865 | rs2523454 | MICA | G>A | 6279 | 307516 | 22.38 | 2.232e-06 | 1.078 |
| chr22:42062767 | rs11703638 | - | G>A | 4996 | 271207 | 20.91 | 4.82e-06 | 0.9257 |
| chr20:49375022 | rs80235356 | - | T>A | 1272 | 57611 | 20.81 | 5.065e-06 | 1.144 |
| chr6:31364707 | rs2251396 | - | G>A | 6100 | 299225 | 20.16 | 7.138e-06 | 1.075 |
| chr6:31221668 | rs3095254 | - | G>C | 5664 | 305719 | 20.13 | 7.248e-06 | 0.9295 |
| chr2:68536253 | rs766405 | CNRIP1 | C>T | 2601 | 144867 | 19.49 | 1.01e-05 | 0.9097 |
| chr16:75104764 | rs62059178 | ZNRF1 | G>A | 1001 | 58838 | 18.9 | 1.378e-05 | 0.8671 |
| chr17:41689963 | rs4793006 | - | C>T | 2598 | 123318 | 18.88 | 1.395e-05 | 1.098 |
| chr6:22321910 | rs12189716 | - | G>A | 243 | 9466 | 18.53 | 1.67e-05 | 1.324 |
| chr14:21049212 | rs1243611 | - | T>G | 5674 | 278097 | 18.52 | 1.685e-05 | 1.073 |
| chr2:104991388 | rs17029778 | - | A>G | 4324 | 210074 | 18.37 | 1.816e-05 | 1.079 |
| chr8:34236992 | rs2609653 | - | T>C | 1192 | 54281 | 18.33 | 1.857e-05 | 1.139 |
| chr15:86765897 | rs1566091 | AGBL1 | T>C | 5088 | 248206 | 18.22 | 1.973e-05 | 1.074 |
| chr6:29548775 | rs6936331 | GABBR1 | C>T | 470 | 29387 | 18.19 | 2.001e-05 | 0.8182 |
| chr19:34068603 | rs75411447 | - | C>T | 586 | 35830 | 18.05 | 2.148e-05 | 0.8355 |
| chr8:34678632 | rs78591047 | - | G>C | 1014 | 45738 | 18.02 | 2.185e-05 | 1.149 |
| chr7:26154344 | rs2158362 | - | C>T | 3891 | 188381 | 17.97 | 2.243e-05 | 1.081 |
| chr6:30781381 | rs915665 | - | G>A | 251 | 16834 | 17.89 | 2.338e-05 | 0.7633 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr17:41689963 | rs4793006 | - | C>T | 2598 | 30511 | 21.38 | 3.767e-06 | 1.108 |
| chr2:119474615 | rs114211048 | - | C>A | 556 | 5841 | 20.84 | 4.996e-06 | 1.228 |
| chr15:86765897 | rs1566091 | AGBL1 | T>C | 5088 | 61605 | 20.66 | 5.497e-06 | 1.082 |
| chr21:43625274 | rs1117640 | ABCG1 | T>G | 1901 | 26940 | 20.24 | 6.828e-06 | 0.8931 |
| chr3:94649263 | rs73179467 | - | T>C | 312 | 5178 | 19.89 | 8.21e-06 | 0.7697 |
| chr16:75104764 | rs62059178 | ZNRF1 | G>A | 1001 | 14754 | 19.49 | 1.009e-05 | 0.8621 |
| chr2:68536253 | rs766405 | CNRIP1 | C>T | 2601 | 36187 | 19.3 | 1.114e-05 | 0.9079 |
| chr20:49375022 | rs80235356 | - | T>A | 1272 | 14411 | 18.69 | 1.537e-05 | 1.14 |
| chr23:32216572 | rs150488914 | DMD | C>T | 279 | 2907 | 18.6 | 1.609e-05 | 1.313 |
| chr3:69359093 | rs78872816 | FRMD4B | G>A | 621 | 6669 | 18.58 | 1.63e-05 | 1.202 |
| chr6:29548775 | rs6936331 | GABBR1 | C>T | 470 | 7364 | 18.23 | 1.958e-05 | 0.8142 |
| chr14:21049212 | rs1243611 | - | T>G | 5674 | 69315 | 18.21 | 1.974e-05 | 1.075 |
| chr12:129510169 | rs11060078 | - | C>T | 1997 | 23296 | 18.08 | 2.121e-05 | 1.111 |
| chr7:26154344 | rs2158362 | - | C>T | 3891 | 46873 | 18.06 | 2.136e-05 | 1.084 |
| chr16:72992763 | rs16971436 | ZFHX3 | T>G | 266 | 2609 | 18.04 | 2.166e-05 | 1.316 |
| chr3:28307354 | rs17695097 | CMC1 | A>G | 938 | 10452 | 18.02 | 2.18e-05 | 1.16 |
| chr9:130294187 | rs41305453 | NIBAN2 | C>T | 615 | 6613 | 18.0 | 2.211e-05 | 1.199 |
| chr23:32882441 | rs5928095 | DMD | A>G | 1658 | 20374 | 18.0 | 2.204e-05 | 1.123 |
| chr5:117745699 | rs75164146 | - | G>A | 697 | 7571 | 17.94 | 2.279e-05 | 1.186 |
| chr15:57869422 | rs117939133 | - | C>T | 344 | 3487 | 17.77 | 2.496e-05 | 1.271 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: B24 | Unspecified human immunodeficiency virus [HIV] disease | 1/20 |
| ICD: C772 | Intra-abdominal lymph nodes | 1/20 |