Abnormal ear morphology

0031703

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

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Interactive Plot

Statistics

Case	Control
54495	405699

Phenotype Definition

Any structural anomaly of the ear. []

Top SNP Information

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr15:48426484	rs1426654	SLC24A5	A>G	2707	24819	107.7	3.135e-25	0.8088
chr8:145639681	rs1871534	SLC39A4	G>C	1705	16440	104.6	1.475e-24	0.7699
chr15:48392165	rs1834640	-	A>G	3188	28436	95.33	1.608e-22	0.8313
chr24:14850341	rs2032598	USP9Y	T>C	217	2595	87.52	8.346e-21	0.5209
chr1:159174683	rs2814778	ACKR1	T>C	1876	17501	87.07	1.045e-20	0.796
chr1:173579034	rs12065033	AL139142.2	C>T	1478	13863	71.71	2.493e-17	0.7924
chr2:163216109	rs3213843	GCA	C>T	1140	11012	70.55	4.484e-17	0.7696
chr13:113979968	rs200506581	GRTP1	C>CCACA	1204	11522	69.25	8.672e-17	0.7767
chr13:113979972	Affx-80297025	GRTP1	A>ACACT	1203	11504	68.67	1.164e-16	0.7774
chr6:170242949	rs9396958	-	T>C	1569	14545	68.59	1.211e-16	0.8016
chr5:147671850	rs7724380	-	G>A	2011	18172	68.45	1.303e-16	0.8221
chr17:29350769	rs8073072	-	T>G	2624	23082	66.17	4.146e-16	0.8442
chr3:188327555	rs7645635	LPP	T>C	1388	12988	65.93	4.673e-16	0.7944
chr10:1411012	rs12762472	ADARB2	G>C	911	8978	65.55	5.659e-16	0.7545
chr6:85483926	rs9450025	-	T>C	933	9151	65.05	7.315e-16	0.7577
chr10:31495974	rs1250307	-	A>G	2305	20467	64.86	8.032e-16	0.8365
chr10:45243171	rs10900107	-	T>C	2525	22220	64.08	1.193e-15	0.8438
chr13:72441665	rs3759505	-	C>T	1646	15069	63.86	1.338e-15	0.8117
chr15:28388274	rs56013620	HERC2	G>A	914	8966	63.41	1.675e-15	0.7582
chr6:136505700	rs6570070	PDE7B	G>C	994	9643	63.39	1.7e-15	0.7667
chr6:396321	rs12203592	IRF4	C>T	24411	174504	42.96	5.584e-11	1.052
chr6:161010118	rs10455872	LPA	A>G	9144	63606	40.18	2.313e-10	1.077
chr6:160997118	rs74617384	LPA	A>T	8906	61982	38.95	4.352e-10	1.077
chr6:421281	rs62389423	-	G>A	19871	141994	35.54	2.501e-09	1.051
chr6:160922870	rs117733303	-	A>G	2253	14731	33.59	6.82e-09	1.142
chr6:160848743	rs9457925	SLC22A3	G>A	2255	14790	32.1	1.462e-08	1.138
chr6:160961137	rs3798220	LPA	T>C	2221	14561	31.71	1.787e-08	1.138
chr2:22594027	rs12616949	-	G>A	37600	272447	30.19	3.917e-08	1.039
chr1:146994158	rs72698227	-	G>A	12701	90183	27.88	1.293e-07	1.055
chr5:141044179	rs62380786	ARAP3	C>T	9655	68083	26.86	2.189e-07	1.061
chr7:107455339	rs117999267	-	T>G	7771	54513	26.7	2.374e-07	1.067
chr8:124760369	rs7460871	-	G>T	6533	51920	26.36	2.827e-07	0.9328
chr9:22096055	rs10757274	-	A>G	54092	396061	26.13	3.194e-07	1.034
chr17:38544624	rs2715555	-	G>A	16031	114673	25.99	3.425e-07	1.048
chr3:116125225	rs13100341	LSAMP	C>T	8237	64931	25.86	3.68e-07	0.94
chr9:22098574	rs4977574	-	A>G	53927	394799	25.69	4.013e-07	1.033
chr8:124758189	rs4870865	-	G>A	4821	38694	25.51	4.392e-07	0.9241
chr6:31364707	rs2251396	-	G>A	36881	268444	25.14	5.334e-07	1.035
chr17:38364764	rs55673000	-	C>T	17188	123276	24.98	5.781e-07	1.045
chr6:94838258	rs577247	-	C>T	46380	351805	24.96	5.855e-07	0.9679

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr4:106488192	rs2866794	ARHGEF38	G>C	3130	611	22.14	2.539e-06	0.8095
chr4:2371942	rs114185195	ZFYVE28	C>T	1152	253	22.07	2.628e-06	0.7211
chr4:106493969	rs2189229	ARHGEF38	G>A	3157	614	21.48	3.57e-06	0.8125
chr4:106488750	rs2903392	ARHGEF38	T>A	3169	616	21.39	3.745e-06	0.8131
chr4:106491203	rs10019722	ARHGEF38	G>T	3139	609	20.87	4.909e-06	0.8142
chr4:106502513	rs199323	ARHGEF38	T>G	3152	611	20.71	5.356e-06	0.8152
chr4:106504630	rs199328	ARHGEF38	A>G	3169	614	20.69	5.396e-06	0.8156
chr17:11438164	rs34970754	SHISA6	G>A	2552	501	19.08	1.255e-05	0.8057
chr9:31669518	rs2044401	-	G>A	23240	3949	18.85	1.412e-05	0.9185
chr2:77649106	rs12713910	LRRTM4	T>G	40612	6165	18.65	1.568e-05	1.077
chr10:131867736	rs1886902	C10orf143	G>A	10018	1420	18.07	2.131e-05	1.134
chr5:115837772	rs154466	SEMA6A	A>G	25662	4340	18.03	2.18e-05	0.9228
chr20:16152550	rs6105537	-	C>T	21246	3615	18.01	2.2e-05	0.9178
chr2:5989536	rs11690032	-	G>T	15681	2705	17.9	2.327e-05	0.9087
chr9:31770522	rs288909	-	C>T	23167	3928	17.53	2.827e-05	0.9212
chr2:75528072	rs115177932	-	C>T	2908	559	17.42	2.994e-05	0.8224
chr16:7467907	rs62015704	RBFOX1	A>G	13727	1989	17.36	3.086e-05	1.112
chr6:55226389	rs114470959	GFRAL	T>C	3406	645	17.08	3.593e-05	0.8348
chr13:84624659	rs9319011	-	A>G	17451	2990	17.05	3.637e-05	0.9142
chr9:21144920	rs10757190	-	C>G	27747	4664	16.94	3.856e-05	0.9267

Associated Diseases ^ⓘ

ID	Name	Top Correlation
ICD: D125	Sigmoid colon	5/20
ICD: H538	Other visual disturbances	2/20
ICD: H544	Blindness, one eye	1/20
ICD: H919	Hearing loss, unspecified	7/20
ICD: I258	Other forms of chronic ischaemic heart disease	2/20
ICD: J039	Acute tonsillitis, unspecified	3/20

ID	Name	Top Correlation
ICD-10: B963	Haemophilus influenzae [H. influenzae] as the cause of diseases classified to other chapters	0/20
ICD-10: C187	Sigmoid colon	0/20
ICD-10: C320	Glottis	0/20
ICD-10: D695	Secondary thrombocytopenia	0/20
ICD-10: F100	Acute intoxication	0/20
ICD-10: F320	Mild depressive episode	0/20
ICD-10: G431	Migraine with aura [classical migraine]	0/20
ICD-10: G438	Other migraine	0/20
ICD-10: G439	Migraine, unspecified	0/20
ICD-10: G519	Disorder of facial nerve, unspecified	0/20
ICD-10: G939	Disorder of brain, unspecified	0/20
ICD-10: G960	Cerebrospinal fluid leak	0/20
ICD-10: H358	Other specified retinal disorders	0/20
ICD-10: H539	Visual disturbance, unspecified	0/20
ICD-10: H571	Ocular pain	0/20
ICD-10: H609	Otitis externa, unspecified	0/20
ICD-10: H611	Non-infective disorders of pinna	0/20
ICD-10: H612	Impacted cerumen	0/20
ICD-10: H618	Other specified disorders of external ear	0/20
ICD-10: H653	Chronic mucoid otitis media	0/20
ICD-10: H654	Other chronic nonsuppurative otitis media	0/20
ICD-10: H659	Nonsuppurative otitis media, unspecified	0/20
ICD-10: H663	Other chronic suppurative otitis media	0/20
ICD-10: H669	Otitis media, unspecified	0/20
ICD-10: H699	Eustachian tube disorder, unspecified	0/20
ICD-10: H71	Cholesteatoma of middle ear	0/20
ICD-10: H720	Central perforation of tympanic membrane	0/20
ICD-10: H728	Other perforations of tympanic membrane	0/20
ICD-10: H729	Perforation of tympanic membrane, unspecified	0/20
ICD-10: H738	Other specified disorders of tympanic membrane	0/20
ICD-10: H740	Tympanosclerosis	0/20
ICD-10: H743	Other acquired abnormalities of ear ossicles	0/20
ICD-10: H809	Otosclerosis, unspecified	0/20
ICD-10: H810	Meniere's disease	0/20
ICD-10: H811	Benign paroxysmal vertigo	0/20
ICD-10: H812	Vestibular neuronitis	0/20
ICD-10: H830	Labyrinthitis	0/20
ICD-10: H901	Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side	0/20
ICD-10: H902	Conductive hearing loss, unspecified	0/20
ICD-10: H903	Sensorineural hearing loss, bilateral	0/20
ICD-10: H904	Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side	0/20
ICD-10: H905	Sensorineural hearing loss, unspecified	0/20
ICD-10: H921	Otorrhoea	0/20
ICD-10: I700	Atherosclerosis of aorta	0/20
ICD-10: I73	Other peripheral vascular diseases	0/20
ICD-10: J029	Acute pharyngitis, unspecified	0/20
ICD-10: J343	Hypertrophy of nasal turbinates	0/20
ICD-10: J392	Other diseases of pharynx	0/20
ICD-10: J398	Other specified diseases of upper respiratory tract	0/20
ICD-10: J61	Pneumoconiosis due to asbestos and other mineral fibres	0/20
ICD-10: L918	Other hypertrophic disorders of skin	0/20
ICD-10: O351	Maternal care for (suspected) chromosomal abnormality in foetus	0/20
ICD-10: Q600	Renal agenesis, unilateral	0/20
ICD-10: R066	Hiccough	0/20
ICD-10: R268	Other and unspecified abnormalities of gait and mobility	0/20
ICD-10: R278	Other and unspecified lack of coordination	0/20
ICD-10: R42	Dizziness and giddiness	0/20
ICD-10: Y450	Opioids and related analgesics	0/20
ICD-10: Y838	Other surgical procedures	0/20
ICD-10: Y839	Surgical procedure, unspecified	0/20
ICD-10: Y86	Sequelae of other accidents	0/20

Abnormal ear morphology

0031703

Normal Case/Contol ⓘ

Sibling Case/Control ⓘ

Links

Statistics

Phenotype Definition

Top SNP Information Show Normal Table Show Sibling SNP

Associated Diseases ⓘ Shared SNP diseases No shared SNP diseases

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

Top SNP Information

Associated Diseases ^ⓘ