Statistics
| Case | Control |
|---|---|
| 19942 | 440252 |
Phenotype Definition
Any anomaly of a reflex, i.e., of an automatic response mediated by the nervous system (a reflex does not need the intervention of conscious thought to occur). []
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr1:32197257 | rs3766823 | ADGRB2 | G>A | 8359 | 173504 | 29.33 | 6.091e-08 | 1.07 |
| chr1:32221913 | rs4949223 | ADGRB2 | G>A | 5886 | 121036 | 26.56 | 2.558e-07 | 1.077 |
| chr1:32178489 | rs4949465 | - | T>C | 6267 | 129284 | 25.88 | 3.637e-07 | 1.074 |
| chr19:1357082 | rs713042 | PWWP3A | C>T | 8888 | 185491 | 25.51 | 4.395e-07 | 1.064 |
| chr22:21385277 | rs76136208 | SLC7A4 | C>T | 438 | 12237 | 25.27 | 4.986e-07 | 0.7826 |
| chr4:101107664 | rs3819182 | DDIT4L | C>A | 17538 | 373401 | 24.57 | 7.155e-07 | 1.051 |
| chr4:101107276 | rs1063821 | DDIT4L | C>A | 19258 | 411134 | 23.48 | 1.265e-06 | 1.049 |
| chr7:13645098 | rs73271426 | - | G>T | 1787 | 34951 | 23.28 | 1.397e-06 | 1.127 |
| chr23:111065460 | rs3027743 | TRPC5 | T>C | 1636 | 32833 | 22.94 | 1.675e-06 | 1.133 |
| chr8:31080602 | rs117879359 | - | T>G | 1063 | 26996 | 22.64 | 1.951e-06 | 0.8602 |
| chr23:109671384 | rs768312 | AMMECR1 | T>C | 781 | 14858 | 22.37 | 2.249e-06 | 1.192 |
| chr7:52140463 | rs4285435 | - | A>G | 17402 | 391982 | 21.9 | 2.873e-06 | 0.9539 |
| chr11:107197606 | rs630693 | CWF19L2 | G>C | 11283 | 257177 | 21.81 | 3.015e-06 | 0.9489 |
| chr8:18362799 | rs17126680 | - | A>G | 1347 | 26016 | 21.24 | 4.043e-06 | 1.14 |
| chr6:93649233 | rs9452168 | - | G>C | 12690 | 288052 | 20.93 | 4.775e-06 | 0.9516 |
| chr16:75130422 | rs62059201 | ZNRF1 | C>G | 1548 | 38101 | 20.62 | 5.604e-06 | 0.887 |
| chr8:18424644 | rs2717720 | PSD3 | A>G | 1051 | 20008 | 20.59 | 5.689e-06 | 1.156 |
| chr9:11504455 | rs117811699 | - | G>A | 923 | 17406 | 20.42 | 6.226e-06 | 1.167 |
| chr5:66227725 | rs16895983 | MAST4 | A>G | 2960 | 59698 | 20.19 | 7.01e-06 | 1.092 |
| chr23:95355485 | rs2808765 | - | C>A | 1576 | 31816 | 20.02 | 7.657e-06 | 1.126 |
| chr19:1357082 | rs713042 | PWWP3A | C>T | 8206 | 171663 | 27.74 | 1.384e-07 | 1.069 |
| chr11:83037095 | rs35727948 | - | G>A | 7418 | 172321 | 23.33 | 1.364e-06 | 0.9385 |
| chr1:154423485 | rs4845626 | IL6R | G>T | 6359 | 148311 | 22.35 | 2.273e-06 | 0.9361 |
| chr8:31080602 | rs117879359 | - | T>G | 1031 | 26322 | 21.6 | 3.366e-06 | 0.8613 |
| chr19:1360575 | rs3826942 | PWWP3A | A>G | 9877 | 209246 | 21.11 | 4.338e-06 | 1.056 |
| chr4:101107276 | rs1063821 | DDIT4L | C>A | 17835 | 383368 | 20.92 | 4.78e-06 | 1.048 |
| chr9:11504455 | rs117811699 | - | G>A | 904 | 17114 | 20.74 | 5.262e-06 | 1.17 |
| chr7:13645098 | rs73271426 | - | G>T | 1431 | 28027 | 20.27 | 6.731e-06 | 1.132 |
| chr7:24405852 | rs17149347 | - | C>T | 2597 | 52561 | 20.23 | 6.857e-06 | 1.098 |
| chr16:75130422 | rs62059201 | ZNRF1 | C>G | 1514 | 37494 | 20.02 | 7.679e-06 | 0.8873 |
| chr20:61370540 | rs3787530 | NTSR1 | A>G | 343 | 9652 | 19.8 | 8.603e-06 | 0.7827 |
| chr4:129878265 | rs35732875 | SCLT1 | C>G | 596 | 15773 | 19.3 | 1.116e-05 | 0.8315 |
| chr19:1361793 | rs2247675 | PWWP3A | C>T | 9847 | 208937 | 19.18 | 1.188e-05 | 1.053 |
| chr4:101107664 | rs3819182 | DDIT4L | C>A | 16332 | 351003 | 18.86 | 1.406e-05 | 1.046 |
| chr6:93649233 | rs9452168 | - | G>C | 12190 | 278117 | 18.64 | 1.575e-05 | 0.9531 |
| chr6:163945092 | rs878096 | QKI | G>A | 1261 | 31420 | 18.53 | 1.67e-05 | 0.882 |
| chr5:89546394 | rs17534590 | - | C>A | 1805 | 35990 | 18.32 | 1.863e-05 | 1.111 |
| chr17:72301432 | rs8073660 | DNAI2 | G>A | 14762 | 316979 | 18.16 | 2.033e-05 | 1.046 |
| chr11:1857243 | rs907608 | SYT8 | G>A | 5710 | 119661 | 18.12 | 2.076e-05 | 1.064 |
| chr20:741847 | rs910857 | SLC52A3 | G>A | 10276 | 235369 | 18.07 | 2.133e-05 | 0.9515 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 3054 | 9980 | 34.38 | 4.535e-09 | 1.134 |
| chr23:102191083 | rs5987498 | - | G>T | 752 | 2280 | 30.18 | 3.93e-08 | 1.263 |
| chr5:33958959 | rs28777 | SLC45A2 | A>C | 2581 | 8445 | 28.22 | 1.083e-07 | 1.131 |
| chr7:13645098 | rs73271426 | - | G>T | 1787 | 5722 | 26.88 | 2.166e-07 | 1.154 |
| chr12:11895194 | rs2724641 | ETV6 | A>G | 1053 | 3245 | 25.23 | 5.093e-07 | 1.197 |
| chr23:101912118 | rs2235804 | GPRASP1 | C>T | 537 | 1597 | 25.12 | 5.397e-07 | 1.286 |
| chr20:62176291 | rs35183165 | SRMS | G>A | 21545 | 77066 | 24.65 | 6.879e-07 | 1.056 |
| chr23:95355485 | rs2808765 | - | C>A | 1576 | 5230 | 24.29 | 8.27e-07 | 1.156 |
| chr23:102201216 | rs725570 | - | A>G | 890 | 2814 | 24.12 | 9.034e-07 | 1.211 |
| chr23:100590471 | rs58400762 | - | C>T | 2711 | 9319 | 24.12 | 9.048e-07 | 1.118 |
| chr1:120057002 | rs6205 | HSD3B1 | T>C | 602 | 1764 | 23.39 | 1.321e-06 | 1.258 |
| chr14:53479254 | rs61094873 | - | C>T | 1505 | 4805 | 23.29 | 1.392e-06 | 1.156 |
| chr5:79685564 | rs6869519 | - | T>C | 2802 | 9307 | 23.24 | 1.427e-06 | 1.113 |
| chr5:33951116 | rs35397 | SLC45A2 | T>G | 4048 | 13709 | 22.53 | 2.068e-06 | 1.093 |
| chr19:1357082 | rs713042 | PWWP3A | C>T | 8888 | 31018 | 22.49 | 2.116e-06 | 1.066 |
| chr23:111065460 | rs3027743 | TRPC5 | T>C | 1636 | 5481 | 22.0 | 2.731e-06 | 1.145 |
| chr3:149925742 | rs7629443 | - | T>C | 985 | 3055 | 21.95 | 2.798e-06 | 1.189 |
| chr5:77118214 | rs353964 | TBCA | C>A | 3787 | 12809 | 21.95 | 2.791e-06 | 1.095 |
| chr2:239916135 | rs12328525 | - | A>G | 8247 | 28763 | 21.69 | 3.207e-06 | 1.067 |
| chr1:32197257 | rs3766823 | ADGRB2 | G>A | 8359 | 29147 | 21.63 | 3.31e-06 | 1.066 |
| chr4:26831827 | rs6448475 | - | T>C | 19685 | 71101 | 21.08 | 4.406e-06 | 1.053 |
| chr19:1357082 | rs713042 | PWWP3A | C>T | 8206 | 28927 | 20.87 | 4.925e-06 | 1.066 |
| chr19:54900248 | rs12973712 | - | C>G | 15776 | 56726 | 20.82 | 5.052e-06 | 1.054 |
| chr8:31080602 | rs117879359 | - | T>G | 1031 | 4437 | 18.85 | 1.412e-05 | 0.859 |
| chr9:137730026 | rs4841939 | COL5A1 | G>A | 10155 | 39280 | 18.48 | 1.715e-05 | 0.946 |
| chr14:77604358 | rs4903546 | AC007375.2 | G>A | 18629 | 67372 | 18.36 | 1.824e-05 | 1.05 |
| chr9:11504455 | rs117811699 | - | G>A | 904 | 2854 | 18.34 | 1.846e-05 | 1.18 |
| chr7:13645098 | rs73271426 | - | G>T | 1431 | 4683 | 18.05 | 2.154e-05 | 1.139 |
| chr6:159111993 | rs6937242 | SYTL3 | A>G | 10523 | 40651 | 17.9 | 2.331e-05 | 0.9474 |
| chr6:136597449 | rs141489829 | BCLAF1 | G>C | 987 | 3148 | 17.61 | 2.705e-05 | 1.168 |
| chr21:25390676 | rs76451370 | - | G>A | 2506 | 10181 | 17.61 | 2.715e-05 | 0.9078 |
| chr20:59903057 | rs6071584 | CDH4 | A>G | 5485 | 19172 | 17.58 | 2.759e-05 | 1.071 |
| chr3:101668515 | rs34818757 | - | CT>C | 7413 | 28886 | 17.46 | 2.929e-05 | 0.9414 |
| chr7:116918085 | rs2228946 | WNT2 | C>T | 8334 | 29517 | 17.25 | 3.278e-05 | 1.06 |
| chr20:62176291 | rs35183165 | SRMS | G>A | 19494 | 70643 | 17.15 | 3.461e-05 | 1.048 |
| chr15:25498993 | rs118022948 | - | G>A | 1177 | 3810 | 17.13 | 3.491e-05 | 1.15 |
| chr14:41476821 | rs12883761 | - | G>A | 5899 | 20709 | 17.1 | 3.546e-05 | 1.068 |
| chr1:152453669 | rs476589 | - | T>G | 8835 | 31391 | 16.94 | 3.862e-05 | 1.058 |
| chr7:81673286 | rs76632162 | CACNA2D1 | G>T | 1987 | 6651 | 16.94 | 3.853e-05 | 1.114 |
| chr14:41437842 | rs1176976 | - | G>C | 6177 | 21689 | 16.94 | 3.858e-05 | 1.067 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: M796 | Pain in limb | 3/20 |