Vulvar intraepithelial neoplasia


Normal Case/Contol

GWAS of 0032202

Sibling Case/Control

No sibling GWAS available 0032202


Case Control
4420 455774

Phenotype Definition

Vulvar intraepithelial neoplasia (VIN) is widely accepted as the precursor lesion of vulvar squamous cell carcinoma (VSCC). VSCC arises via either a human papilloma virus (HPV)-associated pathway, or more commonly, via a mechanism independent of HPV, often being linked to chronic inflammatory conditions such as lichen sclerosus (LS). Accordingly, two distinct subtypes of VIN are recognised: the HPV-associated high-grade squamous intraepithelial lesion/usual VIN (HSIL/uVIN) and the non-HPV-associated differentiated VIN (dVIN). HSIL is clinically identified by its multifocal, warty appearance and on histology by conspicuous cytological and architectural atypia. Differentiated VIN, on the other hand, often produces ill-defined lesions, and on histology, notoriously mimics non-neoplastic epithelial disorders (NNED), particularly LS. As a result, dVIN is rarely identified in advance of a diagnosis of invasive malignancy, despite being the precursor lesion of the majority of VSCC. [NCIT:C4756, PMID:30187167]

Top SNP Information

Associated Diseases

ID Name Top Correlation
ICD: C80 Malignant neoplasm without specification of site 1/20
ICD: D071 Vulva 13/20