Statistics
| Case | Control |
|---|---|
| 2633 | 457561 |
Phenotype Definition
Infection by a Coccidioides species fungus. These are dimorphic, soil-dwelling, fungi known to cause a broad spectrum of disease, ranging from a mild febrile illness to severe pulmonary manifestations or disseminated disease. The genus Coccidioides is comprised of two genetically distinct species: Coccidioides immitis and C. posadasii. [PMID:23843703]
Phenotype Comment
Persons with immunodeficiency diseases, diabetics, transplant recipients, and prisoners are also particularly vulnerable to infection by Coccidioides.
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr17:64956212 | rs79947055 | - | G>T | 350 | 78595 | 28.02 | 1.2e-07 | 0.747 |
| chr16:25862272 | rs12925973 | HS3ST4 | A>G | 1876 | 289970 | 26.52 | 2.611e-07 | 1.159 |
| chr17:71463117 | rs4789644 | SDK2 | C>A | 337 | 43912 | 26.3 | 2.924e-07 | 1.334 |
| chr13:103901222 | rs4772532 | - | T>C | 165 | 19540 | 22.86 | 1.739e-06 | 1.458 |
| chr9:16776792 | rs56343038 | BNC2 | G>T | 2049 | 321607 | 22.76 | 1.84e-06 | 1.141 |
| chr9:138271005 | rs62573677 | - | C>T | 1090 | 211867 | 22.6 | 1.992e-06 | 0.8517 |
| chr4:62994611 | rs115373922 | - | C>T | 117 | 13034 | 21.96 | 2.782e-06 | 1.547 |
| chr7:5475036 | rs58047616 | FBXL18 | A>G | 921 | 136599 | 21.79 | 3.039e-06 | 1.183 |
| chr9:78673256 | rs6560492 | PCSK5 | C>A | 174 | 21065 | 21.34 | 3.856e-06 | 1.427 |
| chr5:33955326 | rs35390 | SLC45A2 | A>C | 308 | 40839 | 20.94 | 4.741e-06 | 1.308 |
| chr6:82161751 | rs72907101 | - | C>T | 153 | 18188 | 20.76 | 5.212e-06 | 1.452 |
| chr8:122124302 | rs2196051 | - | A>G | 2076 | 328160 | 20.51 | 5.929e-06 | 1.134 |
| chr5:33955673 | rs35391 | SLC45A2 | C>T | 306 | 40674 | 20.5 | 5.966e-06 | 1.305 |
| chr22:26516603 | rs134732 | - | A>G | 797 | 117394 | 20.43 | 6.188e-06 | 1.189 |
| chr7:98933689 | rs28655791 | AC004922.1 | A>G | 172 | 20956 | 20.25 | 6.787e-06 | 1.416 |
| chr12:91684837 | rs116905061 | - | C>T | 174 | 21302 | 19.96 | 7.893e-06 | 1.41 |
| chr7:70197277 | rs17604378 | AUTS2 | C>T | 375 | 51284 | 19.82 | 8.517e-06 | 1.269 |
| chr6:148851309 | rs6570862 | SASH1 | T>C | 636 | 92073 | 19.62 | 9.465e-06 | 1.205 |
| chr9:137570132 | rs73665732 | COL5A1 | C>T | 101 | 11202 | 19.31 | 1.112e-05 | 1.552 |
| chr15:74420226 | rs12904268 | ISLR2 | G>T | 1874 | 294437 | 19.21 | 1.169e-05 | 1.132 |
| chr16:25862272 | rs12925973 | HS3ST4 | A>G | 1776 | 277283 | 28.23 | 1.079e-07 | 1.171 |
| chr7:5475036 | rs58047616 | FBXL18 | A>G | 895 | 133266 | 24.79 | 6.385e-07 | 1.201 |
| chr4:62994611 | rs115373922 | - | C>T | 115 | 12686 | 24.19 | 8.71e-07 | 1.587 |
| chr17:64956212 | rs79947055 | - | G>T | 342 | 76391 | 23.41 | 1.308e-06 | 0.7631 |
| chr9:138271005 | rs62573677 | - | C>T | 1030 | 204235 | 23.05 | 1.58e-06 | 0.8461 |
| chr12:91684837 | rs116905061 | - | C>T | 173 | 20983 | 22.92 | 1.688e-06 | 1.447 |
| chr22:26516603 | rs134732 | - | A>G | 763 | 113089 | 22.01 | 2.706e-06 | 1.202 |
| chr11:122912408 | rs9665920 | - | T>C | 839 | 168474 | 21.48 | 3.583e-06 | 0.8397 |
| chr13:53238765 | rs17541218 | SUGT1 | A>C | 317 | 42767 | 21.17 | 4.205e-06 | 1.306 |
| chr17:71463117 | rs4789644 | SDK2 | C>A | 297 | 39799 | 21.01 | 4.559e-06 | 1.315 |
| chr1:237513521 | rs80065345 | RYR2 | A>G | 423 | 59339 | 20.76 | 5.199e-06 | 1.26 |
| chr6:148851309 | rs6570862 | SASH1 | T>C | 590 | 85966 | 20.18 | 7.052e-06 | 1.217 |
| chr9:16640779 | rs77983759 | BNC2 | G>A | 24 | 10065 | 20.04 | 7.573e-06 | 0.4116 |
| chr13:34985979 | rs9599117 | - | G>C | 160 | 19659 | 19.75 | 8.841e-06 | 1.428 |
| chr7:5478419 | rs67223650 | FBXL18 | G>A | 906 | 138129 | 19.45 | 1.032e-05 | 1.176 |
| chr9:7173500 | rs7022054 | KDM4C | G>A | 2157 | 401251 | 19.08 | 1.253e-05 | 0.8845 |
| chr9:130493488 | rs4837178 | TTC16 | A>G | 97 | 10907 | 18.78 | 1.463e-05 | 1.557 |
| chr23:5366090 | rs5915538 | - | A>G | 427 | 59078 | 18.72 | 1.514e-05 | 1.248 |
| chr8:97029284 | rs28452034 | - | G>A | 134 | 16124 | 18.46 | 1.732e-05 | 1.456 |
| chr7:70197277 | rs17604378 | AUTS2 | C>T | 356 | 49562 | 18.4 | 1.786e-05 | 1.266 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr5:33955326 | rs35390 | SLC45A2 | A>C | 308 | 245 | 46.27 | 1.029e-11 | 1.799 |
| chr5:33955673 | rs35391 | SLC45A2 | C>T | 306 | 247 | 44.08 | 3.147e-11 | 1.774 |
| chr5:33958959 | rs28777 | SLC45A2 | A>C | 402 | 364 | 38.53 | 5.384e-10 | 1.583 |
| chr17:2815885 | rs12601261 | RAP1GAP2 | G>A | 380 | 353 | 32.93 | 9.551e-09 | 1.543 |
| chr8:122124302 | rs2196051 | - | A>G | 2076 | 2541 | 31.45 | 2.043e-08 | 1.229 |
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 454 | 443 | 31.2 | 2.328e-08 | 1.469 |
| chr3:69230061 | rs9831516 | FRMD4B | A>G | 136 | 93 | 29.81 | 4.772e-08 | 2.066 |
| chr4:146466875 | rs6833260 | SMAD1 | C>T | 316 | 287 | 29.48 | 5.662e-08 | 1.568 |
| chr5:33951116 | rs35397 | SLC45A2 | T>G | 591 | 617 | 28.41 | 9.791e-08 | 1.378 |
| chr3:69225588 | rs11128118 | FRMD4B | G>T | 167 | 130 | 26.27 | 2.973e-07 | 1.818 |
| chr8:136210764 | rs1564469 | - | G>A | 235 | 205 | 25.66 | 4.067e-07 | 1.629 |
| chr6:22283885 | rs849870 | - | C>T | 877 | 985 | 25.6 | 4.206e-07 | 1.288 |
| chr6:11712988 | rs9469927 | ADTRP | A>G | 131 | 96 | 24.29 | 8.297e-07 | 1.928 |
| chr22:50289925 | rs7410534 | - | C>T | 488 | 505 | 24.24 | 8.504e-07 | 1.382 |
| chr22:50260904 | rs2295407 | ZBED4 | G>A | 502 | 522 | 24.13 | 9.024e-07 | 1.375 |
| chr13:103901222 | rs4772532 | - | T>C | 165 | 134 | 22.79 | 1.805e-06 | 1.742 |
| chr10:78197086 | rs1873467 | LRMDA | C>T | 82 | 50 | 22.77 | 1.827e-06 | 2.308 |
| chr6:56126903 | rs10498810 | COL21A1 | C>A | 769 | 862 | 22.55 | 2.047e-06 | 1.286 |
| chr10:73059827 | rs7915111 | UNC5B | C>G | 410 | 417 | 22.21 | 2.438e-06 | 1.401 |
| chr4:142334172 | rs9684853 | - | T>C | 484 | 870 | 22.08 | 2.615e-06 | 0.7563 |
| chr7:5475036 | rs58047616 | FBXL18 | A>G | 895 | 1046 | 24.13 | 9.023e-07 | 1.275 |
| chr13:53238765 | rs17541218 | SUGT1 | A>C | 317 | 314 | 23.09 | 1.545e-06 | 1.478 |
| chr9:103435244 | rs10989209 | - | T>C | 1443 | 1798 | 21.08 | 4.412e-06 | 1.207 |
| chr10:73073459 | rs74384942 | - | C>T | 392 | 411 | 21.08 | 4.408e-06 | 1.396 |
| chr5:57445697 | rs9292154 | - | C>T | 1066 | 1289 | 20.89 | 4.86e-06 | 1.234 |
| chr12:96883627 | rs117115963 | CFAP54 | G>A | 93 | 229 | 20.23 | 6.861e-06 | 0.5755 |
| chr8:88842121 | rs117451394 | - | A>G | 136 | 112 | 19.88 | 8.267e-06 | 1.764 |
| chr10:73059827 | rs7915111 | UNC5B | C>G | 359 | 375 | 19.85 | 8.381e-06 | 1.402 |
| chr4:142334172 | rs9684853 | - | T>C | 466 | 852 | 19.61 | 9.52e-06 | 0.7649 |
| chr5:158650814 | rs7721001 | - | C>T | 2489 | 3280 | 19.56 | 9.77e-06 | 1.173 |
| chr12:64389009 | rs77295207 | SRGAP1 | C>A | 261 | 257 | 19.45 | 1.032e-05 | 1.482 |
| chr10:130583833 | rs1748360 | - | T>C | 2196 | 2853 | 19.4 | 1.061e-05 | 1.176 |
| chr11:133856393 | rs71477468 | - | G>A | 142 | 315 | 19.32 | 1.105e-05 | 0.6389 |
| chr17:71760874 | rs62064069 | - | G>A | 84 | 59 | 18.94 | 1.346e-05 | 2.071 |
| chr7:5478419 | rs67223650 | FBXL18 | G>A | 906 | 1100 | 18.66 | 1.565e-05 | 1.236 |
| chr8:122124302 | rs2196051 | - | A>G | 1769 | 2276 | 18.55 | 1.651e-05 | 1.181 |
| chr21:41454053 | rs2837425 | DSCAM | T>C | 1324 | 2165 | 18.49 | 1.709e-05 | 0.8387 |
| chr16:17872705 | rs117480498 | - | G>A | 106 | 82 | 18.48 | 1.72e-05 | 1.872 |
| chr11:56143977 | rs12272403 | OR8U1 | A>G | 1722 | 2747 | 18.41 | 1.785e-05 | 0.85 |
| chr5:171866325 | rs74925245 | SH3PXD2B | T>G | 330 | 346 | 18.37 | 1.817e-05 | 1.402 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: B349 | Viral infection, unspecified | 5/20 |
| ID | Name | Top Correlation |
|---|---|---|
| ICD-10: B49 | Unspecified mycosis | 0/20 |
| ICD-10: R071 | Chest pain on breathing | 0/20 |