Statistics
| Case | Control |
|---|---|
| 26824 | 433370 |
Phenotype Definition
Any deviation from the normal cell count per volume of granulocytes in the blood circulation. []
Phenotype Comment
Granulocytes belong to the innate immune system and make up the largest proportion of white blood cells. They are myeloid cells and can be classified as neutrophil granulocytes (neutrophils), eosinophils, basophils, monocytes, and mast cells.
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:396321 | rs12203592 | IRF4 | C>T | 12231 | 188974 | 28.29 | 1.047e-07 | 1.058 |
| chr23:123625325 | rs12393597 | TENM1 | A>G | 2025 | 36364 | 26.16 | 3.142e-07 | 0.8874 |
| chr13:85263874 | rs9546810 | - | C>G | 21549 | 357883 | 25.55 | 4.301e-07 | 0.956 |
| chr2:136407479 | rs1446585 | R3HDM1 | A>G | 15026 | 251372 | 23.96 | 9.84e-07 | 0.9532 |
| chr6:25842951 | rs1408272 | SLC17A3 | T>G | 4529 | 68150 | 23.14 | 1.508e-06 | 1.08 |
| chr14:104165753 | rs861539 | KLC1 | G>A | 19924 | 330769 | 23.09 | 1.542e-06 | 0.9573 |
| chr6:25918225 | rs80215559 | SLC17A2 | T>C | 4389 | 65995 | 22.97 | 1.646e-06 | 1.081 |
| chr2:135837906 | rs7570971 | RAB3GAP1 | C>A | 17200 | 286373 | 22.34 | 2.278e-06 | 0.9565 |
| chr1:169075589 | rs115435245 | ATP1B1 | G>T | 1541 | 22019 | 22.19 | 2.464e-06 | 1.134 |
| chr11:107691369 | rs12794905 | SLC35F2 | A>G | 5612 | 96288 | 21.78 | 3.054e-06 | 0.9347 |
| chr16:81497952 | rs898962 | CMIP | G>A | 22997 | 362475 | 21.03 | 4.529e-06 | 1.041 |
| chr13:100526223 | rs35802185 | CLYBL | AC>A | 4566 | 68952 | 20.88 | 4.9e-06 | 1.075 |
| chr2:105984624 | rs55680124 | FHL2 | C>T | 8913 | 137588 | 20.71 | 5.355e-06 | 1.056 |
| chr3:108549022 | rs9817536 | TRAT1 | G>T | 23093 | 382002 | 20.69 | 5.4e-06 | 0.9608 |
| chr14:104072090 | rs11621777 | KLC1 | A>G | 19390 | 321868 | 20.69 | 5.403e-06 | 0.9594 |
| chr3:158525574 | rs3816637 | MFSD1 | T>C | 14957 | 233795 | 20.1 | 7.361e-06 | 1.045 |
| chr16:20327892 | rs4131902 | GP2 | A>G | 2079 | 37070 | 20.0 | 7.755e-06 | 0.9024 |
| chr11:107756568 | rs35228602 | SLC35F2 | C>T | 5281 | 90594 | 19.83 | 8.482e-06 | 0.936 |
| chr1:35379494 | rs10493065 | DLGAP3 | C>T | 8331 | 140883 | 19.8 | 8.612e-06 | 0.9471 |
| chr22:27407146 | rs6005264 | - | T>G | 14463 | 241359 | 19.64 | 9.332e-06 | 0.957 |
| chr14:104165753 | rs861539 | KLC1 | G>A | 19114 | 318060 | 26.55 | 2.563e-07 | 0.9531 |
| chr6:396321 | rs12203592 | IRF4 | C>T | 12076 | 186839 | 26.52 | 2.602e-07 | 1.057 |
| chr14:104072090 | rs11621777 | KLC1 | A>G | 18547 | 308907 | 25.08 | 5.506e-07 | 0.9542 |
| chr14:53879349 | rs58390329 | - | G>A | 4232 | 73463 | 22.35 | 2.275e-06 | 0.925 |
| chr13:85263874 | rs9546810 | - | C>G | 19776 | 328262 | 22.06 | 2.646e-06 | 0.9576 |
| chr1:7513252 | rs1193247 | CAMTA1 | C>T | 11057 | 171348 | 21.55 | 3.442e-06 | 1.053 |
| chr22:27407146 | rs6005264 | - | T>G | 13500 | 225928 | 21.4 | 3.735e-06 | 0.9537 |
| chr14:104028069 | rs28513222 | BAG5 | A>T | 18327 | 304647 | 21.35 | 3.829e-06 | 0.9576 |
| chr22:27413543 | rs134914 | - | G>A | 26544 | 420019 | 21.03 | 4.533e-06 | 1.042 |
| chr6:25842951 | rs1408272 | SLC17A3 | T>G | 4466 | 67418 | 20.95 | 4.708e-06 | 1.077 |
| chr1:169075589 | rs115435245 | ATP1B1 | G>T | 1516 | 21725 | 20.88 | 4.886e-06 | 1.131 |
| chr6:25918225 | rs80215559 | SLC17A2 | T>C | 4333 | 65362 | 20.86 | 4.945e-06 | 1.078 |
| chr2:206117273 | rs72940337 | PARD3B | C>T | 3394 | 59253 | 20.77 | 5.191e-06 | 0.9202 |
| chr13:100526223 | rs35802185 | CLYBL | AC>A | 4459 | 67327 | 20.56 | 5.776e-06 | 1.076 |
| chr6:25411414 | rs9379762 | CARMIL1 | G>A | 16385 | 272850 | 20.39 | 6.33e-06 | 0.9573 |
| chr1:1374834 | rs1892289 | VWA1 | A>G | 11308 | 176361 | 19.85 | 8.394e-06 | 1.05 |
| chr4:86729352 | rs17010991 | ARHGAP24 | C>A | 1436 | 20620 | 19.17 | 1.197e-05 | 1.129 |
| chr14:61358590 | rs4151307 | MNAT1 | T>C | 1933 | 34528 | 19.15 | 1.207e-05 | 0.9011 |
| chr2:242165212 | rs11693214 | - | C>G | 12887 | 215415 | 19.12 | 1.229e-05 | 0.9555 |
| chr4:166030858 | rs17045969 | TMEM192 | C>T | 1732 | 31107 | 19.03 | 1.289e-05 | 0.8963 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr13:100526223 | rs35802185 | CLYBL | AC>A | 4459 | 6704 | 22.92 | 1.686e-06 | 1.101 |
| chr16:90067184 | rs73283869 | - | G>A | 5019 | 8938 | 22.74 | 1.852e-06 | 0.9153 |
| chr22:27407146 | rs6005264 | - | T>G | 13500 | 23199 | 22.45 | 2.156e-06 | 0.9423 |
| chr10:61734980 | rs55668813 | - | T>C | 2415 | 3520 | 21.67 | 3.239e-06 | 1.134 |
| chr19:50217136 | rs12463356 | - | G>T | 11561 | 18084 | 21.67 | 3.24e-06 | 1.064 |
| chr18:3693751 | rs1861805 | DLGAP1 | A>C | 8491 | 14786 | 21.2 | 4.146e-06 | 0.9338 |
| chr14:98241833 | rs61981611 | - | A>G | 1605 | 2276 | 21.13 | 4.292e-06 | 1.164 |
| chr2:238990388 | rs3210400 | UBE2F-SCLY | G>A | 22204 | 37600 | 20.91 | 4.812e-06 | 0.9505 |
| chr16:90048395 | rs45610233 | - | C>T | 4791 | 8515 | 20.77 | 5.166e-06 | 0.9173 |
| chr16:90067136 | rs78800020 | - | G>C | 5056 | 8971 | 20.71 | 5.345e-06 | 0.9192 |
| chr5:131995843 | rs1295686 | IL13 | C>T | 9521 | 16496 | 20.53 | 5.861e-06 | 0.9376 |
| chr19:50228192 | rs76386660 | - | C>T | 5051 | 7679 | 20.5 | 5.96e-06 | 1.09 |
| chr1:7513252 | rs1193247 | CAMTA1 | C>T | 11057 | 17305 | 20.09 | 7.385e-06 | 1.064 |
| chr12:108707647 | rs2138271 | CMKLR1 | A>G | 16731 | 28508 | 19.92 | 8.058e-06 | 0.9487 |
| chr10:93490163 | rs11186669 | - | T>C | 3221 | 5824 | 19.89 | 8.198e-06 | 0.9038 |
| chr4:55900731 | rs74725474 | - | C>T | 871 | 1720 | 19.8 | 8.617e-06 | 0.8299 |
| chr2:60771729 | rs45565333 | BCL11A | G>C | 2971 | 5392 | 19.76 | 8.789e-06 | 0.9007 |
| chr11:113334206 | rs118168024 | DRD2 | A>G | 998 | 1366 | 19.76 | 8.8e-06 | 1.205 |
| chr4:86729352 | rs17010991 | ARHGAP24 | C>A | 1436 | 2031 | 19.56 | 9.76e-06 | 1.167 |
| chr16:89986117 | Affx-35293625 | MC1R | C>T | 5423 | 9572 | 19.2 | 1.176e-05 | 0.9243 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: N390 | Urinary tract infection, site not specified | 6/20 |