Statistics
| Case | Control |
|---|---|
| 9212 | 450982 |
Phenotype Definition
A malignant epithelial tumor with a glandular organization that originates in the large intestine. []
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr18:46453463 | rs4939827 | SMAD7 | T>C | 8633 | 467470 | 104.3 | 1.713e-24 | 0.8607 |
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 984 | 66074 | 91.01 | 1.432e-21 | 0.731 |
| chr5:33958959 | rs28777 | SLC45A2 | A>C | 850 | 56142 | 69.22 | 8.822e-17 | 0.7459 |
| chr11:111125512 | rs2001754 | C11orf53 | A>G | 6851 | 315797 | 68.27 | 1.428e-16 | 1.134 |
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 353 | 27173 | 67.73 | 1.877e-16 | 0.6431 |
| chr11:111165009 | rs7103178 | - | T>C | 6290 | 288593 | 64.99 | 7.524e-16 | 1.134 |
| chr11:111171709 | rs3802842 | COLCA2 | A>C | 6265 | 287432 | 64.98 | 7.549e-16 | 1.134 |
| chr15:33022090 | rs35330276 | GREM1 | G>A | 3980 | 178506 | 57.14 | 4.069e-14 | 1.146 |
| chr20:60921044 | rs4925386 | LAMA5 | C>T | 5757 | 312474 | 56.93 | 4.509e-14 | 0.8869 |
| chr20:60968596 | rs1570027 | CABLES2 | A>G | 3891 | 216280 | 55.3 | 1.036e-13 | 0.8739 |
| chr15:48392165 | rs1834640 | - | A>G | 442 | 31182 | 53.88 | 2.135e-13 | 0.7019 |
| chr20:60958651 | rs11699160 | - | T>C | 6567 | 353124 | 53.85 | 2.169e-13 | 0.8932 |
| chr6:100241479 | rs9495569 | - | A>G | 298 | 22405 | 50.57 | 1.152e-12 | 0.6604 |
| chr5:33951116 | rs35397 | SLC45A2 | T>G | 1488 | 88620 | 49.38 | 2.111e-12 | 0.8261 |
| chr15:73142636 | rs4777559 | - | C>T | 178 | 14808 | 47.18 | 6.485e-12 | 0.5977 |
| chr17:18907029 | rs2074283 | SLC5A10 | A>G | 577 | 38183 | 45.67 | 1.4e-11 | 0.7505 |
| chr17:9586811 | rs73975789 | USP43 | A>G | 160 | 13500 | 44.73 | 2.264e-11 | 0.5898 |
| chr2:3313043 | rs73133173 | EIPR1 | A>C | 173 | 14290 | 44.53 | 2.507e-11 | 0.6021 |
| chr5:33955673 | rs35391 | SLC45A2 | C>T | 621 | 40359 | 44.12 | 3.091e-11 | 0.7617 |
| chr17:5865515 | rs723656 | AC007846.2 | G>A | 566 | 37230 | 43.97 | 3.334e-11 | 0.7526 |
| chr18:46453463 | rs4939827 | SMAD7 | T>C | 8171 | 430507 | 82.72 | 9.466e-20 | 0.8725 |
| chr15:33022090 | rs35330276 | GREM1 | G>A | 3838 | 167384 | 61.71 | 3.986e-15 | 1.155 |
| chr15:32994756 | rs4779584 | - | C>T | 3899 | 170276 | 61.14 | 5.322e-15 | 1.153 |
| chr11:111165009 | rs7103178 | - | T>C | 6053 | 272740 | 57.86 | 2.809e-14 | 1.128 |
| chr11:111171709 | rs3802842 | COLCA2 | A>C | 6038 | 272105 | 57.61 | 3.192e-14 | 1.128 |
| chr20:60968596 | rs1570027 | CABLES2 | A>G | 3743 | 204013 | 55.21 | 1.081e-13 | 0.8717 |
| chr8:128413305 | rs6983267 | POU5F1B | G>T | 8381 | 434380 | 51.59 | 6.849e-13 | 0.8982 |
| chr11:111125512 | rs2001754 | C11orf53 | A>G | 6669 | 304511 | 48.99 | 2.567e-12 | 1.115 |
| chr8:128407443 | rs10505477 | POU5F1B | A>G | 8578 | 442454 | 45.85 | 1.279e-11 | 0.9039 |
| chr8:117630683 | rs16892766 | - | A>C | 1705 | 71407 | 44.05 | 3.201e-11 | 1.186 |
| chr20:60920700 | rs6143035 | LAMA5 | T>C | 4152 | 222423 | 43.9 | 3.462e-11 | 0.8888 |
| chr20:60958651 | rs11699160 | - | T>C | 6142 | 321476 | 42.13 | 8.53e-11 | 0.9025 |
| chr20:60921044 | rs4925386 | LAMA5 | C>T | 5411 | 284658 | 40.86 | 1.633e-10 | 0.9009 |
| chr8:117640315 | rs11986063 | - | C>T | 1852 | 78534 | 40.64 | 1.827e-10 | 1.171 |
| chr15:33066195 | rs75798403 | FMN1 | C>A | 2680 | 117089 | 38.93 | 4.395e-10 | 1.141 |
| chr18:46453754 | rs35352860 | SMAD7 | C>T | 4559 | 240964 | 37.18 | 1.075e-09 | 0.9002 |
| chr8:128428638 | Affx-31548678 | POU5F1B | G>A | 7109 | 367387 | 33.89 | 5.82e-09 | 0.9146 |
| chr20:60981155 | rs2427323 | CABLES2 | A>G | 8617 | 441414 | 31.9 | 1.624e-08 | 0.9191 |
| chr15:32992658 | rs28399071 | - | G>A | 1943 | 84148 | 31.34 | 2.167e-08 | 1.145 |
| chr11:524055 | rs117970553 | - | C>T | 855 | 34707 | 30.4 | 3.517e-08 | 1.215 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr18:46453463 | rs4939827 | SMAD7 | T>C | 8633 | 34027 | 28.2 | 1.092e-07 | 0.9168 |
| chr12:86374785 | rs113447092 | MGAT4C | G>A | 502 | 1445 | 27.64 | 1.464e-07 | 1.316 |
| chr25:2487317 | rs4892816 | - | T>C | 425 | 2081 | 25.28 | 4.96e-07 | 0.7634 |
| chr3:4628541 | rs4685771 | ITPR1 | C>T | 1602 | 6865 | 24.22 | 8.611e-07 | 0.867 |
| chr11:111165009 | rs7103178 | - | T>C | 6290 | 22320 | 24.01 | 9.59e-07 | 1.089 |
| chr11:111171709 | rs3802842 | COLCA2 | A>C | 6265 | 22271 | 22.79 | 1.803e-06 | 1.087 |
| chr11:111125512 | rs2001754 | C11orf53 | A>G | 6851 | 24474 | 22.28 | 2.362e-06 | 1.084 |
| chr19:46497706 | rs62113402 | - | A>G | 1388 | 5965 | 21.49 | 3.549e-06 | 0.8663 |
| chr2:23839819 | rs669531 | KLHL29 | G>A | 250 | 671 | 21.1 | 4.355e-06 | 1.406 |
| chr7:55128339 | rs1024748 | EGFR | T>G | 3717 | 12957 | 20.82 | 5.048e-06 | 1.099 |
| chr8:128413305 | rs6983267 | POU5F1B | G>T | 8631 | 33790 | 20.17 | 7.068e-06 | 0.9293 |
| chr15:57854923 | rs73410481 | - | C>T | 1560 | 5188 | 19.84 | 8.426e-06 | 1.143 |
| chr11:99275361 | rs7480242 | CNTN5 | C>A | 6943 | 24914 | 19.36 | 1.084e-05 | 1.078 |
| chr20:588166 | rs7270847 | TCF15 | G>A | 8765 | 31676 | 19.06 | 1.268e-05 | 1.074 |
| chr3:22900401 | rs298419 | - | A>G | 1853 | 7755 | 18.94 | 1.352e-05 | 0.8883 |
| chr19:49270230 | rs76576741 | - | G>A | 759 | 3386 | 18.92 | 1.361e-05 | 0.8368 |
| chr8:107556907 | rs17257240 | OXR1 | C>T | 1560 | 5201 | 18.87 | 1.399e-05 | 1.14 |
| chr3:70054531 | rs1472109 | - | G>A | 5824 | 23058 | 18.72 | 1.512e-05 | 0.9265 |
| chr10:58757908 | rs7081131 | - | G>A | 5496 | 19531 | 18.68 | 1.544e-05 | 1.081 |
| chr6:32431147 | rs9268877 | - | G>A | 7123 | 28012 | 18.67 | 1.551e-05 | 0.9298 |
| chr12:86374785 | rs113447092 | MGAT4C | G>A | 493 | 1421 | 25.24 | 5.051e-07 | 1.304 |
| chr18:46453463 | rs4939827 | SMAD7 | T>C | 8171 | 31898 | 24.65 | 6.881e-07 | 0.9204 |
| chr19:46497706 | rs62113402 | - | A>G | 1327 | 5713 | 23.74 | 1.101e-06 | 0.8571 |
| chr15:57854923 | rs73410481 | - | C>T | 1488 | 4845 | 22.96 | 1.654e-06 | 1.159 |
| chr3:4628541 | rs4685771 | ITPR1 | C>T | 1364 | 5835 | 22.55 | 2.045e-06 | 0.862 |
| chr3:4609210 | rs17040924 | ITPR1 | C>T | 525 | 2440 | 21.59 | 3.38e-06 | 0.7973 |
| chr8:128413305 | rs6983267 | POU5F1B | G>T | 8381 | 32596 | 21.38 | 3.764e-06 | 0.9259 |
| chr11:111165009 | rs7103178 | - | T>C | 6053 | 21379 | 20.45 | 6.135e-06 | 1.083 |
| chr25:2487317 | rs4892816 | - | T>C | 352 | 1703 | 20.24 | 6.817e-06 | 0.7669 |
| chr11:111171709 | rs3802842 | COLCA2 | A>C | 6038 | 21346 | 19.91 | 8.126e-06 | 1.082 |
| chr8:107556907 | rs17257240 | OXR1 | C>T | 1521 | 5009 | 19.66 | 9.273e-06 | 1.145 |
| chr12:126979753 | rs117172890 | - | C>T | 407 | 1182 | 19.28 | 1.127e-05 | 1.29 |
| chr18:47344725 | rs1942417 | AC090227.2 | C>A | 4321 | 15082 | 19.14 | 1.214e-05 | 1.09 |
| chr6:32431147 | rs9268877 | - | G>A | 6797 | 26561 | 18.97 | 1.328e-05 | 0.9278 |
| chr12:63064799 | rs12581688 | PPM1H | T>C | 1272 | 4145 | 18.84 | 1.424e-05 | 1.155 |
| chr7:55128339 | rs1024748 | EGFR | T>G | 3644 | 12643 | 18.7 | 1.528e-05 | 1.095 |
| chr8:128407443 | rs10505477 | POU5F1B | A>G | 8578 | 33226 | 18.67 | 1.552e-05 | 0.9306 |
| chr2:45449038 | rs10192473 | - | C>T | 2354 | 7989 | 18.63 | 1.584e-05 | 1.114 |
| chr6:32428186 | rs6923504 | - | C>G | 4781 | 18938 | 18.61 | 1.602e-05 | 0.9219 |
| chr14:51016363 | rs77440659 | MAP4K5 | A>C | 877 | 2781 | 18.49 | 1.705e-05 | 1.186 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: D126 | Colon, unspecified | 5/20 |
| ICD: D128 | Rectum | 5/20 |