Statistics
| Case | Control |
|---|---|
| 3793 | 456401 |
Phenotype Definition
A small, skin-lined tract that leads from the surface to deep within the tissues. []
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr2:2302037 | rs2385135 | MYT1L | T>C | 134 | 9985 | 29.46 | 5.71e-08 | 1.602 |
| chr10:112860526 | rs1343449 | - | A>G | 2888 | 315717 | 28.23 | 1.076e-07 | 1.132 |
| chr23:29736072 | rs73456409 | IL1RAPL1 | G>A | 253 | 20920 | 27.58 | 1.508e-07 | 1.401 |
| chr23:19215613 | rs5955734 | - | C>G | 342 | 29683 | 27.24 | 1.798e-07 | 1.337 |
| chr10:50433556 | rs9645532 | - | C>A | 176 | 14152 | 26.99 | 2.042e-07 | 1.486 |
| chr14:30932217 | rs1956970 | - | A>G | 2456 | 266619 | 26.01 | 3.399e-07 | 1.132 |
| chr16:1135797 | rs28379464 | - | C>T | 635 | 62065 | 25.26 | 5.001e-07 | 1.232 |
| chr2:63415932 | rs1850985 | WDPCP | T>C | 2261 | 245104 | 24.59 | 7.086e-07 | 1.131 |
| chr9:26354809 | rs2785094 | - | A>G | 295 | 26273 | 24.32 | 8.158e-07 | 1.341 |
| chr16:11631394 | rs76554681 | - | C>T | 264 | 23219 | 24.04 | 9.433e-07 | 1.36 |
| chr1:71758154 | rs115416871 | - | G>A | 181 | 14978 | 23.82 | 1.058e-06 | 1.443 |
| chr19:48974704 | rs74963118 | AC008403.1 | T>C | 272 | 24149 | 23.4 | 1.315e-06 | 1.348 |
| chr3:24254806 | rs7644151 | THRB | A>T | 211 | 17991 | 23.33 | 1.363e-06 | 1.401 |
| chr1:3127538 | rs3753758 | PRDM16 | G>A | 374 | 34703 | 23.22 | 1.445e-06 | 1.291 |
| chr12:26425021 | rs11048444 | SSPN | T>C | 276 | 24616 | 22.92 | 1.688e-06 | 1.341 |
| chr1:53652786 | rs61565555 | - | T>C | 318 | 28967 | 22.51 | 2.091e-06 | 1.313 |
| chr3:57004407 | rs9874166 | ARHGEF3 | G>A | 250 | 22037 | 22.45 | 2.159e-06 | 1.356 |
| chr3:53113762 | rs11707575 | AC096887.1 | C>A | 985 | 101330 | 21.93 | 2.833e-06 | 1.173 |
| chr16:29035406 | rs74014848 | - | A>G | 241 | 21240 | 21.77 | 3.075e-06 | 1.357 |
| chr23:19504990 | rs5955796 | MAP3K15 | T>C | 544 | 51366 | 21.47 | 3.593e-06 | 1.231 |
| chr16:11631394 | rs76554681 | - | C>T | 258 | 22617 | 26.4 | 2.77e-07 | 1.385 |
| chr1:71758154 | rs115416871 | - | G>A | 175 | 14657 | 23.35 | 1.347e-06 | 1.447 |
| chr20:34886351 | rs117020274 | - | C>T | 205 | 17676 | 23.21 | 1.453e-06 | 1.407 |
| chr10:112860526 | rs1343449 | - | A>G | 2586 | 287726 | 23.02 | 1.602e-06 | 1.124 |
| chr14:30932217 | rs1956970 | - | A>G | 2212 | 244097 | 22.16 | 2.512e-06 | 1.127 |
| chr10:837079 | rs12772869 | - | C>T | 2773 | 355924 | 21.66 | 3.248e-06 | 0.894 |
| chr3:52956023 | rs3733035 | SFMBT1 | A>G | 1117 | 118287 | 21.0 | 4.603e-06 | 1.161 |
| chr3:52949254 | rs11708337 | SFMBT1 | A>G | 1114 | 118077 | 20.47 | 6.061e-06 | 1.159 |
| chr2:63415932 | rs1850985 | WDPCP | T>C | 2022 | 223092 | 19.96 | 7.927e-06 | 1.124 |
| chr1:64505199 | rs80142387 | ROR1 | A>G | 167 | 14276 | 19.83 | 8.473e-06 | 1.417 |
| chr1:90544935 | rs79312341 | - | C>T | 441 | 43133 | 19.57 | 9.72e-06 | 1.243 |
| chr3:52913279 | rs3796352 | STIMATE-MUSTN1 | C>T | 871 | 90998 | 19.29 | 1.124e-05 | 1.172 |
| chr3:53113762 | rs11707575 | AC096887.1 | C>A | 877 | 91602 | 19.23 | 1.157e-05 | 1.171 |
| chr5:83080228 | rs79680695 | - | C>G | 427 | 41775 | 19.1 | 1.238e-05 | 1.244 |
| chr16:11754556 | rs74008124 | - | T>C | 134 | 11099 | 18.87 | 1.402e-05 | 1.46 |
| chr9:107591478 | rs2066717 | ABCA1 | G>A | 385 | 57408 | 18.77 | 1.474e-05 | 0.797 |
| chr9:107588033 | rs2066715 | ABCA1 | C>T | 385 | 57383 | 18.64 | 1.581e-05 | 0.7976 |
| chr23:113019754 | rs3007202 | - | C>T | 217 | 33567 | 18.54 | 1.66e-05 | 0.7426 |
| chr1:56972543 | rs115145200 | AC119674.2 | C>G | 240 | 21922 | 18.49 | 1.712e-05 | 1.327 |
| chr11:91941510 | rs10765541 | - | C>T | 3622 | 414101 | 18.4 | 1.795e-05 | 1.104 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr2:2302037 | rs2385135 | MYT1L | T>C | 134 | 1841 | 55.65 | 8.657e-14 | 1.936 |
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 661 | 13302 | 49.88 | 1.633e-12 | 1.34 |
| chr5:33958959 | rs28777 | SLC45A2 | A>C | 573 | 11363 | 47.34 | 5.963e-12 | 1.356 |
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 288 | 5050 | 47.2 | 6.408e-12 | 1.523 |
| chr10:50433556 | rs9645532 | - | C>A | 176 | 2804 | 43.61 | 3.998e-11 | 1.67 |
| chr23:19215613 | rs5955734 | - | C>G | 342 | 6114 | 42.04 | 8.943e-11 | 1.445 |
| chr16:29035406 | rs74014848 | - | A>G | 241 | 4216 | 39.97 | 2.583e-10 | 1.525 |
| chr15:48392165 | rs1834640 | - | A>G | 322 | 6000 | 38.32 | 5.997e-10 | 1.432 |
| chr10:45243171 | rs10900107 | - | T>C | 267 | 4819 | 38.04 | 6.921e-10 | 1.48 |
| chr23:71628912 | rs3012642 | AL133500.1 | A>G | 257 | 4463 | 36.63 | 1.427e-09 | 1.482 |
| chr8:141716284 | rs10100025 | PTK2 | G>A | 121 | 1847 | 35.12 | 3.104e-09 | 1.739 |
| chr16:28995057 | rs11859822 | SPNS1 | T>C | 310 | 5840 | 34.7 | 3.838e-09 | 1.417 |
| chr6:170242949 | rs9396958 | - | T>C | 180 | 3048 | 34.49 | 4.274e-09 | 1.571 |
| chr11:68817229 | rs4930259 | TPCN2 | T>C | 195 | 3361 | 34.36 | 4.573e-09 | 1.543 |
| chr3:57004407 | rs9874166 | ARHGEF3 | G>A | 250 | 4541 | 34.1 | 5.247e-09 | 1.466 |
| chr12:3417813 | rs729914 | - | G>T | 175 | 2956 | 33.89 | 5.842e-09 | 1.574 |
| chr19:42393286 | rs717225 | ARHGEF1 | A>G | 234 | 4201 | 33.8 | 6.112e-09 | 1.482 |
| chr1:3127538 | rs3753758 | PRDM16 | G>A | 374 | 7314 | 33.22 | 8.231e-09 | 1.365 |
| chr16:28954860 | rs7203982 | - | T>C | 309 | 5864 | 33.14 | 8.561e-09 | 1.406 |
| chr19:2591597 | rs4807302 | GNG7 | A>G | 214 | 3795 | 33.1 | 8.749e-09 | 1.502 |
| chr16:11631394 | rs76554681 | - | C>T | 258 | 5056 | 25.68 | 4.025e-07 | 1.388 |
| chr1:71758154 | rs115416871 | - | G>A | 175 | 3247 | 23.75 | 1.094e-06 | 1.463 |
| chr10:837079 | rs12772869 | - | C>T | 2773 | 79878 | 22.87 | 1.729e-06 | 0.8898 |
| chr20:34886351 | rs117020274 | - | C>T | 205 | 3971 | 21.87 | 2.918e-06 | 1.402 |
| chr1:64505199 | rs80142387 | ROR1 | A>G | 167 | 3133 | 21.34 | 3.854e-06 | 1.446 |
| chr14:30932217 | rs1956970 | - | A>G | 2212 | 54708 | 20.91 | 4.818e-06 | 1.125 |
| chr5:83080228 | rs79680695 | - | C>G | 427 | 9249 | 20.47 | 6.042e-06 | 1.259 |
| chr1:90544935 | rs79312341 | - | C>T | 441 | 9587 | 20.26 | 6.765e-06 | 1.253 |
| chr10:112860526 | rs1343449 | - | A>G | 2586 | 64742 | 19.73 | 8.911e-06 | 1.116 |
| chr16:11754556 | rs74008124 | - | T>C | 134 | 2449 | 19.56 | 9.76e-06 | 1.482 |
| chr2:138144748 | rs116273254 | THSD7B | A>G | 229 | 4611 | 19.1 | 1.239e-05 | 1.349 |
| chr1:56972543 | rs115145200 | AC119674.2 | C>G | 240 | 4873 | 18.76 | 1.485e-05 | 1.336 |
| chr11:91941510 | rs10765541 | - | C>T | 3622 | 92602 | 18.58 | 1.625e-05 | 1.107 |
| chr14:82624339 | rs17664221 | - | G>T | 394 | 8538 | 18.56 | 1.643e-05 | 1.255 |
| chr1:59401753 | rs72680103 | - | A>G | 96 | 4003 | 18.55 | 1.657e-05 | 0.6414 |
| chr7:97715892 | rs62479768 | - | T>C | 1565 | 46419 | 18.34 | 1.85e-05 | 0.8838 |
| chr11:60809542 | rs117813793 | - | G>T | 267 | 5526 | 18.22 | 1.965e-05 | 1.312 |
| chr2:63415932 | rs1850985 | WDPCP | T>C | 2022 | 50101 | 18.1 | 2.094e-05 | 1.119 |
| chr9:107591478 | rs2066717 | ABCA1 | G>A | 385 | 12814 | 17.82 | 2.433e-05 | 0.7996 |
| chr23:113019754 | rs3007202 | - | C>T | 217 | 7462 | 17.58 | 2.757e-05 | 0.746 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: I730 | Raynaud's syndrome | 2/20 |