Statistics
| Case | Control |
|---|---|
| 25861 | 434333 |
Phenotype Definition
Juvenile aseptic necrosis comprises a group of orthopedic diseases characterized by interruption of the blood supply of a bone, followed by localized bony necrosis most often of the epiphyses of bones of children or teenagers. [HPO:sdoelken]
Phenotype Comment
Causes may be rapid growth, heredity, trauma or overuse and anatomic conformation.
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr12:70732745 | rs79482870 | CNOT2 | T>G | 752 | 15829 | 36.72 | 1.363e-09 | 0.7967 |
| chr18:56629776 | rs12606500 | ZNF532 | A>G | 904 | 18622 | 36.19 | 1.791e-09 | 0.8136 |
| chr9:9860780 | rs2147065 | PTPRD | T>C | 933 | 19034 | 33.87 | 5.898e-09 | 0.8216 |
| chr1:236085940 | rs12038310 | - | C>T | 695 | 14581 | 32.84 | 9.995e-09 | 0.7997 |
| chr3:50070763 | rs7621352 | RBM6 | A>C | 25267 | 436793 | 32.72 | 1.064e-08 | 0.9508 |
| chr3:50174848 | rs7642934 | - | G>A | 25661 | 443157 | 31.64 | 1.859e-08 | 0.9516 |
| chr18:77563334 | rs11665567 | - | G>A | 11765 | 189000 | 30.46 | 3.417e-08 | 1.061 |
| chr3:50129399 | Affx-22412948 | RBM6 | C>T | 26084 | 450172 | 29.94 | 4.446e-08 | 0.9529 |
| chr3:129336433 | rs2811441 | - | T>G | 1099 | 21811 | 29.15 | 6.696e-08 | 0.845 |
| chr3:49902544 | rs9821675 | CAMKV | A>G | 27871 | 458162 | 28.74 | 8.274e-08 | 1.048 |
| chr3:49924940 | rs1062633 | MST1R | C>T | 26016 | 448155 | 28.61 | 8.842e-08 | 0.9539 |
| chr5:137438834 | rs12332207 | - | G>A | 1156 | 22817 | 28.13 | 1.136e-07 | 0.8509 |
| chr3:49936102 | rs2230590 | MST1R | C>T | 26129 | 450263 | 27.85 | 1.31e-07 | 0.9545 |
| chr18:74451915 | rs75755544 | - | C>T | 659 | 13642 | 27.53 | 1.548e-07 | 0.8104 |
| chr23:72674054 | rs2075528 | CDX4 | G>T | 1100 | 20830 | 27.31 | 1.735e-07 | 0.8491 |
| chr18:55114612 | rs606196 | ONECUT2 | T>C | 732 | 14964 | 26.9 | 2.144e-07 | 0.8209 |
| chr8:134194441 | rs60082823 | - | G>A | 1045 | 20692 | 26.72 | 2.35e-07 | 0.8476 |
| chr20:19214390 | rs6136658 | SLC24A3 | G>A | 629 | 13046 | 26.69 | 2.39e-07 | 0.8092 |
| chr3:48819376 | rs12496747 | PRKAR2A | G>T | 3309 | 60890 | 26.58 | 2.53e-07 | 0.9094 |
| chr5:30564820 | Affx-36921901 | - | T>C | 2892 | 53512 | 26.4 | 2.782e-07 | 0.9042 |
| chr3:50070763 | rs7621352 | RBM6 | A>C | 23612 | 406437 | 25.29 | 4.936e-07 | 0.9553 |
| chr2:49013655 | rs11125183 | - | C>T | 17828 | 308743 | 25.01 | 5.715e-07 | 0.9534 |
| chr18:77563334 | rs11665567 | - | G>A | 11265 | 181241 | 24.92 | 5.973e-07 | 1.056 |
| chr3:50174848 | rs7642934 | - | G>A | 24000 | 412421 | 23.18 | 1.477e-06 | 0.9572 |
| chr18:77458464 | rs73009307 | CTDP1 | A>C | 10432 | 167714 | 23.16 | 1.492e-06 | 1.056 |
| chr3:50129399 | Affx-22412948 | RBM6 | C>T | 24119 | 414503 | 22.91 | 1.695e-06 | 0.9575 |
| chr7:114015707 | rs12705960 | FOXP2 | A>C | 25649 | 421483 | 22.59 | 2.007e-06 | 1.044 |
| chr3:69984363 | rs9827888 | MITF | G>T | 531 | 7215 | 22.45 | 2.162e-06 | 1.238 |
| chr18:77473127 | rs2279103 | CTDP1 | C>T | 10525 | 169422 | 21.98 | 2.748e-06 | 1.054 |
| chr3:49902544 | rs9821675 | CAMKV | A>G | 26528 | 436322 | 21.71 | 3.178e-06 | 1.043 |
| chr3:49924940 | rs1062633 | MST1R | C>T | 24368 | 417891 | 21.64 | 3.295e-06 | 0.9586 |
| chr18:77418236 | rs73005566 | - | C>T | 10716 | 172749 | 21.54 | 3.462e-06 | 1.053 |
| chr7:1935598 | rs7791299 | MAD1L1 | T>C | 8352 | 147303 | 21.3 | 3.93e-06 | 0.9448 |
| chr4:7985757 | rs35656451 | ABLIM2 | C>A | 7932 | 126860 | 20.92 | 4.782e-06 | 1.059 |
| chr10:101912064 | rs2862954 | ERLIN1 | T>C | 25175 | 431763 | 20.88 | 4.878e-06 | 0.9594 |
| chr21:40502513 | rs2836904 | - | A>C | 15519 | 252564 | 20.46 | 6.077e-06 | 1.046 |
| chr3:49936102 | rs2230590 | MST1R | C>T | 24473 | 419802 | 20.42 | 6.217e-06 | 0.9598 |
| chr7:111359742 | rs112903241 | - | C>T | 2097 | 31861 | 20.42 | 6.213e-06 | 1.11 |
| chr13:106370135 | rs2391235 | - | A>C | 13077 | 227311 | 20.22 | 6.893e-06 | 0.9543 |
| chr18:77522573 | rs72978132 | - | T>C | 10656 | 171978 | 20.2 | 6.984e-06 | 1.052 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|