Statistics
| Case | Control |
|---|---|
| 8495 | 451699 |
Phenotype Definition
Persistence of the urachal canal with drainage of urine from the bladder through the persistent allantois canal to the umbilicus. [Eurenomics:ewuehl]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr11:111171709 | rs3802842 | COLCA2 | A>C | 5932 | 287765 | 108.3 | 2.292e-25 | 1.182 |
| chr11:111165009 | rs7103178 | - | T>C | 5938 | 288945 | 102.1 | 5.283e-24 | 1.176 |
| chr18:46453463 | rs4939827 | SMAD7 | T>C | 7952 | 468151 | 95.23 | 1.695e-22 | 0.8614 |
| chr11:111125512 | rs2001754 | C11orf53 | A>G | 6405 | 316243 | 90.57 | 1.785e-21 | 1.162 |
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 296 | 27230 | 85.23 | 2.657e-20 | 0.5841 |
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 915 | 66143 | 79.12 | 5.845e-19 | 0.7386 |
| chr15:48392165 | rs1834640 | - | A>G | 364 | 31260 | 78.9 | 6.531e-19 | 0.6257 |
| chr5:33958959 | rs28777 | SLC45A2 | A>C | 759 | 56233 | 76.69 | 1.998e-18 | 0.722 |
| chr1:159174683 | rs2814778 | ACKR1 | T>C | 200 | 19177 | 66.62 | 3.298e-16 | 0.5624 |
| chr16:28995057 | rs11859822 | SPNS1 | T>C | 359 | 29077 | 58.68 | 1.853e-14 | 0.6648 |
| chr2:163216109 | rs3213843 | GCA | C>T | 108 | 12044 | 58.57 | 1.962e-14 | 0.4838 |
| chr16:28954860 | rs7203982 | - | T>C | 360 | 29022 | 57.71 | 3.036e-14 | 0.6674 |
| chr15:89154966 | rs7170666 | - | G>A | 696 | 50050 | 56.93 | 4.527e-14 | 0.7462 |
| chr11:111213944 | rs12365324 | - | G>A | 7406 | 376195 | 56.41 | 5.883e-14 | 1.123 |
| chr1:64273591 | rs659592 | ROR1 | A>G | 416 | 32501 | 56.25 | 6.396e-14 | 0.6891 |
| chr15:45491394 | rs1648299 | SHF | T>C | 182 | 16977 | 54.63 | 1.452e-13 | 0.5788 |
| chr6:3185712 | rs7754077 | - | C>T | 204 | 18468 | 54.61 | 1.471e-13 | 0.596 |
| chr8:145639681 | rs1871534 | SLC39A4 | G>C | 199 | 17946 | 52.67 | 3.95e-13 | 0.5977 |
| chr17:58508582 | rs8071181 | C17orf64 | G>A | 160 | 15257 | 52.0 | 5.542e-13 | 0.5666 |
| chr2:242813574 | rs4075286 | RTP5 | T>C | 367 | 28845 | 51.88 | 5.894e-13 | 0.6837 |
| chr11:111171709 | rs3802842 | COLCA2 | A>C | 5712 | 272431 | 94.59 | 2.343e-22 | 1.173 |
| chr11:111165009 | rs7103178 | - | T>C | 5714 | 273079 | 90.25 | 2.1e-21 | 1.168 |
| chr18:46453463 | rs4939827 | SMAD7 | T>C | 7538 | 431140 | 74.75 | 5.344e-18 | 0.8738 |
| chr11:111125512 | rs2001754 | C11orf53 | A>G | 6244 | 304936 | 69.45 | 7.82e-17 | 1.143 |
| chr8:117630683 | rs16892766 | - | A>C | 1613 | 71499 | 56.8 | 4.819e-14 | 1.22 |
| chr8:117640315 | rs11986063 | - | C>T | 1752 | 78634 | 54.4 | 1.638e-13 | 1.207 |
| chr10:8701219 | rs10795668 | - | G>A | 5119 | 294355 | 44.86 | 2.115e-11 | 0.8931 |
| chr12:51213765 | rs11169571 | ATF1 | T>C | 7252 | 363528 | 41.67 | 1.083e-10 | 1.106 |
| chr8:128413305 | rs6983267 | POU5F1B | G>T | 7767 | 434994 | 39.76 | 2.874e-10 | 0.9067 |
| chr12:51171090 | rs12372718 | ATF1 | A>G | 7254 | 363886 | 39.6 | 3.113e-10 | 1.104 |
| chr12:51203371 | rs1129406 | ATF1 | C>T | 7258 | 364320 | 39.55 | 3.202e-10 | 1.103 |
| chr11:111213944 | rs12365324 | - | G>A | 7274 | 366205 | 36.42 | 1.592e-09 | 1.099 |
| chr8:128407443 | rs10505477 | POU5F1B | A>G | 7939 | 443093 | 36.07 | 1.905e-09 | 0.911 |
| chr18:46453754 | rs35352860 | SMAD7 | C>T | 4191 | 241332 | 36.05 | 1.923e-09 | 0.8978 |
| chr15:33022090 | rs35330276 | GREM1 | G>A | 3457 | 167765 | 34.54 | 4.17e-09 | 1.12 |
| chr15:32992658 | rs28399071 | - | G>A | 1809 | 84282 | 33.92 | 5.756e-09 | 1.157 |
| chr12:51032415 | rs12818741 | DIP2B | A>G | 6360 | 318755 | 33.78 | 6.186e-09 | 1.098 |
| chr18:60845776 | rs72943036 | BCL2 | C>T | 1265 | 78434 | 32.28 | 1.338e-08 | 0.846 |
| chr11:111181120 | rs7947952 | - | T>C | 7373 | 411716 | 31.97 | 1.563e-08 | 0.9153 |
| chr7:46866208 | rs9791388 | - | C>T | 5257 | 261711 | 31.84 | 1.672e-08 | 1.099 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr18:46453463 | rs4939827 | SMAD7 | T>C | 7538 | 1689 | 26.06 | 3.313e-07 | 0.8258 |
| chr17:18907029 | rs2074283 | SLC5A10 | A>G | 406 | 134 | 25.33 | 4.821e-07 | 0.603 |
| chr7:78559214 | rs1799006 | MAGI2 | A>G | 5884 | 1339 | 23.83 | 1.051e-06 | 0.8286 |
| chr10:131328940 | rs117698648 | MGMT | C>T | 317 | 108 | 23.06 | 1.573e-06 | 0.5847 |
| chr16:73513735 | rs77863141 | ZFHX3 | G>A | 1352 | 360 | 22.75 | 1.841e-06 | 0.7426 |
| chr2:164396272 | rs16848587 | - | C>G | 1649 | 427 | 22.73 | 1.868e-06 | 0.7592 |
| chr10:4814268 | rs1901631 | - | C>T | 4692 | 1082 | 22.27 | 2.369e-06 | 0.8259 |
| chr17:18901167 | rs73981278 | SLC5A10 | T>C | 401 | 129 | 21.97 | 2.776e-06 | 0.6197 |
| chr14:94388146 | rs76263849 | FAM181A | C>T | 190 | 72 | 21.73 | 3.135e-06 | 0.527 |
| chr17:18923180 | rs12604020 | SLC5A10 | C>T | 349 | 115 | 21.63 | 3.306e-06 | 0.6048 |
| chr17:18918396 | rs2074279 | SLC5A10 | G>C | 350 | 115 | 21.46 | 3.607e-06 | 0.6061 |
| chr13:72438081 | rs7336486 | DACH1 | G>A | 5892 | 1049 | 21.16 | 4.224e-06 | 1.204 |
| chr9:140127546 | rs35643193 | SLC34A3 | G>C | 254 | 89 | 21.05 | 4.465e-06 | 0.5686 |
| chr17:11687521 | rs7215021 | DNAH9 | G>T | 1153 | 307 | 20.03 | 7.622e-06 | 0.7412 |
| chr15:27122002 | rs28588258 | GABRB3 | C>T | 4958 | 874 | 19.63 | 9.405e-06 | 1.208 |
| chr14:37310551 | rs712363 | SLC25A21 | C>T | 999 | 270 | 19.28 | 1.126e-05 | 0.7319 |
| chr1:212298251 | rs4951570 | - | T>C | 166 | 63 | 19.05 | 1.273e-05 | 0.5271 |
| chr15:32994756 | rs4779584 | - | C>T | 3464 | 588 | 18.93 | 1.356e-05 | 1.238 |
| chr11:111171709 | rs3802842 | COLCA2 | A>C | 5712 | 1022 | 18.56 | 1.644e-05 | 1.192 |
| chr9:24520381 | rs117363973 | - | A>G | 588 | 171 | 18.51 | 1.69e-05 | 0.6834 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: C187 | Sigmoid colon | 2/20 |
| ICD: D125 | Sigmoid colon | 16/20 |
| ID | Name | Top Correlation |
|---|