Statistics
| Case | Control |
|---|---|
| 1346 | 458848 |
Phenotype Definition
A rare cancer originating in the lung or pleural cavity that occurs most often in infants and young children but also has been reported in adults. Pleuropulmonary blastoma is regarded as malignant. [HPO:sdoelken]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr1:12751429 | rs72644525 | - | C>T | 125 | 27656 | 25.6 | 4.201e-07 | 1.584 |
| chr14:31960514 | rs72674803 | NUBPL | C>A | 120 | 26554 | 24.55 | 7.248e-07 | 1.583 |
| chr20:57768655 | rs61743779 | ZNF831 | G>A | 57 | 10312 | 24.54 | 7.284e-07 | 1.921 |
| chr9:27341338 | rs7041639 | MOB3B | A>G | 359 | 96889 | 23.79 | 1.074e-06 | 1.317 |
| chr5:96702380 | rs11135509 | - | T>C | 1498 | 471366 | 23.74 | 1.103e-06 | 1.202 |
| chr7:41625519 | rs55739904 | - | C>T | 102 | 22188 | 22.31 | 2.325e-06 | 1.605 |
| chr5:96565280 | rs17630655 | - | A>G | 1433 | 450026 | 21.86 | 2.931e-06 | 1.192 |
| chr10:125756780 | rs4929806 | - | G>A | 1105 | 339510 | 21.77 | 3.08e-06 | 1.197 |
| chr5:96578141 | rs13162261 | - | A>G | 1469 | 463482 | 21.64 | 3.287e-06 | 1.193 |
| chr5:96623059 | rs2697550 | - | A>C | 1436 | 451509 | 21.31 | 3.907e-06 | 1.19 |
| chr1:82869627 | rs12144783 | - | G>A | 438 | 122713 | 21.12 | 4.307e-06 | 1.27 |
| chr6:5104459 | rs17139428 | LYRM4 | A>G | 54 | 10122 | 20.69 | 5.397e-06 | 1.853 |
| chr6:114736654 | rs72958237 | - | C>T | 70 | 14157 | 20.65 | 5.517e-06 | 1.724 |
| chr5:166812293 | rs72829329 | TENM2 | G>C | 91 | 19676 | 20.31 | 6.576e-06 | 1.611 |
| chr5:96611829 | rs1845658 | - | G>T | 1427 | 450446 | 20.28 | 6.704e-06 | 1.185 |
| chr13:77116983 | rs116949149 | - | G>A | 150 | 36052 | 20.26 | 6.744e-06 | 1.457 |
| chr14:102857796 | rs8008097 | TECPR2 | G>A | 1168 | 362903 | 19.74 | 8.855e-06 | 1.185 |
| chr10:13207277 | rs10906317 | MCM10 | G>C | 1119 | 346840 | 19.37 | 1.077e-05 | 1.185 |
| chr19:54257114 | rs3859499 | - | C>T | 945 | 363537 | 18.96 | 1.333e-05 | 0.8406 |
| chr14:31823484 | rs56202161 | HEATR5A | G>A | 95 | 21075 | 18.84 | 1.424e-05 | 1.569 |
| chr9:27341338 | rs7041639 | MOB3B | A>G | 332 | 86064 | 27.69 | 1.426e-07 | 1.36 |
| chr1:82869627 | rs12144783 | - | G>A | 431 | 117785 | 24.02 | 9.554e-07 | 1.294 |
| chr7:41436977 | rs58974745 | - | C>T | 105 | 22463 | 23.76 | 1.094e-06 | 1.619 |
| chr20:57768655 | rs61743779 | ZNF831 | G>A | 56 | 10083 | 23.72 | 1.112e-06 | 1.912 |
| chr1:12751429 | rs72644525 | - | C>T | 121 | 26839 | 23.43 | 1.294e-06 | 1.565 |
| chr5:96702380 | rs11135509 | - | T>C | 1415 | 440725 | 22.49 | 2.118e-06 | 1.201 |
| chr5:96623059 | rs2697550 | - | A>C | 1348 | 417218 | 22.35 | 2.267e-06 | 1.2 |
| chr7:41625519 | rs55739904 | - | C>T | 101 | 21851 | 21.67 | 3.231e-06 | 1.598 |
| chr5:96578141 | rs13162261 | - | A>G | 1377 | 428886 | 21.6 | 3.363e-06 | 1.198 |
| chr14:31960514 | rs72674803 | NUBPL | C>A | 115 | 25674 | 21.58 | 3.4e-06 | 1.553 |
| chr5:96565280 | rs17630655 | - | A>G | 1339 | 415122 | 21.41 | 3.7e-06 | 1.195 |
| chr6:5104459 | rs17139428 | LYRM4 | A>G | 54 | 9937 | 21.3 | 3.919e-06 | 1.87 |
| chr5:96611829 | rs1845658 | - | G>T | 1337 | 415549 | 21.17 | 4.197e-06 | 1.194 |
| chr6:114736654 | rs72958237 | - | C>T | 70 | 14034 | 20.58 | 5.728e-06 | 1.723 |
| chr1:82847334 | rs3901465 | - | T>G | 358 | 97521 | 20.31 | 6.589e-06 | 1.291 |
| chr14:102857796 | rs8008097 | TECPR2 | G>A | 1128 | 346706 | 19.61 | 9.517e-06 | 1.189 |
| chr17:48124582 | rs16948609 | - | T>G | 454 | 128002 | 19.33 | 1.101e-05 | 1.254 |
| chr6:6904100 | rs72653710 | - | C>T | 153 | 36885 | 19.29 | 1.123e-05 | 1.44 |
| chr14:78904267 | rs1861081 | NRXN3 | A>G | 389 | 107694 | 19.18 | 1.187e-05 | 1.271 |
| chr10:125756780 | rs4929806 | - | G>A | 1070 | 327941 | 18.72 | 1.511e-05 | 1.186 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr7:41436977 | rs58974745 | - | C>T | 105 | 153 | 25.38 | 4.708e-07 | 1.894 |
| chr17:48124547 | rs57554498 | - | T>C | 397 | 810 | 24.48 | 7.498e-07 | 1.384 |
| chr2:137263172 | Affx-17931583 | - | T>C | 382 | 785 | 22.01 | 2.707e-06 | 1.368 |
| chr1:82869627 | rs12144783 | - | G>A | 431 | 901 | 21.97 | 2.776e-06 | 1.346 |
| chr2:137202560 | rs718624 | - | A>G | 356 | 725 | 21.65 | 3.268e-06 | 1.378 |
| chr2:137214361 | rs1346822 | - | G>A | 349 | 711 | 21.37 | 3.785e-06 | 1.378 |
| chr9:27341338 | rs7041639 | MOB3B | A>G | 332 | 673 | 21.01 | 4.572e-06 | 1.385 |
| chr2:137289975 | rs12621476 | - | A>G | 361 | 743 | 20.82 | 5.039e-06 | 1.366 |
| chr5:166812293 | rs72829329 | TENM2 | G>C | 87 | 128 | 20.49 | 5.983e-06 | 1.874 |
| chr1:17645082 | rs77074876 | PADI4 | A>G | 125 | 208 | 19.66 | 9.229e-06 | 1.661 |
| chr16:5596301 | rs7196311 | RBFOX1 | C>A | 64 | 85 | 19.62 | 9.424e-06 | 2.064 |
| chr11:41505846 | rs1506715 | - | G>C | 83 | 377 | 19.07 | 1.262e-05 | 0.5866 |
| chr5:162796184 | rs999581 | - | C>T | 760 | 1755 | 18.57 | 1.639e-05 | 1.245 |
| chr23:13635937 | rs5978653 | EGFL6 | C>T | 149 | 235 | 18.49 | 1.706e-05 | 1.588 |
| chr2:126916243 | rs75718435 | - | C>T | 263 | 933 | 18.42 | 1.772e-05 | 0.7285 |
| chr5:62412761 | rs113116568 | - | T>C | 147 | 258 | 18.41 | 1.777e-05 | 1.57 |
| chr17:32700924 | rs159290 | - | A>G | 1083 | 3276 | 18.18 | 2.014e-05 | 0.8224 |
| chr11:85838808 | rs10792830 | - | G>A | 1073 | 3249 | 17.92 | 2.302e-05 | 0.8235 |
| chr5:96578141 | rs13162261 | - | A>G | 1377 | 3377 | 17.89 | 2.339e-05 | 1.212 |
| chr18:74966736 | rs80051207 | GALR1 | T>G | 154 | 276 | 17.8 | 2.45e-05 | 1.541 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: J984 | Other disorders of lung | 19/20 |
| ID | Name | Top Correlation |
|---|