Neoplasm of the endocrine system

0100568

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

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Statistics

Case	Control
30048	430146

Phenotype Definition

A tumor (abnormal growth of tissue) of the endocrine system. [HPO:probinson]

Top SNP Information

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr5:33951693	rs16891982	SLC45A2	G>C	2994	64064	448.7	1.396e-99	0.668
chr5:33958959	rs28777	SLC45A2	A>C	2552	54440	371.7	7.992e-83	0.6728
chr15:48426484	rs1426654	SLC24A5	A>G	1070	26456	297.7	1.028e-66	0.5848
chr6:396321	rs12203592	IRF4	C>T	14518	186687	287.6	1.662e-64	1.182
chr5:33951116	rs35397	SLC45A2	T>G	4627	85481	264.9	1.494e-59	0.775
chr15:48392165	rs1834640	-	A>G	1381	30243	224.9	7.796e-51	0.6607
chr5:33955673	rs35391	SLC45A2	C>T	1894	39086	224.5	9.321e-51	0.7003
chr5:33955326	rs35390	SLC45A2	A>C	1909	39238	221.5	4.356e-50	0.7029
chr1:159174683	rs2814778	ACKR1	T>C	778	18599	187.0	1.459e-42	0.6075
chr2:171380643	rs34020565	MYO3B	T>G	1078	23781	180.2	4.413e-41	0.6579
chr15:28356859	rs1129038	HERC2	T>C	14641	236296	177.9	1.359e-40	0.8782
chr6:421281	rs62389423	-	G>A	11692	152344	177.6	1.655e-40	1.152
chr6:3185712	rs7754077	-	C>T	754	17918	176.9	2.287e-40	0.611
chr15:28365618	rs12913832	HERC2	G>A	14470	233412	175.9	3.901e-40	0.8784
chr19:42393286	rs717225	ARHGEF1	A>G	930	21013	174.4	7.986e-40	0.6425
chr8:145639681	rs1871534	SLC39A4	G>C	731	17414	173.5	1.269e-39	0.6094
chr2:66725070	rs12995572	MEIS1	G>C	1216	25935	171.3	3.777e-39	0.68
chr5:147671850	rs7724380	-	G>A	843	19340	169.4	9.831e-39	0.633
chr17:5865515	rs723656	AC007846.2	G>A	1811	35985	169.1	1.188e-38	0.7286
chr5:54280007	rs1508890	ESM1	C>A	750	17666	169.0	1.205e-38	0.6169
chr6:396321	rs12203592	IRF4	C>T	14394	184521	210.7	9.501e-48	1.155
chr6:421281	rs62389423	-	G>A	11594	150271	130.0	4.172e-30	1.13
chr16:89986117	Affx-35293625	MC1R	C>T	6825	87366	88.27	5.714e-21	1.133
chr16:89818732	rs12931267	FANCA	C>G	6717	86378	79.87	3.993e-19	1.128
chr20:2290333	rs214803	AL121899.2	A>C	11550	153750	69.01	9.786e-17	1.093
chr16:90067184	rs73283869	-	G>A	6287	81439	64.96	7.657e-16	1.118
chr1:17760098	rs4920607	RCC2	A>G	22820	312837	64.2	1.123e-15	1.072
chr20:33171772	rs910873	PIGU	G>A	6824	88864	63.56	1.558e-15	1.112
chr16:90024202	rs8049897	DEF8	G>A	10976	146303	62.82	2.267e-15	1.091
chr16:90048395	rs45610233	-	C>T	5994	77662	62.06	3.339e-15	1.118
chr16:90067136	rs78800020	-	G>C	6308	81885	61.88	3.655e-15	1.115
chr20:2279955	rs62192643	AL121899.2	G>A	9381	124466	59.19	1.429e-14	1.094
chr20:33082171	rs62212235	ITCH	C>T	6799	89040	57.98	2.652e-14	1.107
chr11:89017961	rs1126809	TYR	G>A	18301	249036	57.95	2.695e-14	1.073
chr16:89755903	rs258322	CDK10	G>A	7598	99971	56.79	4.857e-14	1.101
chr10:8944052	rs76407406	-	A>G	6430	100695	56.02	7.182e-14	0.9031
chr20:33889677	rs666006	-	T>C	6115	79704	55.17	1.108e-13	1.11
chr1:17729903	rs2526828	-	G>A	23600	324938	54.94	1.242e-13	1.066
chr20:33355046	rs4911442	NCOA6	A>G	9104	121020	54.21	1.799e-13	1.091
chr16:90084561	rs11648785	DBNDD1	C>T	16702	251124	53.78	2.241e-13	0.9332

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr6:396321	rs12203592	IRF4	C>T	14394	103735	161.3	5.85e-37	1.138
chr6:421281	rs62389423	-	G>A	11594	84349	99.77	1.712e-23	1.116
chr16:89986117	Affx-35293625	MC1R	C>T	6825	48494	85.18	2.717e-20	1.135
chr16:89818732	rs12931267	FANCA	C>G	6717	47942	77.22	1.528e-18	1.129
chr20:2290333	rs214803	AL121899.2	A>C	11550	85451	65.29	6.466e-16	1.093
chr16:90024202	rs8049897	DEF8	G>A	10976	81071	64.39	1.023e-15	1.094
chr16:90067184	rs73283869	-	G>A	6287	45194	63.06	2.002e-15	1.119
chr10:8944052	rs76407406	-	A>G	6430	56293	60.78	6.397e-15	0.8971
chr16:90048395	rs45610233	-	C>T	5994	43096	60.32	8.06e-15	1.119
chr16:90067136	rs78800020	-	G>C	6308	45457	59.75	1.076e-14	1.116
chr16:89755903	rs258322	CDK10	G>A	7598	55366	58.13	2.457e-14	1.105
chr1:17760098	rs4920607	RCC2	A>G	22820	174062	57.97	2.664e-14	1.07
chr20:2279955	rs62192643	AL121899.2	G>A	9381	69272	53.87	2.144e-13	1.092
chr16:89687407	rs2280374	DPEP1	C>T	6524	47397	52.63	4.019e-13	1.107
chr2:202215492	rs13014235	FLACC1	G>C	24373	186507	51.84	6.029e-13	1.066
chr20:33171772	rs910873	PIGU	G>A	6824	49741	51.41	7.506e-13	1.103
chr16:90084561	rs11648785	DBNDD1	C>T	16702	139484	50.52	1.178e-12	0.9336
chr16:90093075	rs77270200	GAS8	G>A	6682	48714	50.04	1.507e-12	1.103
chr1:17729903	rs2526828	-	G>A	23600	180802	49.07	2.474e-12	1.064
chr20:33082171	rs62212235	ITCH	C>T	6799	49875	46.04	1.158e-11	1.098

Associated Diseases ^ⓘ

ID	Name	Top Correlation
ICD: C442	Skin of ear and external auricular canal	15/20
ICD: C443	Skin of other and unspecified parts of face	14/20
ICD: C444	Skin of scalp and neck	15/20
ICD: C446	Skin of upper limb, including shoulder	9/20
ICD: D231	Skin of eyelid, including canthus	3/20
ICD: D233	Skin of other and unspecified parts of face	4/20
ICD: Y433	Other antineoplastic drugs	1/20

ID	Name	Top Correlation
ICD-10: C181	Appendix	0/20
ICD-10: C252	Tail of pancreas	0/20
ICD-10: C260	Intestinal tract, part unspecified	0/20
ICD-10: C73	Malignant neoplasm of thyroid gland	0/20
ICD-10: C770	Lymph nodes of head, face and neck	0/20
ICD-10: C778	Lymph nodes of multiple regions	0/20
ICD-10: C779	Lymph node, unspecified	0/20
ICD-10: C781	Secondary malignant neoplasm of mediastinum	0/20
ICD-10: C784	Secondary malignant neoplasm of small intestine	0/20
ICD-10: C792	Secondary malignant neoplasm of skin	0/20
ICD-10: C797	Secondary malignant neoplasm of adrenal gland	0/20
ICD-10: D046	Skin of upper limb, including shoulder	0/20
ICD-10: D232	Skin of ear and external auricular canal	0/20
ICD-10: D234	Skin of scalp and neck	0/20
ICD-10: D236	Skin of upper limb, including shoulder	0/20
ICD-10: D239	Skin, unspecified	0/20
ICD-10: D333	Cranial nerves	0/20
ICD-10: D34	Benign neoplasm of thyroid gland	0/20
ICD-10: D350	Adrenal gland	0/20
ICD-10: D351	Parathyroid gland	0/20
ICD-10: D377	Other digestive organs	0/20
ICD-10: D381	Trachea, bronchus and lung	0/20
ICD-10: D485	Skin	0/20
ICD-10: E041	Non-toxic single thyroid nodule	0/20
ICD-10: E210	Primary hyperparathyroidism	0/20
ICD-10: E211	Secondary hyperparathyroidism, not elsewhere classified	0/20
ICD-10: E213	Hyperparathyroidism, unspecified	0/20
ICD-10: E220	Acromegaly and pituitary gigantism	0/20
ICD-10: E249	Cushing's syndrome, unspecified	0/20
ICD-10: E279	Disorder of adrenal gland, unspecified	0/20
ICD-10: H490	Third [oculomotor] nerve palsy	0/20
ICD-10: H531	Subjective visual disturbances	0/20
ICD-10: K140	Glossitis	0/20
ICD-10: K350	Acute appendicitis with generalised peritonitis	0/20
ICD-10: L539	Erythematous condition, unspecified	0/20
ICD-10: N489	Disorder of penis, unspecified	0/20
ICD-10: N601	Diffuse cystic mastopathy	0/20
ICD-10: N608	Other benign mammary dysplasias	0/20
ICD-10: N801	Endometriosis of ovary	0/20
ICD-10: Q446	Cystic disease of liver	0/20
ICD-10: R53	Malaise and fatigue	0/20

Neoplasm of the endocrine system

0100568

Normal Case/Contol ⓘ

Sibling Case/Control ⓘ

Links

Statistics

Phenotype Definition

Top SNP Information Show Normal Table Show Sibling SNP

Associated Diseases ⓘ Shared SNP diseases No shared SNP diseases

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

Top SNP Information

Associated Diseases ^ⓘ