Statistics
| Case | Control |
|---|---|
| 5644 | 454550 |
Phenotype Definition
A multidimensional but common male sexual dysfunction that involves an alteration in any of the components of the erectile response, including organic, relational and psychological. [PMID:27188339]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr15:46732997 | rs1385082 | - | C>G | 393 | 24523 | 24.94 | 5.917e-07 | 1.294 |
| chr15:53677933 | rs77256295 | - | C>T | 298 | 18052 | 23.58 | 1.198e-06 | 1.331 |
| chr6:98896185 | rs1389926 | - | G>A | 515 | 33408 | 23.43 | 1.293e-06 | 1.245 |
| chr4:143173258 | rs72722423 | INPP4B | C>T | 264 | 15940 | 21.24 | 4.053e-06 | 1.334 |
| chr4:172675143 | rs836022 | - | T>C | 772 | 52690 | 20.75 | 5.235e-06 | 1.186 |
| chr2:179750087 | rs2130221 | CCDC141 | T>C | 2123 | 155761 | 19.94 | 7.988e-06 | 1.114 |
| chr2:109825516 | rs12328666 | SH3RF3 | G>A | 4292 | 325769 | 19.63 | 9.421e-06 | 1.089 |
| chr7:10089086 | rs10257866 | - | G>A | 411 | 26558 | 19.26 | 1.141e-05 | 1.248 |
| chr21:44187337 | rs9325640 | PDE9A | A>G | 5337 | 408508 | 19.02 | 1.29e-05 | 1.084 |
| chr1:160014637 | rs73021687 | KCNJ10 | A>C | 308 | 19258 | 18.82 | 1.439e-05 | 1.286 |
| chr2:179747430 | rs10183737 | CCDC141 | T>C | 3171 | 237233 | 18.72 | 1.511e-05 | 1.094 |
| chr2:208560001 | rs76100888 | - | T>C | 482 | 31878 | 18.17 | 2.016e-05 | 1.221 |
| chr16:88445005 | rs12445300 | - | A>G | 1713 | 124567 | 18.16 | 2.026e-05 | 1.118 |
| chr13:31138971 | rs9579604 | HMGB1 | G>T | 535 | 35705 | 18.14 | 2.056e-05 | 1.209 |
| chr6:34041952 | rs76638327 | GRM4 | T>C | 376 | 24227 | 18.08 | 2.124e-05 | 1.251 |
| chr6:42958014 | rs2236355 | PPP2R5D | G>A | 813 | 56297 | 18.05 | 2.148e-05 | 1.168 |
| chr16:56105327 | rs7187149 | - | C>A | 218 | 13110 | 18.03 | 2.177e-05 | 1.339 |
| chr16:65762809 | rs4436778 | - | T>C | 374 | 24108 | 17.97 | 2.24e-05 | 1.251 |
| chr5:66809632 | rs74688520 | - | G>A | 596 | 40255 | 17.95 | 2.267e-05 | 1.196 |
| chr1:87175681 | rs506715 | SH3GLB1 | G>A | 169 | 9770 | 17.93 | 2.291e-05 | 1.39 |
| chr15:53677933 | rs77256295 | - | C>T | 289 | 17435 | 24.48 | 7.501e-07 | 1.345 |
| chr13:30737565 | rs9508660 | - | C>T | 1983 | 175514 | 21.87 | 2.921e-06 | 0.8902 |
| chr4:143173258 | rs72722423 | INPP4B | C>T | 256 | 15458 | 21.41 | 3.709e-06 | 1.342 |
| chr2:109825516 | rs12328666 | SH3RF3 | G>A | 4116 | 313496 | 20.5 | 5.953e-06 | 1.093 |
| chr21:44182517 | rs2269169 | PDE9A | A>C | 4169 | 317400 | 20.14 | 7.193e-06 | 1.092 |
| chr2:208560001 | rs76100888 | - | T>C | 465 | 30498 | 20.11 | 7.327e-06 | 1.238 |
| chr3:114816735 | rs112792492 | ZBTB20 | G>A | 867 | 60285 | 19.94 | 7.974e-06 | 1.172 |
| chr1:87175681 | rs506715 | SH3GLB1 | G>A | 169 | 9654 | 19.93 | 8.028e-06 | 1.415 |
| chr5:66809632 | rs74688520 | - | G>A | 588 | 39539 | 19.81 | 8.538e-06 | 1.209 |
| chr21:44189166 | rs1045382 | PDE9A | T>C | 4221 | 321820 | 19.6 | 9.53e-06 | 1.091 |
| chr4:141001765 | rs114528260 | MAML3 | A>C | 653 | 44517 | 18.82 | 1.439e-05 | 1.192 |
| chr20:5004960 | rs6116613 | - | T>C | 1323 | 119086 | 18.63 | 1.587e-05 | 0.8808 |
| chr2:109883853 | rs6755578 | SH3RF3 | G>A | 3706 | 316325 | 18.57 | 1.638e-05 | 0.9166 |
| chr4:74447930 | rs72649118 | RASSF6 | T>C | 347 | 22256 | 18.32 | 1.869e-05 | 1.264 |
| chr21:44189172 | Affx-18091696 | PDE9A | A>C | 4196 | 320190 | 18.17 | 2.025e-05 | 1.087 |
| chr2:179747430 | rs10183737 | CCDC141 | T>C | 2817 | 211030 | 18.13 | 2.06e-05 | 1.098 |
| chr21:44187337 | rs9325640 | PDE9A | A>G | 4899 | 376587 | 18.03 | 2.174e-05 | 1.085 |
| chr2:179750087 | rs2130221 | CCDC141 | T>C | 1966 | 145263 | 17.87 | 2.363e-05 | 1.111 |
| chr5:67092594 | rs75579685 | - | T>C | 401 | 26227 | 17.78 | 2.477e-05 | 1.241 |
| chr2:177830364 | rs114959394 | - | G>A | 224 | 13625 | 17.72 | 2.556e-05 | 1.33 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr4:141001765 | rs114528260 | MAML3 | A>C | 653 | 1032 | 26.43 | 2.733e-07 | 1.301 |
| chr14:44211100 | rs113774629 | - | C>G | 262 | 362 | 23.18 | 1.476e-06 | 1.48 |
| chr1:87175681 | rs506715 | SH3GLB1 | G>A | 169 | 214 | 21.39 | 3.737e-06 | 1.608 |
| chr10:110449452 | rs4344420 | - | G>A | 5253 | 10063 | 21.09 | 4.375e-06 | 1.112 |
| chr20:5004960 | rs6116613 | - | T>C | 1323 | 3087 | 20.61 | 5.637e-06 | 0.8529 |
| chr2:202529514 | rs17468821 | MPP4 | T>C | 1635 | 2924 | 19.91 | 8.138e-06 | 1.16 |
| chr14:88110899 | rs61982031 | - | G>A | 365 | 551 | 19.71 | 9.029e-06 | 1.354 |
| chr22:33894488 | rs7290423 | LARGE1 | G>A | 3775 | 8209 | 19.56 | 9.765e-06 | 0.8983 |
| chr5:157708424 | rs72804517 | - | G>A | 333 | 885 | 18.43 | 1.762e-05 | 0.756 |
| chr10:53493473 | rs7922491 | PRKG1 | G>A | 1212 | 2823 | 18.21 | 1.979e-05 | 0.8561 |
| chr8:64449881 | rs6998998 | - | C>T | 3172 | 6948 | 18.17 | 2.025e-05 | 0.8974 |
| chr6:132093502 | rs12524635 | - | C>T | 973 | 1674 | 18.13 | 2.066e-05 | 1.196 |
| chr5:86438310 | rs56355793 | - | C>A | 522 | 840 | 18.06 | 2.139e-05 | 1.273 |
| chr15:34318964 | rs2684933 | AVEN | T>C | 1765 | 3192 | 17.82 | 2.423e-05 | 1.145 |
| chr7:106283574 | rs73184247 | - | C>T | 376 | 580 | 17.8 | 2.459e-05 | 1.327 |
| chr12:78221766 | rs11106878 | NAV3 | C>T | 352 | 537 | 17.68 | 2.607e-05 | 1.339 |
| chr5:86465225 | rs75797813 | - | T>C | 517 | 834 | 17.66 | 2.645e-05 | 1.271 |
| chr3:127694318 | rs16839641 | MGLL | A>G | 570 | 931 | 17.61 | 2.714e-05 | 1.256 |
| chr15:41810439 | rs932959 | RPAP1 | G>C | 5006 | 9630 | 17.51 | 2.853e-05 | 1.102 |
| chr1:233613851 | rs4317763 | - | G>A | 246 | 355 | 17.44 | 2.97e-05 | 1.416 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD-10: N480 | Leukoplakia of penis | 0/20 |
| ICD-10: N482 | Other inflammatory disorders of penis | 0/20 |
| ICD-10: N489 | Disorder of penis, unspecified | 0/20 |