Cellulitis

0100658

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

Links

Sex Split

Interactive Plot

Statistics

Case	Control
26188	434006

Phenotype Definition

A bacterial infection and inflammation of the skin und subcutaneous tissues. []

Phenotype Comment

In contrast to impetigo, which is a very superficial skin infection, cellulitis involves both the dermis and the underlying subcutaneous tissue.

Top SNP Information

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr5:33951693	rs16891982	SLC45A2	G>C	2306	64752	605.0	1.373e-133	0.5903
chr15:48426484	rs1426654	SLC24A5	A>G	686	26840	501.5	4.552e-111	0.429
chr5:33958959	rs28777	SLC45A2	A>C	1982	55010	489.5	1.822e-108	0.6004
chr15:48392165	rs1834640	-	A>G	980	30644	371.1	1.094e-82	0.5374
chr6:396321	rs12203592	IRF4	C>T	12850	188355	355.9	2.219e-79	1.218
chr5:33951116	rs35397	SLC45A2	T>G	3774	86334	344.5	6.709e-77	0.7269
chr5:33955326	rs35390	SLC45A2	A>C	1479	39668	309.0	3.593e-69	0.6263
chr5:33955673	rs35391	SLC45A2	C>T	1472	39508	308.7	4.095e-69	0.6257
chr6:3185712	rs7754077	-	C>T	521	18151	274.4	1.226e-61	0.4848
chr19:42393286	rs717225	ARHGEF1	A>G	661	21282	273.1	2.391e-61	0.5243
chr1:159174683	rs2814778	ACKR1	T>C	557	18820	267.4	4.082e-60	0.5001
chr16:28995057	rs11859822	SPNS1	T>C	1001	28435	264.7	1.628e-59	0.5931
chr2:66725070	rs12995572	MEIS1	G>C	904	26247	259.6	2.082e-58	0.5809
chr19:42392441	rs16975619	ARHGEF1	T>C	593	19417	258.1	4.506e-58	0.5161
chr6:170242949	rs9396958	-	T>C	431	15683	255.9	1.377e-57	0.4651
chr19:42391425	rs28521795	ARHGEF1	G>A	546	18276	254.8	2.304e-57	0.5048
chr16:28954860	rs7203982	-	T>C	1020	28362	246.8	1.286e-55	0.6063
chr15:45491394	rs1648299	SHF	T>C	486	16673	244.2	4.893e-55	0.4928
chr8:145639681	rs1871534	SLC39A4	G>C	534	17611	238.1	1.019e-53	0.5123
chr5:147863034	rs9325101	HTR4	A>G	477	16263	235.0	4.955e-53	0.4961
chr6:396321	rs12203592	IRF4	C>T	12737	186178	242.8	9.865e-55	1.178
chr6:421281	rs62389423	-	G>A	10203	151662	137.7	8.418e-32	1.143
chr16:89818732	rs12931267	FANCA	C>G	5985	87110	105.7	8.539e-25	1.157
chr16:89986117	Affx-35293625	MC1R	C>T	6046	88145	104.4	1.646e-24	1.155
chr16:89755903	rs258322	CDK10	G>A	6803	100766	90.91	1.502e-21	1.136
chr2:202143928	rs10931936	CASP8	C>T	14969	231670	89.73	2.736e-21	1.099
chr16:90067184	rs73283869	-	G>A	5604	82122	88.04	6.422e-21	1.147
chr16:89687407	rs2280374	DPEP1	C>T	5850	86130	85.37	2.481e-20	1.141
chr16:90067136	rs78800020	-	G>C	5621	82572	84.89	3.16e-20	1.144
chr16:90048395	rs45610233	-	C>T	5348	78308	84.65	3.557e-20	1.147
chr2:202215492	rs13014235	FLACC1	G>C	21436	339000	72.87	1.385e-17	1.081
chr16:90027626	rs8063761	DEF8	A>T	18928	298004	72.03	2.119e-17	1.083
chr16:90093075	rs77270200	GAS8	G>A	5942	88508	71.23	3.18e-17	1.128
chr2:202122995	rs3769823	CASP8	G>A	15624	244558	67.0	2.714e-16	1.084
chr16:90024202	rs8049897	DEF8	G>A	9627	147652	66.03	4.44e-16	1.099
chr6:475489	rs12210050	-	C>T	11305	174691	65.06	7.252e-16	1.092
chr16:89507330	rs74836424	ANKRD11	C>T	4801	70977	64.32	1.06e-15	1.134
chr20:2290333	rs214803	AL121899.2	A>C	10081	155219	62.01	3.41e-15	1.094
chr16:89434541	rs111460975	ANKRD11	A>G	8423	128725	61.39	4.692e-15	1.101
chr16:90066936	rs4785763	-	C>A	19439	307730	58.82	1.73e-14	1.074

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr5:33951693	rs16891982	SLC45A2	G>C	2306	21394	393.8	1.211e-87	0.6429
chr5:33958959	rs28777	SLC45A2	A>C	1982	18105	309.7	2.527e-69	0.6559
chr15:48426484	rs1426654	SLC24A5	A>G	686	8178	300.9	2.144e-67	0.506
chr6:396321	rs12203592	IRF4	C>T	12850	68324	266.5	6.506e-60	1.197
chr5:33951116	rs35397	SLC45A2	T>G	3774	29364	216.2	6.211e-49	0.7685
chr15:48392165	rs1834640	-	A>G	980	9610	209.2	2.021e-47	0.6156
chr5:33955673	rs35391	SLC45A2	C>T	1472	13168	203.0	4.529e-46	0.6738
chr5:33955326	rs35390	SLC45A2	A>C	1479	13219	202.9	4.887e-46	0.6745
chr6:3185712	rs7754077	-	C>T	521	5826	183.7	7.405e-42	0.5414
chr2:66725070	rs12995572	MEIS1	G>C	904	8670	174.1	9.524e-40	0.6305
chr16:28995057	rs11859822	SPNS1	T>C	1001	9354	171.0	4.446e-39	0.6467
chr19:42393286	rs717225	ARHGEF1	A>G	661	6759	166.9	3.569e-38	0.5922
chr1:159174683	rs2814778	ACKR1	T>C	557	5943	165.5	7.051e-38	0.5679
chr16:28954860	rs7203982	-	T>C	1020	9377	160.7	7.976e-37	0.6576
chr15:45491394	rs1648299	SHF	T>C	486	5315	158.1	3e-36	0.5542
chr19:42392441	rs16975619	ARHGEF1	T>C	593	6148	157.8	3.497e-36	0.5846
chr19:42391425	rs28521795	ARHGEF1	G>A	546	5767	156.2	7.64e-36	0.5737
chr6:421281	rs62389423	-	G>A	10299	55682	156.0	8.308e-36	1.16
chr6:3189788	rs4327734	-	C>T	394	4519	150.9	1.118e-34	0.5288
chr6:170242949	rs9396958	-	T>C	431	4802	149.1	2.678e-34	0.5447
chr6:396321	rs12203592	IRF4	C>T	12737	67535	191.5	1.502e-43	1.166
chr6:421281	rs62389423	-	G>A	10203	54955	108.7	1.891e-25	1.133
chr16:89986117	Affx-35293625	MC1R	C>T	6046	31756	91.99	8.691e-22	1.154
chr16:89818732	rs12931267	FANCA	C>G	5985	31448	90.02	2.354e-21	1.152
chr2:202143928	rs10931936	CASP8	C>T	14969	83314	82.38	1.123e-19	1.1
chr16:89755903	rs258322	CDK10	G>A	6803	36259	81.51	1.744e-19	1.136
chr16:89687407	rs2280374	DPEP1	C>T	5850	30925	79.42	5.014e-19	1.144
chr16:90067184	rs73283869	-	G>A	5604	29563	78.36	8.589e-19	1.146
chr16:90048395	rs45610233	-	C>T	5348	28187	75.49	3.674e-18	1.146
chr16:90067136	rs78800020	-	G>C	5621	29729	75.36	3.918e-18	1.143
chr16:90027626	rs8063761	DEF8	A>T	18928	107193	66.19	4.085e-16	1.083
chr16:90024202	rs8049897	DEF8	G>A	9627	52949	64.68	8.805e-16	1.104
chr16:90093075	rs77270200	GAS8	G>A	5942	31865	63.08	1.981e-15	1.126
chr2:202215492	rs13014235	FLACC1	G>C	21436	122103	62.83	2.251e-15	1.079
chr2:202122995	rs3769823	CASP8	G>A	15624	87950	61.59	4.233e-15	1.085
chr16:89434541	rs111460975	ANKRD11	A>G	8423	46153	60.04	9.293e-15	1.105
chr20:2290333	rs214803	AL121899.2	A>C	10081	55714	59.6	1.161e-14	1.097
chr16:90066936	rs4785763	-	C>A	19439	110656	54.65	1.437e-13	1.075
chr16:89507330	rs74836424	ANKRD11	C>T	4801	25666	52.96	3.397e-13	1.127
chr6:475489	rs12210050	-	C>T	11305	63123	51.66	6.592e-13	1.086

Associated Diseases ^ⓘ

ID	Name	Top Correlation
ICD: C442	Skin of ear and external auricular canal	12/20
ICD: C443	Skin of other and unspecified parts of face	18/20
ICD: C444	Skin of scalp and neck	13/20
ICD: C446	Skin of upper limb, including shoulder	7/20
ICD: L031	Cellulitis of other parts of limb	10/20

ID	Name	Top Correlation
ICD-10: A46	Erysipelas	0/20
ICD-10: B963	Haemophilus influenzae [H. influenzae] as the cause of diseases classified to other chapters	0/20
ICD-10: H050	Acute inflammation of orbit	0/20
ICD-10: H601	Cellulitis of external ear	0/20
ICD-10: I801	Phlebitis and thrombophlebitis of femoral vein	0/20
ICD-10: K046	Periapical abscess with sinus	0/20
ICD-10: K047	Periapical abscess without sinus	0/20
ICD-10: K122	Cellulitis and abscess of mouth	0/20
ICD-10: L030	Cellulitis of finger and toe	0/20
ICD-10: L032	Cellulitis of face	0/20
ICD-10: L033	Cellulitis of trunk	0/20
ICD-10: L038	Cellulitis of other sites	0/20
ICD-10: L039	Cellulitis, unspecified	0/20
ICD-10: L088	Other specified local infections of skin and subcutaneous tissue	0/20
ICD-10: L089	Local infection of skin and subcutaneous tissue, unspecified	0/20
ICD-10: L988	Other specified disorders of skin and subcutaneous tissue	0/20
ICD-10: M704	Prepatellar bursitis	0/20