Abnormality of the lymphatic system

0100763

Normal Case/Contol ^ⓘ

Sibling Case/Control ^ⓘ

Links

Sex Split

Interactive Plot

Statistics

Case	Control
73739	386455

Phenotype Definition

An anomaly of the lymphatic system, a network of lymphatic vessels that carry a clear fluid called lymph unidirectionally towards either the right lymphatic duct or the thoracic duct, which in turn drain into the right and left subclavian veins respectively. [HPO:probinson]

Top SNP Information

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr1:169519049	rs6025	F5	C>T	3883	17830	54.89	1.272e-13	1.142
chr23:64367019	rs7064929	-	G>A	3153	14413	49.49	1.992e-12	1.15
chr23:142717383	rs73577386	SLITRK4	A>G	1428	6194	42.15	8.432e-11	1.211
chr23:63423664	rs5964740	AMER1	C>T	4223	19877	41.59	1.127e-10	1.118
chr23:63410110	rs61730681	AMER1	T>C	4221	19912	39.77	2.861e-10	1.115
chr23:67891077	rs7886230	STARD8	T>C	6763	32670	39.16	3.898e-10	1.09
chr23:109671384	rs768312	AMMECR1	T>C	2782	12857	36.82	1.297e-09	1.137
chr2:26113913	rs78404020	-	A>G	1961	11856	36.22	1.766e-09	0.8628
chr23:10722712	rs7878745	MID1	T>C	12319	61069	34.88	3.502e-09	1.063
chr23:110685534	rs16986503	-	C>T	2237	10246	33.9	5.812e-09	1.147
chr9:136143442	rs612169	ABO	A>G	51808	264646	33.52	7.053e-09	1.035
chr9:136149229	rs505922	ABO	T>C	51257	261803	33.23	8.204e-09	1.034
chr23:148151708	Affx-34694529	-	A>C	1614	7237	32.59	1.14e-08	1.171
chr9:136137065	rs687621	ABO	A>G	51712	264253	32.19	1.4e-08	1.034
chr23:10867175	rs6530417	-	C>G	12368	61484	32.19	1.401e-08	1.061
chr23:153733911	rs5986987	-	C>G	2044	9337	32.03	1.516e-08	1.149
chr18:74451915	rs75755544	-	C>T	2053	12248	31.39	2.107e-08	0.8742
chr23:106146349	rs5962774	MORC4	T>C	1980	9046	31.05	2.518e-08	1.149
chr23:55985953	rs7885685	-	A>G	5161	24910	30.11	4.077e-08	1.09
chr9:136142203	rs514659	ABO	A>C	49859	255061	29.98	4.357e-08	1.033
chr1:169519049	rs6025	F5	C>T	3770	17312	55.41	9.772e-14	1.145
chr9:136149229	rs505922	ABO	T>C	47660	244233	28.88	7.685e-08	1.033
chr9:136143442	rs612169	ABO	A>G	47845	245298	27.84	1.318e-07	1.033
chr1:169514006	rs1018827	F5	G>A	9283	45913	27.47	1.596e-07	1.064
chr9:136137065	rs687621	ABO	A>G	47753	244994	26.57	2.547e-07	1.032
chr2:22515568	rs12373752	-	A>G	70284	362613	26.49	2.647e-07	1.03
chr1:169477574	rs6687813	-	C>A	9234	45757	25.75	3.886e-07	1.062
chr1:169491555	rs2420371	F5	A>G	9234	45775	25.29	4.939e-07	1.061
chr9:136155000	rs635634	-	C>T	27424	139538	24.49	7.487e-07	1.037
chr9:136142203	rs514659	ABO	A>C	46147	236987	24.48	7.516e-07	1.031
chr9:136139265	rs657152	ABO	C>A	50805	261166	24.22	8.583e-07	1.03
chr3:3472604	rs6772761	-	C>T	35447	190340	24.05	9.396e-07	0.9679
chr16:30566747	rs17850402	ZNF764	G>A	15112	75963	23.97	9.797e-07	1.047
chr9:136149399	rs507666	ABO	G>A	27603	140521	23.5	1.252e-06	1.036
chr9:10615489	rs6474563	-	A>G	13948	70069	23.23	1.438e-06	1.048
chr9:126701570	rs62579217	-	A>G	8027	39726	23.14	1.509e-06	1.062
chr9:136142355	rs643434	ABO	G>A	50961	262063	23.01	1.609e-06	1.029
chr9:136132908	rs8176719	ABO	T>TC	50804	261479	22.91	1.701e-06	1.029
chr18:50723283	rs17487484	DCC	T>G	74693	386111	22.52	2.076e-06	1.028
chr4:37196736	rs115544851	-	T>C	4743	23073	22.51	2.087e-06	1.08

Location	SNP	Gene	Ref>Alt	Alt in Case	Alt in Control	Chi-square	P-value	Odds ratio
chr1:169519049	rs6025	F5	C>T	3770	9889	62.59	2.543e-15	1.166
chr9:136149229	rs505922	ABO	T>C	47660	141529	33.21	8.271e-09	1.038
chr9:136143442	rs612169	ABO	A>G	47845	142128	32.61	1.126e-08	1.037
chr9:136137065	rs687621	ABO	A>G	47753	141968	30.55	3.245e-08	1.036
chr1:169514006	rs1018827	F5	G>A	9283	26515	30.16	3.986e-08	1.071
chr9:136142203	rs514659	ABO	A>C	46147	137373	28.62	8.826e-08	1.035
chr9:136139265	rs657152	ABO	C>A	50805	151378	28.42	9.779e-08	1.034
chr9:136142355	rs643434	ABO	G>A	50961	151872	27.26	1.774e-07	1.034
chr9:136132908	rs8176719	ABO	T>TC	50804	151580	27.06	1.968e-07	1.034
chr1:169477574	rs6687813	-	C>A	9234	26484	26.5	2.64e-07	1.066
chr1:169491555	rs2420371	F5	A>G	9234	26514	25.4	4.668e-07	1.065
chr9:136155000	rs635634	-	C>T	27424	80984	23.98	9.742e-07	1.039
chr2:63149557	rs2710642	EHBP1	A>G	47492	147771	23.85	1.04e-06	0.9692
chr9:10615489	rs6474563	-	A>G	13948	40604	23.8	1.068e-06	1.052
chr1:169099137	rs75112989	ATP1B1	G>A	8870	25500	23.35	1.347e-06	1.063
chr9:136149399	rs507666	ABO	G>A	27603	81577	22.84	1.764e-06	1.038
chr21:40112319	rs2836654	-	T>C	56653	175341	22.81	1.788e-06	0.9701
chr6:69053045	rs78677827	-	G>A	3030	10180	22.56	2.041e-06	0.9055
chr1:169428944	rs1208134	CCDC181	T>C	8714	25100	21.34	3.843e-06	1.061
chr11:86968612	rs117641739	TMEM135	A>G	6430	18338	21.3	3.935e-06	1.071

Associated Diseases ^ⓘ

ID	Name	Top Correlation
ICD: B24	Unspecified human immunodeficiency virus [HIV] disease	5/20
ICD: D472	Monoclonal gammopathy	2/20
ICD: D869	Sarcoidosis, unspecified	1/20
ICD: H538	Other visual disturbances	1/20
ICD: I800	Phlebitis and thrombophlebitis of superficial vessels of lower extremities	1/20
ICD: I802	Phlebitis and thrombophlebitis of other deep vessels of lower extremities	5/20
ICD: I803	Phlebitis and thrombophlebitis of lower extremities, unspecified	1/20
ICD: J039	Acute tonsillitis, unspecified	1/20
ICD: M254	Effusion of joint	1/20
ICD: M549	Dorsalgia, unspecified	5/20
ICD: O721	Other immediate postpartum haemorrhage	1/20
ICD: R590	Localised enlarged lymph nodes	1/20
ICD: R69	Unknown and unspecified causes of morbidity	3/20

ID	Name	Top Correlation
ICD-10: A045	Campylobacter enteritis	0/20
ICD-10: A081	Acute gastro-enteropathy due to Norwalk agent	0/20
ICD-10: A09	Diarrhoea and gastro-enteritis of presumed infectious origin	0/20
ICD-10: A46	Erysipelas	0/20
ICD-10: A491	Streptococcal infection, unspecified	0/20
ICD-10: B349	Viral infection, unspecified	0/20
ICD-10: B370	Candidal stomatitis	0/20
ICD-10: B80	Enterobiasis	0/20
ICD-10: B963	Haemophilus influenzae [H. influenzae] as the cause of diseases classified to other chapters	0/20
ICD-10: C099	Tonsil, unspecified	0/20
ICD-10: C181	Appendix	0/20
ICD-10: C252	Tail of pancreas	0/20
ICD-10: C770	Lymph nodes of head, face and neck	0/20
ICD-10: C771	Intrathoracic lymph nodes	0/20
ICD-10: C772	Intra-abdominal lymph nodes	0/20
ICD-10: C778	Lymph nodes of multiple regions	0/20
ICD-10: C779	Lymph node, unspecified	0/20
ICD-10: C781	Secondary malignant neoplasm of mediastinum	0/20
ICD-10: C782	Secondary malignant neoplasm of pleura	0/20
ICD-10: C786	Secondary malignant neoplasm of retroperitoneum and peritoneum	0/20
ICD-10: C829	Follicular non-Hodgkin's lymphoma, unspecified	0/20
ICD-10: C857	Other specified types of non-Hodgkin's lymphoma	0/20
ICD-10: D180	Haemangioma, any site	0/20
ICD-10: D695	Secondary thrombocytopenia	0/20
ICD-10: D730	Hyposplenism	0/20
ICD-10: D735	Infarction of spleen	0/20
ICD-10: D759	Disease of blood and blood-forming organs, unspecified	0/20
ICD-10: D860	Sarcoidosis of lung	0/20
ICD-10: D868	Sarcoidosis of other and combined sites	0/20
ICD-10: E789	Disorder of lipoprotein metabolism, unspecified	0/20
ICD-10: E835	Disorders of calcium metabolism	0/20
ICD-10: E854	Organ-limited amyloidosis	0/20
ICD-10: G553	Nerve root and plexus compressions in other dorsopathies	0/20
ICD-10: G700	Myasthenia gravis	0/20
ICD-10: I700	Atherosclerosis of aorta	0/20
ICD-10: I808	Phlebitis and thrombophlebitis of other sites	0/20
ICD-10: I809	Phlebitis and thrombophlebitis of unspecified site	0/20
ICD-10: I81	Portal vein thrombosis	0/20
ICD-10: I850	Oesophageal varices with bleeding	0/20
ICD-10: I859	Oesophageal varices without bleeding	0/20
ICD-10: I891	Lymphangitis	0/20
ICD-10: I898	Other specified non-infective disorders of lymphatic vessels and lymph nodes	0/20
ICD-10: I972	Postmastectomy lymphoedema syndrome	0/20
ICD-10: I982	Oesophageal varices in diseases classified elsewhere	0/20
ICD-10: J029	Acute pharyngitis, unspecified	0/20
ICD-10: J040	Acute laryngitis	0/20
ICD-10: J069	Acute upper respiratory infection, unspecified	0/20
ICD-10: J180	Bronchopneumonia, unspecified	0/20
ICD-10: J209	Acute bronchitis, unspecified	0/20
ICD-10: J312	Chronic pharyngitis	0/20
ICD-10: J343	Hypertrophy of nasal turbinates	0/20
ICD-10: J350	Chronic tonsillitis	0/20
ICD-10: J351	Hypertrophy of tonsils	0/20
ICD-10: J36	Peritonsillar abscess	0/20
ICD-10: J392	Other diseases of pharynx	0/20
ICD-10: J920	Pleural plaque with presence of asbestos	0/20
ICD-10: J929	Pleural plaque without asbestos	0/20
ICD-10: K351	Acute appendicitis with peritoneal abscess	0/20
ICD-10: K358	Acute appendicitis, other and unspecified	0/20
ICD-10: K359	Acute appendicitis, unspecified	0/20
ICD-10: K36	Other appendicitis	0/20
ICD-10: K37	Unspecified appendicitis	0/20
ICD-10: K500	Crohn's disease of small intestine	0/20
ICD-10: K510	Ulcerative (chronic) enterocolitis	0/20
ICD-10: K639	Disease of intestine, unspecified	0/20
ICD-10: K766	Portal hypertension	0/20
ICD-10: K821	Hydrops of gallbladder	0/20
ICD-10: L032	Cellulitis of face	0/20
ICD-10: L088	Other specified local infections of skin and subcutaneous tissue	0/20
ICD-10: L089	Local infection of skin and subcutaneous tissue, unspecified	0/20
ICD-10: L720	Epidermal cyst	0/20
ICD-10: M500	Cervical disk disorder with myelopathy	0/20
ICD-10: N600	Solitary cyst of breast	0/20
ICD-10: N649	Disorder of breast, unspecified	0/20
ICD-10: N760	Acute vaginitis	0/20
ICD-10: Q387	Pharyngeal pouch	0/20
ICD-10: R070	Pain in throat	0/20
ICD-10: R100	Acute abdomen	0/20
ICD-10: R161	Splenomegaly, not elsewhere classified	0/20
ICD-10: R162	Hepatomegaly with splenomegaly, not elsewhere classified	0/20
ICD-10: R500	Fever with chills	0/20
ICD-10: R591	Generalised enlarged lymph nodes	0/20
ICD-10: R599	Enlarged lymph nodes, unspecified	0/20
ICD-10: R688	Other specified general symptoms and signs	0/20
ICD-10: R935	Abnormal findings on diagnostic imaging of other abdominal regions, including retroperitoneum	0/20
ICD-10: Y848	Other medical procedures	0/20

Abnormality of the lymphatic system

0100763

Normal Case/Contol ⓘ

Sibling Case/Control ⓘ