Statistics
| Case | Control |
|---|---|
| 2475 | 457719 |
Phenotype Definition
A tumor (abnormal growth of tissue) of the middle ear. [HPO:probinson]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr16:77643421 | rs280872 | - | T>C | 1360 | 214350 | 42.76 | 6.187e-11 | 1.229 |
| chr8:145639681 | rs1871534 | SLC39A4 | G>C | 42 | 18103 | 32.72 | 1.064e-08 | 0.423 |
| chr2:230524218 | rs12469914 | DNER | A>G | 56 | 21162 | 30.71 | 3.001e-08 | 0.4823 |
| chr6:37328215 | Affx-28571852 | RNF8 | C>CT | 49 | 19267 | 30.04 | 4.232e-08 | 0.4637 |
| chr16:29790864 | rs235636 | ZG16 | A>G | 25 | 12796 | 28.71 | 8.428e-08 | 0.3573 |
| chr2:230526908 | rs7587835 | DNER | T>C | 70 | 24029 | 28.58 | 9.013e-08 | 0.5307 |
| chr1:159174683 | rs2814778 | ACKR1 | T>C | 51 | 19326 | 28.08 | 1.166e-07 | 0.4818 |
| chr3:25315167 | rs118046543 | RARB | A>G | 114 | 12936 | 27.57 | 1.513e-07 | 1.639 |
| chr1:173579034 | rs12065033 | AL139142.2 | C>T | 36 | 15305 | 26.97 | 2.064e-07 | 0.4299 |
| chr18:19763011 | rs3764962 | GATA6 | A>G | 70 | 23565 | 26.84 | 2.209e-07 | 0.5408 |
| chr13:31074486 | rs7326905 | HMGB1 | G>A | 19 | 10590 | 25.99 | 3.43e-07 | 0.3282 |
| chr8:145754187 | rs115228909 | C8orf82 | C>G | 33 | 14304 | 25.95 | 3.509e-07 | 0.4217 |
| chr7:40230346 | rs6462963 | SUGCT | T>C | 2592 | 444420 | 25.55 | 4.31e-07 | 1.15 |
| chr12:123645323 | rs1260317 | MPHOSPH9 | T>C | 58 | 20387 | 25.49 | 4.44e-07 | 0.519 |
| chr6:136480972 | rs9483910 | PDE7B | C>T | 62 | 21308 | 25.34 | 4.814e-07 | 0.5308 |
| chr16:77669306 | rs381534 | - | C>T | 1540 | 254090 | 24.78 | 6.44e-07 | 1.163 |
| chr14:21022833 | rs1620265 | - | G>T | 78 | 24866 | 24.55 | 7.244e-07 | 0.5719 |
| chr5:83128858 | rs7709612 | - | A>G | 22 | 11072 | 24.33 | 8.099e-07 | 0.3637 |
| chr10:65947548 | rs12258356 | - | G>A | 72 | 23364 | 24.2 | 8.689e-07 | 0.5618 |
| chr11:67218909 | rs949252 | GPR152 | A>G | 21 | 10755 | 24.08 | 9.265e-07 | 0.3577 |
| chr16:77643421 | rs280872 | - | T>C | 1287 | 205282 | 36.21 | 1.774e-09 | 1.216 |
| chr3:25315167 | rs118046543 | RARB | A>G | 87 | 9396 | 25.83 | 3.722e-07 | 1.726 |
| chr7:40230346 | rs6462963 | SUGCT | T>C | 2407 | 412746 | 24.98 | 5.799e-07 | 1.153 |
| chr3:171206292 | rs13353477 | - | C>T | 157 | 19688 | 24.4 | 7.844e-07 | 1.491 |
| chr15:39275222 | rs117386953 | - | T>A | 118 | 14128 | 22.76 | 1.839e-06 | 1.557 |
| chr3:93883598 | rs62266122 | - | T>C | 232 | 31635 | 22.34 | 2.29e-06 | 1.374 |
| chr2:175974284 | rs76932609 | ATF2 | A>G | 163 | 21021 | 21.84 | 2.957e-06 | 1.45 |
| chr7:131730348 | rs77008163 | - | C>T | 485 | 73432 | 20.95 | 4.725e-06 | 1.245 |
| chr16:77617417 | rs627237 | - | T>C | 2299 | 454615 | 20.44 | 6.139e-06 | 0.8787 |
| chr2:31496483 | rs77684026 | - | T>A | 195 | 26240 | 20.35 | 6.441e-06 | 1.39 |
| chr7:19052733 | rs57301765 | - | G>A | 875 | 140534 | 20.18 | 7.047e-06 | 1.183 |
| chr1:216608268 | rs11582099 | - | G>A | 719 | 154542 | 19.42 | 1.049e-05 | 0.837 |
| chr5:54053955 | rs116526835 | - | T>G | 129 | 16290 | 19.29 | 1.125e-05 | 1.478 |
| chr7:40096299 | rs12533272 | CDK13 | C>T | 2230 | 383923 | 19.28 | 1.131e-05 | 1.134 |
| chr2:220417364 | rs181520135 | OBSL1 | G>T | 95 | 11283 | 18.91 | 1.37e-05 | 1.566 |
| chr16:77669306 | rs381534 | - | C>T | 1450 | 242722 | 18.67 | 1.553e-05 | 1.145 |
| chr16:77675995 | rs11649438 | - | G>T | 823 | 132874 | 18.06 | 2.14e-05 | 1.177 |
| chr17:68736046 | rs9891034 | - | G>A | 558 | 87136 | 18.02 | 2.19e-05 | 1.211 |
| chr20:12669310 | rs1333387 | - | G>T | 222 | 31037 | 17.92 | 2.302e-05 | 1.337 |
| chr1:19975330 | rs3790744 | NBL1 | G>A | 820 | 132265 | 17.67 | 2.63e-05 | 1.175 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr3:171206292 | rs13353477 | - | C>T | 157 | 548 | 29.89 | 4.582e-08 | 1.644 |
| chr16:77643421 | rs280872 | - | T>C | 1287 | 6343 | 26.86 | 2.186e-07 | 1.201 |
| chr7:40230346 | rs6462963 | SUGCT | T>C | 2407 | 12552 | 25.49 | 4.451e-07 | 1.169 |
| chr7:131730348 | rs77008163 | - | C>T | 485 | 2187 | 22.55 | 2.05e-06 | 1.284 |
| chr1:19975330 | rs3790744 | NBL1 | G>A | 820 | 3925 | 22.31 | 2.326e-06 | 1.219 |
| chr3:25315167 | rs118046543 | RARB | A>G | 87 | 282 | 21.54 | 3.468e-06 | 1.762 |
| chr15:97330588 | rs77846453 | - | G>A | 685 | 4603 | 20.89 | 4.865e-06 | 0.8171 |
| chr17:68736046 | rs9891034 | - | G>A | 558 | 2589 | 20.61 | 5.63e-06 | 1.251 |
| chr4:185862699 | rs75143313 | - | A>C | 563 | 2615 | 20.17 | 7.078e-06 | 1.247 |
| chr7:40096299 | rs12533272 | CDK13 | C>T | 2230 | 11675 | 19.69 | 9.129e-06 | 1.148 |
| chr2:198477131 | rs79647329 | RFTN2 | G>A | 167 | 649 | 19.63 | 9.376e-06 | 1.475 |
| chr10:4175910 | rs79335867 | - | A>G | 275 | 2048 | 19.42 | 1.049e-05 | 0.7477 |
| chr2:31496483 | rs77684026 | - | T>A | 195 | 783 | 19.29 | 1.121e-05 | 1.428 |
| chr15:39275222 | rs117386953 | - | T>A | 118 | 427 | 19.05 | 1.271e-05 | 1.577 |
| chr12:83337951 | rs33984139 | TMTC2 | A>G | 237 | 983 | 18.96 | 1.332e-05 | 1.379 |
| chr3:93883598 | rs62266122 | - | T>C | 232 | 964 | 18.77 | 1.476e-05 | 1.381 |
| chr7:19052733 | rs57301765 | - | G>A | 875 | 4273 | 18.56 | 1.648e-05 | 1.192 |
| chr4:22918823 | rs11937105 | - | T>C | 73 | 235 | 18.45 | 1.744e-05 | 1.771 |
| chr19:31569303 | rs76683701 | - | G>A | 133 | 501 | 18.13 | 2.06e-05 | 1.519 |
| chr20:51952041 | rs79255890 | TSHZ2 | C>A | 350 | 1555 | 17.98 | 2.231e-05 | 1.296 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: H729 | Perforation of tympanic membrane, unspecified | 2/20 |